The molecular structure of TE146 and its derivatives in Drosophila melanogaster.

Abstract:

:TE146 is a giant transposon of Drosophila melanogaster. It carries two copies of the white and roughest genes, normally found on the X chromosome. The structure of this transposon has been studied at the molecular level. TE146 may transpose to new chromosome positions, excise and be lost from the genome or undergo internal rearrangements. The termini of TE146 are foldback DNA elements (FB); the transposon also carries two internal FB elements. Loss or internal rearrangement of TE146 involves recombination between different FB elements. These events have been mapped molecularly, by taking advantage of the fact that the FB sequences are composed largely of a regular 155-bp repeat sequence that is cut by the restriction enzyme TaqI, and are shown to be nonrandom. We suggest that these FB-FB exchange events occur by mitotic sister-chromatid exchange in the premeiotic germ line.

journal_name

Genetics

journal_title

Genetics

authors

Lovering R,Harden N,Ashburner M

keywords:

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

357-72

issue

2

eissn

0016-6731

issn

1943-2631

journal_volume

128

pub_type

杂志文章

相关文献

GENETICS文献大全
  • Selective constraints on intron evolution in Drosophila.

    abstract::Intron sizes show an asymmetrical distribution in a number of organisms, with a large number of "short" introns clustered around a minimal intron length and a much broader distribution of longer introns. In Drosophila melanogaster, the short intron class is centered around 61 bp. The narrow length distribution suggest...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Parsch J

    更新日期:2003-12-01 00:00:00

  • A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.

    abstract::The Caenorhabditis elegans pRb ortholog, LIN-35, functions in a wide range of cellular and developmental processes. This includes a role of LIN-35 in nutrient utilization by the intestine, which it carries out redundantly with SLR-2, a zinc-finger protein. This and other redundant functions of LIN-35 were identified i...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.112.140152

    authors: Polley SR,Fay DS

    更新日期:2012-08-01 00:00:00

  • Correcting the bias of Wright's estimates of the number of genes affecting a quantitative character: a further improved method.

    abstract::Wright's method of estimating the number of genes contributing to the difference in a quantitative character between two populations involves observing the means and variances of the two parental populations and their hybrid populations. Although simple, Wright's method provides seriously biased estimates, largely due...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Zeng ZB

    更新日期:1992-08-01 00:00:00

  • Extraction of the Constituent Subgenomes of the Natural Allopolyploid Rapeseed (Brassica napus L.).

    abstract::As the dynamic nature of progenitor genomes accompanies the speciation by interspecific hybridization, the extraction of the constituent subgenome(s) from a natural allopolyploid species of long history and then restitution of the progenitor(s) provides the unique opportunity to study the genome evolution and interpla...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.116.190967

    authors: Zhu B,Tu Y,Zeng P,Ge X,Li Z

    更新日期:2016-11-01 00:00:00

  • The evolution of isochores: evidence from SNP frequency distributions.

    abstract::The large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here we test whether the compositional variation is due to mutation bias using two new tests, which do not assume composition...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Lercher MJ,Smith NG,Eyre-Walker A,Hurst LD

    更新日期:2002-12-01 00:00:00

  • A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog.

    abstract::During development signaling pathways coordinate cell fates and regulate the choice between cell survival or programmed cell death. The well-conserved Wingless/Wnt pathway is required for many developmental decisions in all animals. One transducer of the Wingless/Wnt signal is Armadillo/beta-catenin. Drosophila Armadi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Cox RT,McEwen DG,Myster DL,Duronio RJ,Loureiro J,Peifer M

    更新日期:2000-08-01 00:00:00

  • The putative RNA helicase Dbp6p functionally interacts with Rpl3p, Nop8p and the novel trans-acting Factor Rsa3p during biogenesis of 60S ribosomal subunits in Saccharomyces cerevisiae.

    abstract::Ribosome biogenesis requires at least 18 putative ATP-dependent RNA helicases in Saccharomyces cerevisiae. To explore the functional environment of one of these putative RNA helicases, Dbp6p, we have performed a synthetic lethal screen with dbp6 alleles. We have previously characterized the nonessential Rsa1p, whose n...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.166.4.1687

    authors: de la Cruz J,Lacombe T,Deloche O,Linder P,Kressler D

    更新日期:2004-04-01 00:00:00

  • New roles for old characters: an educational primer for use with "Vps factors are required for efficient transcription elongation in budding yeast".

    abstract::An article from Alan Hinnebusch's laboratory in the March 2013 issue of GENETICS establishes an exciting new link between proteins with well-established roles in the endomembrane system and the process of transcription elongation. This Primer article provides tools needed for students to fully appreciate, analyze, and...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.113.150763

    authors: Duina AA

    更新日期:2013-05-01 00:00:00

  • Co-segregation of intermale aggression with the pseudoautosomal region of the Y chromosome in mice.

    abstract::The sexual dimorphism of aggression has led to a search for its Y chromosomal correlates. We have previously confirmed that initiation of attack behavior against a conspecific male is Y-dependent in two strains of laboratory mice (NZB and CBA/H). We provide evidence that the non-pseudoautosomal region of the Y is not ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Roubertoux PL,Carlier M,Degrelle H,Haas-Dupertuis MC,Phillips J,Moutier R

    更新日期:1994-01-01 00:00:00

  • Quantitative genetics of response to competitors in Nemophila menziesii: a field experiment.

    abstract::Recent investigations of evolution in heterogeneous environments have begun to accommodate genetic and environmental complexity typical of natural populations. Theoretical studies demonstrate that evolution of polygenic characters depends heavily on the genetic interdependence of the expression of traits in the differ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Shaw RG,Platenkamp GA,Shaw FH,Podolsky RH

    更新日期:1995-01-01 00:00:00

  • Switching of a mating-type a mutant allele in budding yeast Saccharomyces cerevisiae.

    abstract::Aimed at investigating the recovery of a specific mutant allele of the mating type locus (MAT) by switching a defective MAT allele, these experiments provide information bearing on several models proposed for MAT interconversion in bakers yeast, Saccharomyces cerevisiae. Hybrids between heterothallic (ho) cells carryi...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Klar AJ,Fogel S,Radin DN

    更新日期:1979-07-01 00:00:00

  • Regulation of odor receptor genes in trichoid sensilla of the Drosophila antenna.

    abstract::This study concerns the problem of odor receptor gene choice in the fruit fly Drosophila melanogaster. From a family of 60 Odor receptor genes, only one or a small number are selected for expression by each olfactory receptor neuron. Little is known about how an olfactory receptor neuron selects a receptor, or how the...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.110.117622

    authors: Miller CJ,Carlson JR

    更新日期:2010-09-01 00:00:00

  • The conversion gradient at HIS4 of Saccharomyces cerevisiae. II. A role for mismatch repair directed by biased resolution of the recombinational intermediate.

    abstract::Salient features of recombination at ARG4 of Saccharomyces provoke a variation of the double-strand-break repair (DSBR) model that has the following features: (1) Holliday junction cutting is biased in favor of strands upon which DNA synthesis occurred during formation of the joint molecule (this bias ensures that cut...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Foss HM,Hillers KJ,Stahl FW

    更新日期:1999-10-01 00:00:00

  • A case of high rate of spontaneous mutation affecting viability in Drosophila melanogaster.

    abstract::A spontaneous lethal mutation rate approximately twenty to thirty times greater than normal has been discovered in second and third chromosomes derived from an irradiated isogenic line and paired with marked inversion chromosomes. Mutations resulting in reductions of viability of varying magnitude short of complete le...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Kidwell MG,Kidwell JF,Nei M

    更新日期:1973-09-01 00:00:00

  • Depletion of Limiting rDNA Structural Complexes Triggers Chromosomal Instability and Replicative Aging of Saccharomyces cerevisiae.

    abstract::Sir2 is a highly conserved NAD+-dependent histone deacetylase that functions in heterochromatin formation and promotes replicative life span (RLS) in the budding yeast, Saccharomyces cerevisiae Within the yeast rDNA locus, Sir2 is required for efficient cohesin recruitment and maintaining the stability of the tandem a...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.119.302047

    authors: Fine RD,Maqani N,Li M,Franck E,Smith JS

    更新日期:2019-05-01 00:00:00

  • Secondary tetrasomic segregation of MDH-B and preferential pairing of homeologues in rainbow trout.

    abstract::We examined the inheritance of allelic variation at an isozyme locus, MDH-B, duplicated by ancestral polyploidy in salmonid fishes. We detected only disomic segregation in females. Segregation ratios in males were best explained by a mixture of disomic and tetrasomic inheritance. We propose a two-stage model of pairin...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Allendorf FW,Danzmann RG

    更新日期:1997-04-01 00:00:00

  • The island model with stochastic migration.

    abstract::The island model with stochastically variable migration rate and immigrant gene frequency is investigated. It is supposed that the migration rate and the immigrant gene frequency are independent of each other in each generation, and each of them is independently and identically distributed in every generation. The tre...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Nagylaki T

    更新日期:1979-01-01 00:00:00

  • The brood pattern of mitomycin-c-induced translocations in Drosophila melanogaster males: the effect of time.

    abstract::Translocations between the two large autosomes were scored in the progeny of males that had been fed mitomycin-C. The frequencies were the same in spermatogonia sampled after 12 and 25 days and in spermatozoa stored for the same periods in untreated females. ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Shukla PT,Auerbach C

    更新日期:1979-10-01 00:00:00

  • Fine mapping in 94 inbred mouse strains using a high-density haplotype resource.

    abstract::The genetics of phenotypic variation in inbred mice has for nearly a century provided a primary weapon in the medical research arsenal. A catalog of the genetic variation among inbred mouse strains, however, is required to enable powerful positional cloning and association techniques. A recent whole-genome resequencin...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.110.115014

    authors: Kirby A,Kang HM,Wade CM,Cotsapas C,Kostem E,Han B,Furlotte N,Kang EY,Rivas M,Bogue MA,Frazer KA,Johnson FM,Beilharz EJ,Cox DR,Eskin E,Daly MJ

    更新日期:2010-07-01 00:00:00

  • Does Stellate cause meiotic drive in Drosophila melanogaster?

    abstract::Drosophila melanogaster males deficient for the crystal (cry) locus of the Y chromosome that carry between 15 and 60 copies of the X-linked Stellate (Ste) gene are semisterile, have elevated levels of nondisjunction, produce distorted sperm genotype ratios (meiotic drive), and evince hyperactive transcription of Ste i...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Belloni M,Tritto P,Bozzetti MP,Palumbo G,Robbins LG

    更新日期:2002-08-01 00:00:00

  • Re-interpretation of genetic variation in simocephalus (cladocera, daphniidae).

    abstract::Populations of several co-existing species of Simocephalus were examined electrophoretically at 11 enzyme loci. The prevailing pattern was one of extensive allelic substitution between species and low levels of polymorphism (0-10%) within species. Genetic identity values between species were very low (10-50%). These r...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Hann BJ,Hebert PD

    更新日期:1982-09-01 00:00:00

  • Genome Instability Is Promoted by the Chromatin-Binding Protein Spn1 in Saccharomyces cerevisiae.

    abstract::Cells expend a large amount of energy to maintain their DNA sequence. DNA repair pathways, cell cycle checkpoint activation, proofreading polymerases, and chromatin structure are ways in which the cell minimizes changes to the genome. During replication, the DNA-damage tolerance pathway allows the replication forks to...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.118.301600

    authors: Thurston AK,Radebaugh CA,Almeida AR,Argueso JL,Stargell LA

    更新日期:2018-12-01 00:00:00

  • An introgression line population of Lycopersicon pennellii in the cultivated tomato enables the identification and fine mapping of yield-associated QTL.

    abstract::Methodologies for mapping of genes underlying quantitative traits have advanced considerably but have not been accompanied by a parallel development of new population structures. We present a novel population consisting of 50 introgression lines (ILs) originating from a cross between the green-fruited species Lycopers...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Eshed Y,Zamir D

    更新日期:1995-11-01 00:00:00

  • Complexities of chromosome landing in a highly duplicated genome: toward map-based cloning of a gene controlling blackleg resistance in Brassica napus.

    abstract::The LmR1 locus, which controls seedling resistance to the blackleg fungus Leptosphaeria maculans in the Brassica napus cultivar Shiralee, was positioned on linkage group N7. Fine genetic mapping in a population of 2500 backcross lines identified three molecular markers that cosegregated with LmR1. Additional linkage m...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.105.049098

    authors: Mayerhofer R,Wilde K,Mayerhofer M,Lydiate D,Bansal VK,Good AG,Parkin IA

    更新日期:2005-12-01 00:00:00

  • Gene expression intensity shapes evolutionary rates of the proteins encoded by the vertebrate genome.

    abstract::Natural selection leaves its footprints on protein-coding sequences by modulating their silent and replacement evolutionary rates. In highly expressed genes in invertebrates, these footprints are seen in the higher codon usage bias and lower synonymous divergence. In mammals, the highly expressed genes have a shorter ...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.104.028944

    authors: Subramanian S,Kumar S

    更新日期:2004-09-01 00:00:00

  • The G-protein alpha-subunit GasC plays a major role in germination in the dimorphic fungus Penicillium marneffei.

    abstract::The opportunistic human pathogen Penicillium marneffei exhibits a temperature-dependent dimorphic switch. At 25 degrees, multinucleate, septate hyphae that can undergo differentiation to produce asexual spores (conidia) are produced. At 37 degrees hyphae undergo arthroconidiation to produce uninucleate yeast cells tha...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Zuber S,Hynes MJ,Andrianopoulos A

    更新日期:2003-06-01 00:00:00

  • Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7.

    abstract::The Drosophila PS1 and PS2 integrins are required to maintain the connection between the dorsal and ventral wing epithelia. If alphaPS subunits are inappropriately expressed during early pupariation, the epithelia separate, causing a wing blister. Two lines of evidence indicate that this apparent loss-of-function phen...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Baker SE,Lorenzen JA,Miller SW,Bunch TA,Jannuzi AL,Ginsberg MH,Perkins LA,Brower DL

    更新日期:2002-09-01 00:00:00

  • Major regulatory genes in maize contribute to standing variation in teosinte (Zea mays ssp. parviglumis).

    abstract::In plants, many major regulatory genes that control plant growth and development have been identified and characterized. Despite a detailed knowledge of the function of these genes little is known about how they contribute to the natural variation for complex traits. To determine whether major regulatory genes of maiz...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.107.080424

    authors: Weber A,Clark RM,Vaughn L,Sánchez-Gonzalez Jde J,Yu J,Yandell BS,Bradbury P,Doebley J

    更新日期:2007-12-01 00:00:00

  • Bayesian mapping of multiple quantitative trait loci from incomplete inbred line cross data.

    abstract::A novel fine structure mapping method for quantitative traits is presented. It is based on Bayesian modeling and inference, treating the number of quantitative trait loci (QTLs) as an unobserved random variable and using ideas similar to composite interval mapping to account for the effects of QTLs in other chromosome...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:

    authors: Sillanpää MJ,Arjas E

    更新日期:1998-03-01 00:00:00

  • A Bayesian Approach to Inferring Rates of Selfing and Locus-Specific Mutation.

    abstract::We present a Bayesian method for characterizing the mating system of populations reproducing through a mixture of self-fertilization and random outcrossing. Our method uses patterns of genetic variation across the genome as a basis for inference about reproduction under pure hermaphroditism, gynodioecy, and a model de...

    journal_title:Genetics

    pub_type: 杂志文章

    doi:10.1534/genetics.115.179093

    authors: Redelings BD,Kumagai S,Tatarenkov A,Wang L,Sakai AK,Weller SG,Culley TM,Avise JC,Uyenoyama MK

    更新日期:2015-11-01 00:00:00