Molecular evolution and recombination in gender-associated mitochondrial DNAs of the Manila clam Tapes philippinarum.

abstract：:We demonstrate the involvement of suppressor of meiotic silencing-2 (sms-2(+)), a Neurospora gene coding for an Argonaute-like protein, in meiotic silencing and normal sexual development. ...

journal_title：Genetics

authors： Lee DW,Pratt RJ,McLaughlin M,Aramayo R

更新日期：2003-06-01 00:00:00

abstract：:The effective population size (N(e)) is notoriously difficult to accurately estimate in wild populations as it is influenced by a number of parameters that are difficult to delineate in natural systems. The different methods that are used to estimate N(e) are affected variously by different processes at the population...

journal_title：Genetics

authors： Serbezov D,Jorde PE,Bernatchez L,Olsen EM,Vøllestad LA

更新日期：2012-06-01 00:00:00

abstract：:Genomic resources for hundreds of species of evolutionary, agricultural, economic, and medical importance are unavailable due to the expense of well-assembled genome sequences and difficulties with multigenerational studies. Teleost fish provide many models for human disease but possess anciently duplicated genomes th...

journal_title：Genetics

authors： Amores A,Catchen J,Ferrara A,Fontenot Q,Postlethwait JH

更新日期：2011-08-01 00:00:00

abstract：:We discuss the conceptual conflict between a slow series of gene substitutions as the mechanism of evolutionary change, and the apparent need for rapid and coordinated changes at many loci simultaneously in producing complex adaptations. To improve on the limitations of classical theory and accommodate the enormous am...

journal_title：Genetics

authors： Koehler DO,Whitten BL,Gregg TG

更新日期：1980-03-01 00:00:00

abstract：:The Saccharomyces cerevisiae nuclear membrane is part of a complex nuclear envelope environment also containing chromatin, integral and peripheral membrane proteins, and large structures such as nuclear pore complexes (NPCs) and the spindle pole body. To study how properties of the nuclear membrane affect nuclear enve...

journal_title：Genetics

authors： Witkin KL,Friederichs JM,Cohen-Fix O,Jaspersen SL

更新日期：2010-11-01 00:00:00

abstract：:The rate of adaptive evolution of a population ultimately depends on the rate of incorporation of beneficial mutations. Even beneficial mutations may, however, be lost from a population since mutant individuals may, by chance, fail to reproduce. In this paper, we calculate the probability of fixation of beneficial mut...

journal_title：Genetics

authors： Otto SP,Whitlock MC

更新日期：1997-06-01 00:00:00

abstract：:Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that h...

journal_title：Genetics

authors： Zhang S,Binari R,Zhou R,Perrimon N

更新日期：2010-04-01 00:00:00

abstract：:The importance of mitochondrial DNA (mtDNA) deletions in the progeroid phenotype of exonuclease-deficient DNA polymerase γ mice has been intensely debated. We show that disruption of Mip1 exonuclease activity increases mtDNA deletions 160-fold, whereas disease-associated polymerase variants were mostly unaffected, sug...

journal_title：Genetics

authors： Stumpf JD,Copeland WC

更新日期：2013-06-01 00:00:00

abstract：:Mutagenic DNA repair (MDR) employs low-fidelity DNA polymerases capable of replicating past DNA lesions resulting from exposure to high-energy ultraviolet radiation (UVR). MDR confers UVR tolerance and activation initiates a transient mutator phenotype that may provide opportunities for adaptation. To investigate the ...

journal_title：Genetics

authors： Weigand MR,Sundin GW

更新日期：2009-01-01 00:00:00

abstract：:Stress caused by the increased salinity of irrigated fields impairs plant growth and is one of the major constraints that limits crop productivity in many important agricultural areas. As a contribution to solving such agronomic problems, we have carried out a large-scale screening for Arabidopsis thaliana mutants ind...

journal_title：Genetics

authors： Quesada V,Ponce MR,Micol JL

更新日期：2000-01-01 00:00:00

abstract：:There are two distinct reasons for making comparisons of genetic variation for quantitative characters. The first is to compare evolvabilities, or ability to respond to selection, and the second is to make inferences about the forces that maintain genetic variability. Measures of variation that are standardized by the...

journal_title：Genetics

authors： Houle D

更新日期：1992-01-01 00:00:00

abstract：:Self-incompatibility (SI) is a genetic system found in some hermaphrodite plants. Recognition of pollen by pistils expressing cognate specificities at two linked genes leads to rejection of self pollen and pollen from close relatives, i.e., to avoidance of self-fertilization and inbred matings, and thus increased outc...

journal_title：Genetics

authors： Gervais CE,Castric V,Ressayre A,Billiard S

更新日期：2011-07-01 00:00:00

abstract：:Mutations in maternally transmitted symbionts can affect host fitness. In this study we investigate a mutation in an obligate bacterial symbiont (Buchnera), which has dramatic effects on the heat tolerance of pea aphid hosts (Acyrthosiphon pisum). The heat-sensitive allele arises through a single base deletion in a ho...

journal_title：Genetics

authors： Burke GR,McLaughlin HJ,Simon JC,Moran NA

更新日期：2010-09-01 00:00:00

abstract：:Efficient haplotyping in pedigrees is important for the fine mapping of quantitative trait locus (QTL) or complex disease genes. To reconstruct haplotypes efficiently for a large pedigree with a large number of linked loci, two algorithms based on conditional probabilities and likelihood computations are presented. Th...

journal_title：Genetics

authors： Gao G,Hoeschele I,Sorensen P,Du F

更新日期：2004-08-01 00:00:00

abstract：:The B-Peru allele of the maize b regulatory gene is unusual relative to most b alleles in that it is expressed in the aleurone layer of the seed. It is also expressed in a subset of plant vegetative tissues. Transgenic maize plants containing the B-Peru gene with the first 710 bases of upstream sequence conferred the ...

journal_title：Genetics

authors： Selinger DA,Lisch D,Chandler VL

更新日期：1998-06-01 00:00:00

abstract：:Availability of animal protein for human consumption is very low in the developing countries mainly because of low productivity of existing livestock; ways and means to improve productivity through breeding are discussed and some basic issues requiring further research pointed out. ...

journal_title：Genetics

authors： Rendel J

更新日期：1974-09-01 00:00:00

abstract：:In Drosophila there exist several examples of gene expression that can be modified by an interaction between alleles; this effect is known as transvection. The inference that alleles interact comes from the observations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrangements ...

journal_title：Genetics

authors： Golic MM,Golic KG

更新日期：1996-05-01 00:00:00

abstract：:Mta is a cell surface antigen of the mouse and serves as a target for specific T killer lymphocytes. Using a killer cell assay, the antigen has been found in 72 strains of laboratory mice and, with one exception, in all tested samples of mice caught in the wild or bred from such, including Mus molossinus, Mus castaneu...

journal_title：Genetics

authors： Lindahl KF,Hausmann B

更新日期：1983-03-01 00:00:00

abstract：:The protist Physarum polycephalum is useful for analysis of several aspects of cellular and developmental biology. To expand the opportunities for experimental analysis of this organism, we have developed a method for gene replacement. We transformed Physarum amoebae with plasmid DNA carrying a mutant allele, ardD del...

journal_title：Genetics

authors： Burland TG,Pallotta D

更新日期：1995-01-01 00:00:00

abstract：:Methodology for mapping quantitative trait loci (QTL) has focused primarily on treating the QTL as a fixed effect. These methods differ from the usual models of genetic variation that treat genetic effects as random. Computationally expensive methods that allow QTL to be treated as random have been explicitly develope...

journal_title：Genetics

authors： Zimmer D,Mayer M,Reinsch N

更新日期：2011-01-01 00:00:00

abstract：:Many genetic variants identified in genome-wide association studies (GWAS) are associated with multiple, sometimes seemingly unrelated, traits. This motivates multi-trait association analyses, which have successfully identified novel associated loci for many complex diseases. While appealing, most existing methods foc...

journal_title：Genetics

authors： Wu C

更新日期：2020-08-01 00:00:00

abstract：:Two replications of a complete diallel cross experiment were performed among four partially inbred lines of mice. These inbred lines originated from a random-bred ICR strain and were produced by 12 generations of full sibbing (F congruent to 92%). Individual body weight was recorded for each animal at 12, 21, 42 and 5...

journal_title：Genetics

authors： Jamison MG,White JM,Vinson WE,Hinkelmann K

更新日期：1975-10-01 00:00:00

abstract：:This work demonstrates that environmental conditions experienced by individuals can shape their development and affect the stability of genetic associations. The implication of this observation is that the environmental response may influence the evolution of traits in the wild. Here, we examined how the genetic archi...

journal_title：Genetics

authors： Robinson MR,Wilson AJ,Pilkington JG,Clutton-Brock TH,Pemberton JM,Kruuk LE

更新日期：2009-04-01 00:00:00

abstract：:We show that MED15, a key component of the transcription complex Mediator, lies within the nonrecombining segment of nascent sex chromosomes in the male-heterogametic Hyla arborea. Both X and Y alleles are expressed during embryonic development and differ by three frame-preserving indels (eight amino acids in total) w...

journal_title：Genetics

authors： Niculita-Hirzel H,Stöck M,Perrin N

更新日期：2008-07-01 00:00:00

abstract：:Precocious entry into S phase due to overproduction of G1 regulators can cause genomic instability. The mechanisms of this phenomenon are largely unknown. We explored the consequences of precocious S phase in yeast by overproducing a deregulated form of Swi4 (Swi4-t). Swi4 is a late G1-specific transcriptional activat...

journal_title：Genetics

authors： Sidorova JM,Breeden LL

更新日期：2002-01-01 00:00:00

abstract：:Tetrazolium oxidase from the blood and liver of rainbow trout was found to be genetically polymorphic. The inheritance pattern of the liver enzyme was compatible only with a one locus-two allele hypothesis. The enzymes in the blood while having an electrophoretically identical polymorphism could differ genotypically f...

journal_title：Genetics

authors： Cederbaum SD,Yoshida A

更新日期：1972-10-01 00:00:00

abstract：:Forty-eight new mutations at the am locus of Neurospora crassa have been characterized. Nineteen mutations were induced by UV; of these, eight were missense, two were frameshifts, two were nonsense, three were deletions and four were unidentified. Twenty-nine mutations were induced with nitrous acid; of these, twenty-...

journal_title：Genetics

authors： Kinsey JA,Hung BS

更新日期：1981-11-01 00:00:00

abstract：:Satellite DNA is an enigmatic component of genomic DNA with unclear function that has been regarded as "junk." Yet, persistence of these tandem highly repetitive sequences in heterochromatic regions of most eukaryotic chromosomes attests to their importance in the genome. We explored the Anopheles gambiae genome for t...

journal_title：Genetics

authors： Krzywinski J,Sangaré D,Besansky NJ

更新日期：2005-01-01 00:00:00

abstract：:Some mutant strains of the filamentous fungus Podospora anserina spontaneously present a growth impairment, which has been called Crippled Growth (CG). CG is caused by a cytoplasmic and infectious factor, C. C is efficiently transmitted during mitosis but is not transmitted to the progeny after sexual crosses. C is in...

journal_title：Genetics

authors： Silar P,Haedens V,Rossignol M,Lalucque H

更新日期：1999-01-01 00:00:00

abstract：:The process of close recombinant formation in bacteriophage T5 crosses has been studied by examining the structure of internal heterozygotes (HETs), the immediate products of recombination events. The T5 system was chosen because it permits the study of internal heterozygotes exclusively, thus avoiding the ambiguities...

journal_title：Genetics

authors： Beck BN

更新日期：1980-09-01 00:00:00