Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor.

abstract：:The genetic basis of stochastic variation within a defined environment, and the consequences of such micro-environmental variance for fitness are poorly understood . Using a multigenerational breeding design in Drosophila serrata, we demonstrated that the micro-environmental variance in a set of morphological wing tra...

journal_title：Genetics

authors： Sztepanacz JL,McGuigan K,Blows MW

更新日期：2017-08-01 00:00:00

abstract：:The results from a simulation model of selection, mutation and genetic drift in a geographically subdivided population are presented. The infinite-alleles mutation model of Kimura and Crow (1964) is asumed, and both advantageous and deleterious mutations are considered. It is shown that the average frequency of an all...

journal_title：Genetics

authors： Slatkin M

更新日期：1981-10-01 00:00:00

abstract：:The yeast pheromone/filamentous growth MAPK pathway mediates both mating and invasive-growth responses. The interface between this MAPK module and the transcriptional machinery consists of a network of two MAPKs, Fus3 and Kss1; two regulators, Rst1 and Rst2 (a.k.a. Dig1 and Dig2); and two transcription factors, Ste12 ...

journal_title：Genetics

authors： Breitkreutz A,Boucher L,Breitkreutz BJ,Sultan M,Jurisica I,Tyers M

更新日期：2003-11-01 00:00:00

abstract：:Primary cilia have essential roles in transducing signals in eukaryotes. At their core is the ciliary axoneme, a microtubule-based structure that defines cilium morphology and provides a substrate for intraflagellar transport. However, the extent to which axonemal microtubules are specialized for sensory cilium functi...

journal_title：Genetics

authors： Hurd DD,Miller RM,Núñez L,Portman DS

更新日期：2010-07-01 00:00:00

abstract：:Previous mathematical analyses of mutation-selection balance for metric traits assume that selection acts on the relevant loci only through the character(s) under study. Thus, they implicitly assume that all of the relevant mutation and selection parameters are estimable. A more realistic analysis must recognize that ...

journal_title：Genetics

authors： Turelli M

更新日期：1985-09-01 00:00:00

abstract：:F1 hybrid females between the sibling species Drosophila simulans, Drosophila mauritiana and Drosophila sechellia are completely fertile. However, we have found that female sterility can be observed in F2 backcross females who are homozygous for D. simulans X chromosomes and homozygous for autosomal regions from eithe...

journal_title：Genetics

authors： Davis AW,Noonburg EG,Wu CI

更新日期：1994-05-01 00:00:00

abstract：:Meiosis is a specialized cell division that generates gametes, such as eggs and sperm. Errors in meiosis result in miscarriages and are the leading cause of birth defects; however, the molecular origins of these defects remain unknown. Studies in model organisms are beginning to identify the genes and pathways importa...

journal_title：Genetics

authors： Blyth J,Makrantoni V,Barton RE,Spanos C,Rappsilber J,Marston AL

更新日期：2018-02-01 00:00:00

abstract：:Fruit flies of the genus Drosophila have been an attractive and effective genetic model organism since Thomas Hunt Morgan and colleagues made seminal discoveries with them a century ago. Work with Drosophila has enabled dramatic advances in cell and developmental biology, neurobiology and behavior, molecular biology, ...

journal_title：Genetics

authors： Hales KG,Korey CA,Larracuente AM,Roberts DM

更新日期：2015-11-01 00:00:00

abstract：:Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabi...

journal_title：Genetics

authors： Teuscher F,Broman KW

更新日期：2007-03-01 00:00:00

abstract：:To study the functions of DNA topoisomerase I and Hpr1 protein, a suppressor mutant of the temperature-sensitive growth of an hpr1 top1-5ts double mutant was isolated. The isolated triple mutant showed cold-sensitive growth. By complementation of this phenotype, the suppressor gene was cloned. DNA sequencing showed it...

journal_title：Genetics

authors： Uemura H,Pandit S,Jigami Y,Sternglanz R

更新日期：1996-04-01 00:00:00

abstract：:The transmission profiles of sperm mtDNA introduced into fertilized eggs were examined in detail in F1 hybrids of mouse interspecific crosses by addressing three aspects. The first is whether the leaked paternal mtDNA in fertilized eggs produced by interspecific crosses was distributed stably to all tissues after the ...

journal_title：Genetics

authors： Shitara H,Hayashi JI,Takahama S,Kaneda H,Yonekawa H

更新日期：1998-02-01 00:00:00

abstract：:The interval mapping method is widely used for the mapping of quantitative trait loci (QTLs) in segregating generations derived from crosses between inbred lines. The efficiency of detecting and the accuracy of mapping multiple QTLs by using genetic markers are much increased by employing multiple QTL models instead o...

journal_title：Genetics

authors： Jansen RC

更新日期：1993-09-01 00:00:00

abstract：:We have characterized a Saccharomyces cerevisiae mutant strain that is hypersensitive to cyclosporin A (CsA) and FK506, immunosuppressants that inhibit calcineurin, a serine-threonine-specific phosphatase (PP2B). A single nuclear mutation, designated cev1 for calcineurin essential for viability, is responsible for the...

journal_title：Genetics

authors： Hemenway CS,Dolinski K,Cardenas ME,Hiller MA,Jones EW,Heitman J

更新日期：1995-11-01 00:00:00

abstract：:As millions of single-nucleotide polymorphisms (SNPs) have been identified and high-throughput genotyping technologies have been rapidly developed, large-scale genomewide association studies are soon within reach. However, since a genomewide association study involves a large number of SNPs it is therefore nearly impo...

journal_title：Genetics

authors： Zhao J,Jin L,Xiong M

更新日期：2006-11-01 00:00:00

abstract：:An article from Alan Hinnebusch's laboratory in the March 2013 issue of GENETICS establishes an exciting new link between proteins with well-established roles in the endomembrane system and the process of transcription elongation. This Primer article provides tools needed for students to fully appreciate, analyze, and...

journal_title：Genetics

authors： Duina AA

更新日期：2013-05-01 00:00:00

abstract：:We address the task of genotype imputation to a dense reference panel given genotype likelihoods computed from ultralow coverage sequencing as inputs. In this setting, the data have a high-level of missingness or uncertainty, and are thus more amenable to a probabilistic representation. Most existing imputation algori...

journal_title：Genetics

authors： Spiliopoulou A,Colombo M,Orchard P,Agakov F,McKeigue P

更新日期：2017-05-01 00:00:00

abstract：:In California, Drosophila simulans females from some populations (type W) produce relatively few adult progeny when crossed to males from some other populations (type R), but the productivity of the reciprocal cross is comparable to within-population controls. These two incompatibility types are widespread in North Am...

journal_title：Genetics

authors： Hoffmann AA,Turelli M

更新日期：1988-06-01 00:00:00

abstract：:When a polygenic character is exposed to natural selection in which the curve giving fitness as a function of phenotype is a mixture of two Gaussian (normal) curves, the population may respond either by evolving to a specialized phenotype near one of the two optimum phenotypes, or by evolving to a generalized phenotyp...

journal_title：Genetics

authors： Felsenstein J

更新日期：1979-11-01 00:00:00

abstract：:There are many types of DNA damage that are repaired by a multiplicity of different repair pathways. All damage and repair occur in the context of chromatin, and histone modifications are involved in many repair processes. We have analyzed the roles of H2A and its modifications in repair by mutagenizing modifiable res...

journal_title：Genetics

authors： Moore JD,Yazgan O,Ataian Y,Krebs JE

更新日期：2007-05-01 00:00:00

abstract：:Electrophoretic comparisons of 40S and 55S ribosomal subunit proteins from 18 strains of Drosophila melanogaster revealed the virtual absence of allelic variation. More detailed two-dimensional studies on the large subunit proteins in 6 of the strains demonstrated additional complexity but still no interstrain variati...

journal_title：Genetics

authors： Berger EM,Weber L

更新日期：1974-12-01 00:00:00

abstract：:Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combatin...

journal_title：Genetics

authors： Bradford BR,Briand NE,Fassnacht N,Gervasio ED,Nowakowski AM,FitzGibbon TC,Maurina S,Benjamin AV,Kelly M,Checchi PM

更新日期：2020-12-01 00:00:00

abstract：:We extensively phenotyped 6000 Arabidopsis plants with experimentally perturbed DNA methylomes as well as a diverse panel of natural accessions in a common garden. We found that alterations in DNA methylation not only caused heritable phenotypic diversity but also produced heritability patterns closely resembling thos...

journal_title：Genetics

authors： Roux F,Colomé-Tatché M,Edelist C,Wardenaar R,Guerche P,Hospital F,Colot V,Jansen RC,Johannes F

更新日期：2011-08-01 00:00:00

abstract：:Notch signaling pathways can be regulated through a variety of cellular mechanisms, and genetically compromised systems provide useful platforms from which to search for the responsible modulators. The Caenorhabditis elegans gene aph-1 encodes a component of γ-secretase, which is essential for Notch signaling events t...

journal_title：Genetics

authors： Hale VA,Guiney EL,Goldberg LY,Haduong JH,Kwartler CS,Scangos KW,Goutte C

更新日期：2012-03-01 00:00:00

abstract：:Evidence from many organisms indicates that the conserved RecQ helicases function in the maintenance of genomic stability. Mutation of SGS1 and WRN, which encode RecQ homologues in budding yeast and humans, respectively, results in phenotypes characteristic of premature aging. Mutation of SRS2, another DNA helicase, c...

journal_title：Genetics

authors： McVey M,Kaeberlein M,Tissenbaum HA,Guarente L

更新日期：2001-04-01 00:00:00

abstract：:Many genes that affect axon pathfinding and cell migration have been identified. Mechanisms by which these genes and the molecules they encode interact with one another in pathways and networks to control developmental events are unclear. Rac GTPases, the cytoskeletal signaling molecule Enabled, and NIK kinase have al...

journal_title：Genetics

authors： Shakir MA,Gill JS,Lundquist EA

更新日期：2006-02-01 00:00:00

abstract：:A new suppressor of +1 frameshift mutations has been isolated in Salmonella typhimurium. This suppressor, sufJ, maps at minute 89 on the Salmonella genetic map between the argH and rpo(rif) loci, closely linked to the gene for the ochre suppressor tyrU(supM). The suppressor mutation is dominant to its wild-type allele...

journal_title：Genetics

authors： Bossi L,Kohno T,Roth JR

更新日期：1983-01-01 00:00:00

abstract：:Dosage compensation refers to the equal expression of X-linked genes despite the difference in copy number between the two sexes. The male-specific lethal (MSL) complex is concentrated on the X chromosome in males. A gene expression assay for embryos was developed to examine the function of this complex. In mutant mal...

journal_title：Genetics

authors： Bhadra MP,Bhadra U,Kundu J,Birchler JA

更新日期：2005-04-01 00:00:00

abstract：:Genetic analysis of 131 independent transpositions of the tetracycline-resistance element Tn10 from a single site in phage P22 into the histidine operon of Salmonella typhimurium reveals that Tn10 insertions are not randomly distributed along this chromosomal target. The insertions occur in 22 different "clusters"; in...

journal_title：Genetics

authors： Kleckner N,Steele DA,Reichardt K,Botstein D

更新日期：1979-08-01 00:00:00

abstract：:The N-terminal tail of Ndc80 is essential for kinetochore-microtubule binding in human cells but is not required for viability in yeast. We show that the yeast Ndc80 tail is required for timely mitotic progression and accurate chromosome segregation. The tail is essential when cells are limited for Dam1, demonstrating...

journal_title：Genetics

authors： Demirel PB,Keyes BE,Chaterjee M,Remington CE,Burke DJ

更新日期：2012-10-01 00:00:00

abstract：:The degree to which genomic architecture varies across space and time is central to the evolution of genomes in response to natural selection. Bulked-segregant mapping combined with pooled sequencing provides an efficient means to estimate the effect of genetic variants on quantitative traits. We develop a novel likel...

journal_title：Genetics

authors： Monnahan PJ,Kelly JK

更新日期：2017-07-01 00:00:00