Abstract：
:The human pathogen Candida albicans is considered an obligate commensal of animals, yet it is occasionally isolated from trees, shrubs, and grass. We generated genome sequence data for three strains of C. albicans that we isolated from oak trees in an ancient wood pasture, and compared these to the genomes of over 200 clinical strains. C. albicans strains from oak are similar to clinical C. albicans in that they are predominantly diploid and can become homozygous at the mating locus through whole-chromosome loss of heterozygosity. Oak strains differed from clinical strains in showing slightly higher levels of heterozygosity genome-wide. Using phylogenomic analyses and in silico chromosome painting, we show that each oak strain is more closely related to strains from humans and other animals than to strains from other oaks. The high genetic diversity of C. albicans from old oaks shows that they can live in this environment for extended periods of time.
journal_name
Geneticsjournal_title
Geneticsauthors
Bensasson D,Dicks J,Ludwig JM,Bond CJ,Elliston A,Roberts IN,James SAdoi
10.1534/genetics.118.301482subject
Has Abstractpub_date
2019-01-01 00:00:00pages
277-288issue
1eissn
0016-6731issn
1943-2631pii
genetics.118.301482journal_volume
211pub_type
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