Abstract：
:Evolutionary rescue describes a situation where adaptive evolution prevents the extinction of a population facing a stressing environment. Models of evolutionary rescue could in principle be used to predict the level of stress beyond which extinction becomes likely for species of conservation concern, or, conversely, the treatment levels most likely to limit the emergence of resistant pests or pathogens. Stress levels are known to affect both the rate of population decline (demographic effect) and the speed of adaptation (evolutionary effect), but the latter aspect has received less attention. Here, we address this issue using Fisher's geometric model of adaptation. In this model, the fitness effects of mutations depend both on the genotype and the environment in which they arise. In particular, the model introduces a dependence between the level of stress, the proportion of rescue mutants, and their costs before the onset of stress. We obtain analytic results under a strong-selection-weak-mutation regime, which we compare to simulations. We show that the effect of the environment on evolutionary rescue can be summarized into a single composite parameter quantifying the effective stress level, which is amenable to empirical measurement. We describe a narrow characteristic stress window over which the rescue probability drops from very likely to very unlikely as the level of stress increases. This drop is sharper than in previous models, as a result of the decreasing proportion of stress-resistant mutations as stress increases. We discuss how to test these predictions with rescue experiments across gradients of stress.
journal_name
Geneticsjournal_title
Geneticsauthors
Anciaux Y,Chevin LM,Ronce O,Martin Gdoi
10.1534/genetics.118.300908subject
Has Abstractpub_date
2018-05-01 00:00:00pages
265-279issue
1eissn
0016-6731issn
1943-2631pii
genetics.118.300908journal_volume
209pub_type
杂志文章相关文献
GENETICS文献大全abstract：:Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations are identified based on loss-of-function phenotypes, which cannot differentiate between separation-of-...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.112.147801
更新日期：2013-03-01 00:00:00
abstract：:Some populations of maize's closest relatives, the annual teosintes of Mexico, are unreceptive to maize pollen. When present in the pistil (silk and ovary) a number of maize genes discriminate against or exclude pollen not carrying the same allele. An analogous gene Tcb1-s was found in some teosinte populations but no...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.048645
更新日期：2006-01-01 00:00:00
abstract：:Drosophila melanogaster heterochromatin protein 2 (HP2) interacts with heterochromatin protein 1 (HP1). In polytene chromosomes, HP2 and HP1 colocalize at the chromocenter, telomeres, and the small fourth chromosome. We show here that HP2 is present in the arms as well as the centromeric regions of mitotic chromosomes...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.057604
更新日期：2006-11-01 00:00:00
abstract：:We have isolated and characterized deletions arising within a P transposon, P[hswa], in the presence of P transposase. P[hswa] carries white-apricot (wa) sequences, including a complete copia element, under the control of an hsp70 promoter, and resembles the original wa allele in eye color phenotype. In the presence o...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:DNA repair of single-strand breaks (produced by ionizing radiation) and of base damage (produced by ultraviolet (UV) light) are two repair mechanisms that most mammalian cells possess. Genetic defects in these repair mechanisms are exemplified by cells from the human premature-aging disease, progeria, which fail to re...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-06-01 00:00:00
abstract：:Hepatic glucocorticoid receptor binding activity was measured in A/J, C57BL/6J, their F1 reciprocal crosses and their F1 recombinant inbred (RI) lines. The glucocorticoid binding capacity was measured in Hepes buffer and Hepes buffer plus dithiothreitol (DTT). The A/J parental strain showed higher levels, and a greate...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:The behaviour of two "meiotic drive" systems, Segregation-Distorter (SD) and the sex chromosome sc(4)sc(8) has been examined in the same meiocyte. It has been found that the two systems interact in a specific way. When the distorting effects of SD and sc(4)sc(8) are against each other, there is no detectable interacti...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1972-09-01 00:00:00
abstract：:Hydroxyurea (HU) has been used for the treatment of multiple diseases, such as cancer. The therapeutic effect is generally believed to be due to the suppression of ribonucleotide reductase (RNR), which slows DNA polymerase movement at replication forks and induces an S phase cell cycle arrest in proliferating cells. A...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.191536
更新日期：2016-11-01 00:00:00
abstract：:To identify genes involved in stress resistance and heat hardening, replicate lines of Drosophila melanogaster were selected for increased resistance to knockdown by a 39 degrees heat stress. Two selective regimes were used, one with and one without prior hardening. Mean knockdown times were increased from approximate...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：:Intron sizes show an asymmetrical distribution in a number of organisms, with a large number of "short" introns clustered around a minimal intron length and a much broader distribution of longer introns. In Drosophila melanogaster, the short intron class is centered around 61 bp. The narrow length distribution suggest...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:In a genetic screen for mutants showing modified splicing of an alternatively spliced GFP reporter gene in Arabidopsis thaliana, we identified mutations in genes encoding the putative U1 small nuclear ribonucleoprotein (snRNP) factors RBM25 and PRP39a. The latter has not yet been studied for its role in pre-messenger ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.117.300149
更新日期：2017-12-01 00:00:00
abstract：:Interactions with bacteria play a major role in immune responses, ecology, and evolution of all animals, but they have been neglected until recently in the case of C. elegans. We report a genetic investigation of the interaction of C. elegans with the nematode-specific pathogen Microbacterium nematophilum, which colon...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.045716
更新日期：2005-11-01 00:00:00
abstract：:Repair replication of DNA has been studied in first instar larvae of Drosophila melanogaster with isopycnic centrifugation techniques. Larvae were fed BUdR, FUdR, streptomycin, penicillin, and Fungazone for two to four hours prior to exposure to UV, X-rays, MMS, or EMS. Feeding was continued for four hours in the pres...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1974-08-01 00:00:00
abstract：:There are two common alleles at the Amylase-2 locus in populations of Gammarus palustris, the salt marsh amphipod. Intensive sampling of individuals from two localities at Jamaica Bay revealed a consistent pattern of heterozygote deficiency.-Five possible sources of heterozygote deficiency were examined in this study....
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-10-01 00:00:00
abstract：:High baselines of transcription factor activities represent fundamental obstacles to regulated signaling. Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) si...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.086298
更新日期：2008-04-01 00:00:00
abstract：:Heparan sulfates (HS) are linear polysaccharides with complex modification patterns, which are covalently bound via conserved attachment sites to core proteins to form heparan sulfate proteoglycans (HSPGs). HSPGs regulate many aspects of the development and function of the nervous system, including cell migration, mor...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.198739
更新日期：2017-08-01 00:00:00
abstract：:The Arabidopsis short integuments 2-1 (sin2-1) mutant produces ovules with short integuments due to early cessation of cell division in these structures. SIN2 was isolated and encodes a putative GTPase sharing features found in the novel DAR GTPase family. DAR proteins share a signature DAR motif and a unique arrangem...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.060657
更新日期：2006-10-01 00:00:00
abstract：:The mitochondrial DNA (mtDNA) in animals is generally a circular molecule of approximately 15 kb, but there are many exceptions such as linear molecules and larger ones. RFLP studies indicated that the mtDNA in the terrestrial isopod Armadillidium vulgare varied from 20 to 42 kb. This variation depended on the restric...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:We examined the prevalence of interactions between pairs of short chromosomal regions from one species (Solanum habrochaites) co-introgressed into a heterospecific genetic background (Solanum lycopersicum). Of 105 double introgression line (DIL) families generated from a complete diallele combination of 15 chromosomal...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.095679
更新日期：2009-01-01 00:00:00
abstract：:Individual inbreeding and historical demography can be estimated by analyzing runs of homozygosity (ROH), which are indicative of chromosomal segments of identity by descent (IBD). Such analyses have so far been rare in natural populations due to limited genomic resources. We analyzed ROH in whole genome sequences fro...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.198861
更新日期：2017-03-01 00:00:00
abstract：:In finite populations, an allele disappears or reaches fixation due to two main forces, selection and drift. Selection is generally thought to accelerate the process: a selected mutation will reach fixation faster than a neutral one, and a disadvantageous one will quickly disappear from the population. We show that ev...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.178160
更新日期：2015-12-01 00:00:00
abstract：:Distance- as well as marker-dependence of genetic recombination of bacteriophage T4 was studied in crosses between rIIB mutants with known base sequences. The notion of a "basic recombination," which is the recombination within distances shorter than hybrid DNA length in the absence of mismatch repair and any marker e...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Many genetic variants identified in genome-wide association studies (GWAS) are associated with multiple, sometimes seemingly unrelated, traits. This motivates multi-trait association analyses, which have successfully identified novel associated loci for many complex diseases. While appealing, most existing methods foc...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.120.303242
更新日期：2020-08-01 00:00:00
abstract：:The r-X1 deficiency in maize induces nondisjunction at the second mitotic division during embryo sac formation. However, it was not known if this deficiency also induces nondisjunction during the microspore divisions. Microsporogenesis in plants lacking or containing this deficiency was compared using two approaches. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：:We propose a new method for calculating probabilities for pedigree genetic data that incorporates crossover interference using the chi-square models. Applications include relationship inference, genetic map construction, and linkage analysis. The method is based on importance sampling of unobserved inheritance pattern...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：:The double-strand break repair models for homologous recombination propose that a double-strand break in a duplex DNA segment is repaired by gene conversion copying a homologous DNA segment. This is a type of conservative recombination, or two-progeny recombination, which generates two duplex DNA segments from two dup...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Biological robustness, the ability of an organism to maintain a steady-state output as genetic or environmental inputs change, is critical for proper development. MicroRNAs have been implicated in biological robustness mechanisms through their post-transcriptional regulation of genes and gene networks. Previous resear...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.179184
更新日期：2015-08-01 00:00:00
abstract：:The occurrence and patterns of linkage disequilibrium between an inversion and allozymic loci within it or nearby have been used in attempts to discriminate among different hypotheses for the maintenance of variability. The interpretation of the data on the best-documented case, that of the nonrandom association betwe...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:We have performed an F2 genetic screen to identify lethal mutations within the 63E-64A genomic region. We have isolated 122 mutations in 20 different complementation groups. Of these groups, 16 are represented by multiple alleles. We have also established that the Rop and Ras2 genes are located within the 63E-64A geno...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:The DNMT1 cytosine methyltransferase enzyme contains a large ∼300-aa intrinsically disordered domain (IDD) that we previously showed regulated DNA methylation patterns in mouse ES cells. Here we generated seven mouse lines with different mutations in the IDD. Homozygous mutant mice of five lines developed normally, wi...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.114.173609
更新日期：2015-02-01 00:00:00
