Haplotype probabilities for multiple-strain recombinant inbred lines.

abstract：:The Drosophila gene exuperantia (exu) is a maternal effect gene which is needed for proper localization of the bcd RNA during the formation of oocytes. We have extended the characterization of the exu phenotype and find that the gene functions in the male as well as the female germline. Six of seven exu alleles are ma...

journal_title：Genetics

authors： Hazelrigg T,Watkins WS,Marcey D,Tu C,Karow M,Lin XR

更新日期：1990-11-01 00:00:00

abstract：:Life-history traits or "fitness components"-such as age and size at maturity, fecundity and fertility, age-specific rates of survival, and life span-are the major phenotypic determinants of Darwinian fitness. Analyzing the evolution and genetics of these phenotypic targets of selection is central to our understanding ...

journal_title：Genetics

authors： Flatt T

更新日期：2020-01-01 00:00:00

abstract：:New rudimentary (r) mutants have been isolated following mutagenesis with ethyl methanesulfonate (r(LE)), ICR-170 (r(LI)) and X rays (r(LX)). From wing phenotype measurements on homoallelic females, it has been shown that the r(LE) mutant series includes several leaky alleles, as well as alleles that produce moderate ...

journal_title：Genetics

authors： Rawls JM,Porter LA

更新日期：1979-09-01 00:00:00

abstract：:Genome-wide association studies have identified thousands of variants implicated in dozens of complex diseases. Most studies collect individuals with and without disease and search for variants with different frequencies between the groups. For many of these studies, additional disease traits are also collected. Joint...

journal_title：Genetics

authors： Bilow M,Crespo F,Pan Z,Eskin E,Eyheramendy S

更新日期：2017-03-01 00:00:00

abstract：:Plants with mutations in one of three maize genes, mop1, rmr1, and rmr2, are defective in paramutation, an allele-specific interaction that leads to meiotically heritable chromatin changes. Experiments reported here demonstrate that these genes are required to maintain the transcriptional silencing of two different tr...

journal_title：Genetics

authors： McGinnis KM,Springer C,Lin Y,Carey CC,Chandler V

更新日期：2006-07-01 00:00:00

abstract：:The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection ...

journal_title：Genetics

authors： Harbison ST,Yamamoto AH,Fanara JJ,Norga KK,Mackay TF

更新日期：2004-04-01 00:00:00

abstract：:Dosage compensation in Drosophila has been studied at the steady state RNA level for several single-copy genes; however, an important point is addressed by analyzing a repetitive, transposable element for dosage compensation. The two issues of gene-specific cis control and genomic position can be studied by determinin...

journal_title：Genetics

authors： Hiebert JC,Birchler JA

更新日期：1992-03-01 00:00:00

abstract：:During selection for protein content in mice at the Technical University of Berlin, individuals showing high protein content and a compact exterior were noted. Animals showing this "Compact" phenotype were separated to form a new line. The present investigations were carried out on a Hungarian subpopulation of this li...

journal_title：Genetics

authors： Varga L,Szabó G,Darvasi A,Müller G,Sass M,Soller M

更新日期：1997-10-01 00:00:00

abstract：:During meiosis homologous chromosomes replicate once, pair, experience recombination, and undergo two rounds of segregation to produce haploid meiotic products. The rec8(+), rec10(+), and rec11(+) genes of the fission yeast Schizosaccharomyces pombe exhibit similar specificities for meiotic recombination and rec8(+) i...

journal_title：Genetics

authors： Krawchuk MD,DeVeaux LC,Wahls WP

更新日期：1999-09-01 00:00:00

abstract：:The involvement of Schizosaccharomyces pombe prm1(+) in cell fusion during mating and its relationship with other genes required for this process have been addressed. S. pombe prm1Δ mutant exhibits an almost complete blockade in cell fusion and an abnormal distribution of the plasma membrane and cell wall in the area ...

journal_title：Genetics

authors： Curto MÁ,Sharifmoghadam MR,Calpena E,De León N,Hoya M,Doncel C,Leatherwood J,Valdivieso MH

更新日期：2014-04-01 00:00:00

abstract：:Progress in understanding the evolution of variation at the MHC has been slowed by an inability to assess the relative roles of mutation vs. intragenic recombination in contributing to observed polymorphism. Recent theoretical advances now permit a quantitative treatment of the problem, with the result that the amount...

journal_title：Genetics

authors： Richman AD,Herrera LG,Nash D

更新日期：2003-05-01 00:00:00

abstract：:The X chromosome requires special treatment in the mapping of quantitative trait loci (QTL). However, most QTL mapping methods, and most computer programs for QTL mapping, have focused exclusively on autosomal loci. We describe a method for appropriate treatment of the X chromosome for QTL mapping in experimental cros...

journal_title：Genetics

authors： Broman KW,Sen S,Owens SE,Manichaikul A,Southard-Smith EM,Churchill GA

更新日期：2006-12-01 00:00:00

abstract：:Brassica self-incompatibility (SI) is controlled by SLG and SRK expressed in the stigma and by SP11/SCR expressed in the anther. We determined the sequences of the S domains of 36 SRK alleles, 13 SLG alleles, and 14 SP11 alleles from Brassica oleracea and B. rapa. We found three S haplotypes lacking SLG genes in B. ra...

journal_title：Genetics

authors： Sato K,Nishio T,Kimura R,Kusaba M,Suzuki T,Hatakeyama K,Ockendon DJ,Satta Y

更新日期：2002-10-01 00:00:00

abstract：:Schizosaccharomyces pombe cells that contain a mutation within rad9 are sensitive to ionizing radiation, UV light and hydroxyurea, relative to wild-type strains. In addition, the mutants are moderately hypomutable by UV and unable to delay initiation of mitosis after treatment with radiation or hydroxyurea. Three radi...

journal_title：Genetics

authors： Lieberman HB

更新日期：1995-09-01 00:00:00

abstract：:Phenoxazinone synthetase, which catalyzes the condensation of 3-hydroxykynurenine to xanthommatin, the brown eye pigment of Drosophila, is shown to exist in association with a particle which resembles the cytologically defined Type I pigment granule. Several classical eye color mutants (v, cn, st, ltd, cd, w), includi...

journal_title：Genetics

authors： Phillips JP,Forrest HS,Kulkarni AD

更新日期：1973-01-01 00:00:00

abstract：:Transcriptional silencing involves the formation of specialized repressive chromatin structures. Previous studies have shown that the histone H3-H4 chaperone known as chromatin assembly factor 1 (CAF-1) contributes to transcriptional silencing in yeast, although the molecular basis for this was unknown. In this work w...

journal_title：Genetics

authors： Tamburini BA,Carson JJ,Linger JG,Tyler JK

更新日期：2006-06-01 00:00:00

abstract：:The genomes of all organisms are subject to continuous bombardment of deleterious genomic mutations (DGM). Our ability to accurately estimate various parameters of DGM has profound significance in population and evolutionary genetics. The Deng-Lynch method can estimate the parameters of DGM in natural selfing and outc...

journal_title：Genetics

authors： Deng HW,Gao G,Li JL

更新日期：2002-11-01 00:00:00

abstract：:The recombination frequency as influenced by five independent recessive ds genes was measured on three segments of different chromosomes of rice, Oryza sativa L. Each ds gene in the homozygous condition resulted in an almost equally reduced recombination frequency in the three segments. When the mean reduction in reco...

journal_title：Genetics

authors： Kitada K,Omura T

更新日期：1984-11-01 00:00:00

abstract：:The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, thus the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA variation may play in diverse cellular functions, aside from ribosome production, hig...

journal_title：Genetics

authors： Sanchez JC,Ollodart A,Large CRL,Clough C,Alvino GM,Tsuchiya M,Crane M,Kwan EX,Kaeberlein M,Dunham MJ,Raghuraman MK,Brewer BJ

更新日期：2019-09-01 00:00:00

abstract：:Following transformation of a Drosophila melanogaster true M strain with an autonomous P element, six lines were established and monitored for their molecular and phenotypic properties during a 4-yr period. The number of P elements increased with time in all the lines but the rate of increase differed among lines. Fur...

journal_title：Genetics

authors： Daniels SB,Clark SH,Kidwell MG,Chovnick A

更新日期：1987-04-01 00:00:00

abstract：:Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of meiotic recombination have been proposed. These models differ in the arrangement of heteroduplex DNA (hDNA) in recombination ...

journal_title：Genetics

authors： Radford SJ,Sabourin MM,McMahan S,Sekelsky J

更新日期：2007-05-01 00:00:00

abstract：:Host mutations in Escherichia coli K12 selected for the temperature-sensitive replication of the bacterial plasmid colicinogenic factor E(1) (ColE(1)) exhibit a pleiotropic effect with respect to the effect of the mutation on other extra-chromosomal elements. The mutations also vary with respect to the time of incubat...

journal_title：Genetics

authors： Kingsbury DT,Sieckmann DG,Helinski DR

更新日期：1973-05-01 00:00:00

abstract：:A consensus map for loblolly pine (Pinus taeda L.) was constructed from the integration of linkage data from two unrelated three-generation outbred pedigrees. The progeny segregation data from restriction fragment length polymorphism, random amplified polymorphic DNA, and isozyme genetic markers from each pedigree wer...

journal_title：Genetics

authors： Sewell MM,Sherman BK,Neale DB

更新日期：1999-01-01 00:00:00

abstract：:Evolutionary forces shape patterns of genetic diversity within populations and contribute to phenotypic variation. In particular, recurrent positive selection has attracted significant interest in both theoretical and empirical studies. However, most existing theoretical models of recurrent positive selection cannot e...

journal_title：Genetics

authors： Uricchio LH,Hernandez RD

更新日期：2014-05-01 00:00:00

abstract：:Evolutionary models appropriate for analyzing nucleotide sequences that are subject to constraints on secondary structure are developed. The models consider the evolution of pairs of nucleotides, and they incorporate the effects of base-pairing constraints on nucleotide substitution rates by introducing a new paramete...

journal_title：Genetics

authors： Muse SV

更新日期：1995-03-01 00:00:00

abstract：:Proper levels of gene expression are important for normal mammalian development. Typically, altered gene dosage caused by karyotypic abnormalities results in embryonic lethality or birth defects. Segmental aneuploidy can be compatible with life but often results in contiguous gene syndromes. The ability to manipulate ...

journal_title：Genetics

authors： Browning VL,Bergstrom RA,Daigle S,Schimenti JC

更新日期：2002-02-01 00:00:00

abstract：:The satellite DNA's from the embryos of five species of Drosophila (D. melanogaster, D. simulans, D. nasuta, D. virilis and D. hydei) have been analyzed for the presence of closed circular duplex DNA molecules, as determined by CsCl-EBr gradients. Circular DNA molecules were found in every species but D. melanogaster....

journal_title：Genetics

authors： Travaglini EC,Schultz J

更新日期：1972-11-01 00:00:00

abstract：:Ribosome biogenesis requires at least 18 putative ATP-dependent RNA helicases in Saccharomyces cerevisiae. To explore the functional environment of one of these putative RNA helicases, Dbp6p, we have performed a synthetic lethal screen with dbp6 alleles. We have previously characterized the nonessential Rsa1p, whose n...

journal_title：Genetics

authors： de la Cruz J,Lacombe T,Deloche O,Linder P,Kressler D

更新日期：2004-04-01 00:00:00

abstract：:Phosphatidylinositol catabolism in Saccharomyces cerevisiae cells cultured in media containing inositol results in the release of glycerophosphoinositol (GroPIns) into the medium. As the extracellular concentration of inositol decreases with growth, the released GroPIns is transported back into the cell. Exploiting th...

journal_title：Genetics

authors： Patton-Vogt JL,Henry SA

更新日期：1998-08-01 00:00:00

abstract：:Divergent phenotypes are often detected in domesticated plants despite the existence of invariant phenotypes in their wild forms. One such example in rice is the occurrence of varying degrees of apiculus coloration due to anthocyanin pigmentation, which was previously reported to be caused by a series of alleles at th...

journal_title：Genetics

authors： Saitoh K,Onishi K,Mikami I,Thidar K,Sano Y

更新日期：2004-10-01 00:00:00