unc-44 Ankyrin and stn-2 gamma-syntrophin regulate sax-7 L1CAM function in maintaining neuronal positioning in Caenorhabditis elegans.

abstract：:Many aspects of plant biology depend on the ubiquitin proteasome system for degradation of regulatory proteins. Ubiquitin E3 ligases confer substrate specificity in this pathway, and SCF-type ligases comprise a major class of E3s. SCF ligases have four subunits: SKP1, CUL1, RBX1, and an F-box protein for substrate rec...

journal_title：Genetics

authors： Gilkerson J,Hu J,Brown J,Jones A,Sun TP,Callis J

更新日期：2009-03-01 00:00:00

abstract：:Phylogenetic analyses of non-LTR retrotransposons suggest that all elements can be divided into 11 lineages. The 3 oldest lineages show target site specificity for unique locations in the genome and encode an endonuclease with an active site similar to certain restriction enzymes. The more "modern" non-LTR lineages po...

journal_title：Genetics

authors： Malik HS,Eickbush TH

更新日期：2000-01-01 00:00:00

abstract：:The size of the genome in the opportunistic fungus Candida albicans is 15.6 Mb. Whole-genome shotgun sequencing was carried out at Stanford University where the sequences were assembled into 412 contigs. C. albicans is a diploid basically, and analysis of the sequence is complicated due to repeated sequences and to se...

journal_title：Genetics

authors： Chibana H,Oka N,Nakayama H,Aoyama T,Magee BB,Magee PT,Mikami Y

更新日期：2005-08-01 00:00:00

abstract：:Chromatin organization and structure are crucial for transcriptional regulation, DNA replication, and damage repair. Although initially characterized in remodeling cell wall glucans, the β-1,3-glucanosyltransferase Gas1 was recently discovered to regulate transcriptional silencing in a manner separable from its activi...

journal_title：Genetics

authors： Eustice M,Pillus L

更新日期：2014-04-01 00:00:00

abstract：:Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism. In this study, fission yeast genes homologous to TSC1 and TSC2 were identified, and their protein products were shown to physically interact like th...

journal_title：Genetics

authors： Matsumoto S,Bandyopadhyay A,Kwiatkowski DJ,Maitra U,Matsumoto T

更新日期：2002-07-01 00:00:00

abstract：:Although neurons are highly polarized, how neuronal polarity is generated remains poorly understood. An evolutionarily conserved inositol-producing enzyme myo-inositol monophosphatase (IMPase) is essential for polarized localization of synaptic molecules in Caenorhabditis elegans and can be inhibited by lithium, a dru...

journal_title：Genetics

authors： Kimata T,Tanizawa Y,Can Y,Ikeda S,Kuhara A,Mori I

更新日期：2012-06-01 00:00:00

abstract：:Several hypotheses and concepts have tended to oversimplify the problem of mutagenesis and can be misleading when used for genetic risk estimation. These include: (1) the hypothesis that radiation-induced mutation frequency depends primarily on the DNA content per haploid genome, (2) the extension of this concept to c...

journal_title：Genetics

authors： Russell WL

更新日期：1979-05-01 00:00:00

abstract：:The nonparametric bootstrap approach is known to be suitable for calculating central confidence intervals for the locations of quantitative trait loci (QTL). However, the distribution of the bootstrap QTL position estimates along the chromosome is peaked at the positions of the markers and is not tailed equally. This ...

journal_title：Genetics

authors： Bennewitz J,Reinsch N,Kalm E

更新日期：2002-04-01 00:00:00

abstract：:In Neurospora crassa, DNA sequence duplications are detected and altered efficiently during the sexual cycle by a process known as RIP (repeat-induced point mutation). Affected sequences are subjected to multiple GC-to-AT mutations. To explore the pattern in which base changes are laid down by RIP we examined two sets...

journal_title：Genetics

authors： Watters MK,Randall TA,Margolin BS,Selker EU,Stadler DR

更新日期：1999-10-01 00:00:00

abstract：:In this article we define and characterize the smellblind gene (sbl). We show that two mutants, sbl and olfDx9, both isolated by virtue of their olfactory phenotypes and analyzed extensively by others with respect to courtship behavior, contain mutations at a single locus. Meiotic recombination, duplication, and defic...

journal_title：Genetics

authors： Lilly M,Carlson J

更新日期：1990-02-01 00:00:00

abstract：:Genomic prediction methods based on multiple markers have potential to include nonadditive effects in prediction and analysis of complex traits. However, most developments assume a Hardy-Weinberg equilibrium (HWE). Statistical approaches for genomic selection that account for dominance and epistasis in a general conte...

journal_title：Genetics

authors： Vitezica ZG,Legarra A,Toro MA,Varona L

更新日期：2017-07-01 00:00:00

abstract：:Doubly uniparental inheritance (DUI) provides an intriguing system for addressing aspects of molecular evolution and intermolecular recombination of mitochondrial DNA. For this reason, a large sequence analysis has been performed on Tapes philippinarum (Bivalvia, Veneridae), which has mitochondrial DNA heteroplasmy th...

journal_title：Genetics

authors： Passamonti M,Boore JL,Scali V

更新日期：2003-06-01 00:00:00

abstract：:Multilocus surveys of sequence variation can be used to identify targets of directional selection, which are expected to have reduced levels of variation. Following a population bottleneck, the signal of directional selection may be hard to detect because many loci may have low variation by chance and the frequency sp...

journal_title：Genetics

authors： Hamblin MT,Casa AM,Sun H,Murray SC,Paterson AH,Aquadro CF,Kresovich S

更新日期：2006-06-01 00:00:00

abstract：:The Su(f) protein of Drosophila melanogaster shares extensive homologies with proteins from yeast (RNA14) and man (77 kD subunit of cleavage stimulation factor) that are required for 3' end processing of mRNA. These homologies suggest that su(f) is involved in mRNA 3' end formation and that some aspects of this proces...

journal_title：Genetics

authors： Simonelig M,Elliott K,Mitchelson A,O'Hare K

更新日期：1996-04-01 00:00:00

abstract：:X chromosome duplications have been used previously to vary the dose of specific regions of the X chromosome to study dosage compensation and sex determination in Caenorhabditis elegans. We show here that duplications suppress and X-linked hypomorphic mutation and elevate the level of activity of an X-linked enzyme, a...

journal_title：Genetics

authors： Meneely PM,Nordstrom KD

更新日期：1988-06-01 00:00:00

abstract：:The ade6-M26 mutation of Schizosaccharomyces pombe has previously been reported to stimulate ade6 intragenic meiotic recombination. We report here that the ade6-M26 mutation is a single G----T nucleotide change, that M26 stimulated recombination within ade6 but not at other distinct loci, and that M26 stimulated meiot...

journal_title：Genetics

authors： Ponticelli AS,Sena EP,Smith GR

更新日期：1988-07-01 00:00:00

abstract：:The percentage of crossovers is consistently higher in plants hypoploid for six B-A translocations when crossed as males than when crossed as females; in most instances, this excess of male crossing over exceeds that found in control crosses (involving normal chromosomes). Thus, there seems to be something about the h...

journal_title：Genetics

authors： Robertson DS

更新日期：1984-05-01 00:00:00

abstract：:Gene expression in Anopheles gambiae shows a deficiency of testis-expressed genes on the X chromosome associated with an excessive movement of retrogene duplication. We suggest that the degeneration of sex chromosomes in this monandrous species is likely the result of pressures from X inactivation, dosage compensation...

journal_title：Genetics

authors： Baker DA,Russell S

更新日期：2011-11-01 00:00:00

abstract：:Neurospora crassa is an established reference organism to investigate carotene biosynthesis and light regulation. However, there is little evidence of its capacity to produce secondary metabolites. Here, we report the role of the fungal-specific regulatory velvet complexes in development and secondary metabolism (SM) ...

journal_title：Genetics

authors： Bayram ÖS,Dettmann A,Karahoda B,Moloney NM,Ormsby T,McGowan J,Cea-Sánchez S,Miralles-Durán A,Brancini GTP,Luque EM,Fitzpatrick DA,Cánovas D,Corrochano LM,Doyle S,Selker EU,Seiler S,Bayram Ö

更新日期：2019-07-01 00:00:00

abstract：:Previously a deletion in mouse chromosome 17, T(22H), was shown to behave like a t allele of the t complex distorter gene Tcd1, and this was attributed to deletion of this locus. Seven further deletions are studied here, with the aim of narrowing the critical region in which Tcd1 must lie. One deletion, T(30H), togeth...

journal_title：Genetics

authors： Lyon MF,Schimenti JC,Evans EP

更新日期：2000-06-01 00:00:00

abstract：:The past century has seen substantial theoretical and empirical progress on the genetic basis of adaptation. Over this same period, a pressing need to prevent the evolution of drug resistance has uncovered much about the potential genetic basis of persistence in declining populations. However, we have little theory to...

journal_title：Genetics

authors： Osmond MM,Otto SP,Martin G

更新日期：2020-02-01 00:00:00

abstract：:Though much has been learned about the process of ovarian follicle maturation through studies of oogenesis in both vertebrate and invertebrate systems, less is known about how follicles form initially. In Drosophila, two somatic follicle stem cells (FSCs) in each ovariole give rise to all polar cells, stalk cells, and...

journal_title：Genetics

authors： Nystul T,Spradling A

更新日期：2010-02-01 00:00:00

abstract：:Polyhomeotic is a member of the Polycomb group (Pc-G) of homeotic repressors. The proteins encoded by the Pc-G genes form repressive complexes on the polycomb group response element sites. The phP1 mutation was induced by insertion of a 1.2-kb P element into the 5' transcribed nontranslated region of the proximal poly...

journal_title：Genetics

authors： Belenkaya T,Soldatov A,Nabirochkina E,Biryukova I,Georgieva S,Georgiev P

更新日期：1998-10-01 00:00:00

abstract：:The contributions of direct and inverted repeats to deletion formation were studied by characterizing Ampr revertants of plasmids with a series of insertion mutations at a specific site in the pBR322 ampicillin resistance (amp) gene. The inserts at this site are palindromic, variable in length, and bracketed by 9- or ...

journal_title：Genetics

authors： Weston-Hafer K,Berg DE

更新日期：1989-04-01 00:00:00

abstract：:Sexual isolating mechanisms that act before fertilization are often considered the most important genetic barriers leading to speciation in animals. While recent progress has been made toward understanding the genetic basis of the postzygotic isolating mechanisms of hybrid sterility and inviability, little is known ab...

journal_title：Genetics

authors： Moehring AJ,Li J,Schug MD,Smith SG,deAngelis M,Mackay TF,Coyne JA

更新日期：2004-07-01 00:00:00

abstract：:We previously identified Caenorhabditis elegans mutants in which certain of the six vulval precursor cells adopt fates normally expressed by other vulval precursor cells. These mutants define genes that appear to function in the response to an intercellular signal that induces vulval development. The multivulva (Muv) ...

journal_title：Genetics

authors： Ferguson EL,Horvitz HR

更新日期：1989-09-01 00:00:00

abstract：:Groucho functions as a general corepressor by modulating chromatin structure and has a widespread role in many developmental processes. Here we show that Groucho may also interact with the basal transcriptional machinery. Mutations in Caenorhabditis elegans groucho interact with mutations in components of the transcri...

journal_title：Genetics

authors： Zhang H,Emmons SW

更新日期：2002-02-01 00:00:00

abstract：:We study levels of X-linked vs. autosomal diversity using a model developed to analyze the hitchhiking effect. Repeated bouts of hitchhiking are thought to lower X-linked diversity for two reasons: first, because sojourn times of beneficial mutations are shorter on the X, and second, because adaptive substitutions may...

journal_title：Genetics

authors： Betancourt AJ,Kim Y,Orr HA

更新日期：2004-12-01 00:00:00

abstract：:In Arabidopsis thaliana, significant efforts to determine the extent of genomic variation between phenotypically divergent accessions are under way, but virtually nothing is known about variation at the transcription level. We used microarrays to examine variation in transcript abundance among three inbred lines and t...

journal_title：Genetics

authors： Vuylsteke M,van Eeuwijk F,Van Hummelen P,Kuiper M,Zabeau M

更新日期：2005-11-01 00:00:00

abstract：:We performed a comparative study of four subfamilies of olfactory receptor genes first identified in the dog to assess changes in the gene family during mammalian evolution, and to begin linking the dog genetic map to that of humans. The human subfamilies were localized to chromosomes 7, 11, and 19. The two subfamilie...

journal_title：Genetics

authors： Issel-Tarver L,Rine J

更新日期：1997-01-01 00:00:00