Abstract：
:Nontandem terminal chromosome duplications derived from N. crassa translocation T(I-->VI)NM103 give rise mitotically to some daughter nuclei which have become euploid by loss of one or the other of the two duplicated segments. Loss of the segment in normal sequence occurs as often as loss of the translocated segment. This is in contrast to all of several other Neurospora duplications that have been studied, where loss of the segment in normal sequence is absent or rare.--T(NM103) has the distal two thirds of linkage group IR exchanged with the right tip of VI. Crosses to normal sequence produce a class of morphologically distinct progeny with IR chromosome duplications. For a few days after germination, test crosses of these progeny are barren (make perithecia but few or no spores, as observed commonly with Neurospora duplications). Growing duplication cultures become fertile by accumulating nuclei which have been reduced to either normal sequence (by loss of the segment in translocation sequence) or translocation sequence (by loss of the segment in normal sequence). Both types usually appear within the first week of growth. Naturally formed mixtures or heterokaryons of NM103 duplication nuclei and their reduced euploid products have been studied by plating and by progeny testing. Determination of nuclear type is based on culture morphology, expression of genetic markers, and crossing behavior. Within the limits of testing, loss is found to begin precisely at the interchange points. The unique finding of frequent breakdown of normal-sequence linkage group I chromosomes is not dependent on the strain from which the chromosome was derived. Many different strains were tested, and for each one evidence was found that nuclei reduced to translocation sequence had been produced from duplication nuclei by loss of the segment in normal sequence.
journal_name
Geneticsjournal_title
Geneticsauthors
Turner BCsubject
Has Abstractpub_date
1977-03-01 00:00:00pages
439-60issue
3eissn
0016-6731issn
1943-2631journal_volume
85pub_type
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