Abstract：
:Enhancer of split [E(spl)] is one of the neurogenic loci of Drosophila and, as such, is required for normal segregation of neural and epidermal cell progenitors. Genetic observations indicate that the E(spl) locus is in fact a gene complex comprising a cluster of related genes and that other genes of the region are also required for normal early neurogenesis. Three of the genes of the complex were known to encode helix-loop-helix (HLH) proteins and to be transcribed in nearly identical patterns. Here, we show that four other genes in the vicinity also encode HLH proteins and, during neuroblast segregation, three of them are expressed in the same pattern. We show by germ-line transformation that these three genes are also necessary to allow epidermal development of the neuroectodermal cells.
journal_name
Geneticsjournal_title
Geneticsauthors
Knust E,Schrons H,Grawe F,Campos-Ortega JAkeywords:
subject
Has Abstractpub_date
1992-10-01 00:00:00pages
505-18issue
2eissn
0016-6731issn
1943-2631journal_volume
132pub_type
杂志文章相关文献
GENETICS文献大全abstract：:An analysis of the effects of spontaneous mutations affecting age-specific mortality was conducted using 29 lines of Drosophila melanogaster that had accumulated spontaneous mutations for 19 generations. Divergence among the lines was used to estimate the mutational variance for weekly mortality rates and the covarian...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Mutations identified in zebrafish genetic screens allow the dissection of a wide array of problems in vertebrate biology. Most screens have examined mutations induced by treatment of spermatogonial (premeiotic) cells with the chemical mutagen N-ethyl-N-nitrosourea (ENU). Treatment of postmeiotic gametes with ENU induc...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:The distribution of genetic polymorphisms in a population contains information about evolutionary processes. The Poisson random field (PRF) model uses the polymorphism frequency spectrum to infer the mutation rate and the strength of directional selection. The PRF model relies on an infinite-sites approximation that i...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.087361
更新日期：2008-12-01 00:00:00
abstract：:Spontaneous tandem chromosomal duplications are common in populations of Escherichia coli and Salmonella typhimurium. They range in frequency for a given locus from 10(-2) to 10(-4) and probably form by RecA-dependent unequal sister strand exchanges between repetitive sequences in direct order. Certain duplications ha...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:Samples of mtDNA isolated from each of 92 lizards representing all color pattern classes of Cnemidophorus tesselatus and two populations of C. tigris marmoratus were digested with the restriction endonucleases MboI, TaqI, RsaI and MspI. The mtDNA fragment sizes were compared after radioactive labeling and gel electrop...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1985-08-01 00:00:00
abstract：:The pathogenic life cycle of the rice blast fungus Magnaporthe oryzae involves a series of morphogenetic changes, essential for its ability to cause disease. The smo mutation was identified > 25 years ago, and affects the shape and development of diverse cell types in M. oryzae, including conidia, appressoria, and asc...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301490
更新日期：2019-01-01 00:00:00
abstract：:With the rise of both the number and the complexity of traits of interest, control of the false discovery rate (FDR) in genetic association studies has become an increasingly appealing and accepted target for multiple comparison adjustment. While a number of robust FDR-controlling strategies exist, the nature of this ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.193987
更新日期：2017-01-01 00:00:00
abstract：:The vacuolar hydrolase protease B in Saccharomyces cerevisiae is synthesized as an inactive precursor (Prb1p). The precursor undergoes post-translational modifications while transiting the secretory pathway. In addition to N- and O-linked glycosylations, four proteolytic cleavages occur during the maturation of Prb1p....
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-07-01 00:00:00
abstract：:A recent sperm-typing study by Jeffreys and Neumann suggested that recombination rates in different individuals at the DNA2 recombination hotspot appeared to be highly dependent on their genotype at a particular A/G SNP, FG11. Specifically, individuals who carried at least one copy of the A allele at this SNP exhibite...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.039271
更新日期：2006-03-01 00:00:00
abstract：:We have tested the hypothesis that genetic differences among conspecific populations may result in diverse responses to selection, using natural populations of Drosophila melanogaster. Selection for ethanol tolerance in a tube measuring knockdown resistance was imposed on five West Coast populations. In 24 generations...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
abstract：:A simple method of replica plating has been used to isolate mutants of Neurospora crassa that have increased sensitivity to methyl methanesulfonate (MMS) and/or to histidine. Twelve mutants with increased sensitivity to MMS and one mutant with increased sensitivity to histidine showed Mendelian segregation of the muta...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1981-02-01 00:00:00
abstract：:The Caenorhabditis elegans pRb ortholog, LIN-35, functions in a wide range of cellular and developmental processes. This includes a role of LIN-35 in nutrient utilization by the intestine, which it carries out redundantly with SLR-2, a zinc-finger protein. This and other redundant functions of LIN-35 were identified i...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.112.140152
更新日期：2012-08-01 00:00:00
abstract：:Accumulation of RNA was measured in adult males of two genotypes: car bb/Ybb- and car bb/YbbSuVar-5. The two genotypes have similar amounts of rDNA, which is reduced in comparison to wild type (CLARK, STRAUSBAUGH and KIEFER 1977). Although genotypically bobbed, car bb/YbbSuVar-5 flies have a wild-type phenotype; car b...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:The translation elongation factor EF-Tu is a GTPase that delivers amino-acylated tRNAs to the ribosome during the elongation step of translation. EF-Tu/GDP is recycled by the guanine nucleotide exchange factor EF-Ts. Whereas EF-Ts is lacking in S. cerevisiae, both translation factors are found in S. pombe and H. sapie...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.037473
更新日期：2005-04-01 00:00:00
abstract：:Selection of suppressor mutations that correct growth defects caused by substitutions in an RNA or protein can reveal functionally important molecular structures and interactions in living cells. This approach is particularly useful for the study of complex biological pathways involving many macromolecules, such as pr...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.301922
更新日期：2019-05-01 00:00:00
abstract：:Paramutation generates heritable changes affecting regulation of specific alleles found at several Zea mays (maize) loci that encode transcriptional regulators of anthocyanin biosynthetic genes. Although the direction and extent of paramutation is influenced by poorly understood allelic interactions occurring in diplo...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.045260
更新日期：2005-10-01 00:00:00
abstract：:Persistence time of a mutant allele, the expected number of generations before its elimination from the population, can be estimated as the ratio of the number of segregating mutations per individual over the mutation rate per generation. We screened two natural populations of Drosophila melanogaster for mutations cau...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.046094
更新日期：2005-12-01 00:00:00
abstract：:Studies of transcriptional gene silencing in Drosophila melanogaster suggest that most of chromosome 4 resembles pericentric heterochromatin. However, some modifiers of position-effect variegation, including chromosome 4 dosage and loss of SU(VAR)3-9, have different effects on silencing in pericentric vs. distal arm c...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.066407
更新日期：2007-03-01 00:00:00
abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.091272
更新日期：2008-11-01 00:00:00
abstract：:Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determin...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
abstract：:The Saccharomyces cerevisiae GAL/MEL regulon genes are normally induced within minutes of galactose addition, but gal3 mutants exhibit a 3-5-day induction lag. We have discovered that this long-term adaptation (LTA) phenotype conferred by gal3 is complemented by multiple copies of the GAL1 gene. Based on this result a...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-06-01 00:00:00
abstract：:The biological basis of exercise behavior is increasingly relevant for maintaining healthy lifestyles. Various quantitative genetic studies and selection experiments have conclusively demonstrated substantial heritability for exercise behavior in both humans and laboratory rodents. In the "High Runner" selection exper...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.120.303668
更新日期：2020-11-01 00:00:00
abstract：:A location of the structural gene(s) for dopa decarboxylase (EC 4.1.1.26) is proposed on the basis of enzyme determinations in a set of duplication-bearing aneuploids, which revealed only one dosage-sensitive region in the Drosophila genome. This region lies between 36EF and 37D on the left arm of chromosome 2. ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:We developed stochastic population genetic theory for mitochondrial and chloroplast genes, using an infinite alleles model appropriate for molecular genetic data. We considered the effects of mutation, random drift, and migration in a finite island model on selectively neutral alleles. Recurrence equations were obtain...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:Cyclin E together with its kinase partner Cdk2 is a critical regulator of entry into S phase. To identify novel genes that regulate the G1- to S-phase transition within a whole animal we made use of a hypomorphic cyclin E mutation, DmcycEJP, which results in a rough eye phenotype. We screened the X and third chromosom...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.026617
更新日期：2004-09-01 00:00:00
abstract：:One crossover point between a pair of homologous chromosomes in meiosis appears to interfere with occurrence of another in the neighborhood. It has been revealed that Drosophila and Neurospora, in spite of their large difference in the frequency of crossover points, show very similar plots of coincidence-a measure of ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：:The results of deficiency mapping experiments reveal the presence of a compensatory response (cr+) locus that is located distal to the cluster of ribosomal RNA (rRNA) genes and is responsible for disproportionately replicating these genes when cr+ locus is present in a single dose, as in X/O males or X/sc4-sc8 females...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Ribosome biogenesis is tightly regulated through stress-sensing pathways that impact genome stability, aging and senescence. In Saccharomyces cerevisiae, ribosomal RNAs are transcribed from rDNA located on the right arm of chromosome XII. Numerous studies reveal that rDNA decondenses into a puff-like structure during ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302994
更新日期：2020-03-01 00:00:00
abstract：:Five bivariate distributions of wing dimensions of Drosophila melanogaster were measured, in flies 1) subjected to four defined environmental regimes during development, 2) taken directly from nature in seven U.S. states, 3) selected in ten populations for change in wing form, and 4) sampled from 21 long inbred wild-t...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:We reported previously that the product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, belongs to a family of proteins that are involved in DNA repair and replication. The family includes S. cerevisiae proteins Rad2p and its human homolog XPGC, Rad27p and its mammalian homolog FEN-1, and Exonuclea...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
