Multiplicative genotype-environment interaction as a cause of reversed response to directional selection.

abstract：:Methodologies for mapping of genes underlying quantitative traits have advanced considerably but have not been accompanied by a parallel development of new population structures. We present a novel population consisting of 50 introgression lines (ILs) originating from a cross between the green-fruited species Lycopers...

journal_title：Genetics

authors： Eshed Y,Zamir D

更新日期：1995-11-01 00:00:00

abstract：:The ability of a virus population to colonize a novel host is predicted to depend on the equilibrium frequency of potential colonists (i.e., genotypes capable of infecting the novel host) in the source population. In this study, we investigated the determinants of the equilibrium frequency of potential colonists in th...

journal_title：Genetics

authors： Ferris MT,Joyce P,Burch CL

更新日期：2007-06-01 00:00:00

abstract：:Signaling by the second messenger inositol 1,4,5-trisphosphate is thought to affect several developmental and physiological processes. Mutants in the inositol 1,4,5-trisphosphate receptor (itpr) gene of Drosophila exhibit delays in molting while stronger alleles are also larval lethal. In a freshly generated set of EM...

journal_title：Genetics

authors： Joshi R,Venkatesh K,Srinivas R,Nair S,Hasan G

更新日期：2004-01-01 00:00:00

abstract：:The long-term population genetics of multigene families is influenced by several biased and unbiased mechanisms of nonreciprocal exchanges (gene conversion, unequal exchanges, transposition) between member genes, often distributed on several chromosomes. These mechanisms cause fluctuations in the copy number of varian...

journal_title：Genetics

authors： Ohta T,Dover GA

更新日期：1984-10-01 00:00:00

abstract：:X chromosome duplications have been used previously to vary the dose of specific regions of the X chromosome to study dosage compensation and sex determination in Caenorhabditis elegans. We show here that duplications suppress and X-linked hypomorphic mutation and elevate the level of activity of an X-linked enzyme, a...

journal_title：Genetics

authors： Meneely PM,Nordstrom KD

更新日期：1988-06-01 00:00:00

abstract：:We demonstrate the involvement of suppressor of meiotic silencing-2 (sms-2(+)), a Neurospora gene coding for an Argonaute-like protein, in meiotic silencing and normal sexual development. ...

journal_title：Genetics

authors： Lee DW,Pratt RJ,McLaughlin M,Aramayo R

更新日期：2003-06-01 00:00:00

abstract：:Diversity in insect pigmentation, encompassing a wide range of colors and spatial patterns, is among the most noticeable features distinguishing species, individuals, and body regions within individuals. In holometabolous species, a significant portion of such diversity can be attributed to the melanin synthesis genes...

journal_title：Genetics

authors： Liu J,Lemonds TR,Marden JH,Popadić A

更新日期：2016-05-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are secreted signaling molecules that control important developmental events in many different organisms. Previous studies have shown that BMPs are expressed at the earliest stages of skeletal development, and are required for formation of specific skeletal features, strongly suggest...

journal_title：Genetics

authors： DiLeone RJ,Russell LB,Kingsley DM

更新日期：1998-01-01 00:00:00

abstract：:Fluorescent in situ hybridization was used to examine the distribution of six abundant long terminal repeat (LTR) retroelements, Opie, Huck, Cinful-1, Prem-2/Ji, Grande, and Tekay/Prem-1 on maize pachytene chromosomes. Retroelement staining in euchromatin was remarkably uniform, even when we included the structurally ...

journal_title：Genetics

authors： Mroczek RJ,Dawe RK

更新日期：2003-10-01 00:00:00

abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...

journal_title：Genetics

authors： Zhou S,Opperman K,Wang X,Chen L

更新日期：2008-11-01 00:00:00

abstract：:Diversity of the founding population of Human Immunodeficiency Virus Type 1 (HIV-1) transmissions raises many important biological, clinical, and epidemiological issues. In up to 40% of sexual infections, there is clear evidence for multiple founding variants, which can influence the efficacy of putative prevention me...

journal_title：Genetics

authors： Romero-Severson EO,Bulla I,Hengartner N,Bártolo I,Abecasis A,Azevedo-Pereira JM,Taveira N,Leitner T

更新日期：2017-11-01 00:00:00

abstract：:The adaptive character of inversion polymorphism in Drosophila subobscura is well established. The O(ST) and O(3+4) chromosomal arrangements of this species differ by two overlapping inversions that arose independently on O(3) chromosomes. Nucleotide variation in eight gene regions distributed along inversion O(3) was...

journal_title：Genetics

authors： Munté A,Rozas J,Aguadé M,Segarra C

更新日期：2005-03-01 00:00:00

abstract：:Linkage relationships of nine enzyme loci; aconitase (Acon ), esterase (Est), glucosephosphate isomerase A and B ( Gpi), glycerate-2-dehydrogenase (G2dh), malic enzyme (Me ), phosphoglycerate kinase (Pgk), phosphoglucomutase (Pgm ) and superoxide dismutase (Sod), were investigated in sunfishes (Lepomis, Centrarchidae)...

journal_title：Genetics

authors： Pasdar M,Philipp DP,Whitt GS

更新日期：1984-07-01 00:00:00

abstract：:We have studied a genome-wide set of single-nucleotide polymorphism (SNP) allele frequency measures for African-American, East Asian, and European-American samples. For this analysis we derived a simple, closed mathematical formulation for the spectrum of expected allele frequencies when the sampled populations have e...

journal_title：Genetics

authors： Marth GT,Czabarka E,Murvai J,Sherry ST

更新日期：2004-01-01 00:00:00

abstract：:The availability of the complete DNA sequence of the Chlamydomonas reinhardtii genome and advanced computational biology tools has allowed elucidation and study of the small ubiquitin-like modifier (SUMO) system in this unicellular photosynthetic alga and model eukaryotic cell system. SUMO is a member of a ubiquitin-l...

journal_title：Genetics

authors： Wang Y,Ladunga I,Miller AR,Horken KM,Plucinak T,Weeks DP,Bailey CP

更新日期：2008-05-01 00:00:00

abstract：:Homothallic strains of Saccharomyes cerevisiae are able to switch efficiently from one mating genotype to another. From a single haploid spore arise both a and mating type cells, which then self-mate to produce a colony consisting almost exclusively of nonmating a/ diploid cells. We have isolated a mutant homothallic ...

journal_title：Genetics

authors： Haber JE,Garvik B

更新日期：1977-09-01 00:00:00

abstract：:Previous models suggested that regulation of telomere length in Saccharomyces cerevisiae by Tel1(ATM) and Mec1(ATR) would parallel the established pathways regulating the DNA damage response. Here, we provide evidence that telomere length regulation differs from the DNA damage response in both the Tel1 and Mec1 pathwa...

journal_title：Genetics

authors： Keener R,Connelly CJ,Greider CW

更新日期：2019-12-01 00:00:00

abstract：:The HML and HMR loci carry unexpressed copies of MATa and MAT alpha information, and a replica of that information is transposed to MAT during mating-type interchange in Saccharomyces yeasts. A negative control mechanism keeps silent the information located at the HML and HMR loci. We mapped these loci by constructing...

journal_title：Genetics

authors： Klar AJ,McIndoo J,Hicks JB,Strathern JN

更新日期：1980-10-01 00:00:00

abstract：:Secondary trisomics and telotrisomics representing the 12 chromosomes of rice were isolated from the progenies of primary trisomics. A large population of each primary trisomic was grown. Plants showing variation in gross morphology compared to the primary trisomics and disomic sibs were selected and analyzed cytologi...

journal_title：Genetics

authors： Singh K,Multani DS,Khush GS

更新日期：1996-05-01 00:00:00

abstract：:RAD53 encodes a conserved protein kinase that acts as a central transducer in the DNA damage and the DNA replication checkpoint pathways in Saccharomyces cerevisiae. To identify new elements of these pathways acting with or downstream of RAD53, we searched for genes whose overexpression suppressed the toxicity of a do...

journal_title：Genetics

authors： Marsolier MC,Roussel P,Leroy C,Mann C

更新日期：2000-04-01 00:00:00

abstract：:Yip1p is the first identified Rab-interacting membrane protein and the founder member of the YIP1 family, with both orthologs and paralogs found in all eukaryotic genomes. The exact role of Yip1p is unclear; YIP1 is an essential gene and defective alleles severely disrupt membrane transport and inhibit ER vesicle budd...

journal_title：Genetics

authors： Chen CZ,Calero M,DeRegis CJ,Heidtman M,Barlowe C,Collins RN

更新日期：2004-12-01 00:00:00

abstract：:Previous association analyses showed that variation at major regulatory genes contributes to standing variation for complex traits in Balsas teosinte, the progenitor of maize. This study expands our previous association mapping effort in teosinte by testing 123 markers in 52 candidate genes for association with 31 tra...

journal_title：Genetics

authors： Weber AL,Briggs WH,Rucker J,Baltazar BM,de Jesús Sánchez-Gonzalez J,Feng P,Buckler ES,Doebley J

更新日期：2008-10-01 00:00:00

abstract：:Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...

journal_title：Genetics

authors： Cutter AD,Agrawal AF

更新日期：2010-06-01 00:00:00

abstract：:Evolutionary forces shape patterns of genetic diversity within populations and contribute to phenotypic variation. In particular, recurrent positive selection has attracted significant interest in both theoretical and empirical studies. However, most existing theoretical models of recurrent positive selection cannot e...

journal_title：Genetics

authors： Uricchio LH,Hernandez RD

更新日期：2014-05-01 00:00:00

abstract：:We describe a fast hierarchical Bayesian method for mapping quantitative trait loci by haplotype-based association, applicable when haplotypes are not observed directly but are inferred from multiple marker genotypes. The method avoids the use of a Monte Carlo Markov chain by employing priors for which the likelihood ...

journal_title：Genetics

authors： Durrant C,Mott R

更新日期：2010-03-01 00:00:00

abstract：:Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects; however, the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes and pathways importa...

journal_title：Genetics

authors： Blyth J,Makrantoni V,Barton RE,Spanos C,Rappsilber J,Marston AL

更新日期：2018-02-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions are associated with sporadic and inherited diseases and age-associated neurodegenerative disorders. Approximately 85% of mtDNA deletions identified in humans are flanked by short directly repeated sequences; however, mechanisms by which these deletions arise are unknown. A limitatio...

journal_title：Genetics

authors： Kalifa L,Quintana DF,Schiraldi LK,Phadnis N,Coles GL,Sia RA,Sia EA

更新日期：2012-03-01 00:00:00

abstract：:To identify genes involved in stress resistance and heat hardening, replicate lines of Drosophila melanogaster were selected for increased resistance to knockdown by a 39 degrees heat stress. Two selective regimes were used, one with and one without prior hardening. Mean knockdown times were increased from approximate...

journal_title：Genetics

authors： McColl G,Hoffmann AA,McKechnie SW

更新日期：1996-08-01 00:00:00

abstract：:The rate of decline in reproductive fitness in populations of Drosophila melanogaster inbred at an initial rate of approximately 1% per generation has been investigated under both competitive and noncompetitive conditions. Breeding population size was variable in the inbred lines with an estimated harmonic mean of 66....

journal_title：Genetics

authors： Latter BD,Mulley JC,Reid D,Pascoe L

更新日期：1995-01-01 00:00:00

abstract：:Cell-cell fusion is essential for a variety of developmental steps in many eukaryotic organisms, during both fertilization and vegetative cell growth. Although the molecular mechanisms associated with intracellular membrane fusion are well characterized, the molecular mechanisms of plasma membrane merger between cells...

journal_title：Genetics

authors： Fleissner A,Diamond S,Glass NL

更新日期：2009-02-01 00:00:00