New insights on homology-dependent silencing of I factor activity by transgenes containing ORF1 in Drosophila melanogaster.

abstract：:In Drosophila melanogaster, the endogenous retrovirus gypsy is repressed by the functional alleles (restrictive) of an as-yet-uncloned heterochromatic gene called flamenco. Using gypsy-lacZ transcriptional fusions, we show here that this repression takes place not only in the follicle cells of restrictive ovaries, as ...

journal_title：Genetics

authors： Sarot E,Payen-Groschêne G,Bucheton A,Pélisson A

更新日期：2004-03-01 00:00:00

abstract：:The worldwide pattern of single nucleotide polymorphism (SNP) variation is of great interest to human geneticists, population geneticists, and evolutionists, but remains incompletely understood. We studied the pattern in noncoding regions, because they are less affected by natural selection than are coding regions. Th...

journal_title：Genetics

authors： Yu N,Chen FC,Ota S,Jorde LB,Pamilo P,Patthy L,Ramsay M,Jenkins T,Shyue SK,Li WH

更新日期：2002-05-01 00:00:00

abstract：:Pontocerebellar hypoplasia type 1b (PCH1b) is an autosomal recessive disorder that causes cerebellar hypoplasia and spinal motor neuron degeneration, leading to mortality in early childhood. PCH1b is caused by mutations in the RNA exosome subunit gene, EXOSC3 The RNA exosome is an evolutionarily conserved complex, con...

journal_title：Genetics

authors： Fasken MB,Losh JS,Leung SW,Brutus S,Avin B,Vaught JC,Potter-Birriel J,Craig T,Conn GL,Mills-Lujan K,Corbett AH,van Hoof A

更新日期：2017-01-01 00:00:00

abstract：:The consequences of asymmetric dispersion on the maintenance of an allele in a one-dimensional environmental pocket are examined. The diffusion model of migration and selection is restricted to a single diallelic locus in a monoecious population in the absence of mutation and random drift. It is further supposed that ...

journal_title：Genetics

authors： Nagylaki T

更新日期：1978-04-01 00:00:00

abstract：:We have previously isolated mutants of Escherichia coli that replicate their DNA with increased fidelity. These mutants have a mutation in the dnaE gene, encoding the alpha subunit of DNA polymerase III. They were isolated in a mismatch-repair-defective mutL background, in which mutations can be considered to represen...

journal_title：Genetics

authors： Oller AR,Schaaper RM

更新日期：1994-10-01 00:00:00

abstract：:Genetic material sequenced from ancient samples is revolutionizing our understanding of the recent evolutionary past. However, ancient DNA is often degraded, resulting in low coverage, error-prone sequencing. Several solutions exist to this problem, ranging from simple approach, such as selecting a read at random for ...

journal_title：Genetics

authors： Schraiber JG

更新日期：2018-01-01 00:00:00

abstract：:Genes with unstable transcripts often encode proteins that play important regulatory roles. ATL2 is a member of a multigene family coding highly related RING-H2 zinc-finger proteins that may function as E3 ubiquitin ligases. ATL2 mRNA accumulation occurs rapidly and transiently after incubation with elicitors of patho...

journal_title：Genetics

authors： Serrano M,Guzmán P

更新日期：2004-06-01 00:00:00

abstract：:It has been hypothesized that the ratio of X-linked to autosomal sequence diversity is influenced by unequal sex ratios in Drosophila melanogaster populations. We conducted a genome scan of single nucleotide polymorphism (SNP) of 378 autosomal loci in a derived European population and of a subset of 53 loci in an ance...

journal_title：Genetics

authors： Hutter S,Li H,Beisswanger S,De Lorenzo D,Stephan W

更新日期：2007-09-01 00:00:00

abstract：:Interspecific hybridization in the genus Mus results in male sterility and X-linked placental dysplasia. We have generated several congenic laboratory mouse lines (Mus musculus) in which different parts of the maternal X chromosome were derived from M. spretus. A strict positive correlation between placental weight an...

journal_title：Genetics

authors： Hemberger MC,Pearsall RS,Zechner U,Orth A,Otto S,Rüschendorf F,Fundele R,Elliott R

更新日期：1999-09-01 00:00:00

abstract：:Enhancer of split [E(spl)] is one of the neurogenic loci of Drosophila and, as such, is required for normal segregation of neural and epidermal cell progenitors. Genetic observations indicate that the E(spl) locus is in fact a gene complex comprising a cluster of related genes and that other genes of the region are al...

journal_title：Genetics

authors： Knust E,Schrons H,Grawe F,Campos-Ortega JA

更新日期：1992-10-01 00:00:00

abstract：:fl(2)d, the Drosophila homolog of Wilms'-tumor-1-associated protein (WTAP), regulates the alternative splicing of Sex-lethal (Sxl), transformer (tra), and Ultrabithorax (Ubx). Although WTAP has been found in functional human spliceosomes, exactly how it contributes to the splicing process remains unknown. Here we atte...

journal_title：Genetics

authors： Penn JK,Graham P,Deshpande G,Calhoun G,Chaouki AS,Salz HK,Schedl P

更新日期：2008-02-01 00:00:00

abstract：:Prions have revived interest in hereditary change that is due to change in cellular structure. How pervasive is structural inheritance and what are its mechanisms? Described here is the initial characterization of [Leu(P)], a heritable structural change of the mitochondrion of Saccharomyces cerevisiae that often but n...

journal_title：Genetics

authors： Lockshon D

更新日期：2002-08-01 00:00:00

abstract：:Three previously described genes, enhancer of yellow, 1, 2 and 3, are shown to cooperate with the zeste gene in the control of white gene expression. The mutations e(y)1u1, e(y)3u1, and to a lesser extent e(y)2u1, enhance the effect of the zeste null allele zv77h. Different combinations of e(y)1u1, e(y)2u1 and e(y)3u1...

journal_title：Genetics

authors： Georgiev PG

更新日期：1994-11-01 00:00:00

abstract：:In this article we investigate multiplicative effects between genes in relation to heterosis. The extensive literature on heterosis due to multiplicative effects between characters is reviewed, as is earlier work on the genetic description of heterosis. A two-locus diallelic model of arbitrary gene action is used to d...

journal_title：Genetics

authors： Schnell FW,Cockerham CC

更新日期：1992-06-01 00:00:00

abstract：:Theoretically, one of the most general benefits of sex is given by its function in facilitating selection against deleterious mutations. This advantage of sex may be deterministic if deleterious mutations affect the fitness of an individual in a synergistic way, i.e., if mutations increase each others' negative fitnes...

journal_title：Genetics

authors： de Visser JA,Hoekstra RF,van den Ende H

更新日期：1997-03-01 00:00:00

abstract：:We have characterized a Saccharomyces cerevisiae mutant strain that is hypersensitive to cyclosporin A (CsA) and FK506, immunosuppressants that inhibit calcineurin, a serine-threonine-specific phosphatase (PP2B). A single nuclear mutation, designated cev1 for calcineurin essential for viability, is responsible for the...

journal_title：Genetics

authors： Hemenway CS,Dolinski K,Cardenas ME,Hiller MA,Jones EW,Heitman J

更新日期：1995-11-01 00:00:00

abstract：:Many of the transcription factors and target genes that pattern the developing adult remain unknown. In the present study, we find that an ortholog of the poorly understood transcription factor, glucose transporter (GLUT4) enhancer factor (Glut4EF, GEF) [also known as the Huntington's disease gene regulatory region-bi...

journal_title：Genetics

authors： Yazdani U,Huang Z,Terman JR

更新日期：2008-02-01 00:00:00

abstract：:Neural ganglia of wild type third-instar larvae of Drosophila melanogaster were incubated for 13 hours at various concentrations of BUdR (1, 3, 9, 27 micrograms/ml). Metaphases were collected with colchicine, stained with Hoechst 33258, and scored under a fluorescence microscope. Metaphases in which the sister chromat...

journal_title：Genetics

authors： Gatti M,Santini G,Pimpinelli S,Olivieri G

更新日期：1979-02-01 00:00:00

abstract：:Repeated elements are remarkably important for male meiosis and spermiogenesis in Drosophila melanogaster. Pairing of the X and Y chromosomes is mediated by the ribosomal RNA genes of the Y chromosome and X chromosome heterochromatin, spermiogenesis depends on the fertility factors of the Y chromosome. Intriguingly, a...

journal_title：Genetics

authors： Palumbo G,Bonaccorsi S,Robbins LG,Pimpinelli S

更新日期：1994-12-01 00:00:00

abstract：:In(2LR)PL is a large pericentric inversion polymorphic in populations of Drosophila melanogaster on two Indian Ocean islands. This polymorphism is puzzling: because crossing over in female heterokaryotypes produces inviable zygotes, such inversions are thought to be underdominant and should be quickly eliminated from ...

journal_title：Genetics

authors： Coyne JA,Aulard S,Berry A

更新日期：1991-11-01 00:00:00

abstract：:Mitochondrial DNAs (mtDNAs) from 167 American Indians including 87 Amerind-speakers (Amerinds) and 80 Nadene-speakers (Nadene) were surveyed for sequence variation by detailed restriction analysis. All Native American mtDNAs clustered into one of four distinct lineages, defined by the restriction site variants: HincII...

journal_title：Genetics

authors： Torroni A,Schurr TG,Yang CC,Szathmary EJ,Williams RC,Schanfield MS,Troup GA,Knowler WC,Lawrence DN,Weiss KM

更新日期：1992-01-01 00:00:00

abstract：:We have analyzed the 2E1-3A1 area of the X chromosome with special attention to loci related to embryogenesis. Published maps indicate that this chromosomal segment contains ten bands. Our genetic analysis has identified 11 complementation groups: one recessive visible (prune), two female steriles and eight lethals. O...

journal_title：Genetics

authors： Perrimon N,Engstrom L,Mahowald AP

更新日期：1984-11-01 00:00:00

abstract：:To identify in vivo pathways that compensate for impaired proliferating cell nuclear antigen (PCNA or Pol30p in yeast) activity, we performed a synthetic lethal screen with the yeast pol30-104 mutation. We identified nine mutations that display synthetic lethality with pol30-104; three mutations affected the structura...

journal_title：Genetics

authors： Merrill BJ,Holm C

更新日期：1998-02-01 00:00:00

abstract：:Phytochromes play an important role in light signaling and photoperiodic control of flowering time in plants. Here we propose that the red/far-red light photoreceptor HvPHYTOCHROME C (HvPHYC), carrying a mutation in a conserved region of the GAF domain, is a candidate underlying the early maturity 5 locus in barley (H...

journal_title：Genetics

authors： Pankin A,Campoli C,Dong X,Kilian B,Sharma R,Himmelbach A,Saini R,Davis SJ,Stein N,Schneeberger K,von Korff M

更新日期：2014-09-01 00:00:00

abstract：:The human fungal pathogen Candida albicans can reversibly switch between two cell types named "white" and "opaque," each of which is stable through many cell divisions. These two cell types differ in their ability to mate, their metabolic preferences and their interactions with the mammalian innate immune system. A hi...

journal_title：Genetics

authors： Lohse MB,Ene IV,Craik VB,Hernday AD,Mancera E,Morschhäuser J,Bennett RJ,Johnson AD

更新日期：2016-08-01 00:00:00

abstract：:Dopamine acts through two classes of G protein-coupled receptor (D1-like and D2-like) to modulate neuron activity in the brain. While subtypes of D1- and D2-like receptors are coexpressed in many neurons of the mammalian brain, it is unclear how signaling by these coexpressed receptors interacts to modulate the activi...

journal_title：Genetics

authors： Allen AT,Maher KN,Wani KA,Betts KE,Chase DL

更新日期：2011-07-01 00:00:00

abstract：:Many data sets one could use for population genetics contain artifactual sites, i.e., sequencing errors. Here, we first explore the impact of such errors on several common summary statistics, assuming that sequencing errors are mostly singletons. We thus show that in the presence of those errors, estimators of can be ...

journal_title：Genetics

authors： Achaz G

更新日期：2008-07-01 00:00:00

abstract：:Competition among domesticated plants or animals can have a dramatic negative impact on yield of a stand or farm. The usual quantitative genetic model ignores these competitive interactions and could result in seriously incorrect breeding decisions and acerbate animal well-being. A general solution to this problem is ...

journal_title：Genetics

authors： Muir WM

更新日期：2005-07-01 00:00:00

abstract：:A method is proposed for estimating the intensity of overdominant selection scaled by the effective population size, S = 2Ns, from allele frequencies. The method is based on the assumption that, with strong overdominant selection, allele frequencies are nearly at their deterministic equilibrium values and that, to a f...

journal_title：Genetics

authors： Slatkin M,Muirhead CA

更新日期：2000-12-01 00:00:00

abstract：:RNA interference (RNAi) in tissue culture cells has emerged as an excellent methodology for identifying gene functions systematically and in an unbiased manner. Here, we describe how RNAi high-throughput screening (HTS) in Drosophila cells are currently being performed and emphasize the strengths and weaknesses of the...

journal_title：Genetics

authors： Perrimon N,Mathey-Prevot B

更新日期：2007-01-01 00:00:00