Abstract：
:Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabilities for 2(n)-way RIL; the former required hefty computation to infer the symbolic results, and the latter were strictly numerical. We describe a simpler approach for the calculation of these probabilities, which allowed us to derive the symbolic form of the three-point haplotype probabilities. We also extend the two-point results for the case of additional generations of intermating, including the case of 2(n)-way intermated recombinant inbred populations (IRIP).
journal_name
Geneticsjournal_title
Geneticsauthors
Teuscher F,Broman KWdoi
10.1534/genetics.106.064063subject
Has Abstractpub_date
2007-03-01 00:00:00pages
1267-74issue
3eissn
0016-6731issn
1943-2631pii
genetics.106.064063journal_volume
175pub_type
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