Novel interallelic complementation at the his1 locus of yeast.

abstract：:In this article we define and characterize the smellblind gene (sbl). We show that two mutants, sbl and olfDx9, both isolated by virtue of their olfactory phenotypes and analyzed extensively by others with respect to courtship behavior, contain mutations at a single locus. Meiotic recombination, duplication, and defic...

journal_title：Genetics

authors： Lilly M,Carlson J

更新日期：1990-02-01 00:00:00

abstract：:We have analyzed donor and target sites of the mobile element Activator (Ac) that are altered as a result of somatic transposition from the P locus in maize. Previous genetic analysis has indicated that the two mitotic daughter lineages which result from Ac transposition from P differ in their Ac constitution at the P...

journal_title：Genetics

authors： Chen J,Greenblatt IM,Dellaporta SL

更新日期：1987-09-01 00:00:00

abstract：:The infinite-sites model with no recombination is extended to include mutations that affect electrophoretic mobility. The model allows the effect of a single-site mutation to have a continuous effect on mobility. Formulae are obtained for the variance of electrophoretic mobility of alleles after an arbitrary lenght of...

journal_title：Genetics

authors： Cobbs G

更新日期：1979-06-01 00:00:00

abstract：:Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at leas...

journal_title：Genetics

authors： Vary PS,Stocker BA

更新日期：1973-02-01 00:00:00

abstract：:In female mammalian cells, the inactive X chromosome is replicated late in S phase while the active X chromosome is replicated earlier. The replication times of the X chromosomes reflect a general trend in which late replication is associated with gene repression and earlier replication with transcriptional competence...

journal_title：Genetics

authors： Diaz-Perez S,Ouyang Y,Perez V,Cisneros R,Regelson M,Marahrens Y

更新日期：2005-10-01 00:00:00

abstract：:A genetic linkage map was constructed in a backcross family of the red flour beetle, Tribolium castaneum, based largely on sequences from bacterial artificial chromosome (BAC) ends and untranslated regions from random cDNA's. In most cases, dimorphisms were detected using heteroduplex or single-strand conformational p...

journal_title：Genetics

authors： Lorenzen MD,Doyungan Z,Savard J,Snow K,Crumly LR,Shippy TD,Stuart JJ,Brown SJ,Beeman RW

更新日期：2005-06-01 00:00:00

abstract：:Electrophoretic comparisons of 40S and 55S ribosomal subunit proteins from 18 strains of Drosophila melanogaster revealed the virtual absence of allelic variation. More detailed two-dimensional studies on the large subunit proteins in 6 of the strains demonstrated additional complexity but still no interstrain variati...

journal_title：Genetics

authors： Berger EM,Weber L

更新日期：1974-12-01 00:00:00

abstract：:Heterozygotes for three long inversions on chromosome 1 were analyzed by serial reconstruction from electron micrographs. Measurements of loop lengths at different meiotic prophase substages revealed that the homologous synapsis of the inverted region was gradually replaced by nonhomologous synapsis as loops were elim...

journal_title：Genetics

authors： Bojko M

更新日期：1990-03-01 00:00:00

abstract：:The walls of Aspergillus nidulans conidia contain a green pigment that protects the spores from damage by ultraviolet light. At least two genes, wA and yA, are required for pigment synthesis: yA mutants produce yellow spores, wA mutants produce white spores, and wA mutations are epistatic to yA mutations. We cloned wA...

journal_title：Genetics

authors： Mayorga ME,Timberlake WE

更新日期：1990-09-01 00:00:00

abstract：:Neurospora crassa has been a model organism for the study of circadian clocks for the past four decades. Among natural accessions of Neurospora crassa, there is significant variation in clock phenotypes. In an attempt to investigate natural allelic variants contributing to quantitative variation, we used a quantitativ...

journal_title：Genetics

authors： Kim TS,Logsdon BA,Park S,Mezey JG,Lee K

更新日期：2007-12-01 00:00:00

abstract：:Stress caused by the increased salinity of irrigated fields impairs plant growth and is one of the major constraints that limits crop productivity in many important agricultural areas. As a contribution to solving such agronomic problems, we have carried out a large-scale screening for Arabidopsis thaliana mutants ind...

journal_title：Genetics

authors： Quesada V,Ponce MR,Micol JL

更新日期：2000-01-01 00:00:00

abstract：:To avoid a loss in statistical power as a result of homozygous individuals being selected as parents of a mapping population, one can use multiple families of line crosses for quantitative trait genetic linkage analysis. Two strategies of combining data are investigated: the fixed-model and the random-model strategies...

journal_title：Genetics

authors： Xu S

更新日期：1998-01-01 00:00:00

abstract：:Host mutations in Escherichia coli K12 selected for the temperature-sensitive replication of the bacterial plasmid colicinogenic factor E(1) (ColE(1)) exhibit a pleiotropic effect with respect to the effect of the mutation on other extra-chromosomal elements. The mutations also vary with respect to the time of incubat...

journal_title：Genetics

authors： Kingsbury DT,Sieckmann DG,Helinski DR

更新日期：1973-05-01 00:00:00

abstract：:With the rise of both the number and the complexity of traits of interest, control of the false discovery rate (FDR) in genetic association studies has become an increasingly appealing and accepted target for multiple comparison adjustment. While a number of robust FDR-controlling strategies exist, the nature of this ...

journal_title：Genetics

authors： Brzyski D,Peterson CB,Sobczyk P,Candès EJ,Bogdan M,Sabatti C

更新日期：2017-01-01 00:00:00

abstract：:Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabi...

journal_title：Genetics

authors： Teuscher F,Broman KW

更新日期：2007-03-01 00:00:00

abstract：:USING A NEWLY DEVELOPED PLATING SYSTEM, WE HAVE MEASURED CELL SURVIVAL AND THE FREQUENCIES OF VARIATION IN AN INHERITED TRAIT AFTER TREATMENT OF SOYBEAN CELL SUSPENSIONS WITH DIFFERENT MUTAGENS: ethyl methanesulfonate (EMS), methyl methanesulfonate (MMS), N-Methyl-N'-nitro-N-nitroso-guanidine (MNNG), hycanthone (1-{[2...

journal_title：Genetics

authors： Weber G,Lark KG

更新日期：1980-09-01 00:00:00

abstract：:As an ancient segmental tetraploid, the maize (Zea mays L.) genome contains large numbers of paralogs that are expected to have diverged by a minimum of 10% over time. Nearly identical paralogs (NIPs) are defined as paralogous genes that exhibit > or = 98% identity. Sequence analyses of the "gene space" of the maize i...

journal_title：Genetics

authors： Emrich SJ,Li L,Wen TJ,Yandeau-Nelson MD,Fu Y,Guo L,Chou HH,Aluru S,Ashlock DA,Schnable PS

更新日期：2007-01-01 00:00:00

abstract：:During selection for protein content in mice at the Technical University of Berlin, individuals showing high protein content and a compact exterior were noted. Animals showing this "Compact" phenotype were separated to form a new line. The present investigations were carried out on a Hungarian subpopulation of this li...

journal_title：Genetics

authors： Varga L,Szabó G,Darvasi A,Müller G,Sass M,Soller M

更新日期：1997-10-01 00:00:00

abstract：:To identify genes regulating the development of the six touch receptor neurons, we screened the F(2) progeny of mutated animals expressing an integrated mec-2::gfp transgene that is expressed mainly in these touch cells. From 2638 mutated haploid genomes, we obtained 11 mutations representing 11 genes that affected th...

journal_title：Genetics

authors： Du H,Chalfie M

更新日期：2001-05-01 00:00:00

abstract：:Circadian clocks organize the metabolism, physiology, and behavior of organisms throughout the day-night cycle by controlling daily rhythms in gene expression at the transcriptional and post-transcriptional levels. While many transcription factors underlying circadian oscillations are known, the splicing factors that ...

journal_title：Genetics

authors： Beckwith EJ,Hernando CE,Polcowñuk S,Bertolin AP,Mancini E,Ceriani MF,Yanovsky MJ

更新日期：2017-10-01 00:00:00

abstract：:Genetic drift is an important evolutionary force of strength inversely proportional to Ne , the effective population size. The impact of drift on genome diversity and evolution is known to vary among species, but quantifying this effect is a difficult task. Here we assess the magnitude of variation in drift power amon...

journal_title：Genetics

authors： Galtier N,Rousselle M

更新日期：2020-10-01 00:00:00

abstract：:The evolutionary processes governing variability within genomic regions of low recombination have been the focus of many studies. Here, I investigate the statistical properties of a measure of interlocus genetic associations under the assumption that mutations are selectively neutral and sites are completely linked. T...

journal_title：Genetics

authors： Kelly JK

更新日期：1997-07-01 00:00:00

abstract：:The homozygosity of a population will be influenced by any recent change in the population size. The "homozygosity test" of the neutral mutation hypothesis might also be influenced by a population change. A computer simulation method is described that establishes the significance levels of observed homozygosities afte...

journal_title：Genetics

authors： Watterson GA

更新日期：1986-04-01 00:00:00

abstract：:The Drosophila mei-S332 gene acts to maintain sister-chromatid cohesion before anaphase II of meiosis in both males and females. By isolating and analyzing seven new alleles and a deficiency uncovering the mei-S332 gene we have demonstrated that the onset of the requirement for mei-S332 is not until late anaphase I. A...

journal_title：Genetics

authors： Kerrebrock AW,Miyazaki WY,Birnby D,Orr-Weaver TL

更新日期：1992-04-01 00:00:00

abstract：:Allorecognition is ubiquitous, or nearly so, amongst colonial invertebrates. Despite the prominent role that such phenomena have played both in evolutionary theory and in on the origin of the vertebrate immune system, unambiguous data on the transmission genetics of fusibility (i.e., the ability of two individuals to ...

journal_title：Genetics

authors： Mokady O,Buss LW

更新日期：1996-06-01 00:00:00

abstract：:The distribution within anthers of maize plants of microsporocytes of differing crossover class was studied by application of the serial-sectioning technique to plants heterozygous for a paracentric inversion. In such material, cells with four-strand double crossovers within the inversion are distinguishable from cell...

journal_title：Genetics

authors： Maguire MP

更新日期：1980-05-01 00:00:00

abstract：:The recessive mutation, hop1-1, was isolated by use of a screen designed to detect mutations defective in homologous chromosomal pairing during meiosis in Saccharomyces cerevisiae. Mutants in HOP1 displayed decreased levels of meiotic crossing over and intragenic recombination between markers on homologous chromosomes...

journal_title：Genetics

authors： Hollingsworth NM,Byers B

更新日期：1989-03-01 00:00:00

abstract：:Heteroduplexes with single base pair mismatches of known sequence were prepared by annealing separated strands of bacteriophage lambda DNA and used to transfect Escherichia coli. A series of transition (G:T and A:C) and transversion (G:A and C:T) mismatches located throughout most of the bacteriophage lambda cI gene h...

journal_title：Genetics

authors： Jones M,Wagner R,Radman M

更新日期：1987-04-01 00:00:00

abstract：:Obligate pathogenic and endosymbiotic bacteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift. We hypothesize that reduced genomes increase their functional complexity through protein multitasking, in which many genes adopt new roles to counteract gene loss. Comparisons of i...

journal_title：Genetics

authors： Kelkar YD,Ochman H

更新日期：2013-01-01 00:00:00

abstract：:In a subdivided population, the interaction between natural selection and stochastic change in allele frequency is affected by the occurrence of local extinction and subsequent recolonization. The relative importance of selection can be diminished by this additional source of stochastic change in allele frequency. Res...

journal_title：Genetics

authors： Cherry JL

更新日期：2004-02-01 00:00:00