Abstract：
:The heat-shock response is a programmed change in gene expression carried out by cells in response to environmental stress, such as heat. This response is universal and is characterized by the synthesis of a small group of conserved protein chaperones. In Drosophila melanogaster the Hsp70 chaperone dominates the profile of protein synthesis during the heat-shock response. We recently generated precise deletion alleles of the Hsp70 genes of D. melanogaster and have used those alleles to characterize the phenotypes of Hsp70-deficient flies. Flies with Hsp70 deletions have reduced thermotolerance. We find that Hsp70 is essential to survive a severe heat shock, but is not required to survive a milder heat shock, indicating that a significant degree of thermotolerance remains in the absence of Hsp70. However, flies without Hsp70 have a lengthened heat-shock response and an extended developmental delay after a non-lethal heat shock, indicating Hsp70 has an important role in recovery from stress, even at lower temperatures. Lack of Hsp70 also confers enhanced sensitivity to a temperature-sensitive lethal mutation and to the neurodegenerative effects produced by expression of a human polyglutamine disease protein.
journal_name
Geneticsjournal_title
Geneticsauthors
Gong WJ,Golic KGdoi
10.1534/genetics.105.048793keywords:
subject
Has Abstractpub_date
2006-01-01 00:00:00pages
275-86issue
1eissn
0016-6731issn
1943-2631pii
genetics.105.048793journal_volume
172pub_type
杂志文章相关文献
GENETICS文献大全abstract：:This FlyBook chapter summarizes the history and the current state of our understanding of the Wingless signaling pathway. Wingless, the fly homolog of the mammalian Wnt oncoproteins, plays a central role in pattern generation during development. Much of what we know about the pathway was learned from genetic and molec...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.117.300157
更新日期：2018-04-01 00:00:00
abstract：:The forest tent caterpillar is polymorphic for two melanic genes affecting wing color of moths. These are the first genetically determined morphological traits reported for the genus. Dark (D) is a sex-limited, autosomal dominant with a phenotype of dark brown males. Frequencies in population samples varied from 8 to ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：:Apomixis (asexual seed formation) is the result of a plant gaining the ability to bypass the most fundamental aspects of sexual reproduction: meiosis and fertilization. Without the need for male fertilization, the resulting seed germinates a plant that develops as a maternal clone. This dramatic shift in reproductive ...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.114.163105
更新日期：2014-06-01 00:00:00
abstract：:DNA sequence variation in a 1410-bp region including the Cu,Zn Sod locus was examined in 41 homozygous lines of Drosophila melanogaster. Fourteen lines were from Barcelona, Spain, 25 were from California populations and the other two were from laboratory stocks. Two common electromorphs, SODS and SODF, are segregating...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-04-01 00:00:00
abstract：:The parasitoid wasp Nasonia represents a genus of four species that is emerging as a powerful genetic model system that has made and will continue to make important contributions to our understanding of evolutionary biology, development, ecology, and behavior. Particularly powerful are the haplodiploid genetics of the...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.112.147512
更新日期：2015-04-01 00:00:00
abstract：:Mitomycin C (MMC) is a genotoxic agent that induces DNA cross-links, DNA alkylation, and the production of reactive oxygen species (ROS). MMC induces the SOS response and RpoS regulons in Escherichia coli SOS-encoded functions are required for DNA repair, whereas the RpoS regulon is typically induced by metabolic stre...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.199471
更新日期：2017-07-01 00:00:00
abstract：:Notch is a receptor that mediates cell-cell interactions in animal development, and aberrations in Notch signal transduction can cause cancer and other human diseases. Here, I describe the major advances in the Notch field from the identification of the first mutant in Drosophila almost a century ago through the eluci...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.112.141812
更新日期：2012-07-01 00:00:00
abstract：:Site-specific recombinases are widely used tools for analysis of genetics, development, and cell biology, and many schemes have been devised to alter gene expression by recombinase-mediated DNA rearrangements. Because the FRT and lox target sites for the commonly used FLP and Cre recombinases are asymmetrical, and mus...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.120.303394
更新日期：2020-08-01 00:00:00
abstract：:Septin proteins bind GTP and heterooligomerize into filaments with conserved functions across a wide range of eukaryotes. Most septins hydrolyze GTP, altering the oligomerization interfaces; yet mutations designed to abolish nucleotide binding or hydrolysis by yeast septins perturb function only at high temperatures. ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.114.161182
更新日期：2014-03-01 00:00:00
abstract：:Trans-species polymorphism, meaning the presence of alleles in different species that are more similar to each other than they are to alleles in the same species, has been found at loci associated with vegetative incompatibility in filamentous fungi. If individuals differ at one or more of these loci (termed het for h...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-06-01 00:00:00
abstract：:Genic variation in natural populations of Drosophila simulans was surveyed using allozymic and two-dimensional electrophoretic techniques. Consistent with some previous reports, allozymic heterozygosity appeared lower than in the sibling species D. melanogaster (0.07 vs. 0.16). No variation was detected by two-dimensi...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The adaptive character of inversion polymorphism in Drosophila subobscura is well established. The O(ST) and O(3+4) chromosomal arrangements of this species differ by two overlapping inversions that arose independently on O(3) chromosomes. Nucleotide variation in eight gene regions distributed along inversion O(3) was...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.032748
更新日期：2005-03-01 00:00:00
abstract：:Due to issues of practicality and confidentiality of genomic data sharing on a large scale, typically only meta- or mega-analyzed genome-wide association study (GWAS) summary data, not individual-level data, are publicly available. Reanalyses of such GWAS summary data for a wide range of applications have become more ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.300813
更新日期：2018-06-01 00:00:00
abstract：:By using both numerical and analytical approaches, we have shown that heterosis alone is not a mechanism for maintaining many alleles segregating at a locus. Even when all heterozygous are more fit than all homozygotes, the proportion of fitness arrays that will lead to a stable, feasible equilibrium of more than 6 or...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:This study attempted to assay the zygotic contribution of X chromosome genes to the genetic control of embryonic morphogenesis in Drosophila melanogaster. A systematic screen for X-linked genes which affect the morphology of the embryo was undertaken, employing the phenotype of whole mount embryos as the major screeni...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：:DNA topoisomerases, enzymes that alter the superhelicity of DNA, have been implicated in such critical cellular functions as transcription, DNA replication, and recombination. In the yeast Saccharomyces cerevisiae, a null mutation in the gene encoding topoisomerase I (TOP1) causes elevated levels of mitotic recombinat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1993-04-01 00:00:00
abstract：:We examine the influence of nonrandom mating and immigration on the evolutionary dynamics of cytonuclear associations in hybrid zones. Recursion equations for allelic and genotypic cytonuclear disequilibria were generated under models of (1) migration alone, assuming hybrid zone matings are random with respect to cyto...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-08-01 00:00:00
abstract：:We discuss the conceptual conflict between a slow series of gene substitutions as the mechanism of evolutionary change, and the apparent need for rapid and coordinated changes at many loci simultaneously in producing complex adaptations. To improve on the limitations of classical theory and accommodate the enormous am...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:The rate of microsatellite mutation is dependent upon both the allele length and the repeat motif, but the exact nature of this relationship is still unknown. We analyzed data on the inheritance of human Y-chromosomal microsatellites in father-son duos, taken from 24 published reports and comprising 15,285 directly ob...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.111.132308
更新日期：2011-12-01 00:00:00
abstract：:Heterochromatin protein 1a (HP1a) is a highly conserved and versatile epigenetic factor that can both silence and activate transcription. However, the function of HP1a in development has been underinvestigated. Here, we report the role of maternal HP1a in producing maternal transcripts that drive early Drosophila embr...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301704
更新日期：2019-01-01 00:00:00
abstract：:The F(1) hybrids of Nicotiana suaveolens (subgenus Petunioides, 2n = 32) and N. glutinosa (subgenus Tabacum, 2n = 24), were examined during their development, from seedlings to mature plants. It was observed that in the hybrids, there was a progressive change of dominant N. glutinosa morphological characteristics towa...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1973-04-01 00:00:00
abstract：:The African fish Nothobranchius furzeri is the shortest-lived vertebrate species that can reproduce in captivity, with a median life span of 9-11 weeks for the shortest-lived strain. Natural populations of N. furzeri display differences in life span, aging biomarkers, behavior, and color, which make N. furzeri a uniqu...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.108670
更新日期：2009-12-01 00:00:00
abstract：:Ataxia telangiectasia mutated (ATM) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the DNA damage response in eukaryotic cells. In humans, mutations in ATM cause the devastating neurodegenerative disease ataxia telangiectasia. Previously, we characterized the homolog of ATM ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.080879
更新日期：2008-02-01 00:00:00
abstract：:Divergent phenotypes are often detected in domesticated plants despite the existence of invariant phenotypes in their wild forms. One such example in rice is the occurrence of varying degrees of apiculus coloration due to anthocyanin pigmentation, which was previously reported to be caused by a series of alleles at th...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.103.018390
更新日期：2004-10-01 00:00:00
abstract：:AFLP markers are becoming one of the most popular tools for genetic analysis in the fields of evolutionary genetics and ecology and conservation of genetic resources. The technique combines a high-information content and fidelity with the possibility of carrying out genomewide scans. However, a potential problem with ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.083246
更新日期：2008-05-01 00:00:00
abstract：:The heterochromatin of the third chromosome is the largest uncharacterized region of the Drosophila melanogaster genome, and the last major block of D. melanogaster heterochromatin to be thoroughly analyzed. In the present study, this region was genetically dissected by generating and analyzing a series of attached, d...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:Cryptococcus neoformans is a fungal pathogen that causes meningitis in immunocompromised hosts. The organism has a known sexual cycle, and strains of the MATalpha mating type are more virulent than isogenic MATa strains in mice, and they are more common in the environment and infected hosts. A C. neoformans homolog of...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:TE146 is a giant transposon of Drosophila melanogaster. It carries two copies of the white and roughest genes, normally found on the X chromosome. The structure of this transposon has been studied at the molecular level. TE146 may transpose to new chromosome positions, excise and be lost from the genome or undergo int...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-06-01 00:00:00
abstract：:We have characterized a Saccharomyces cerevisiae mutant strain that is hypersensitive to cyclosporin A (CsA) and FK506, immunosuppressants that inhibit calcineurin, a serine-threonine-specific phosphatase (PP2B). A single nuclear mutation, designated cev1 for calcineurin essential for viability, is responsible for the...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:Regulation of development and entry into sporulation is critical for fungi to ensure survival of unfavorable environmental conditions. Here we present an analysis of gene sets regulating sporulation in the homothallic ascomycete Ashbya gossypii. Deletion of components of the conserved pheromone/starvation MAP kinase c...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.151019
更新日期：2013-09-01 00:00:00
