Abstract：
:Additive genetic variance in natural populations is commonly estimated using mixed models, in which the covariance of the genetic effects is modeled by a genetic similarity matrix derived from a dense set of markers. An important but usually implicit assumption is that the presence of any nonadditive genetic effect increases only the residual variance and does not affect estimates of additive genetic variance. Here we show that this is true only for panels of unrelated individuals. In the case that there is genetic relatedness, the combination of population structure and epistatic interactions can lead to inflated estimates of additive genetic variance.
journal_name
Geneticsjournal_title
Geneticsauthors
Kruijer Wdoi
10.1534/genetics.115.177212subject
Has Abstractpub_date
2016-01-01 00:00:00pages
363-6issue
1eissn
0016-6731issn
1943-2631pii
genetics.115.177212journal_volume
202pub_type
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