A genetic linkage map of the model legume Lotus japonicus and strategies for fast mapping of new loci.

abstract：:Although most living organisms reproduce sexually, some have developed a uniparental reproduction where the embryo usually derives from the female parent. A unique case of paternal apomixis in plants has been recently reported in Cupressus dupreziana, an endangered Mediterranean conifer. This species produces unreduce...

journal_title：Genetics

authors： Pichot C,Liens B,Nava JL,Bachelier JB,El Maâtaoui M

更新日期：2008-01-01 00:00:00

abstract：:The trace element iron is crucial for living organisms, since it plays essential roles in numerous cellular functions. Systemic iron overload and the elevated level of ferritin, a ubiquitous intracellular protein that stores and releases iron to maintain the iron homeostasis in cells, has long been epidemiologically a...

journal_title：Genetics

authors： Wang H,Jiang X,Wu J,Zhang L,Huang J,Zhang Y,Zou X,Liang B

更新日期：2016-05-01 00:00:00

abstract：:We develop the theory for computing the joint frequency spectra of alleles in two closely related species. We allow for arbitrary population growth in both species after they had a common ancestor. We focus on the case in which a single chromosome is sequenced from one of the species. We use classical diffusion theory...

journal_title：Genetics

authors： Chen H,Green RE,Pääbo S,Slatkin M

更新日期：2007-09-01 00:00:00

abstract：:Notch is a receptor that mediates cell-cell interactions in animal development, and aberrations in Notch signal transduction can cause cancer and other human diseases. Here, I describe the major advances in the Notch field from the identification of the first mutant in Drosophila almost a century ago through the eluci...

journal_title：Genetics

authors： Greenwald I

更新日期：2012-07-01 00:00:00

abstract：:Mitochondria of Neurospora crassa contain a cyanide-resistant alternative respiratory pathway in addition to the cytochrome pathway. The alternative oxidase is present only when electron flow through the cytochrome chain is restricted. Both genomic and cDNA copies for the alternative oxidase gene have been isolated an...

journal_title：Genetics

authors： Li Q,Ritzel RG,McLean LL,McIntosh L,Ko T,Bertrand H,Nargang FE

更新日期：1996-01-01 00:00:00

abstract：:A key quantity in the analysis of structured populations is the parameter K, which describes the number of subpopulations that make up the total population. Inference of K ideally proceeds via the model evidence, which is equivalent to the likelihood of the model. However, the evidence in favor of a particular value o...

journal_title：Genetics

authors： Verity R,Nichols RA

更新日期：2016-08-01 00:00:00

abstract：:The pattern of mutational covariance among traits plays a central, but largely untested, role in many theories in evolutionary genetics. Here we estimate the pattern of phenotypic, environmental, and mutational correlations for a set of life-history, behavioral, and morphological traits using 67 self-fertilizing lines...

journal_title：Genetics

authors： Estes S,Ajie BC,Lynch M,Phillips PC

更新日期：2005-06-01 00:00:00

abstract：:The value of molecular markers and pedigree records, separately or in combination, to assist in the management of conserved populations has been tested. The general strategy for managing the population was to optimize contributions of parents to the next generation for minimizing the global weighted coancestry. Strate...

journal_title：Genetics

authors： Fernández J,Villanueva B,Pong-Wong R,Toro MA

更新日期：2005-07-01 00:00:00

abstract：:The plant mitochondrial genome is composed of a set of molecules of various sizes that generate each other through recombination between repeated sequences. Molecular observations indicate that these different molecules are present in an equilibrium state. Different compositions of molecules have been observed within ...

journal_title：Genetics

authors： Albert B,Godelle B,Atlan A,De Paepe R,Gouyon PH

更新日期：1996-09-01 00:00:00

abstract：:We analyzed linkage and chromosomal positions of genes in A. lyrata ssp. petraea that are located near the centromere (CEN) regions of A. thaliana, using at least two genes from the short and long arms of each chromosome. In our map, genes from all 10 A. thaliana chromosome arms are also tightly linked in A. lyrata. G...

journal_title：Genetics

authors： Kawabe A,Hansson B,Hagenblad J,Forrest A,Charlesworth D

更新日期：2006-07-01 00:00:00

abstract：:Amoebae of the Colonia (CL) strain, which normally produce plasmodia in clones, are shown to cross with mt3 and mt4 amoebae under appropriate conditions. Strains carrying mt3 and mt4 in a CL genetic background were constructed and used in the genetic analysis of mutants isolated in CL. ...

journal_title：Genetics

authors： Adler PN,Holt CE

更新日期：1974-12-01 00:00:00

abstract：:We have previously isolated mutants of Escherichia coli that replicate their DNA with increased fidelity. These mutants have a mutation in the dnaE gene, encoding the alpha subunit of DNA polymerase III. They were isolated in a mismatch-repair-defective mutL background, in which mutations can be considered to represen...

journal_title：Genetics

authors： Oller AR,Schaaper RM

更新日期：1994-10-01 00:00:00

abstract：:CarD is the only reported prokaryotic protein showing structural and functional features typical of eukaryotic high-mobility group A transcription factors. In prokaryotes, proteins similar to CarD appear to be confined primarily to myxobacteria. In Myxococcus xanthus, CarD has been previously shown to act as a positiv...

journal_title：Genetics

authors： Galbis-Martínez M,Fontes M,Murillo FJ

更新日期：2004-08-01 00:00:00

abstract：:Mutants of Paramecium caudatum with abnormal swimming behavior or responses to cations were obtained by mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. Some of the mutants, like pawn in P. tetraurelia, cannot swim backward and are called CNR. Seven independently obtained CNR mutants belonged to three complement...

journal_title：Genetics

authors： Takahashi M

更新日期：1979-03-01 00:00:00

abstract：:The SMK1 mitogen-activated protein kinase is required for spore morphogenesis in Saccharomyces cerevisiae. In contrast to the multiple aberrant spore wall assembly patterns seen even within a single smk1 null ascus, different smk1 missense mutants block in a coordinated fashion at intermediate stages. One smk1 mutant ...

journal_title：Genetics

authors： Wagner M,Briza P,Pierce M,Winter E

更新日期：1999-04-01 00:00:00

abstract：:In this article we investigate multiplicative effects between genes in relation to heterosis. The extensive literature on heterosis due to multiplicative effects between characters is reviewed, as is earlier work on the genetic description of heterosis. A two-locus diallelic model of arbitrary gene action is used to d...

journal_title：Genetics

authors： Schnell FW,Cockerham CC

更新日期：1992-06-01 00:00:00

abstract：:A mouse homolog of the Drosophila pair-rule gene Odd Oz (Odz4) maps to the critical region of the l7Rn3 locus on mouse chromosome 7. Here we show that Odz4 is an excellent candidate for this allelic series because (1) it spans the entire critical region, (2) the phenotypes correlate with embryonic expression, (3) the ...

journal_title：Genetics

authors： Lossie AC,Nakamura H,Thomas SE,Justice MJ

更新日期：2005-01-01 00:00:00

abstract：:We examined the prevalence of interactions between pairs of short chromosomal regions from one species (Solanum habrochaites) co-introgressed into a heterospecific genetic background (Solanum lycopersicum). Of 105 double introgression line (DIL) families generated from a complete diallele combination of 15 chromosomal...

journal_title：Genetics

authors： Moyle LC,Nakazato T

更新日期：2009-01-01 00:00:00

abstract：:The distribution within anthers of maize plants of microsporocytes of differing crossover class was studied by application of the serial-sectioning technique to plants heterozygous for a paracentric inversion. In such material, cells with four-strand double crossovers within the inversion are distinguishable from cell...

journal_title：Genetics

authors： Maguire MP

更新日期：1980-05-01 00:00:00

abstract：:Centromeres are responsible for the correct segregation of chromosomes during mitosis and meiosis. Holocentric chromosomes, characterized by multiple centromere units along each chromatid, have particular adaptations to ensure regular disjunction during meiosis. Here we show by detecting CENH3, CENP-C, tubulin, and ce...

journal_title：Genetics

authors： Marques A,Schubert V,Houben A,Pedrosa-Harand A

更新日期：2016-10-01 00:00:00

abstract：:The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that i...

journal_title：Genetics

authors： Desai MM,Plotkin JB

更新日期：2008-12-01 00:00:00

abstract：:The extent of conservation of synteny and gene order in the Lepidoptera has been investigated previously only by comparing a small subset of linkage groups between the moth Bombyx mori and the butterfly Heliconius melpomene. Here we report the mapping of 64 additional conserved genes in H. melpomene, which contributed...

journal_title：Genetics

authors： Pringle EG,Baxter SW,Webster CL,Papanicolaou A,Lee SF,Jiggins CD

更新日期：2007-09-01 00:00:00

abstract：:Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...

journal_title：Genetics

authors： Cutter AD,Agrawal AF

更新日期：2010-06-01 00:00:00

abstract：:The genetic basis of stochastic variation within a defined environment, and the consequences of such micro-environmental variance for fitness are poorly understood . Using a multigenerational breeding design in Drosophila serrata, we demonstrated that the micro-environmental variance in a set of morphological wing tra...

journal_title：Genetics

authors： Sztepanacz JL,McGuigan K,Blows MW

更新日期：2017-08-01 00:00:00

abstract：:The point mutation rate of phage PhiX174 was determined using the fluctuation test. After identifying the genetic changes associated with the selected phenotype, we obtained an estimate of 1.0x10(-6) substitutions per base per round of copying, which is consistent with Drake's rule (0.003 mutations per genome per roun...

journal_title：Genetics

authors： Cuevas JM,Duffy S,Sanjuán R

更新日期：2009-10-01 00:00:00

abstract：:We estimated DNA sequence variation in a 5.7-kb fragment of the furrowed (fw) gene region within and between four populations of Drosophila ananassae; fw is located in a chromosomal region of very low recombination. We analyzed gene flow between these four populations along a latitudinal transect on the Indian subcont...

journal_title：Genetics

authors： Chen Y,Marsh BJ,Stephan W

更新日期：2000-07-01 00:00:00

abstract：:Selective sweeps are typically associated with a local reduction of genetic diversity around the adaptive site. However, selective sweeps can also quickly carry neutral mutations to observable population frequencies if they arise early in a sweep and hitchhike with the adaptive allele. We show that the interplay betwe...

journal_title：Genetics

authors： Messer PW,Neher RA

更新日期：2012-06-01 00:00:00

abstract：:In order to learn more about other proteins that may be involved in repression of HML and HMR in Saccharomyces cerevisiae, extragenic suppressor mutations were identified that could restore repression in cells defective in SIR4, a gene required for function of the silencer elements flanking HML and HMR. These suppress...

journal_title：Genetics

authors： Schnell R,D'Ari L,Foss M,Goodman D,Rine J

更新日期：1989-05-01 00:00:00

abstract：:Demonstrating that naturally occurring enzyme polymorphisms significantly impact metabolic pathway flux is a fundamental step in examining the possible adaptive significance of such polymorphisms. In earlier studies of the glucose-6-phosphate dehydrogenase (G6PD) polymorphism in Drosophila melanogaster, we used two di...

journal_title：Genetics

authors： Labate J,Eanes WF

更新日期：1992-11-01 00:00:00

abstract：:Hepatic glucocorticoid receptor binding activity was measured in A/J, C57BL/6J, their F1 reciprocal crosses and their F1 recombinant inbred (RI) lines. The glucocorticoid binding capacity was measured in Hepes buffer and Hepes buffer plus dithiothreitol (DTT). The A/J parental strain showed higher levels, and a greate...

journal_title：Genetics

authors： Liu SL,Erickson RP

更新日期：1986-07-01 00:00:00