Evidence for polygenic epistatic interactions in man?

abstract：:R1 and R2 elements are non-LTR retrotransposons that insert specifically into the 28S rRNA genes of arthropods. The process of concerted evolution of the rDNA locus should give rise to rapid turnover of these mobile elements compared to elements that insert at sites throughout a genome. To estimate the rate of R1 and ...

journal_title：Genetics

authors： Pérez-González CE,Eickbush TH

更新日期：2002-10-01 00:00:00

abstract：:Interspecific hybridization in the genus Mus results in male sterility and X-linked placental dysplasia. We have generated several congenic laboratory mouse lines (Mus musculus) in which different parts of the maternal X chromosome were derived from M. spretus. A strict positive correlation between placental weight an...

journal_title：Genetics

authors： Hemberger MC,Pearsall RS,Zechner U,Orth A,Otto S,Rüschendorf F,Fundele R,Elliott R

更新日期：1999-09-01 00:00:00

abstract：:Recessive lethal or semilethal alleles at the T/t locus in the mouse generate new t-variants, with characteristics different from the parent allele at a rate of about 10(-3). Almost invariably the variant chromosome carries marker genes derived from the opposite parental chromosome. New t-mutations obtained in this wa...

journal_title：Genetics

authors： Bennett D,Dunn LC,Artzt K

更新日期：1976-06-01 00:00:00

abstract：:Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determin...

journal_title：Genetics

authors： Koval TM,Hart RW,Myser WC,Hink WF

更新日期：1977-11-01 00:00:00

abstract：:A mouse homolog of the Drosophila pair-rule gene Odd Oz (Odz4) maps to the critical region of the l7Rn3 locus on mouse chromosome 7. Here we show that Odz4 is an excellent candidate for this allelic series because (1) it spans the entire critical region, (2) the phenotypes correlate with embryonic expression, (3) the ...

journal_title：Genetics

authors： Lossie AC,Nakamura H,Thomas SE,Justice MJ

更新日期：2005-01-01 00:00:00

abstract：:A leucine, leucyl-tRNA synthetase-dependent pathway activates TorC1 kinase and its downstream stimulation of protein synthesis, a major nitrogen consumer. We previously demonstrated, however, that control of Gln3, a transcription activator of catabolic genes whose products generate the nitrogenous precursors for prote...

journal_title：Genetics

authors： Tate JJ,Rai R,Cooper TG

更新日期：2015-02-01 00:00:00

abstract：:The consequences of a discontinuity in the migration rate and of a geographical barrier in the habitat are studied in a diffusion model of migration and selection. The treatment is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is supposed further that...

journal_title：Genetics

authors： Nagylaki T

更新日期：1976-08-01 00:00:00

abstract：:Timely spindle disassembly is essential for coordination of mitotic exit with cytokinesis. In the budding yeast Saccharomyces cerevisiae, the microtubule-associated protein She1 functions in one of at least three parallel pathways that promote spindle disassembly. She1 phosphorylation by the Aurora kinase Ipl1 facilit...

journal_title：Genetics

authors： Pigula A,Drubin DG,Barnes G

更新日期：2014-11-01 00:00:00

abstract：:I report a framework for assessing whether one mitochondrial genome is significantly more rearranged than another. This relative rate of gene rearrangement test (RGR) behaves according to expectation, distinguishing between highly rearranged and mildly rearranged insect mitochondrial genomes. It may be more broadly ap...

journal_title：Genetics

authors： Dowton M

更新日期：2004-06-01 00:00:00

abstract：:The Acp26Aa and Acp26Ab genes that code for male accessory gland proteins are tandemly arranged in the species of the Drosophila melanogaster complex. An approximately 1.6-kb region encompassing both genes has been sequenced in 10, 24, and 18 lines from Spain, Ivory Coast, and Malawi, respectively; the previously stud...

journal_title：Genetics

authors： Aguadé M

更新日期：1998-11-01 00:00:00

abstract：:The Spt-Ada-Gcn5-acetyltransferase (SAGA) complex of Saccharomyces cerevisiae is a multifunctional coactivator complex that has been shown to regulate transcription by distinct mechanisms. Previous results have shown that the Spt3 and Spt8 components of SAGA regulate initiation of transcription of particular genes by ...

journal_title：Genetics

authors： Laprade L,Rose D,Winston F

更新日期：2007-12-01 00:00:00

abstract：:The genetics of phenotypic variation in inbred mice has for nearly a century provided a primary weapon in the medical research arsenal. A catalog of the genetic variation among inbred mouse strains, however, is required to enable powerful positional cloning and association techniques. A recent whole-genome resequencin...

journal_title：Genetics

authors： Kirby A,Kang HM,Wade CM,Cotsapas C,Kostem E,Han B,Furlotte N,Kang EY,Rivas M,Bogue MA,Frazer KA,Johnson FM,Beilharz EJ,Cox DR,Eskin E,Daly MJ

更新日期：2010-07-01 00:00:00

abstract：:Sir2 is a highly conserved NAD+-dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, Saccharomyces cerevisiae Within the yeast rDNA locus, Sir2 is required for efficient cohesin recruitment and maintaining the stability of the tandem a...

journal_title：Genetics

authors： Fine RD,Maqani N,Li M,Franck E,Smith JS

更新日期：2019-05-01 00:00:00

abstract：:Complementation and polarity suppression data are interpreted in terms of the genetic structure of the maltose B region. It is proposed that this region comprises two divergent operons. One operon includes malK, a cistron involved in maltose permeation, and lamB the only known cistron specifically involved in lambda r...

journal_title：Genetics

authors： Hofnung M

更新日期：1974-02-01 00:00:00

abstract：:RNAs are localized by microtubule-based pathways to both the anterior and posterior poles of the developing Drosophila oocyte. We describe a new gene, wispy, required for localization of mRNAs to both poles of the egg. Embryos from wispy mothers arrest development after abnormal oocyte meiosis and failure of pronuclei...

journal_title：Genetics

authors： Brent AE,MacQueen A,Hazelrigg T

更新日期：2000-04-01 00:00:00

abstract：:Plants regenerated from tissue culture often display somaclonal variation, that is, somatic and often meiotically heritable phenotypic variation that can result from both genetic and epigenetic modifications. To better understand the molecular basis of somaclonal variation, we have characterized four unique tissue cul...

journal_title：Genetics

authors： Rhee Y,Sekhon RS,Chopra S,Kaeppler S

更新日期：2010-11-01 00:00:00

abstract：:We have analyzed the 2E1-3A1 area of the X chromosome with special attention to loci related to embryogenesis. Published maps indicate that this chromosomal segment contains ten bands. Our genetic analysis has identified 11 complementation groups: one recessive visible (prune), two female steriles and eight lethals. O...

journal_title：Genetics

authors： Perrimon N,Engstrom L,Mahowald AP

更新日期：1984-11-01 00:00:00

abstract：:Dosage compensation refers to the equal expression of X-linked genes despite the difference in copy number between the two sexes. The male-specific lethal (MSL) complex is concentrated on the X chromosome in males. A gene expression assay for embryos was developed to examine the function of this complex. In mutant mal...

journal_title：Genetics

authors： Bhadra MP,Bhadra U,Kundu J,Birchler JA

更新日期：2005-04-01 00:00:00

abstract：:Immunosenescence, the age-related decline in immune system function, is a general hallmark of aging. While much is known about the cellular and physiological changes that accompany immunosenescence, we know little about the genetic influences on this phenomenon. In this study we combined age-specific measurements of b...

journal_title：Genetics

authors： Felix TM,Hughes KA,Stone EA,Drnevich JM,Leips J

更新日期：2012-07-01 00:00:00

abstract：:We consider the effect on the distribution of pairwise differences between mitochondrial DNA sequences of the incorporation into the underlying population genetics model of two particular effects that seem realistic for human populations. The first is that the population size was roughly constant before growing to its...

journal_title：Genetics

authors： Marjoram P,Donnelly P

更新日期：1994-02-01 00:00:00

abstract：:The Neurospora crassa super-suppressor mutation, ssu-1, suppresses the auxotrophic phenotype of the mutant am(17) by inserting tyrosine at residue 313 of NADP-specific glutamate dehydrogenase, a position occupied in the wild type by glutamate. Two classes of am(17) revertants due to further mutation within the am gene...

journal_title：Genetics

authors： Seale TW,Brett M,Baron AJ,Fincham JR

更新日期：1977-06-01 00:00:00

abstract：:In a genetic screen for mutants showing modified splicing of an alternatively spliced GFP reporter gene in Arabidopsis thaliana, we identified mutations in genes encoding the putative U1 small nuclear ribonucleoprotein (snRNP) factors RBM25 and PRP39a. The latter has not yet been studied for its role in pre-messenger ...

journal_title：Genetics

authors： Kanno T,Lin WD,Fu JL,Chang CL,Matzke AJM,Matzke M

更新日期：2017-12-01 00:00:00

abstract：:We have shown that the phenotypes resulting from hypomorphic mutations (causing reduction but not complete loss of function) in two X-linked genes can be used as a genetic assay for X-chromosome dosage compensation in Caenorhabditis elegans between males (XO) and hermaphrodites (XX). In addition we show that recessive...

journal_title：Genetics

authors： Meneely PM,Wood WB

更新日期：1987-09-01 00:00:00

abstract：:Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase c...

journal_title：Genetics

authors： Wasserstrom L,Lengeler KB,Walther A,Wendland J

更新日期：2013-09-01 00:00:00

abstract：:Efficient haplotyping in pedigrees is important for the fine mapping of quantitative trait locus (QTL) or complex disease genes. To reconstruct haplotypes efficiently for a large pedigree with a large number of linked loci, two algorithms based on conditional probabilities and likelihood computations are presented. Th...

journal_title：Genetics

authors： Gao G,Hoeschele I,Sorensen P,Du F

更新日期：2004-08-01 00:00:00

abstract：:Paramutation generates heritable changes affecting regulation of specific alleles found at several Zea mays (maize) loci that encode transcriptional regulators of anthocyanin biosynthetic genes. Although the direction and extent of paramutation is influenced by poorly understood allelic interactions occurring in diplo...

journal_title：Genetics

authors： Hollick JB,Kermicle JL,Parkinson SE

更新日期：2005-10-01 00:00:00

abstract：:Two alternate transcripts of the single copy Alcohol dehydrogenase (Adh) gene accumulate with developmental specificity in all of 12 species of Hawaiian picture-winged Drosophila which have been examined. Relative to the paradigm species D. affinidisjuncta, the Adh transcript normally restricted to larvae is found to ...

journal_title：Genetics

authors： Rowan RG,Dickinson WJ

更新日期：1986-10-01 00:00:00

abstract：:While a variety of methods have been developed to deal with incomplete parental genotype information in family-based association tests, sampling design issues with incomplete parental genotype data still have not received much attention. In this article, we present simulation studies with four genetic models and vario...

journal_title：Genetics

authors： Yang Q,Xu X,Laird N

更新日期：2003-05-01 00:00:00

abstract：:Here I show that the mean codon usage bias of a genome, and of the lowly expressed genes in a genome, is largely similar across eukaryotes ranging from unicellular protists to vertebrates. Conversely, this bias in housekeeping genes and in highly expressed genes has a remarkable inverse relationship with species gener...

journal_title：Genetics

authors： Subramanian S

更新日期：2008-04-01 00:00:00

abstract：:The mammalian GADD45 (growth arrest and DNA-damage inducible) gene family is composed of three highly homologous small, acidic, nuclear proteins: GADD45alpha, GADD45beta, and GADD45gamma. GADD45 proteins are involved in important processes such as regulation of DNA repair, cell cycle control, and apoptosis. Annotation...

journal_title：Genetics

authors： Peretz G,Bakhrat A,Abdu U

更新日期：2007-11-01 00:00:00