Patterns of recombination and MLH1 foci density along mouse chromosomes: modeling effects of interference and obligate chiasma.

abstract：:The genetics of phenotypic variation in inbred mice has for nearly a century provided a primary weapon in the medical research arsenal. A catalog of the genetic variation among inbred mouse strains, however, is required to enable powerful positional cloning and association techniques. A recent whole-genome resequencin...

journal_title：Genetics

authors： Kirby A,Kang HM,Wade CM,Cotsapas C,Kostem E,Han B,Furlotte N,Kang EY,Rivas M,Bogue MA,Frazer KA,Johnson FM,Beilharz EJ,Cox DR,Eskin E,Daly MJ

更新日期：2010-07-01 00:00:00

abstract：:A model system for studying double-strand-break (DSB)-induced genetic recombination in vivo based on the ets1 segCDelta strain of bacteriophage T4 was developed. The ets1, a 66-bp DNA fragment of phage T2L containing the cleavage site for the T4 SegC site-specific endonuclease, was inserted into the proximal part of t...

journal_title：Genetics

authors： Shcherbakov V,Granovsky I,Plugina L,Shcherbakova T,Sizova S,Pyatkov K,Shlyapnikov M,Shubina O

更新日期：2002-10-01 00:00:00

abstract：:A natural population of Culex tritaeniorhynchus was sampled to test the efficacy of a proposed method to detect and measure concealed variability. Thirty-nine lethals and ten recessive visible mutations were uncovered out of a total of 125 chromosomes tested. ...

journal_title：Genetics

authors： Sakai RK,Baker RH

更新日期：1972-06-01 00:00:00

abstract：:Two alternative hypotheses attribute different benefits to codon-anticodon adaptation. The first assumes that protein production is rate limited by both initiation and elongation and that codon-anticodon adaptation would result in higher elongation efficiency and more efficient and accurate protein production, especia...

journal_title：Genetics

authors： Xia X

更新日期：2015-02-01 00:00:00

abstract：:The RPS5 disease resistance gene of Arabidopsis mediates recognition of Pseudomonas syringae strains that possess the avirulence gene avrPphB. By screening for loss of RPS5-specified resistance, we identified five pbs (avrPphB susceptible) mutants that represent three different genes. Mutations in PBS1 completely bloc...

journal_title：Genetics

authors： Warren RF,Merritt PM,Holub E,Innes RW

更新日期：1999-05-01 00:00:00

abstract：:During meiotic prophase, assembly of the synaptonemal complex (SC) brings homologous chromosomes into close apposition along their lengths. The Zip1 protein is a major building block of the SC in Saccharomyces cerevisiae. In the absence of Zip1, SC fails to form, cells arrest or delay in meiotic prophase (depending on...

journal_title：Genetics

authors： Mitra N,Roeder GS

更新日期：2007-06-01 00:00:00

abstract：:The evolutionary process leading to the fixation of newly duplicated genes is not well understood. It was recently proposed that the fixation of duplicate genes is frequently driven by positive selection for increased gene dosage (i.e., the gene dosage hypothesis), because haploinsufficient genes were reported to have...

journal_title：Genetics

authors： Qian W,Zhang J

更新日期：2008-08-01 00:00:00

abstract：:The genetic basis of body weight in the mouse was investigated by measuring frequency changes of microsatellite marker alleles in lines divergently selected for body weight from a base population of a cross between two inbred strains. In several regions of the genome, sharp peaks of frequency change at linked markers ...

journal_title：Genetics

authors： Keightley PD,Hardge T,May L,Bulfield G

更新日期：1996-01-01 00:00:00

abstract：:During meiosis homologous chromosomes replicate once, pair, experience recombination, and undergo two rounds of segregation to produce haploid meiotic products. The rec8(+), rec10(+), and rec11(+) genes of the fission yeast Schizosaccharomyces pombe exhibit similar specificities for meiotic recombination and rec8(+) i...

journal_title：Genetics

authors： Krawchuk MD,DeVeaux LC,Wahls WP

更新日期：1999-09-01 00:00:00

abstract：:We compared allele sequences of two loci near the Arabidopsis lyrata self-incompatibility (S) loci with sequences of A. thaliana orthologs and found high numbers of shared polymorphisms, even excluding singletons and sites likely to be highly mutable. This suggests maintenance of entire S-haplotypes for long evolution...

journal_title：Genetics

authors： Charlesworth D,Kamau E,Hagenblad J,Tang C

更新日期：2006-04-01 00:00:00

abstract：:Heterozygotes for three long inversions on chromosome 1 were analyzed by serial reconstruction from electron micrographs. Measurements of loop lengths at different meiotic prophase substages revealed that the homologous synapsis of the inverted region was gradually replaced by nonhomologous synapsis as loops were elim...

journal_title：Genetics

authors： Bojko M

更新日期：1990-03-01 00:00:00

abstract：:Signaling by the second messenger inositol 1,4,5-trisphosphate is thought to affect several developmental and physiological processes. Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene of Drosophila exhibit delays in molting while stronger alleles are also larval lethal. In a freshly generated set of EM...

journal_title：Genetics

authors： Joshi R,Venkatesh K,Srinivas R,Nair S,Hasan G

更新日期：2004-01-01 00:00:00

abstract：:Rapid and high wing-beat frequencies achieved during insect flight are powered by the indirect flight muscles, the largest group of muscles present in the thorax. Any anomaly during the assembly and/or structural impairment of the indirect flight muscles gives rise to a flightless phenotype. Multiple mutagenesis scree...

journal_title：Genetics

authors： Firdaus H,Mohan J,Naz S,Arathi P,Ramesh SR,Nongthomba U

更新日期：2015-05-01 00:00:00

abstract：:Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combatin...

journal_title：Genetics

authors： Bradford BR,Briand NE,Fassnacht N,Gervasio ED,Nowakowski AM,FitzGibbon TC,Maurina S,Benjamin AV,Kelly M,Checchi PM

更新日期：2020-12-01 00:00:00

abstract：:The third hypervariable (V3) region of the HIV-1 gp120 protein is responsible for many aspects of viral infectivity. The tertiary structure of the V3 loop seems to influence the coreceptor usage of the virus, which is an important determinant of HIV pathogenesis. Hence, the information about preferred conformations of...

journal_title：Genetics

authors： Watabe T,Kishino H,Okuhara Y,Kitazoe Y

更新日期：2006-03-01 00:00:00

abstract：:A strain of Caenorhabditis elegans was constructed that permits selection of dominant or sex-linked mutations that transform XO animals (normally male) into fertile females, using a feminizing mutation, tra-2(e2046gf), which by itself does not sexually transform XO males. Twenty-three mutations were isolated after che...

journal_title：Genetics

authors： Hodgkin J,Albertson DG

更新日期：1995-10-01 00:00:00

abstract：:MiRNAs bear an increasing number of functions throughout development and in the aging adult. Here we address their role in establishing sexually dimorphic traits and sexual identity in male and female Drosophila. Our survey of miRNA populations in each sex identifies sets of miRNAs differentially expressed in male and...

journal_title：Genetics

authors： Fagegaltier D,König A,Gordon A,Lai EC,Gingeras TR,Hannon GJ,Shcherbata HR

更新日期：2014-10-01 00:00:00

abstract：:Statistical tests of the neutrality hypothesis that are based on the sampling theory of Ewens (1972) require the assumption of panmixia. It is proposed that for a population comprising numerous local populations with weak gene flow among them, tests based on Ewens' theory can be applied separately to samples from each...

journal_title：Genetics

authors： Slatkin M

更新日期：1982-03-01 00:00:00

abstract：:Yeast DNA fragments that confer multiple drug resistance when amplified were isolated. Cells containing a yeast genomic library cloned in the high copy autonomously replicating vector, YEp24, were plated on medium containing cycloheximide. Five out of 100 cycloheximide-resistant colonies were cross-resistant to the un...

journal_title：Genetics

authors： Leppert G,McDevitt R,Falco SC,Van Dyk TK,Ficke MB,Golin J

更新日期：1990-05-01 00:00:00

abstract：:In the present study, we investigated intrachromosomal homologous recombination in a murine hybridoma in which the recipient for recombination, the haploid, endogenous chromosomal immunoglobulin mu-gene bearing a mutation in the constant (Cmu) region, was separated from the integrated single copy wild-type donor Cmu r...

journal_title：Genetics

authors： Baker MD,Read LR,Ng P,Beatty BG

更新日期：1999-06-01 00:00:00

abstract：:Dosage compensation refers to the equal expression of X-linked genes despite the difference in copy number between the two sexes. The male-specific lethal (MSL) complex is concentrated on the X chromosome in males. A gene expression assay for embryos was developed to examine the function of this complex. In mutant mal...

journal_title：Genetics

authors： Bhadra MP,Bhadra U,Kundu J,Birchler JA

更新日期：2005-04-01 00:00:00

abstract：:For most common diseases with heritable components, not a single or a few single-nucleotide polymorphisms (SNPs) explain most of the variance for these disorders. Instead, much of the variance may be caused by interactions (epistasis) among multiple SNPs or interactions with environmental conditions. We present a new ...

journal_title：Genetics

authors： Albrechtsen A,Castella S,Andersen G,Hansen T,Pedersen O,Nielsen R

更新日期：2007-06-01 00:00:00

abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...

journal_title：Genetics

authors： Zhou S,Opperman K,Wang X,Chen L

更新日期：2008-11-01 00:00:00

abstract：:The isozymic patterns of tyrosine aminotransferase, NADP malate dehydrogenase, NADP isocitrate dehydrogenase, and tetrazolium oxidase were examined by starch-gel electrophoresis in Tetrahymena pyriformis, syngen 1. The genetics of the alleles controlling these enzymes was studied through a breeding program. Each enzym...

journal_title：Genetics

authors： Borden D,Miller ET,Nanney DL,Whitt GS

更新日期：1973-08-01 00:00:00

abstract：:Brassica self-incompatibility (SI) is controlled by SLG and SRK expressed in the stigma and by SP11/SCR expressed in the anther. We determined the sequences of the S domains of 36 SRK alleles, 13 SLG alleles, and 14 SP11 alleles from Brassica oleracea and B. rapa. We found three S haplotypes lacking SLG genes in B. ra...

journal_title：Genetics

authors： Sato K,Nishio T,Kimura R,Kusaba M,Suzuki T,Hatakeyama K,Ockendon DJ,Satta Y

更新日期：2002-10-01 00:00:00

abstract：:Several adhesins are induced by pheromones during mating in Saccharomyces cerevisiae, including Aga1p, Aga2p, Sag1p (Agalpha1p), and Fig2p. These four proteins all participate in or influence a well-studied agglutinin interaction mediated by Aga1p-Aga2p complexes and Sag1p; however, they also play redundant and essent...

journal_title：Genetics

authors： Huang G,Dougherty SD,Erdman SE

更新日期：2009-05-01 00:00:00

abstract：:The infinite-sites model with no recombination is extended to include mutations that affect electrophoretic mobility. The model allows the effect of a single-site mutation to have a continuous effect on mobility. Formulae are obtained for the variance of electrophoretic mobility of alleles after an arbitrary lenght of...

journal_title：Genetics

authors： Cobbs G

更新日期：1979-06-01 00:00:00

abstract：:We have isolated and characterized deletions arising within a P transposon, P[hswa], in the presence of P transposase. P[hswa] carries white-apricot (wa) sequences, including a complete copia element, under the control of an hsp70 promoter, and resembles the original wa allele in eye color phenotype. In the presence o...

journal_title：Genetics

authors： Kurkulos M,Weinberg JM,Roy D,Mount SM

更新日期：1994-03-01 00:00:00

abstract：:Explanations of the evolution of diploidy have focused on the advantages gained from masking deleterious alleles. Recent theory has shown, however, that masking does not always provide an advantage to diploidy and would never favor diploidy in predominantly asexual organisms. We explore a neglected alternative theory ...

journal_title：Genetics

authors： Orr HA,Otto SP

更新日期：1994-04-01 00:00:00

abstract：:The ability to withstand periods of scarce food resources is an important fitness trait. Starvation resistance is a quantitative trait controlled by multiple interacting genes and exhibits considerable genetic variation in natural populations. This genetic variation could be maintained in the face of strong selection ...

journal_title：Genetics

authors： Harbison ST,Yamamoto AH,Fanara JJ,Norga KK,Mackay TF

更新日期：2004-04-01 00:00:00