On recombination among In(2L)t, alpha-Gpdh and Adh in Drosophila melanogaster.

abstract：:The human fungal pathogen Candida albicans can reversibly switch between two cell types named "white" and "opaque," each of which is stable through many cell divisions. These two cell types differ in their ability to mate, their metabolic preferences and their interactions with the mammalian innate immune system. A hi...

journal_title：Genetics

authors： Lohse MB,Ene IV,Craik VB,Hernday AD,Mancera E,Morschhäuser J,Bennett RJ,Johnson AD

更新日期：2016-08-01 00:00:00

abstract：:To study the interdependence of Gcr1p and Rap1p, we prepared a series of synthetic regulatory sequences that contained various numbers and combinations of CT-boxes (Gcr1p-binding sites) and RPG-boxes (Rap1p-binding sites). The ability of the synthetic oligonucleotides to function as regulatory sequences was tested usi...

journal_title：Genetics

authors： Uemura H,Koshio M,Inoue Y,Lopez MC,Baker HV

更新日期：1997-10-01 00:00:00

abstract：:Mating behavior in adult male nematodes can be assayed by mating efficiency, i.e., the number of cross progeny sired by males under standard conditions. Mutant males from 220 strains, representing most of the known complementation groups of C. elegans, have been examined for mating efficiency and for anatomical abnorm...

journal_title：Genetics

authors： Hodgkin J

更新日期：1983-01-01 00:00:00

abstract：:Argonaute2 (Ago2) is a rapidly evolving nuclease in the Drosophila melanogaster RNA interference (RNAi) pathway that targets viruses and transposable elements in somatic tissues. Here we reconstruct the history of Ago2 duplications across the D. obscura group and use patterns of gene expression to infer new functional...

journal_title：Genetics

authors： Lewis SH,Webster CL,Salmela H,Obbard DJ

更新日期：2016-10-01 00:00:00

abstract：:In mismatch repair (MMR), members of the MLH gene family have been proposed to act as key molecular matchmakers to coordinate mismatch recognition with downstream repair functions that result in mispair excision. Two members of this gene family, MLH1 and MLH3, have also been implicated in meiotic crossing over. These ...

journal_title：Genetics

authors： Argueso JL,Smith D,Yi J,Waase M,Sarin S,Alani E

更新日期：2002-03-01 00:00:00

abstract：:A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals....

journal_title：Genetics

authors： Fu YX

更新日期：1997-08-01 00:00:00

abstract：:Palindromic sequences have the potential to form hairpin or cruciform structures, which are putative substrates for several nucleases and mismatch repair enzymes. A genetic method was developed to detect such structures in vivo in the yeast Saccharomyces cerevisiae. Using this method we previously showed that short ha...

journal_title：Genetics

authors： Nag DK,Kurst A

更新日期：1997-07-01 00:00:00

abstract：:Cell differentiation in yeast species is controlled by a reversible, programmed DNA-rearrangement process called mating-type switching. Switching is achieved by two functionally similar but structurally distinct processes in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe In ...

journal_title：Genetics

authors： Hanson SJ,Wolfe KH

更新日期：2017-05-01 00:00:00

abstract：:Genomic sequences provide powerful new tools in genetic analysis, making it possible to combine classical genetics with genomics to characterize the genes in a particular chromosome region. These approaches have been applied successfully to the euchromatin, but analysis of the heterochromatin has lagged somewhat behin...

journal_title：Genetics

authors： Myster SH,Wang F,Cavallo R,Christian W,Bhotika S,Anderson CT,Peifer M

更新日期：2004-02-01 00:00:00

abstract：:Brassica carinata, an allotetraploid with B and C genomes, has a number of traits that would be valuable to introgress into B. napus. Interspecific hybrids were created between B. carinata (BBCC) and B. napus (AACC), using an advanced backcross approach to identify and introgress traits of agronomic interest from the ...

journal_title：Genetics

authors： Navabi ZK,Stead KE,Pires JC,Xiong Z,Sharpe AG,Parkin IA,Rahman MH,Good AG

更新日期：2011-03-01 00:00:00

abstract：:Gene expression in Anopheles gambiae shows a deficiency of testis-expressed genes on the X chromosome associated with an excessive movement of retrogene duplication. We suggest that the degeneration of sex chromosomes in this monandrous species is likely the result of pressures from X inactivation, dosage compensation...

journal_title：Genetics

authors： Baker DA,Russell S

更新日期：2011-11-01 00:00:00

abstract：:The fixation probability is determined when population size and selection change over time and differs from Kimura's result, with long-term implications for a population. It is found that changes in population size are not equivalent to the corresponding changes in selection and can result in less drift than anticipat...

journal_title：Genetics

authors： Waxman D

更新日期：2011-08-01 00:00:00

abstract：:Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in SCN1A To characterize the pathogenic substitution (p.H939R) of a local individual with Dravet syndrome, fibroblast cells from the individual were reprogrammed to pluripotent stem cells and differentiated into neurons. Sodium ...

journal_title：Genetics

authors： Dyment DA,Schock SC,Deloughery K,Tran MH,Ure K,Nutter LMJ,Creighton A,Yuan J,Banderali U,Comas T,Baumann E,Jezierski A,Care4Rare Canada Consortium,.,Boycott KM,Mackenzie AE,Martina M

更新日期：2020-08-01 00:00:00

abstract：:When individuals' fitnesses depend on the genetic composition of the population in which they are found, selection is then frequency dependent. Frequency-dependent selection (FDS) is often invoked as a heuristic explanation for the maintenance of large numbers of alleles at a locus. The pairwise interaction model is a...

journal_title：Genetics

authors： Trotter MV,Spencer HG

更新日期：2007-07-01 00:00:00

abstract：:Preliminary studies with restriction fragment length polymorphisms of mitochondrial DNA (mtDNA) in natural populations of Drosophila melanogaster revealed considerable variation in terms of nucleotide sequence and overall size. In this report we present data from more isofemale lines and more restriction enzymes, and ...

journal_title：Genetics

authors： Hale LR,Singh RS

更新日期：1991-09-01 00:00:00

abstract：:Genetic control over chromosome stability in the interspecific hybrid embryos of Hordeum vulgare and H. bulbosum has been hypothesized to reside on specific chromosomes. In this study, crosses between the primary trisomic lines for the seven different H. vulgare chromosomes and tetraploid H. bulbosum revealed that bot...

journal_title：Genetics

authors： Ho KM,Kasha KJ

更新日期：1975-10-01 00:00:00

abstract：:RNA interference (RNAi) in tissue culture cells has emerged as an excellent methodology for identifying gene functions systematically and in an unbiased manner. Here, we describe how RNAi high-throughput screening (HTS) in Drosophila cells are currently being performed and emphasize the strengths and weaknesses of the...

journal_title：Genetics

authors： Perrimon N,Mathey-Prevot B

更新日期：2007-01-01 00:00:00

abstract：:Despite its importance to agriculture, the genetic basis of heterosis is still not well understood. The main competing hypotheses include dominance, overdominance, and epistasis. NC design III is an experimental design that has been used for estimating the average degree of dominance of quantitative trait loci (QTL) a...

journal_title：Genetics

authors： Garcia AA,Wang S,Melchinger AE,Zeng ZB

更新日期：2008-11-01 00:00:00

abstract：:The genomic prediction of phenotypes and breeding values in animals and plants has developed rapidly into its own research field. Results of genomic prediction studies are often difficult to compare because data simulation varies, real or simulated data are not fully described, and not all relevant results are reporte...

journal_title：Genetics

authors： Daetwyler HD,Calus MP,Pong-Wong R,de Los Campos G,Hickey JM

更新日期：2013-02-01 00:00:00

abstract：:We have amplified and sequenced the gene encoding Esterase-P (Est-P) in 10 strains of Drosophila melanogaster. Three premature termination codons occur in the coding region of the gene in two strains. This observation, together with other indirect evidence, leads us to propose that Est-P may be a pseudogene in D. mela...

journal_title：Genetics

authors： Balakirev ES,Ayala FJ

更新日期：1996-12-01 00:00:00

abstract：:We have analyzed two variants of Drosophila melanogaster (RS and RE) which lead to the dual phenotype of elevated DDC activity and increased resistance to dietary alpha-methyldopa relative to Oregon-R controls. Both phenotypes show tight genetic linkage to the dopa decarboxylase, Ddc, and l(2)amd genes (i.e., less tha...

journal_title：Genetics

authors： Marsh JL,Wright TR

更新日期：1986-02-01 00:00:00

abstract：:A spontaneous lethal mutation rate approximately twenty to thirty times greater than normal has been discovered in second and third chromosomes derived from an irradiated isogenic line and paired with marked inversion chromosomes. Mutations resulting in reductions of viability of varying magnitude short of complete le...

journal_title：Genetics

authors： Kidwell MG,Kidwell JF,Nei M

更新日期：1973-09-01 00:00:00

abstract：:The walls of Aspergillus nidulans conidia contain a green pigment that protects the spores from damage by ultraviolet light. At least two genes, wA and yA, are required for pigment synthesis: yA mutants produce yellow spores, wA mutants produce white spores, and wA mutations are epistatic to yA mutations. We cloned wA...

journal_title：Genetics

authors： Mayorga ME,Timberlake WE

更新日期：1990-09-01 00:00:00

abstract：:Several quantitative trait loci (QTL) mapping strategies can successfully identify major-effect loci, but often have poor success detecting loci with minor effects, potentially due to the confounding effects of major loci, epistasis, and limited sample sizes. To overcome such difficulties, we used a targeted backcross...

journal_title：Genetics

authors： Sinha H,David L,Pascon RC,Clauder-Münster S,Krishnakumar S,Nguyen M,Shi G,Dean J,Davis RW,Oefner PJ,McCusker JH,Steinmetz LM

更新日期：2008-11-01 00:00:00

abstract：:Key steps of essential metabolic pathways are housed in plant peroxisomes. We conducted a microscopy-based screen for anomalous distribution of peroxisomally targeted fluorescence in Arabidopsis thaliana This screen uncovered 34 novel alleles in 15 genes affecting oil body mobilization, fatty acid β-oxidation, the gly...

journal_title：Genetics

authors： Rinaldi MA,Patel AB,Park J,Lee K,Strader LC,Bartel B

更新日期：2016-11-01 00:00:00

abstract：:Pairwise linkage disequilibrium values (D) were estimated for 14 allozyme loci in two natural populations of lodgepole pine (Pinus contorta ssp. latifolia). Maternal multilocus genotypes were inferred from samples of (haploid) megagametophytic seed-endosperms. Coupling/repulsion double heterozygotes were distinguished...

journal_title：Genetics

authors： Epperson BK,Allard RW

更新日期：1987-02-01 00:00:00

abstract：:Flowering is indicative of the transition from vegetative to reproductive phase, a critical event in the life cycle of plants. In soybean (Glycine max), a flowering quantitative trait locus, FT2, corresponding to the maturity locus E2, was detected in recombinant inbred lines (RILs) derived from the varieties "Misuzud...

journal_title：Genetics

authors： Watanabe S,Xia Z,Hideshima R,Tsubokura Y,Sato S,Yamanaka N,Takahashi R,Anai T,Tabata S,Kitamura K,Harada K

更新日期：2011-06-01 00:00:00

abstract：:The small ovary gene (sov) is required for the development of the Drosophila ovary. Six EMS-induced recessive alleles have been identified. Hypomorphic alleles are female sterile and have no effect on male fertility, whereas more severe mutations result in lethality. The female-sterile alleles produce a range of mutan...

journal_title：Genetics

authors： Wayne S,Liggett K,Pettus J,Nagoshi RN

更新日期：1995-03-01 00:00:00

abstract：:This article focuses on conducting global testing for association between a binary trait and a set of rare variants (RVs), although its application can be much broader to other types of traits, common variants (CVs), and gene set or pathway analysis. We show that many of the existing tests have deteriorating performan...

journal_title：Genetics

authors： Pan W,Kim J,Zhang Y,Shen X,Wei P

更新日期：2014-08-01 00:00:00

abstract：:A sib analysis of adult life-history characters was performed on about twelve hundred females from a laboratory Drosophila melanogaster population that had been sampled from nature and cultured so as to preserve its genetic variability. The following results were found. There was no detectable trend with age in additi...

journal_title：Genetics

authors： Rose MR,Charlesworth B

更新日期：1981-01-01 00:00:00