Abstract：
:Sixty independent UGA suppressors of Saccharomyces cerevisiae have been studied. They are dominant and are divided into 16 groups (loci) by recombination. Suppressors representing these loci are divided into two classes by action spectra; four in class 1 (a broad action spectrum) and 12 in class 2 (a narrow action spectrum). Class 1 suppressors are less frequent in terms of not only total number but also number per locus than class 2 suppressors, indicating difference in either or both mutation frequency and selective pressure between suppressors of the two classes. Two of the class 1 suppressors, SUP152 and SUP161, do not recombine with SUP28 and SUP33, leucine-inserting UAA suppressors, respectively, indicating that they are mutations in genes coding for tRNA(Leu)UUA. Of the remaining two class 1 suppressors, SUP160 which causes lethality in the psi+ cytoplasm is mapped on chromosome XV very close to the centromere, and SUP165 on the right arm of chromosome XIV 44 cM distal to lys9. Of the class 2 suppressors, ten do not recombine with one or another of previously known UGA suppressors. The remaining two class 2 suppressors, SUP154 and SUP155, are mapped on the left and right arms of chromosome VII, respectively.
journal_name
Geneticsjournal_title
Geneticsauthors
Ono BI,Fujimoto R,Ohno Y,Maeda N,Tsuchiya Y,Usui T,Ishino-Arao Ysubject
Has Abstractpub_date
1988-01-01 00:00:00pages
41-7issue
1eissn
0016-6731issn
1943-2631journal_volume
118pub_type
杂志文章相关文献
GENETICS文献大全abstract：:Precocious entry into S phase due to overproduction of G1 regulators can cause genomic instability. The mechanisms of this phenomenon are largely unknown. We explored the consequences of precocious S phase in yeast by overproducing a deregulated form of Swi4 (Swi4-t). Swi4 is a late G1-specific transcriptional activat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:The wild-type Salmonella typhimurium strain LT2 contains six copies of the insertion sequence element IS200 which is unique to Salmonella. We have determined the chromosomal locations of all six copies of IS200 in strain LT2. This was done by mapping the positions of Tn10 elements inserted near each copy of IS200. Suc...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1983-12-01 00:00:00
abstract：:The cut gene in Drosophila is necessary in at least one cell type, the external sensory organs, for proper cell type specification and morphogenesis. It is also expressed in a variety of other tissues, where its function is less well characterized. Previous work has demonstrated that mutations affecting all the tissue...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Rodent inbred line crosses are widely used to map genetic loci associated with complex traits. This approach has proven to be powerful for detecting quantitative trait loci (QTL); however, the resolution of QTL locations, typically approximately 20 cM, means that hundreds of genes are implicated as potential candidate...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.033993
更新日期：2005-03-01 00:00:00
abstract：:Automated image acquisition, a custom analysis algorithm, and a distributed computing resource were used to add time as a third dimension to a quantitative trait locus (QTL) map for plant root gravitropism, a model growth response to an environmental cue. Digital images of Arabidopsis thaliana seedling roots from two ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.153346
更新日期：2013-11-01 00:00:00
abstract：:Four genes encoding the major egg yolk polypeptides of the Mediterranean fruit fly Ceratitis capitata, vitellogenins 1 and 2 (VG1 and VG2), were cloned, characterized and partially sequenced. The genes are located on the same region of chromosome 5 and are organized in pairs, each encoding the two polypeptides on oppo...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：:To identify in vivo pathways that compensate for impaired proliferating cell nuclear antigen (PCNA or Pol30p in yeast) activity, we performed a synthetic lethal screen with the yeast pol30-104 mutation. We identified nine mutations that display synthetic lethality with pol30-104; three mutations affected the structura...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
abstract：:Understanding the initiation of meiosis and the relationship of this event with other key cytogenetic processes are major goals in studying the genetic control of meiosis in higher plants. Our genetic and structural analysis of two mutant alleles of the ameiotic1 gene (am1 and am1-praI) suggest that this locus plays a...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:DNA topoisomerases, enzymes that alter the superhelicity of DNA, have been implicated in such critical cellular functions as transcription, DNA replication, and recombination. In the yeast Saccharomyces cerevisiae, a null mutation in the gene encoding topoisomerase I (TOP1) causes elevated levels of mitotic recombinat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:When a local colonization in a new niche occurs, the new derived population should be subject to different selective pressures from that in the original parental population; consequently it is likely that many loci will be subject to directional selection. In such a quick adaptation event through environmental changes...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.086835
更新日期：2008-07-01 00:00:00
abstract：:Mutator and antimutator alleles often arise and spread in both natural microbial populations and laboratory evolution experiments. The evolutionary dynamics of these mutation rate modifiers are determined by indirect selection on linked beneficial and deleterious mutations. These indirect selection pressures have been...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.193565
更新日期：2016-11-01 00:00:00
abstract：:Previously a deletion in mouse chromosome 17, T(22H), was shown to behave like a t allele of the t complex distorter gene Tcd1, and this was attributed to deletion of this locus. Seven further deletions are studied here, with the aim of narrowing the critical region in which Tcd1 must lie. One deletion, T(30H), togeth...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:Transmission ratio distortion (TRD) is the departure from the expected genotypic frequencies under Mendelian inheritance. This departure can be due to multiple physiological mechanisms during gametogenesis, fertilization, fetal and embryonic development, and early neonatal life. Although a few TRD loci have been repor...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.111.135988
更新日期：2012-05-01 00:00:00
abstract：:Many genes that affect axon pathfinding and cell migration have been identified. Mechanisms by which these genes and the molecules they encode interact with one another in pathways and networks to control developmental events are unclear. Rac GTPases, the cytoskeletal signaling molecule Enabled, and NIK kinase have al...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.046359
更新日期：2006-02-01 00:00:00
abstract：:Reproductive isolation that initiates speciation is likely caused by incompatibility among multiple loci in organisms belonging to genetically diverging populations. Laboratory C57BL/6J mice, which predominantly originated from Mus musculus domesticus, and a MSM/Ms strain derived from Japanese wild mice (M. m. molossi...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.062976
更新日期：2007-01-01 00:00:00
abstract：:Mismatch repair of palindromic loops in the presence or absence of single-base mismatches was investigated in wild-type and mismatch-binding defective mutant Chinese hamster ovary cells. Recombination intermediates with a maximum heteroduplex DNA (hDNA) region of 697 bp contained a centrally located, phenotypically si...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：:We consider inference for demographic models and parameters based upon postprocessing the output of an MCMC method that generates samples of genealogical trees (from the posterior distribution for a specific prior distribution of the genealogy). This approach has the advantage of taking account of the uncertainty in t...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.071910
更新日期：2007-09-01 00:00:00
abstract：:To identify genes involved in stress resistance and heat hardening, replicate lines of Drosophila melanogaster were selected for increased resistance to knockdown by a 39 degrees heat stress. Two selective regimes were used, one with and one without prior hardening. Mean knockdown times were increased from approximate...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：:Preliminary studies with restriction fragment length polymorphisms of mitochondrial DNA (mtDNA) in natural populations of Drosophila melanogaster revealed considerable variation in terms of nucleotide sequence and overall size. In this report we present data from more isofemale lines and more restriction enzymes, and ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-09-01 00:00:00
abstract：:We define a new gene, SRD1, involved in the processing of pre-rRNA to mature rRNA. The SRD1 gene was identified by selecting for second-site suppressors of the previously described rrp1-1 mutation. The rrp1-1 mutation causes temperature-sensitive growth, a conditional defect in processing of 27S pre-rRNA to mature 25S...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:The Thomas Hunt Morgan Medal is awarded to an individual Genetics Society of America member for lifetime achievement in the field of genetics. It recognizes the full body of work of an exceptional geneticist. The 2016 recipient is Nancy Kleckner, who has made many significant contributions to our understanding of chro...
journal_title：Genetics
pub_type： 历史文章,杂志文章
doi：10.1534/genetics.116.197608
更新日期：2016-12-01 00:00:00
abstract：:Repeated elements are remarkably important for male meiosis and spermiogenesis in Drosophila melanogaster. Pairing of the X and Y chromosomes is mediated by the ribosomal RNA genes of the Y chromosome and X chromosome heterochromatin, spermiogenesis depends on the fertility factors of the Y chromosome. Intriguingly, a...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:mod(mdg4), also known as E(var)3-93D, is involved in a variety of processes, such as gene silencing in position effect variegation (PEV), the control of gypsy insulator sequences, regulation of homeotic gene expression, and programmed cell death. We have isolated a large number of mod(mdg4) cDNAs, representing 21 diff...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:The genetic structure of green turtle (Chelonia mydas) rookeries located around the Australian coast was assessed by (1) comparing the structure found within and among geographic regions, (2) comparing microsatellite loci vs. restriction fragment length polymorphism analyses of anonymous single copy nuclear DNA (ascnD...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:The Drosophila piwi gene is the founding member of the only known family of genes whose function in stem cell maintenance is highly conserved in both animal and plant kingdoms. piwi mutants fail to maintain germline stem cells in both male and female gonads. The identification of piwi-interacting genes is essential fo...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-12-01 00:00:00
abstract：:We have studied a genome-wide set of single-nucleotide polymorphism (SNP) allele frequency measures for African-American, East Asian, and European-American samples. For this analysis we derived a simple, closed mathematical formulation for the spectrum of expected allele frequencies when the sampled populations have e...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.166.1.351
更新日期：2004-01-01 00:00:00
abstract：:Antisuppressor mutations in the eEF1A gene of Podospora anserina were previously shown to impair ascospore formation, to drastically increase life span, and to permit the development of the Crippled Growth degenerative process. Here, we show that eEF1A controls ascospore formation through accuracy level maintenance. E...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-08-01 00:00:00
abstract：:The Caenorhabditis elegans gene gld-1 is essential for oocyte development; in gld-1 (null) hermaphrodites, a tumor forms where oogenesis would normally occur. We use genetic epistasis analysis to demonstrate that tumor formation is dependent on the sexual fate of the germline. When the germline sex determination pathw...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:Statistical tests of the neutrality hypothesis that are based on the sampling theory of Ewens (1972) require the assumption of panmixia. It is proposed that for a population comprising numerous local populations with weak gene flow among them, tests based on Ewens' theory can be applied separately to samples from each...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：:Cse4p is an essential histone H3 variant in Saccharomyces cerevisiae that defines centromere identity and is required for proper segregation of chromosomes. In this study, we investigated phenotypic consequences of Cse4p mislocalization and increased dosage of histone H3 and Cse4p, and established a direct link betwee...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.088518
更新日期：2008-05-01 00:00:00
