Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity.

abstract：:The multigene family of rDNA in Drosophila reveals high levels of within-species homogeneity and between-species diversity. This pattern of mutation distribution is known as concerted evolution and is considered to be due to a variety of genomic mechanisms of turnover (e.g., unequal crossing over and gene conversion) ...

journal_title：Genetics

authors： Polanco C,González AI,de la Fuente,Dover GA

更新日期：1998-05-01 00:00:00

abstract：:Putzig (Pzg) was originally identified as being an integral component of the TRF2/DREF complex in Drosophila melanogaster, thereby regulating the transcriptional activation of replication-related genes. In a DREF-independent manner, Pzg was shown to mediate Notch target gene activation. This function of Pzg entails an...

journal_title：Genetics

authors： Kugler SJ,Gehring EM,Wallkamm V,Krüger V,Nagel AC

更新日期：2011-05-01 00:00:00

abstract：:Advances in medicine, agriculture, and an understanding of evolution depend on resolving the genetic architecture of quantitative traits, which is challenging since variation for complex traits is caused by multiple interacting quantitative trait loci (QTL) with small and conditional effects. Here, we show that the ke...

journal_title：Genetics

authors： Robin C,Lyman RF,Long AD,Langley CH,Mackay TF

更新日期：2002-09-01 00:00:00

abstract：:We present the results of a restriction site survey of variation at five loci in Drosophila athabasca, complimenting a previous study of the period locus. There is considerably greater differentiation between the three semispecies of D. athabasca at the period locus and two other X-linked genes (no-on-transient-A and ...

journal_title：Genetics

authors： Ford MJ,Aquadro CF

更新日期：1996-10-01 00:00:00

abstract：:Paramecium has long been a model eukaryote. The sequence of the Paramecium tetraurelia genome reveals a history of three successive whole-genome duplications (WGDs), and the sequences of P. biaurelia and P. sexaurelia suggest that these WGDs are shared by all members of the aurelia species complex. Here, we present th...

journal_title：Genetics

authors： McGrath CL,Gout JF,Doak TG,Yanagi A,Lynch M

更新日期：2014-08-01 00:00:00

abstract：:We examine the efficiency of different genotyping and phenotyping strategies in inbred line crosses from an information perspective. This provides a mathematical framework for the statistical aspects of QTL experimental design, while guiding our intuition. Our central result is a simple formula that quantifies the fra...

journal_title：Genetics

authors： Sen S,Satagopan JM,Churchill GA

更新日期：2005-05-01 00:00:00

abstract：:Rates of molecular evolution at some loci are more irregular than described by simple Poisson processes. Three situations under which molecular evolution would not follow simple Poisson processes are reevaluated from the viewpoint of the neutrality hypothesis: concomitant or multiple substitutions in a gene, fluctuati...

journal_title：Genetics

authors： Takahata N

更新日期：1987-05-01 00:00:00

abstract：:Stabilizing selection for an intermediate optimum is generally considered to deplete genetic variation in quantitative traits. However, conflicting results from various types of models have been obtained. While classical analyses assuming a large number of independent additive loci with individually small effects indi...

journal_title：Genetics

authors： Bürger R,Gimelfarb A

更新日期：1999-06-01 00:00:00

abstract：:During meiosis, the stable pairing of the homologous chromosomes is mediated by the assembly of the synaptonemal complex (SC). Its tripartite structure is well conserved in Metazoa and consists of two lateral elements (LEs) and a central region (CR) that in turn is formed by several transverse filaments (TFs) and a ce...

journal_title：Genetics

authors： Fraune J,Brochier-Armanet C,Alsheimer M,Benavente R

更新日期：2013-11-01 00:00:00

abstract：:Drosophila melanogaster X chromosomes were mutagenized by feeding males sucrose solutions containing ethyl methanesulfonate (EMS); the concentrations of EMS in the food were 2.5 mM, 5.0 mM, and 10.0 mM. Chromosomes were exposed to the mutagen up to three times by treating males in succeeding generations. After treatme...

journal_title：Genetics

authors： Mitchell JA

更新日期：1977-12-01 00:00:00

abstract：:Biology is characterized by complex interactions between phenotypes, such as recursive and simultaneous relationships between substrates and enzymes in biochemical systems. Structural equation models (SEMs) can be used to study such relationships in multivariate analyses, e.g., with multiple traits in a quantitative g...

journal_title：Genetics

authors： Valente BD,Rosa GJ,de Los Campos G,Gianola D,Silva MA

更新日期：2010-06-01 00:00:00

abstract：:Regulation of cytoskeletal structure and dynamics is essential for multiple aspects of cellular behavior, yet there is much to learn about the molecular machinery underlying the coordination between the cytoskeleton and its effector systems. One group of proteins that regulate microtubule behavior and its interaction ...

journal_title：Genetics

authors： Lowery LA,Lee H,Lu C,Murphy R,Obar RA,Zhai B,Schedl M,Van Vactor D,Zhan Y

更新日期：2010-08-01 00:00:00

abstract：:Dis3 encodes a conserved RNase that degrades or processes all RNA species via an N-terminal PilT N terminus (PIN) domain and C-terminal RNB domain that harbor, respectively, endonuclease activity and 3'-5' exonuclease activity. In Schizosaccharomyces pombe, dis3 mutations cause chromosome missegregation and failure in...

journal_title：Genetics

authors： Snee MJ,Wilson WC,Zhu Y,Chen SY,Wilson BA,Kseib C,O'Neal J,Mahajan N,Tomasson MH,Arur S,Skeath JB

更新日期：2016-06-01 00:00:00

abstract：:Although neurons are highly polarized, how neuronal polarity is generated remains poorly understood. An evolutionarily conserved inositol-producing enzyme myo-inositol monophosphatase (IMPase) is essential for polarized localization of synaptic molecules in Caenorhabditis elegans and can be inhibited by lithium, a dru...

journal_title：Genetics

authors： Kimata T,Tanizawa Y,Can Y,Ikeda S,Kuhara A,Mori I

更新日期：2012-06-01 00:00:00

abstract：:Rapid and high wing-beat frequencies achieved during insect flight are powered by the indirect flight muscles, the largest group of muscles present in the thorax. Any anomaly during the assembly and/or structural impairment of the indirect flight muscles gives rise to a flightless phenotype. Multiple mutagenesis scree...

journal_title：Genetics

authors： Firdaus H,Mohan J,Naz S,Arathi P,Ramesh SR,Nongthomba U

更新日期：2015-05-01 00:00:00

abstract：:A major challenge in undergraduate life science curricula is the continual evaluation and development of courses that reflect the constantly shifting face of contemporary biological research. Synthetic biology offers an excellent framework within which students may participate in cutting-edge interdisciplinary researc...

journal_title：Genetics

authors： Dymond JS,Scheifele LZ,Richardson S,Lee P,Chandrasegaran S,Bader JS,Boeke JD

更新日期：2009-01-01 00:00:00

abstract：:In the absence of a vg+ gene, extensive cell death occurs in third instar imaginal discs, which results in a complete loss of adult wing margin structures. Essentially all molecularly characterized vg alleles are associated with deletions or insertions of DNA into the vg locus. These alterations reduce or eliminate a ...

journal_title：Genetics

authors： Williams JA,Scott IM,Atkin AL,Brook WJ,Russell MA,Bell JB

更新日期：1990-08-01 00:00:00

abstract：:The translation elongation factor EF-Tu is a GTPase that delivers amino-acylated tRNAs to the ribosome during the elongation step of translation. EF-Tu/GDP is recycled by the guanine nucleotide exchange factor EF-Ts. Whereas EF-Ts is lacking in S. cerevisiae, both translation factors are found in S. pombe and H. sapie...

journal_title：Genetics

authors： Chiron S,Suleau A,Bonnefoy N

更新日期：2005-04-01 00:00:00

abstract：:Sixty independent UGA suppressors of Saccharomyces cerevisiae have been studied. They are dominant and are divided into 16 groups (loci) by recombination. Suppressors representing these loci are divided into two classes by action spectra; four in class 1 (a broad action spectrum) and 12 in class 2 (a narrow action spe...

journal_title：Genetics

authors： Ono BI,Fujimoto R,Ohno Y,Maeda N,Tsuchiya Y,Usui T,Ishino-Arao Y

更新日期：1988-01-01 00:00:00

abstract：:Nucleosome-depleted regions (NDRs) are present immediately adjacent to the transcription start site in most eukaryotic promoters. Here we show that NDRs in the upstream promoter region can profoundly affect gene regulation. Chromatin at the yeast HO promoter is highly repressive and numerous coactivators are required ...

journal_title：Genetics

authors： Yarrington RM,Goodrum JM,Stillman DJ

更新日期：2016-02-01 00:00:00

abstract：:Microarray experiments have been used recently in genetical genomics studies, as an additional tool to understand the genetic mechanisms governing variation in complex traits, such as for estimating heritabilities of mRNA transcript abundances, for mapping expression quantitative trait loci, and for inferring regulato...

journal_title：Genetics

authors： Bueno Filho JS,Gilmour SG,Rosa GJ

更新日期：2006-10-01 00:00:00

abstract：:Sponsored by the National Science Foundation and the U.S. Department of Agriculture, a wheat genome sequencing workshop was held November 10-11, 2003, in Washington, DC. It brought together 63 scientists of diverse research interests and institutions, including 45 from the United States and 18 from a dozen foreign cou...

journal_title：Genetics

authors： Gill BS,Appels R,Botha-Oberholster AM,Buell CR,Bennetzen JL,Chalhoub B,Chumley F,Dvorák J,Iwanaga M,Keller B,Li W,McCombie WR,Ogihara Y,Quetier F,Sasaki T

更新日期：2004-10-01 00:00:00

abstract：:In hybrids between Drosophila simulans and D. mauritiana, males are sterile and females are fertile, in compliance with HALDANE's rule. The genetic basis of this phenomenon was investigated by introgression of segments of the mauritiana genome into a simulans background. A total of 87 positions throughout the mauritia...

journal_title：Genetics

authors： True JR,Weir BS,Laurie CC

更新日期：1996-03-01 00:00:00

abstract：:The change in frequencies of D. melanogaster and D. simulans in competition experiments was used to measure the effect of radiation on the fitness of a population. A dose of 250 or 500 rads given to the males of highly inbred lines of D. simulans at the beginning of competition and every three weeks thereafter increas...

journal_title：Genetics

authors： Blaylock BG,Shugart HH Jr

更新日期：1972-11-01 00:00:00

abstract：:A variety of Saccharomyces strains were examined for the presence of 2micro DNA and, if present, for the pattern of fragments produced by its digestion with site-specific (restriction) endonucleases. Two strains were found that did not contain detectable levels of 2micro DNA, and two strains contained 2micro DNA molec...

journal_title：Genetics

authors： Livingston DM

更新日期：1977-05-01 00:00:00

abstract：:Magnesium (Mg) is an essential enzyme cofactor and a key structural component of biological molecules, but relatively little is known about the molecular components required for Mg homeostasis in eukaryotic cells. The yeast genome encodes four characterized members of the CorA Mg transporter superfamily located in the...

journal_title：Genetics

authors： Pisat NP,Pandey A,Macdiarmid CW

更新日期：2009-11-01 00:00:00

abstract：:Genetic material sequenced from ancient samples is revolutionizing our understanding of the recent evolutionary past. However, ancient DNA is often degraded, resulting in low coverage, error-prone sequencing. Several solutions exist to this problem, ranging from simple approach, such as selecting a read at random for ...

journal_title：Genetics

authors： Schraiber JG

更新日期：2018-01-01 00:00:00

abstract：:Heteroduplexes with single base pair mismatches of known sequence were prepared by annealing separated strands of bacteriophage lambda DNA and used to transfect Escherichia coli. A series of transition (G:T and A:C) and transversion (G:A and C:T) mismatches located throughout most of the bacteriophage lambda cI gene h...

journal_title：Genetics

authors： Jones M,Wagner R,Radman M

更新日期：1987-04-01 00:00:00

abstract：:The rate of adaptive evolution of a population ultimately depends on the rate of incorporation of beneficial mutations. Even beneficial mutations may, however, be lost from a population since mutant individuals may, by chance, fail to reproduce. In this paper, we calculate the probability of fixation of beneficial mut...

journal_title：Genetics

authors： Otto SP,Whitlock MC

更新日期：1997-06-01 00:00:00

abstract：:Mutations were induced in synchronous Chinese hamster cells by bromodeoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle. There was a very pronounced temporal dependence during the first half of the DNA synthesis period for the induction of damage leading to 6-thioguanine (6TG) and ouabai...

journal_title：Genetics

authors： Burki HJ,Aebersold PM

更新日期：1978-10-01 00:00:00