Abstract：
:Enhancer of split [E(spl)] is one of the neurogenic loci of Drosophila and, as such, is required for normal segregation of neural and epidermal cell progenitors. Genetic observations indicate that the E(spl) locus is in fact a gene complex comprising a cluster of related genes and that other genes of the region are also required for normal early neurogenesis. Three of the genes of the complex were known to encode helix-loop-helix (HLH) proteins and to be transcribed in nearly identical patterns. Here, we show that four other genes in the vicinity also encode HLH proteins and, during neuroblast segregation, three of them are expressed in the same pattern. We show by germ-line transformation that these three genes are also necessary to allow epidermal development of the neuroectodermal cells.
journal_name
Geneticsjournal_title
Geneticsauthors
Knust E,Schrons H,Grawe F,Campos-Ortega JAkeywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
505-18issue
2eissn
0016-6731issn
1943-2631journal_volume
132pub_type
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