Abstract：
:We develop the theory for computing the joint frequency spectra of alleles in two closely related species. We allow for arbitrary population growth in both species after they had a common ancestor. We focus on the case in which a single chromosome is sequenced from one of the species. We use classical diffusion theory to show that, if the ancestral species was at equilibrium under mutation and drift and a chromosome from one of the descendant species carries the derived allele, the frequency spectrum in the other species is uniform, independently of the demographic history of both species. We also predict the expected densities of segregating and fixed sites when the chromosome from the other species carries the ancestral allele. We compare the predictions of our model with the site-frequency spectra of SNPs in the four HapMap populations of humans when the nucleotide present in the Neanderthal DNA sequence is ancestral or derived, using the chimp genome as the outgroup.
journal_name
Geneticsjournal_title
Geneticsauthors
Chen H,Green RE,Pääbo S,Slatkin Mdoi
10.1534/genetics.107.070730subject
Has Abstractpub_date
2007-09-01 00:00:00pages
387-98issue
1eissn
0016-6731issn
1943-2631pii
genetics.107.070730journal_volume
177pub_type
杂志文章相关文献
GENETICS文献大全abstract：:The glp-1 gene product mediates cell-cell interactions required for cell fate specification during development in Caenorhabditis elegans. To identify genes that interact with glp-1, we screened for dominant suppressors of two temperature-sensitive glp-1 alleles and recovered 18 mutations that suppress both germline an...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Cyclin E together with its kinase partner Cdk2 is a critical regulator of entry into S phase. To identify novel genes that regulate the G1- to S-phase transition within a whole animal we made use of a hypomorphic cyclin E mutation, DmcycEJP, which results in a rough eye phenotype. We screened the X and third chromosom...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.026617
更新日期：2004-09-01 00:00:00
abstract：:Crossover interference in meiosis is often modeled via stationary renewal processes. Here we consider a new model to incorporate the known biological feature of "obligate chiasma" whereby in most organisms each bivalent almost always has at least one crossover. The initial crossover is modeled as uniformly distributed...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.070235
更新日期：2007-07-01 00:00:00
abstract：:An extending axon growth cone is subjected to attractant and repellent cues. It is not clear how these growth cones discriminate the two opposing forces and select their projection paths. Here, we report that in the Drosophila nerve cord the growth cones of longitudinal tracts are subjected to attraction by the Netrin...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.036863
更新日期：2005-05-01 00:00:00
abstract：:Evolutionary forces shape patterns of genetic diversity within populations and contribute to phenotypic variation. In particular, recurrent positive selection has attracted significant interest in both theoretical and empirical studies. However, most existing theoretical models of recurrent positive selection cannot e...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.156935
更新日期：2014-05-01 00:00:00
abstract：:The Drosophila melanogaster sex-peptide (melSP) is a seminal fluid component that induces postmating responses (PMR) of females via the sex-peptide receptor (SPR) . Although SP orthologs are found in many Drosophila species, their functions remain poorly characterized. It is unknown whether SP functions are conserved ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.177550
更新日期：2015-08-01 00:00:00
abstract：:About 450 black rats (Rattus rattus) were collected from 25 localities in Asia and Oceania. Their serum transferrins were analyzed by a newly developed thin layer acrylamide gel electrophoresis accompanied with acrinol pretreatment, exhibiting 12 transferrin bands. Generally, Asian type rats (2N=42) had fast-moving tr...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-02-01 00:00:00
abstract：:Proper levels of gene expression are important for normal mammalian development. Typically, altered gene dosage caused by karyotypic abnormalities results in embryonic lethality or birth defects. Segmental aneuploidy can be compatible with life but often results in contiguous gene syndromes. The ability to manipulate ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-02-01 00:00:00
abstract：:We studied the control of pharyngeal excitation in Caenorhabditis elegans. By laser ablating subsets of the pharyngeal nervous system, we found that the MC neuron type is necessary and probably sufficient for rapid pharyngeal pumping. Electropharyngeograms showed that MC transmits excitatory postsynaptic potentials, s...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Meiotically driven sex chromosomes can quickly spread to fixation and cause population extinction unless balanced by selection or suppressed by genetic modifiers. We report results of genetic analyses that demonstrate that extreme female-biased sex ratios in two sister species of stalk-eyed flies, Cyrtodiopsis dalmann...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：:Peroxisomes are organelles containing a diverse array of enzymes. In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by the inactivation o...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.085795
更新日期：2008-03-01 00:00:00
abstract：:Parameters of continuous distributions of effects and rates of spontaneous mutation for relative viability in Drosophila are estimated by maximum likelihood from data of two published experiments on accumulation of mutations on protected second chromosomes. A model of equal mutant effects gives a poor fit to the data ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:In Drosophila melanogaster, heterochromatin-induced silencing or position-effect variegation (PEV) of a reporter gene has provided insights into the properties of heterochromatin. Class I modifiers suppress PEV, and class II modifiers enhance PEV when the modifier gene is present in fewer than two doses. We have exami...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
abstract：:The transcription factors Adr1 and Cat8 act in concert to regulate the expression of numerous yeast genes after the diauxic shift. Their activities are regulated by Snf1, the yeast homolog of the AMP-activated protein kinase of higher eukaryotes. Cat8 is regulated directly by Snf1, but how Snf1 regulates Adr1 is unkno...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.103432
更新日期：2009-07-01 00:00:00
abstract：:Cell cycle arrest in response to DNA damage depends upon coordinated interactions between DNA repair and checkpoint pathways. Here we examine the role of DNA repair and checkpoint genes in responding to unprotected telomeres in budding yeast cdc13-1 mutants. We show that Exo1 is unique among the repair genes tested be...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.027904
更新日期：2004-09-01 00:00:00
abstract：:Selective genotyping and phenotyping strategies are used to lower the cost of quantitative trait locus studies. Their efficiency has been studied primarily in simplified contexts--when a single locus contributes to the phenotype, and when the residual error (phenotype conditional on the genotype) is normally distribut...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.094607
更新日期：2009-04-01 00:00:00
abstract：:A maximum-likelihood method to estimate the recombination fraction and its sampling variance using informative and noninformative half-sib offspring is derived. Estimates of the recombination fraction are biased up to 20 cM when noninformative offspring are discarded. In certain scenarios, the sampling variance can be...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-03-01 00:00:00
abstract：:We studied microgeographic and temporal genetic differentiation in natural populations of Drosophila persimilis with respect to chromosome inversion and enzyme polymorphisms. Both inversion frequencies and allozyme frequencies varied significantly over short distances. Neither differed significantly between morning an...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1977-04-01 00:00:00
abstract：:The Drosophila melanogaster Chd3 gene encodes a member of the CHD group of SNF2/RAD54 ATPases. CHD proteins are conserved from yeast to man and many are subunits of chromatin-remodeling complexes that facilitate transcription. Drosophila CHD3 proteins are not found in protein complexes, but as monomers that remodel ch...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.115121
更新日期：2010-07-01 00:00:00
abstract：:A two-locus model is used to analyze the effectiveness of a mixture of insecticides in delaying resistance, compared to the use of the insecticides singly. The effects of factors such as recombination, effective dominance, initial value of allele frequencies and initial value of linkage disequilibrium are considered. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：:The Drosophila melanogaster genome contains a single region (at 83DE on the polytene chromosome map) for which both heterozygous deficiency and heterozygous duplication are inviable. Seven EMS-induced mutations have been recovered that are viable in combination with a duplication of this region. Two classes of mutatio...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1980-06-01 00:00:00
abstract：:Genomic integrity is threatened by multiple sources of DNA damage. DNA double-strand breaks (DSBs) are among the most dangerous types of DNA lesions and can be generated by endogenous or exogenous agents, but they can arise also during DNA replication. Sister chromatid recombination (SCR) is a key mechanism for the re...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.101899
更新日期：2009-06-01 00:00:00
abstract：:Plants with mutations in one of three maize genes, mop1, rmr1, and rmr2, are defective in paramutation, an allele-specific interaction that leads to meiotically heritable chromatin changes. Experiments reported here demonstrate that these genes are required to maintain the transcriptional silencing of two different tr...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.058669
更新日期：2006-07-01 00:00:00
abstract：:The sex-ratio trait described in several Drosophila species is a type of naturally occurring X-linked meiotic drive that causes males bearing a sex-ratio X chromosome to produce progenies with a large excess of females. We have previously reported the occurrence of sex-ratio X chromosomes in Drosophila simulans. In th...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:A spontaneous antimycin A-resistant mutant carrying approximately four extra copies of ADH2 on chromosome XII was isolated from yeast strain 315-1D which lacks a functional copy of ADH1 and thus is antimycin A-sensitive. The additional copies of the normally glucose-repressed ADH2 are expressed during growth on glucos...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：:Mating type interconversion in Saccharomyces cerevisiae occurs by transposition of copies of the a or alpha mating type cassettes from inactive loci, HML and HMR, to an active locus, MAT. The lack of expression of the a and alpha genes at the silent loci results from repression by trans-acting regulators encoded by SI...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1987-05-01 00:00:00
abstract：:Mapping markers from linkage data continues to be a task performed in many genetic epidemiological studies. Data collected in a study may be used to refine published map estimates and a study may use markers that do not appear in any published map. Furthermore, inaccuracies in meiotic maps can seriously bias linkage f...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.042705
更新日期：2005-10-01 00:00:00
abstract：:In Saccharomyces cerevisiae, the Rad52 protein plays a role in both RAD51-dependent and RAD51-independent recombination pathways. We characterized a rad52 mutant, rad52-329, which lacks the C-terminal Rad51-interacting domain, and studied its role in RAD51-independent recombination. The rad52-329 mutant is completely ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:Individuals within a species vary in their responses to a wide range of stimuli, partly as a result of differences in their genetic makeup. Relatively little is known about the genetic and neuronal mechanisms contributing to diversity of behavior in natural populations. By studying intraspecies variation in innate avo...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.178491
更新日期：2015-08-01 00:00:00
abstract：:Studies of multifactorial inheritance in man have ignored nonadditive gene action or attributed it entirely to dominance. Reanalyses of dermatoglyphic data on monozygotic and dizygotic twins, siblings and parents and offspring suggest that a substantial proportion of variation in total finger pattern intensity is due ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-04-01 00:00:00
