Abstract:
:We propose a new method for calculating probabilities for pedigree genetic data that incorporates crossover interference using the chi-square models. Applications include relationship inference, genetic map construction, and linkage analysis. The method is based on importance sampling of unobserved inheritance patterns conditional on the observed genotype data and takes advantage of fast algorithms for no-interference models while using reweighting to allow for interference. We show that the method is effective for arbitrarily many markers with small pedigrees.
journal_name
Geneticsjournal_title
Geneticsauthors
Browning Skeywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
1561-6issue
4eissn
0016-6731issn
1943-2631journal_volume
164pub_type
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