Abstract：
:In female mammalian cells, the inactive X chromosome is replicated late in S phase while the active X chromosome is replicated earlier. The replication times of the X chromosomes reflect a general trend in which late replication is associated with gene repression and earlier replication with transcriptional competence. The X-linked Xist gene is expressed exclusively from the inactive X chromosome where it is involved in the initiation and maintenance of X-inactivation. In contrast, no biological activity has been assigned to the Xist locus of the active X chromosome where the Xist gene is transcriptionally silenced. Here, we provide evidence that the element(s) at the nontranscribed Xist locus of the active X chromosome controls chromosomal replication timing in cis.
journal_name
Geneticsjournal_title
Geneticsauthors
Diaz-Perez S,Ouyang Y,Perez V,Cisneros R,Regelson M,Marahrens Ydoi
10.1534/genetics.105.043026keywords:
subject
Has Abstractpub_date
2005-10-01 00:00:00pages
663-72issue
2eissn
0016-6731issn
1943-2631pii
genetics.105.043026journal_volume
171pub_type
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