A comparison of survival and repair of UV-induced DNA damage in cultured insect versus mammalian cells.

abstract：:Molecular heterogeneity in human breast cancer has challenged diagnosis, prognosis, and clinical treatment. It is well known that molecular subtypes of breast tumors are associated with significant differences in prognosis and survival. Assuming that the differences are attributed to subtype-specific pathways, we then...

journal_title：Genetics

authors： Li R,Campos J,Iida J

更新日期：2015-12-01 00:00:00

abstract：:Pathogen resistance is an ecologically important phenotype increasingly well understood at the molecular genetic level. In this article, we examine levels of avrRpt2-dependent resistance and Rps2 locus DNA sequence variability in a worldwide sample of 27 accessions of Arabidopsis thaliana. The rooted parsimony tree of...

journal_title：Genetics

authors： Mauricio R,Stahl EA,Korves T,Tian D,Kreitman M,Bergelson J

更新日期：2003-02-01 00:00:00

abstract：:A mouse homolog of the Drosophila pair-rule gene Odd Oz (Odz4) maps to the critical region of the l7Rn3 locus on mouse chromosome 7. Here we show that Odz4 is an excellent candidate for this allelic series because (1) it spans the entire critical region, (2) the phenotypes correlate with embryonic expression, (3) the ...

journal_title：Genetics

authors： Lossie AC,Nakamura H,Thomas SE,Justice MJ

更新日期：2005-01-01 00:00:00

abstract：:Stress caused by the increased salinity of irrigated fields impairs plant growth and is one of the major constraints that limits crop productivity in many important agricultural areas. As a contribution to solving such agronomic problems, we have carried out a large-scale screening for Arabidopsis thaliana mutants ind...

journal_title：Genetics

authors： Quesada V,Ponce MR,Micol JL

更新日期：2000-01-01 00:00:00

abstract：:In both pedigree linkage studies and in population-based association studies there has been much interest in the use of modern dense genetic marker data to infer segments of gene identity by descent (ibd) among individuals not known to be related, to increase power and resolution in localizing genes affecting complex ...

journal_title：Genetics

authors： Brown MD,Glazner CG,Zheng C,Thompson EA

更新日期：2012-04-01 00:00:00

abstract：:The relationship between multidimensional form of the adult mouse mandible and body size is examined from an ontogenetic perspective. The origin and ontogeny of phenotypic correlations are described in terms of genetic and environmental covariance patterns between adult skeletal morphology and growth in body weight. D...

journal_title：Genetics

authors： Atchley WR,Plummer AA,Riska B

更新日期：1985-11-01 00:00:00

abstract：:This work demonstrates that environmental conditions experienced by individuals can shape their development and affect the stability of genetic associations. The implication of this observation is that the environmental response may influence the evolution of traits in the wild. Here, we examined how the genetic archi...

journal_title：Genetics

authors： Robinson MR,Wilson AJ,Pilkington JG,Clutton-Brock TH,Pemberton JM,Kruuk LE

更新日期：2009-04-01 00:00:00

abstract：:To investigate the regulation of Drosophila melanogaster behavior by biogenic amines, we have exploited the broad requirement of the vesicular monoamine transporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters. We used the Drosophila VMAT (dVMAT) null mutant to globally ab...

journal_title：Genetics

authors： Chen A,Ng F,Lebestky T,Grygoruk A,Djapri C,Lawal HO,Zaveri HA,Mehanzel F,Najibi R,Seidman G,Murphy NP,Kelly RL,Ackerson LC,Maidment NT,Jackson FR,Krantz DE

更新日期：2013-01-01 00:00:00

abstract：:Gastrulation is fundamental to the development of multicellular animals. Along with neurulation, gastrulation is one of the major processes of morphogenesis in which cells or whole tissues move from the surface of an embryo to its interior. Cell internalization mechanisms that have been discovered to date in Caenorhab...

journal_title：Genetics

authors： Goldstein B,Nance J

更新日期：2020-02-01 00:00:00

abstract：:Cytoplasmic male sterility (CMS), the maternally inherited failure to produce functional pollen, has been used in the breeding of sugar beet (Beta vulgaris ssp. vulgaris). At least three different sources of CMS can be distinguished from one another as well as from normal fertile cytoplasm by polymorphisms in their mi...

journal_title：Genetics

authors： Nishizawa S,Mikami T,Kubo T

更新日期：2007-11-01 00:00:00

abstract：:Neurospora crassa has been a model organism for the study of circadian clocks for the past four decades. Among natural accessions of Neurospora crassa, there is significant variation in clock phenotypes. In an attempt to investigate natural allelic variants contributing to quantitative variation, we used a quantitativ...

journal_title：Genetics

authors： Kim TS,Logsdon BA,Park S,Mezey JG,Lee K

更新日期：2007-12-01 00:00:00

abstract：:The type and frequency of simple sequence repeats (SSRs) in plant genomes was investigated using the expanding quantity of DNA sequence data deposited in public databases. In Arabidopsis, 306 genomic DNA sequences longer than 10 kb and 36,199 EST sequences were searched for all possible mono- to pentanucleotide repeat...

journal_title：Genetics

authors： Cardle L,Ramsay L,Milbourne D,Macaulay M,Marshall D,Waugh R

更新日期：2000-10-01 00:00:00

abstract：:Reproductive isolation that initiates speciation is likely caused by incompatibility among multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossi...

journal_title：Genetics

authors： Oka A,Aoto T,Totsuka Y,Takahashi R,Ueda M,Mita A,Sakurai-Yamatani N,Yamamoto H,Kuriki S,Takagi N,Moriwaki K,Shiroishi T

更新日期：2007-01-01 00:00:00

abstract：:Mutations in mes-2, mes-3, mes-4, and mes-6 result in maternal-effect sterility: hermaphrodite offspring of mes/mes mothers are sterile because of underproliferation and death of the germ cells, as well as an absence of gametes. Mutant germ cells do not undergo programmed cell death, but instead undergo a necrotic-typ...

journal_title：Genetics

authors： Garvin C,Holdeman R,Strome S

更新日期：1998-01-01 00:00:00

abstract：:Bacteriophages are the most abundant biological entities in our biosphere, characterized by their hyperplasticity, mosaic composition, and the many unknown functions (ORFans) encoded by their immense genetic repertoire. These genes are potentially maintained by the bacteriophage to allow efficient propagation on hosts...

journal_title：Genetics

authors： Ang D,Georgopoulos C

更新日期：2012-03-01 00:00:00

abstract：:The T4 mutations px, y and 1206 inactivate an error-prone recombination-like repair system, reducing or abolishing mutagenesis by UV irradiation, MMS, and white light irradiation in the presence of the photosensitizer 8MOP. Both px and y increase some spontaneous mutation rates and slightly enhance proflavin mutagenes...

journal_title：Genetics

authors： Green RR,Drake JW

更新日期：1974-09-01 00:00:00

abstract：:I factors in Drosophila melanogaster are non-LTR retrotransposons that transpose at very high frequencies in the germ line of females resulting from crosses between reactive females (devoid of active I factors) and inducer males (containing active I factors). Constructs containing I factor ORF1 under the control of th...

journal_title：Genetics

authors： Malinsky S,Bucheton A,Busseau I

更新日期：2000-11-01 00:00:00

abstract：:We studied thorax formation in Drosophila melanogaster using a misexpression screen with EP lines and thoracic Gal4 drivers that provide a genetically sensitized background. We identified 191 interacting lines showing alterations of thoracic bristles (number and/or location), thorax and scutellum malformations, lethal...

journal_title：Genetics

authors： Peña-Rangel MT,Rodriguez I,Riesgo-Escovar JR

更新日期：2002-03-01 00:00:00

abstract：:The isozymic patterns of tyrosine aminotransferase, NADP malate dehydrogenase, NADP isocitrate dehydrogenase, and tetrazolium oxidase were examined by starch-gel electrophoresis in Tetrahymena pyriformis, syngen 1. The genetics of the alleles controlling these enzymes was studied through a breeding program. Each enzym...

journal_title：Genetics

authors： Borden D,Miller ET,Nanney DL,Whitt GS

更新日期：1973-08-01 00:00:00

abstract：:Previously a deletion in mouse chromosome 17, T(22H), was shown to behave like a t allele of the t complex distorter gene Tcd1, and this was attributed to deletion of this locus. Seven further deletions are studied here, with the aim of narrowing the critical region in which Tcd1 must lie. One deletion, T(30H), togeth...

journal_title：Genetics

authors： Lyon MF,Schimenti JC,Evans EP

更新日期：2000-06-01 00:00:00

abstract：:Retrotransposons are mobile genetic elements that colonize eukaryotic genomes by replicating through an RNA intermediate. As retrotransposons can move within the host genome, defense mechanisms have evolved to repress their potential mutagenic activities. In the fission yeast Schizosaccharomyces pombe, the mRNA of Tf2...

journal_title：Genetics

authors： Mallet PL,Larochelle M,Bachand F

更新日期：2017-02-01 00:00:00

abstract：:Several hypotheses and concepts have tended to oversimplify the problem of mutagenesis and can be misleading when used for genetic risk estimation. These include: (1) the hypothesis that radiation-induced mutation frequency depends primarily on the DNA content per haploid genome, (2) the extension of this concept to c...

journal_title：Genetics

authors： Russell WL

更新日期：1979-05-01 00:00:00

abstract：:Timely spindle disassembly is essential for coordination of mitotic exit with cytokinesis. In the budding yeast Saccharomyces cerevisiae, the microtubule-associated protein She1 functions in one of at least three parallel pathways that promote spindle disassembly. She1 phosphorylation by the Aurora kinase Ipl1 facilit...

journal_title：Genetics

authors： Pigula A,Drubin DG,Barnes G

更新日期：2014-11-01 00:00:00

abstract：:We employed F-statistics to analyze quantitative and isozyme variation among five populations of Pinus contorta ssp. latifolia, a wind-pollinated outcrossing conifer with wide and continuous distribution in west North America. Estimates of population differentiation (FST) for six quantitative traits were compared with...

journal_title：Genetics

authors： Yang RC,Yeh FC,Yanchuk AD

更新日期：1996-03-01 00:00:00

abstract：:Restriction fragment length polymorphisms in mitochondrial DNA (mtDNA) were used to reconstruct evolutionary relationships of conspecific populations in four species of freshwater fish-Amia calva, Lepomis punctatus, L. gulosus, and L. microlophus. A suite of 14-17 endonucleases was employed to assay mtDNAs from 305 sp...

journal_title：Genetics

authors： Bermingham E,Avise JC

更新日期：1986-08-01 00:00:00

abstract：:The yeast pheromone/filamentous growth MAPK pathway mediates both mating and invasive-growth responses. The interface between this MAPK module and the transcriptional machinery consists of a network of two MAPKs, Fus3 and Kss1; two regulators, Rst1 and Rst2 (a.k.a. Dig1 and Dig2); and two transcription factors, Ste12 ...

journal_title：Genetics

authors： Breitkreutz A,Boucher L,Breitkreutz BJ,Sultan M,Jurisica I,Tyers M

更新日期：2003-11-01 00:00:00

abstract：:THE FOLLOWING MODELS ARE CONSIDERED FOR THE GENETIC DETERMINATION OF QUANTITATIVE TRAITS: segregation at one locus, at two linked loci, at any number of equal and additive unlinked loci, and at one major locus and an indefinite number of equal and additive loci. In each case an appropriate likelihood is given for data...

journal_title：Genetics

authors： Elston RC,Stewart J

更新日期：1973-04-01 00:00:00

abstract：:The identity of a given cell type is determined by the expression of a set of genes sharing common cis-regulatory motifs and being regulated by shared transcription factors. Here, we identify cis and trans regulatory elements that drive gene expression in the bilateral sensory neuron ASJ, located in the head of the ne...

journal_title：Genetics

authors： González-Barrios M,Fierro-González JC,Krpelanova E,Mora-Lorca JA,Pedrajas JR,Peñate X,Chavez S,Swoboda P,Jansen G,Miranda-Vizuete A

更新日期：2015-05-01 00:00:00

abstract：:Bayesian posterior distributions are obtained for the time to the most recent common ancestor (MRCA) for a nonrecombining segment of DNA (such as the nonpseudoautosomal arm of the Y chromosome or the mitochondrial genome) for two individuals given that they match at k out of n scored markers. We argue that the distrib...

journal_title：Genetics

authors： Walsh B

更新日期：2001-06-01 00:00:00

abstract：:Injury triggers regeneration of axons and dendrites. Research has identified factors required for axonal regeneration outside the CNS, but little is known about regeneration triggered by dendrotomy. Here, we study neuronal plasticity triggered by dendrotomy and determine the fate of complex PVD arbors following laser ...

journal_title：Genetics

authors： Oren-Suissa M,Gattegno T,Kravtsov V,Podbilewicz B

更新日期：2017-05-01 00:00:00