Abstract：
:Remarkably complex patterns of aneuploidy have been observed in the genomes of many eukaryotic cell types, ranging from brewing yeasts to tumor cells. Such aberrant karyotypes are generally thought to take shape progressively over many generations, but evidence also suggests that genomes may undergo faster modes of evolution. Here, we used diploid Saccharomyces cerevisiae cells to investigate the dynamics with which aneuploidies arise. We found that cells selected for the loss of a single chromosome often acquired additional unselected aneuploidies concomitantly. The degrees to which these genomes were altered fell along a spectrum, ranging from simple events affecting just a single chromosome, to systemic events involving many. The striking complexity of karyotypes arising from systemic events, combined with the high frequency at which we detected them, demonstrates that cells can rapidly achieve highly altered genomic configurations during temporally restricted episodes of genomic instability.
journal_name
Geneticsjournal_title
Geneticsauthors
Heasley LR,Watson RA,Argueso JLdoi
10.1534/genetics.120.303536subject
Has Abstractpub_date
2020-09-01 00:00:00pages
43-50issue
1eissn
0016-6731issn
1943-2631pii
genetics.120.303536journal_volume
216pub_type
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