Abstract：
:Persistence time of a mutant allele, the expected number of generations before its elimination from the population, can be estimated as the ratio of the number of segregating mutations per individual over the mutation rate per generation. We screened two natural populations of Drosophila melanogaster for mutations causing clear-cut eye phenotypes and detected 25 mutant alleles, falling into 19 complementation groups, in 1164 haploid genomes, which implies 0.021 eye mutations/genome. The de novo haploid mutation rate for the same set of loci was estimated as 2 x 10(-4) in a 10-generation mutation-accumulation experiment. Thus, the average persistence time of all mutations causing clear-cut eye phenotypes is approximately 100 generations (95% confidence interval: 61-219). This estimate shows that the strength of selection against phenotypically drastic alleles of nonessential loci is close to that against recessive lethals. In both cases, deleterious alleles are apparently eliminated by selection against heterozygous individuals, which show no visible phenotypic differences from wild type.
journal_name
Geneticsjournal_title
Geneticsauthors
Yampolsky LY,Allen C,Shabalina SA,Kondrashov ASdoi
10.1534/genetics.105.046094keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
2133-8issue
4eissn
0016-6731issn
1943-2631pii
genetics.105.046094journal_volume
171pub_type
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