FLAGS: A Flexible and Adaptive Association Test for Gene Sets Using Summary Statistics.

abstract：:Changes in genome structure and gene expression have been documented in both resynthesized and natural allopolyploids that contain two or more divergent genomes. The underlying mechanisms for rapid and stochastic changes in gene expression are unknown. Arabidopsis suecica is a natural allotetraploid derived from the e...

journal_title：Genetics

authors： Chen M,Ha M,Lackey E,Wang J,Chen ZJ

更新日期：2008-04-01 00:00:00

abstract：:Divergent phenotypes are often detected in domesticated plants despite the existence of invariant phenotypes in their wild forms. One such example in rice is the occurrence of varying degrees of apiculus coloration due to anthocyanin pigmentation, which was previously reported to be caused by a series of alleles at th...

journal_title：Genetics

authors： Saitoh K,Onishi K,Mikami I,Thidar K,Sano Y

更新日期：2004-10-01 00:00:00

abstract：:An elevated mutation rate can provide cells with a source of mutations to adapt to changing environments. We identified a negative epistatic interaction involving naturally occurring variants in the MLH1 and PMS1 mismatch repair (MMR) genes of Saccharomyces cerevisiae We hypothesized that this MMR incompatibility, cre...

journal_title：Genetics

authors： Bui DT,Friedrich A,Al-Sweel N,Liti G,Schacherer J,Aquadro CF,Alani E

更新日期：2017-04-01 00:00:00

abstract：:A spontaneous lethal mutation rate approximately twenty to thirty times greater than normal has been discovered in second and third chromosomes derived from an irradiated isogenic line and paired with marked inversion chromosomes. Mutations resulting in reductions of viability of varying magnitude short of complete le...

journal_title：Genetics

authors： Kidwell MG,Kidwell JF,Nei M

更新日期：1973-09-01 00:00:00

abstract：:Phytochromes play an important role in light signaling and photoperiodic control of flowering time in plants. Here we propose that the red/far-red light photoreceptor HvPHYTOCHROME C (HvPHYC), carrying a mutation in a conserved region of the GAF domain, is a candidate underlying the early maturity 5 locus in barley (H...

journal_title：Genetics

authors： Pankin A,Campoli C,Dong X,Kilian B,Sharma R,Himmelbach A,Saini R,Davis SJ,Stein N,Schneeberger K,von Korff M

更新日期：2014-09-01 00:00:00

abstract：:We explicitly solve and analyze a series of deterministic continent-island models to delimit the effects of pollen and seed migration on cytonuclear frequencies and disequilibria in random-mating, mixed-mating and self-fertilized populations. Given the critical assumption of maternal cytoplasmic inheritance, five majo...

journal_title：Genetics

authors： Asmussen MA,Schnabel A

更新日期：1991-07-01 00:00:00

abstract：:The occurrence and patterns of linkage disequilibrium between an inversion and allozymic loci within it or nearby have been used in attempts to discriminate among different hypotheses for the maintenance of variability. The interpretation of the data on the best-documented case, that of the nonrandom association betwe...

journal_title：Genetics

authors： Malpica JM,Vassallo JM,Frías A,Fuentes-Bol F

更新日期：1987-01-01 00:00:00

abstract：:The mutational origin and subsequent evolution of de novo genes, which are hypothesized to be genes of recent origin that are not obviously related to ancestral coding sequence, are poorly understood. However, accumulating evidence suggests that such genes may often function in male reproduction. Here we use testis-de...

journal_title：Genetics

authors： Begun DJ,Lindfors HA,Kern AD,Jones CD

更新日期：2007-06-01 00:00:00

abstract：:The infinite-sites model with no recombination is extended to include mutations that affect electrophoretic mobility. The model allows the effect of a single-site mutation to have a continuous effect on mobility. Formulae are obtained for the variance of electrophoretic mobility of alleles after an arbitrary lenght of...

journal_title：Genetics

authors： Cobbs G

更新日期：1979-06-01 00:00:00

abstract：:Functional analyses of the Arabidopsis genome require analysis of the gametophytic generation, since approximately 10% of the genes are expressed in the male gametophyte and approximately 9% in the female gametophyte. Here we describe the genetic and molecular characterization of 67 Ds insertion lines that show reduce...

journal_title：Genetics

authors： Boavida LC,Shuai B,Yu HJ,Pagnussat GC,Sundaresan V,McCormick S

更新日期：2009-04-01 00:00:00

abstract：:We have mapped quantitative trait loci (QTL) for Drosophila mechanosensory bristle number in six recombinant isogenic line (RIL) mapping populations, each of which was derived from an isogenic chromosome extracted from a line selected for high or low, sternopleural or abdominal bristle number and an isogenic wild-type...

journal_title：Genetics

authors： Dilda CL,Mackay TF

更新日期：2002-12-01 00:00:00

abstract：:The heterochromatin of the third chromosome is the largest uncharacterized region of the Drosophila melanogaster genome, and the last major block of D. melanogaster heterochromatin to be thoroughly analyzed. In the present study, this region was genetically dissected by generating and analyzing a series of attached, d...

journal_title：Genetics

authors： Marchant GE,Holm DG

更新日期：1988-10-01 00:00:00

abstract：:The mammalian GADD45 (growth arrest and DNA-damage inducible) gene family is composed of three highly homologous small, acidic, nuclear proteins: GADD45alpha, GADD45beta, and GADD45gamma. GADD45 proteins are involved in important processes such as regulation of DNA repair, cell cycle control, and apoptosis. Annotation...

journal_title：Genetics

authors： Peretz G,Bakhrat A,Abdu U

更新日期：2007-11-01 00:00:00

abstract：:The Standard and Sex Ratio gene arrangements of the X chromosome of D. pseudobscura differ from each other in allele frequencies at the four X chromosome loci, esterase-5, adult acid phosphatase-6, phosphoglucomutase-1 and octanol dehydrogenase-3. The Standard arrangement which is the common arrangement in all populat...

journal_title：Genetics

authors： Prakash S

更新日期：1974-08-01 00:00:00

abstract：:Twenty-two markers located on Muller's elements D or E have been mapped by in situ hybridization in six species of the obscura group of Drosophila and in D. melanogaster. The obscura species can be grouped into a Palearctic cluster (D. subobscura, D. madeirensis and D. guanche) and a Nearctic one (D. pseudoobscura, D....

journal_title：Genetics

authors： Segarra C,Ribó G,Aguadé M

更新日期：1996-09-01 00:00:00

abstract：:The prion-like behavior of Sup35p, the eRF3 homolog in the yeast Saccharomyces cerevisiae, mediates the activity of the cytoplasmic nonsense suppressor known as [PSI(+)]. Sup35p is divided into three regions of distinct function. The N-terminal and middle (M) regions are required for the induction and propagation of [...

journal_title：Genetics

authors： Jensen MA,True HL,Chernoff YO,Lindquist S

更新日期：2001-10-01 00:00:00

abstract：:Hybrid male sterility (HMS) contributes to reproductive isolation commonly observed among house mouse (Mus musculus) subspecies, both in the wild and in laboratory crosses. Incompatibilities involving specific Prdm9 alleles and certain Chromosome (Chr) X genotypes are known determinants of fertility and HMS, and previ...

journal_title：Genetics

authors： Widmayer SJ,Handel MA,Aylor DL

更新日期：2020-10-01 00:00:00

abstract：:The detection of adaptive evolution at the molecular level is of interest not only as an insight into the process of evolution but also because of its functional implications for genes of interest. Here, we present the first genomics approach to detecting positive selection operating on the Bos taurus lineage, an impo...

journal_title：Genetics

authors： Lynn DJ,Freeman AR,Murray C,Bradley DG

更新日期：2005-07-01 00:00:00

abstract：:The cosQ site of bacteriophage lambda is required for DNA packaging termination. Previous studies have shown that cosQ mutations can be suppressed in three ways: by a local suppressor within cosQ, an increase in the length of the lambda chromosome, and missense mutations affecting the prohead's portal protein, gpB. In...

journal_title：Genetics

authors： Wieczorek DJ,Didion L,Feiss M

更新日期：2002-05-01 00:00:00

abstract：:As millions of single-nucleotide polymorphisms (SNPs) have been identified and high-throughput genotyping technologies have been rapidly developed, large-scale genomewide association studies are soon within reach. However, since a genomewide association study involves a large number of SNPs it is therefore nearly impo...

journal_title：Genetics

authors： Zhao J,Jin L,Xiong M

更新日期：2006-11-01 00:00:00

abstract：:Mutations in the Saccharomyces cerevisiae SPT8 gene were previously isolated as suppressors of retrotransposon insertion mutations in the 5' regions of the HIS4 and LYS2 genes. Mutations in SPT8 confer phenotypes similar to those caused by particular mutations in SPT15, which encodes the TATA-binding protein (TBP). Th...

journal_title：Genetics

authors： Eisenmann DM,Chapon C,Roberts SM,Dollard C,Winston F

更新日期：1994-07-01 00:00:00

abstract：:Our previous work suggests that the Nhp6 HMGB protein stimulates RNA polymerase II transcription via the TATA-binding protein TBP and that Nhp6 functions in the same functional pathway as the Gcn5 histone acetyltransferase. In this report we examine the genetic relationship between Nhp6 and Gcn5 with the Mot1 and Ccr4...

journal_title：Genetics

authors： Biswas D,Yu Y,Mitra D,Stillman DJ

更新日期：2006-02-01 00:00:00

abstract：:The genetic effects of one generation of spermatogonial X-irradiation in rats, by a single dose of 600r in one experiment and by a fractionated dose of 450r in another, were measured in three generations of their descendants. Estimates of dominant lethal mutation rates--(2 to 3) X 10-4/gamete/r--from litter size diffe...

journal_title：Genetics

authors： Chambers JR,Chapman AB

更新日期：1977-02-01 00:00:00

abstract：:There is increasing recognition that genetic diversity can affect the spread of diseases, potentially affecting plant and livestock disease control as well as the emergence of human disease outbreaks. Nevertheless, even though computational tools can guide the control of infectious diseases, few epidemiological models...

journal_title：Genetics

authors： Anacleto O,Garcia-Cortés LA,Lipschutz-Powell D,Woolliams JA,Doeschl-Wilson AB

更新日期：2015-11-01 00:00:00

abstract：:Constitutive transport of cellular materials is essential for cell survival. Although multiple small GTPase Rab proteins are required for the process, few regulators of Rabs are known. Here we report that EAT-17, a novel GTPase-activating protein (GAP), regulates RAB-6.2 function in grinder formation in Caenorhabditis...

journal_title：Genetics

authors： Straud S,Lee I,Song B,Avery L,You YJ

更新日期：2013-09-01 00:00:00

abstract：:Salient features of recombination at ARG4 of Saccharomyces provoke a variation of the double-strand-break repair (DSBR) model that has the following features: (1) Holliday junction cutting is biased in favor of strands upon which DNA synthesis occurred during formation of the joint molecule (this bias ensures that cut...

journal_title：Genetics

authors： Foss HM,Hillers KJ,Stahl FW

更新日期：1999-10-01 00:00:00

abstract：:We have used mutational and revertant analysis to study the elements of the 54-nucleotide COX2 5'-untranslated leader involved in translation initiation in yeast mitochondria and in activation by the COX2 translational activator. Pet111p. We generated a collection of mutants with substitutions spanning the entire COX2...

journal_title：Genetics

authors： Dunstan HM,Green-Willms NS,Fox TD

更新日期：1997-09-01 00:00:00

abstract：:Correlation and regression analyses indicate that isofemale strains extracted from a population of the parasitic wasp, Nasonia vitripennis, differ in the fit of their second sex ratios (those produced in previously parasitized hosts) to the predictions of the theory of optimal facultative sex ratio adjustment. Under t...

journal_title：Genetics

authors： Orzack SH

更新日期：1990-02-01 00:00:00

abstract：:Ten mutations are described that transform genotypic hermaphrodites of the nematode Caenorhabditis elegans into phenotypic males. These fall into three autosomal complementation groups, termed tra-1, tra-2, and tra-3. Two alleles of tra-1 produce almost complete transformation, to a fertile male phenotype; such transf...

journal_title：Genetics

authors： Hodgkin JA,Brenner S

更新日期：1977-06-01 00:00:00

abstract：:Transposons can impact the host genome by altering gene expression and participating in chromosome rearrangements. Therefore, organisms evolved different ways to minimize the level of transposition. In Saccharomyces cerevisiae and its close relative S. paradoxus, Ty1 copy number control (CNC) is mediated by the self-e...

journal_title：Genetics

authors： Ahn HW,Tucker JM,Arribere JA,Garfinkel DJ

更新日期：2017-12-01 00:00:00