Genetic dissection of clonally inherited genomes of Poeciliopsis: II. Investigation of a silent carboxylesterase allele.

abstract：:Seed component structures were grouped into maternal and offspring (embryo and endosperm) tissues to characterize a dormancy quantitative trait locus (QTL) for tissue-specific function using a marker-assisted genetic approach. The approach was devised to test if genotypic/allelic frequencies of a marker tightly linked...

journal_title：Genetics

authors： Gu XY,Turnipseed EB,Foley ME

更新日期：2008-08-01 00:00:00

abstract：:The Genetics Society of America (GSA) Medal recognizes researchers who have made outstanding contributions to the field of genetics in the past 15 years. The 2019 GSA Medal is awarded to Bonnie L. Bassler of Princeton University and the Howard Hughes Medical Institute in recognition of her groundbreaking studies of ba...

journal_title：Genetics

authors： Bassler BL

更新日期：2020-06-01 00:00:00

abstract：:Methodologies for mapping of genes underlying quantitative traits have advanced considerably but have not been accompanied by a parallel development of new population structures. We present a novel population consisting of 50 introgression lines (ILs) originating from a cross between the green-fruited species Lycopers...

journal_title：Genetics

authors： Eshed Y,Zamir D

更新日期：1995-11-01 00:00:00

abstract：:Gene targeting using sequence insertion vectors generally results in integration of one copy of the targeting vector generating a tandem duplication of the cognate chromosomal region of homology. However, occasionally the target locus is found to contain >1 copy of the integrated vector. The mechanism by which the lat...

journal_title：Genetics

authors： Ng P,Baker MD

更新日期：1999-03-01 00:00:00

abstract：:Detecting and quantifying the differences in individual genomes (i.e., genotyping), plays a fundamental role in most modern bioinformatics pipelines. Many scientists now use reduced representation next-generation sequencing (NGS) approaches for genotyping. Genotyping diploid individuals using NGS is a well-studied fie...

journal_title：Genetics

authors： Gerard D,Ferrão LFV,Garcia AAF,Stephens M

更新日期：2018-11-01 00:00:00

abstract：:Septin proteins bind GTP and heterooligomerize into filaments with conserved functions across a wide range of eukaryotes. Most septins hydrolyze GTP, altering the oligomerization interfaces; yet mutations designed to abolish nucleotide binding or hydrolysis by yeast septins perturb function only at high temperatures. ...

journal_title：Genetics

authors： Weems AD,Johnson CR,Argueso JL,McMurray MA

更新日期：2014-03-01 00:00:00

abstract：:The translation elongation factor EF-Tu is a GTPase that delivers amino-acylated tRNAs to the ribosome during the elongation step of translation. EF-Tu/GDP is recycled by the guanine nucleotide exchange factor EF-Ts. Whereas EF-Ts is lacking in S. cerevisiae, both translation factors are found in S. pombe and H. sapie...

journal_title：Genetics

authors： Chiron S,Suleau A,Bonnefoy N

更新日期：2005-04-01 00:00:00

abstract：:Hybrid sterility in the heterogametic sex is a common feature of speciation in animals. In house mice, the contribution of the Mus musculus musculus X chromosome to hybrid male sterility is large. It is not known, however, whether F1 male sterility is caused by X-Y or X-autosome incompatibilities or a combination of b...

journal_title：Genetics

authors： Campbell P,Good JM,Dean MD,Tucker PK,Nachman MW

更新日期：2012-08-01 00:00:00

abstract：:Obligate pathogenic and endosymbiotic bacteria typically experience gene loss due to functional redundancy, asexuality, and genetic drift. We hypothesize that reduced genomes increase their functional complexity through protein multitasking, in which many genes adopt new roles to counteract gene loss. Comparisons of i...

journal_title：Genetics

authors： Kelkar YD,Ochman H

更新日期：2013-01-01 00:00:00

abstract：:Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one DNA strand through another. The central role of type II topoisomera...

journal_title：Genetics

authors： Hohl AM,Thompson M,Soshnev AA,Wu J,Morris J,Hsieh TS,Wu CT,Geyer PK

更新日期：2012-11-01 00:00:00

abstract：:Genes at the SerH locus of the ciliated protist Tetrahymena thermophila specify the major (H) surface protein on cells grown at 20-36 degrees. Alternative proteins L, T, S and I are expressed under different conditions of temperature and culture media. Mutants unable to express SerH genes were examined for expression ...

journal_title：Genetics

authors： Smith DL,Doerder FP

更新日期：1992-01-01 00:00:00

abstract：:Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects; however, the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes and pathways importa...

journal_title：Genetics

authors： Blyth J,Makrantoni V,Barton RE,Spanos C,Rappsilber J,Marston AL

更新日期：2018-02-01 00:00:00

abstract：:Microarray experiments have been used recently in genetical genomics studies, as an additional tool to understand the genetic mechanisms governing variation in complex traits, such as for estimating heritabilities of mRNA transcript abundances, for mapping expression quantitative trait loci, and for inferring regulato...

journal_title：Genetics

authors： Bueno Filho JS,Gilmour SG,Rosa GJ

更新日期：2006-10-01 00:00:00

abstract：:Drosophila melanogaster males dosage compensate by twofold upregulation of the expression of genes on their single X chromosome. This process requires at least five proteins and two noncoding RNAs, roX1 and roX2, which paint the male X chromosome. We used a deletion analysis to search for functional RNA domains within...

journal_title：Genetics

authors： Stuckenholz C,Meller VH,Kuroda MI

更新日期：2003-07-01 00:00:00

abstract：:Repeated elements are remarkably important for male meiosis and spermiogenesis in Drosophila melanogaster. Pairing of the X and Y chromosomes is mediated by the ribosomal RNA genes of the Y chromosome and X chromosome heterochromatin, spermiogenesis depends on the fertility factors of the Y chromosome. Intriguingly, a...

journal_title：Genetics

authors： Palumbo G,Bonaccorsi S,Robbins LG,Pimpinelli S

更新日期：1994-12-01 00:00:00

abstract：:Comparison of population differentiation in neutral marker genes and in genes coding quantitative traits by means of F(ST) and Q(ST) indexes has become commonplace practice. While the properties and estimation of F(ST) have been the subject of much interest, little is known about the precision and possible bias in Q(S...

journal_title：Genetics

authors： O'Hara RB,Merilä J

更新日期：2005-11-01 00:00:00

abstract：:Strand misalignments at DNA repeats during replication are implicated in mutational hotspots. To study these events, we have generated strains carrying mutations in the Escherichia coli chromosomal lacZ gene that revert via deletion of a short duplicated sequence or by template switching within imperfect inverted repe...

journal_title：Genetics

authors： Seier T,Padgett DR,Zilberberg G,Sutera VA Jr,Toha N,Lovett ST

更新日期：2011-06-01 00:00:00

abstract：:Yeast DNA fragments that confer multiple drug resistance when amplified were isolated. Cells containing a yeast genomic library cloned in the high copy autonomously replicating vector, YEp24, were plated on medium containing cycloheximide. Five out of 100 cycloheximide-resistant colonies were cross-resistant to the un...

journal_title：Genetics

authors： Leppert G,McDevitt R,Falco SC,Van Dyk TK,Ficke MB,Golin J

更新日期：1990-05-01 00:00:00

abstract：:A genetic strategy identified Salmonella typhimurium strains carrying large (> 40 kb) Tn 10-catalyzed inversions; the inverted segments were characterized by XbaI digestion and pulsed field gel electrophoresis. Two size classes of large inversions were found. More than half of the inversions extended 40-80 kb either c...

journal_title：Genetics

authors： Krug PJ,Gileski AZ,Code RJ,Torjussen A,Schmid MB

更新日期：1994-03-01 00:00:00

abstract：:Transmission ratio distortion (TRD) is the departure from the expected genotypic frequencies under Mendelian inheritance. This departure can be due to multiple physiological mechanisms during gametogenesis, fertilization, fetal and embryonic development, and early neonatal life. Although a few TRD loci have been repor...

journal_title：Genetics

authors： Casellas J,Gularte RJ,Farber CR,Varona L,Mehrabian M,Schadt EE,Lusis AJ,Attie AD,Yandell BS,Medrano JF

更新日期：2012-05-01 00:00:00

abstract：:The primary signal for Drosophila sex determination is the number of X chromosomes relative to the number of sets of autosomes. The present report shows that the numerator of this X/A signal appears to be determined by the cumulative dose of a relatively limited number of discrete X-linked genetic elements, two of whi...

journal_title：Genetics

authors： Cline TW

更新日期：1988-08-01 00:00:00

abstract：:doublesex (dsx) is unusual among the known sex-determination genes of Drosophila melanogaster in that functional homologs are found in distantly related species. In flies, dsx occupies a position near the bottom of the sex determination hierarchy. It is expressed in male- and female-specific forms and these proteins f...

journal_title：Genetics

authors： Waterbury JA,Jackson LL,Schedl P

更新日期：1999-08-01 00:00:00

abstract：:An association was found earlier between the Ep(1) gene locus coding for an endopeptidase and the endosperm color gene Y(1) on chromosome 6 of Zea mays. By employing primary trisomics we have unequivocally placed the Ep(1) gene on chromosome 6, closely linked to the Y(1) locus. Additionally we describe new alleles at ...

journal_title：Genetics

authors： Nielsen G,Scandalios JG

更新日期：1974-08-01 00:00:00

abstract：:The small heat-shock proteins have undergone a tremendous diversification in plants; whereas only a single small heat-shock protein is found in fungi and many animals, over 20 different small heat-shock proteins are found in higher plants. The small heat-shock proteins in plants have diversified in both sequence and c...

journal_title：Genetics

authors： Waters ER

更新日期：1995-10-01 00:00:00

abstract：:Laboratory crosses between wild strains of the two European house mouse subspecies Mus musculus domesticus (2n = 34) and M. m. musculus (2n = 40) were performed to analyze the selective processes involved in the non-introgression of centromeric regions of Robertsonian (Rb) fusions in the Danish hybrid zone. The chromo...

journal_title：Genetics

authors： Lenormand T,Fel-Clair F,Manolakou K,Alibert P,Britton-Davidian J

更新日期：1997-11-01 00:00:00

abstract：:The heat-shock response is a programmed change in gene expression carried out by cells in response to environmental stress, such as heat. This response is universal and is characterized by the synthesis of a small group of conserved protein chaperones. In Drosophila melanogaster the Hsp70 chaperone dominates the profi...

journal_title：Genetics

authors： Gong WJ,Golic KG

更新日期：2006-01-01 00:00:00

abstract：:We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretation...

journal_title：Genetics

authors： Housworth EA,Stahl FW

更新日期：2009-09-01 00:00:00

abstract：:The eight enzymes of the tricarboxylic acid (TCA) cycle are encoded by at least 15 different nuclear genes in Saccharomyces cerevisiae. We have constructed a set of yeast strains defective in these genes as part of a comprehensive analysis of the interactions among the TCA cycle proteins. The 15 major TCA cycle genes ...

journal_title：Genetics

authors： Przybyla-Zawislak B,Gadde DM,Ducharme K,McCammon MT

更新日期：1999-05-01 00:00:00

abstract：:Codon usage bias in Drosophila melanogaster genes has been attributed to negative selection of those codons whose cellular tRNA abundance restricts rates of mRNA translation. Previous studies, which involved limited numbers of genes, can now be compared against analyses of the entire gene complements of 12 Drosophila ...

journal_title：Genetics

authors： Heger A,Ponting CP

更新日期：2007-11-01 00:00:00

abstract：:I reexamine the use of isolation by distance models as a basis for the estimation of demographic parameters from measures of population subdivision. To that aim, I first provide results for values of F-statistics in one-dimensional models and coalescence times in two-dimensional models, and make more precise earlier r...

journal_title：Genetics

authors： Rousset F

更新日期：1997-04-01 00:00:00