Mapping quantitative trait loci using multiple families of line crosses.

abstract：:In yeast, 17 histidine-requiring mutants derived from and interallelically complementary to his1-7 were analyzed. The genetic basis of the complementation response was elucidated by mitotic and meiotic gene conversion. Each allele probably carries an unaltered 7-site mutation and a unique second-site alteration. The s...

journal_title：Genetics

authors： Lax C,Fogel S

更新日期：1978-11-01 00:00:00

abstract：:Cyclin E together with its kinase partner Cdk2 is a critical regulator of entry into S phase. To identify novel genes that regulate the G1- to S-phase transition within a whole animal we made use of a hypomorphic cyclin E mutation, DmcycEJP, which results in a rough eye phenotype. We screened the X and third chromosom...

journal_title：Genetics

authors： Brumby A,Secombe J,Horsfield J,Coombe M,Amin N,Coates D,Saint R,Richardson H

更新日期：2004-09-01 00:00:00

abstract：:We use the ancestral influence graph (AIG) for a two-locus, two-allele selection model in the limit of a large population size to obtain an analytic approximation for the probability of ultimate fixation of a single mutant allele A. We assume that this new mutant is introduced at a given locus into a finite population...

journal_title：Genetics

authors： Lessard S,Kermany AR

更新日期：2012-02-01 00:00:00

abstract：:The DC2 gene was isolated previously on the basis of sequence similarity to DC0, the major Drosophila protein kinase A (PKA) catalytic subunit gene. We show here that the 67-kD Drosophila DC2 protein behaves as a PKA catalytic subunit in vitro. DC2 is transcribed in mesodermal anlagen of early embryos. This expression...

journal_title：Genetics

authors： Meléndez A,Li W,Kalderon D

更新日期：1995-12-01 00:00:00

abstract：:We leverage two complementary Drosophila melanogaster mapping panels to genetically dissect starvation resistance-an important fitness trait. Using >1600 genotypes from the multiparental Drosophila Synthetic Population Resource (DSPR), we map numerous starvation stress QTL that collectively explain a substantial fract...

journal_title：Genetics

authors： Everman ER,McNeil CL,Hackett JL,Bain CL,Macdonald SJ

更新日期：2019-04-01 00:00:00

abstract：:Understanding adaptive genetic responses to climate change is a main challenge for preserving biological diversity. Successful predictive models for climate-driven range shifts of species depend on the integration of information on adaptation, including that derived from genomic studies. Long-lived forest trees can ex...

journal_title：Genetics

authors： Jaramillo-Correa JP,Rodríguez-Quilón I,Grivet D,Lepoittevin C,Sebastiani F,Heuertz M,Garnier-Géré PH,Alía R,Plomion C,Vendramin GG,González-Martínez SC

更新日期：2015-03-01 00:00:00

abstract：:The agouti locus on mouse chromosome 2 encodes a secreted cysteine-rich protein of 131 amino acids that acts as a molecular switch to instruct the melanocyte to make either yellow pigment (phaeomelanin) or black pigment (eumelanin). Mutations that up-regulate agouti expression are dominant to those causing decreased e...

journal_title：Genetics

authors： Hustad CM,Perry WL,Siracusa LD,Rasberry C,Cobb L,Cattanach BM,Kovatch R,Copeland NG,Jenkins NA

更新日期：1995-05-01 00:00:00

abstract：:In somatic cells of Drosophila, the ratio of X chromosomes to autosomes (X:A ratio) determines sex and dosage compensation. The present paper addresses the question of whether germ cells also use the X:A ratio for sex determination and dosage compensation. Triploid female embryos were generated which, through the loss...

journal_title：Genetics

authors： Schüpbach T

更新日期：1985-03-01 00:00:00

abstract：:In this article, we utilize stochastic search variable selection methodology to develop a Bayesian method for identifying multiple quantitative trait loci (QTL) for complex traits in experimental designs. The proposed procedure entails embedding multiple regression in a hierarchical normal mixture model, where latent ...

journal_title：Genetics

authors： Yi N,George V,Allison DB

更新日期：2003-07-01 00:00:00

abstract：:Triose phosphate isomerase (TPI) deficiency glycolytic enzymopathy is a progressive neurodegenerative condition that remains poorly understood. The disease is caused exclusively by specific missense mutations affecting the TPI protein and clinically features hemolytic anemia, adult-onset neurological impairment, degen...

journal_title：Genetics

authors： Seigle JL,Celotto AM,Palladino MJ

更新日期：2008-06-01 00:00:00

abstract：:Analysis of raw pooled data from distinct studies of a single question generates a single statistical conclusion with greater power and precision than conventional metaanalysis based on within-study estimates. However, conducting analyses with pooled genetic data, in particular, is a daunting task that raises importan...

journal_title：Genetics

authors： Heo M,Leibel RL,Boyer BB,Chung WK,Koulu M,Karvonen MK,Pesonen U,Rissanen A,Laakso M,Uusitupa MI,Chagnon Y,Bouchard C,Donohoue PA,Burns TL,Shuldiner AR,Silver K,Andersen RE,Pedersen O,Echwald S,Sørensen TI,Behn P,

更新日期：2001-11-01 00:00:00

abstract：:The RecQ helicase family is critical during DNA damage repair, and mutations in these proteins are associated with Bloom, Werner, or Rothmund-Thompson syndromes in humans, leading to cancer predisposition and/or premature aging. In the budding yeast Saccharomyces cerevisiae, mutations in the RecQ homolog, SGS1, phenoc...

journal_title：Genetics

authors： Bernstein KA,Mimitou EP,Mihalevic MJ,Chen H,Sunjaveric I,Symington LS,Rothstein R

更新日期：2013-12-01 00:00:00

abstract：:All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...

journal_title：Genetics

authors： Cyert MS,Philpott CC

更新日期：2013-03-01 00:00:00

abstract：:Heterochromatin protein 1a (HP1a) is a highly conserved and versatile epigenetic factor that can both silence and activate transcription. However, the function of HP1a in development has been underinvestigated. Here, we report the role of maternal HP1a in producing maternal transcripts that drive early Drosophila embr...

journal_title：Genetics

authors： Park AR,Liu N,Neuenkirchen N,Guo Q,Lin H

更新日期：2019-01-01 00:00:00

abstract：:Molecular heterogeneity in human breast cancer has challenged diagnosis, prognosis, and clinical treatment. It is well known that molecular subtypes of breast tumors are associated with significant differences in prognosis and survival. Assuming that the differences are attributed to subtype-specific pathways, we then...

journal_title：Genetics

authors： Li R,Campos J,Iida J

更新日期：2015-12-01 00:00:00

abstract：:The initiation of growth cessation and dormancy represents a critical ecological and evolutionary trade-off between survival and growth in most forest trees. The most important environmental cue regulating the initiation of dormancy is a shortening of the photoperiod and phytochrome genes have been implicated in short...

journal_title：Genetics

authors： Ingvarsson PK,García MV,Hall D,Luquez V,Jansson S

更新日期：2006-03-01 00:00:00

abstract：:Extensive length polymorphism and heteroplasmy (multiple forms within an individual) of the D-loop region are observed in mitochondrial DNA of the white sturgeon (Acipenser transmontanus). The nucleotide sequence of this region, for both a short and a long form, shows that the differences are due to variable numbers o...

journal_title：Genetics

authors： Buroker NE,Brown JR,Gilbert TA,O'Hara PJ,Beckenbach AT,Thomas WK,Smith MJ

更新日期：1990-01-01 00:00:00

abstract：:Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of meiotic recombination have been proposed. These models differ in the arrangement of heteroduplex DNA (hDNA) in recombination ...

journal_title：Genetics

authors： Radford SJ,Sabourin MM,McMahan S,Sekelsky J

更新日期：2007-05-01 00:00:00

abstract：:Two sets of overlapping experiments were conducted to examine recombination and spontaneous mutation events within clusters of resistance genes in lettuce. Multiple generations were screened for recombinants using PCR-based markers flanking Dm3. The Dm3 region is not highly recombinagenic, exhibiting a recombination f...

journal_title：Genetics

authors： Chin DB,Arroyo-Garcia R,Ochoa OE,Kesseli RV,Lavelle DO,Michelmore RW

更新日期：2001-02-01 00:00:00

abstract：:T (Texas) cytoplasm is associated with a mitochondrial disruption that is phenotypically expressed during microsporogenesis resulting in male sterility. Restoration of pollen fertility in T-cytoplasm maize is controlled by dominant alleles at two unlinked, complementary, nuclear-encoded genes, rf1 and rf2. As a first ...

journal_title：Genetics

authors： Schnable PS,Wise RP

更新日期：1994-03-01 00:00:00

abstract：:Changes in genome structure and gene expression have been documented in both resynthesized and natural allopolyploids that contain two or more divergent genomes. The underlying mechanisms for rapid and stochastic changes in gene expression are unknown. Arabidopsis suecica is a natural allotetraploid derived from the e...

journal_title：Genetics

authors： Chen M,Ha M,Lackey E,Wang J,Chen ZJ

更新日期：2008-04-01 00:00:00

abstract：:In Neurospora crassa, DNA sequence duplications are detected and altered efficiently during the sexual cycle by a process known as RIP (repeat-induced point mutation). Affected sequences are subjected to multiple GC-to-AT mutations. To explore the pattern in which base changes are laid down by RIP we examined two sets...

journal_title：Genetics

authors： Watters MK,Randall TA,Margolin BS,Selker EU,Stadler DR

更新日期：1999-10-01 00:00:00

abstract：:A lethal locus (l(2)br7;35B6-10), near Adh on chromosome arm 2L of D. melanogaster, is identified with Plunkett's dominant suppressor of Hairless (H). Of eight new alleles, seven act as dominant suppressors of H, the eighth is a dominant enhancer of H. One of the suppressor alleles is both a leaky lethal and a weak s...

journal_title：Genetics

authors： Ashburner M

更新日期：1982-07-01 00:00:00

abstract：:Preliminary studies with restriction fragment length polymorphisms of mitochondrial DNA (mtDNA) in natural populations of Drosophila melanogaster revealed considerable variation in terms of nucleotide sequence and overall size. In this report we present data from more isofemale lines and more restriction enzymes, and ...

journal_title：Genetics

authors： Hale LR,Singh RS

更新日期：1991-09-01 00:00:00

abstract：:The timing of lethality caused by homozygosity for a null allele of the epidermal growth factor receptor (Egfrtm1Mag) in mice is strongly dependent on genetic background. Initial attempts to genetically map background modifiers using Swiss-derived, outbred CD-1 mice were unsuccessful. To investigate the genetic archit...

journal_title：Genetics

authors： Strunk KE,Amann V,Threadgill DW

更新日期：2004-08-01 00:00:00

abstract：:Specialized insect mouthparts, such as those of Drosophila, are derived from an ancestral mandibulate state, but little is known about the developmental genetics of mandibulate mouthparts. Here, we study the metamorphic patterning of mandibulate mouthparts of the beetle Tribolium castaneum, using RNA interference to d...

journal_title：Genetics

authors： Angelini DR,Smith FW,Aspiras AC,Kikuchi M,Jockusch EL

更新日期：2012-02-01 00:00:00

abstract：:Natural selection leaves its footprints on protein-coding sequences by modulating their silent and replacement evolutionary rates. In highly expressed genes in invertebrates, these footprints are seen in the higher codon usage bias and lower synonymous divergence. In mammals, the highly expressed genes have a shorter ...

journal_title：Genetics

authors： Subramanian S,Kumar S

更新日期：2004-09-01 00:00:00

abstract：:Genome-wide association mapping is a popular method for using natural variation within a species to generate a genotype-phenotype map. Statistical association between an allele at a locus and the trait in question is used as evidence that variation at the locus is responsible for variation of the trait. Indirect assoc...

journal_title：Genetics

authors： Platt A,Vilhjálmsson BJ,Nordborg M

更新日期：2010-11-01 00:00:00

abstract：:Knowledge of multigenic family organization should provide insight into their mode of evolution. Accordingly, we characterized the 5S ribosomal gene family in the Drosophila melanogaster strain ry506. The 5S genes in this strain display a striking HindIII restriction difference compared to the "standard" D. melanogast...

journal_title：Genetics

authors： Samson ML,Wegnez M

更新日期：1988-04-01 00:00:00

abstract：:The neutral rate of allelic substitution is analyzed for a class-structured population subject to a stationary stochastic demographic process. The substitution rate is shown to be generally equal to the effective mutation rate, and under overlapping generations it can be expressed as the effective mutation rate in new...

journal_title：Genetics

authors： Lehmann L

更新日期：2014-05-01 00:00:00