The Genomic Architecture of Flowering Time Varies Across Space and Time in Mimulus guttatus.

abstract：:OrthoList, a compendium of Caenorhabditis elegans genes with human orthologs compiled in 2011 by a meta-analysis of four orthology-prediction methods, has been a popular tool for identifying conserved genes for research into biological and disease mechanisms. However, the efficacy of orthology prediction depends on th...

journal_title：Genetics

authors： Kim W,Underwood RS,Greenwald I,Shaye DD

更新日期：2018-10-01 00:00:00

abstract：:Nontandem terminal chromosome duplications derived from N. crassa translocation T(I-->VI)NM103 give rise mitotically to some daughter nuclei which have become euploid by loss of one or the other of the two duplicated segments. Loss of the segment in normal sequence occurs as often as loss of the translocated segment. ...

journal_title：Genetics

authors： Turner BC

更新日期：1977-03-01 00:00:00

abstract：:Prions have revived interest in hereditary change that is due to change in cellular structure. How pervasive is structural inheritance and what are its mechanisms? Described here is the initial characterization of [Leu(P)], a heritable structural change of the mitochondrion of Saccharomyces cerevisiae that often but n...

journal_title：Genetics

authors： Lockshon D

更新日期：2002-08-01 00:00:00

abstract：:Forty-eight new mutations at the am locus of Neurospora crassa have been characterized. Nineteen mutations were induced by UV; of these, eight were missense, two were frameshifts, two were nonsense, three were deletions and four were unidentified. Twenty-nine mutations were induced with nitrous acid; of these, twenty-...

journal_title：Genetics

authors： Kinsey JA,Hung BS

更新日期：1981-11-01 00:00:00

abstract：:The Polymerase Associated Factor 1 complex (Paf1C) is a multifunctional regulator of eukaryotic gene expression important for the coordination of transcription with chromatin modification and post-transcriptional processes. In this study, we investigated the extent to which the functions of Paf1C combine to regulate t...

journal_title：Genetics

authors： Ellison MA,Lederer AR,Warner MH,Mavrich TN,Raupach EA,Heisler LE,Nislow C,Lee MT,Arndt KM

更新日期：2019-07-01 00:00:00

abstract：:Using conditional probabilities and moment-generating matrices, I derived approximate algebraic equations that give expectations of gene frequency, population mean, gene frequency variance within lines, or heterozygosity, and gene frequency variance between lines, or drift, for repeated cycles of recurrent selection i...

journal_title：Genetics

authors： Silvela L

更新日期：1980-07-01 00:00:00

abstract：:Genetic analysis of 131 independent transpositions of the tetracycline-resistance element Tn10 from a single site in phage P22 into the histidine operon of Salmonella typhimurium reveals that Tn10 insertions are not randomly distributed along this chromosomal target. The insertions occur in 22 different "clusters"; in...

journal_title：Genetics

authors： Kleckner N,Steele DA,Reichardt K,Botstein D

更新日期：1979-08-01 00:00:00

abstract：:The term "micro-evo-devo" refers to the combined study of the genetic and developmental bases of natural variation in populations and the evolutionary forces that have shaped this variation. It thus represents a synthesis of the fields of evolutionary developmental biology and population genetics. As has been pointed ...

journal_title：Genetics

authors： Nunes MD,Arif S,Schlötterer C,McGregor AP

更新日期：2013-11-01 00:00:00

abstract：:Genetic material sequenced from ancient samples is revolutionizing our understanding of the recent evolutionary past. However, ancient DNA is often degraded, resulting in low coverage, error-prone sequencing. Several solutions exist to this problem, ranging from simple approach, such as selecting a read at random for ...

journal_title：Genetics

authors： Schraiber JG

更新日期：2018-01-01 00:00:00

abstract：:Previously a deletion in mouse chromosome 17, T(22H), was shown to behave like a t allele of the t complex distorter gene Tcd1, and this was attributed to deletion of this locus. Seven further deletions are studied here, with the aim of narrowing the critical region in which Tcd1 must lie. One deletion, T(30H), togeth...

journal_title：Genetics

authors： Lyon MF,Schimenti JC,Evans EP

更新日期：2000-06-01 00:00:00

abstract：:Early embryogenesis in Drosophila melanogaster is controlled by maternal gene products, which are deposited in the egg during oogenesis. It is not well understood how maternal gene expression is controlled during germline development. pipsqueak (psq) is a complex locus that encodes several nuclear protein variants con...

journal_title：Genetics

authors： Grillo M,Furriols M,Casanova J,Luschnig S

更新日期：2011-02-01 00:00:00

abstract：:We have identified two Saccharomyces cerevisiae genes that, in high copy, confer resistance to Kluyveromyces lactis zymocin, an inhibitor that blocks cells in the G(1) phase of the cell cycle prior to budding and DNA replication. One gene (GRX3) encodes a glutaredoxin and is likely to act at the level of zymocin entry...

journal_title：Genetics

authors： Jablonowski D,Butler AR,Fichtner L,Gardiner D,Schaffrath R,Stark MJ

更新日期：2001-12-01 00:00:00

abstract：:The fixation of a beneficial allele in a population leaves a well-characterized signature in patterns of nucleotide variation at linked sites. This signature can be used to estimate the time since fixation from patterns of polymorphism in extant individuals. I introduce a method to assess the support in polymorphism d...

journal_title：Genetics

authors： Przeworski M

更新日期：2003-08-01 00:00:00

abstract：:Variable numbers of tandem repeats (VNTRs) are a class of highly informative and widely dispersed genetic markers. Despite their wide application in biological science, little is known about their mutational mechanisms or population dynamics. The objective of this work was to investigate four summary measures of VNTR ...

journal_title：Genetics

authors： Shriver MD,Jin L,Chakraborty R,Boerwinkle E

更新日期：1993-07-01 00:00:00

abstract：:The Spt-Ada-Gcn5-acetyltransferase (SAGA) complex of Saccharomyces cerevisiae is a multifunctional coactivator complex that has been shown to regulate transcription by distinct mechanisms. Previous results have shown that the Spt3 and Spt8 components of SAGA regulate initiation of transcription of particular genes by ...

journal_title：Genetics

authors： Laprade L,Rose D,Winston F

更新日期：2007-12-01 00:00:00

abstract：:Genic variation in natural populations of Drosophila simulans was surveyed using allozymic and two-dimensional electrophoretic techniques. Consistent with some previous reports, allozymic heterozygosity appeared lower than in the sibling species D. melanogaster (0.07 vs. 0.16). No variation was detected by two-dimensi...

journal_title：Genetics

authors： Ohnishi S,Leigh Brown AJ,Voelker RA,Langley CH

更新日期：1982-01-01 00:00:00

abstract：:Mutations were induced in synchronous Chinese hamster cells by bromodeoxyuridine (BUdR) incorporated into cells for one-hour periods in the cell cycle. There was a very pronounced temporal dependence during the first half of the DNA synthesis period for the induction of damage leading to 6-thioguanine (6TG) and ouabai...

journal_title：Genetics

authors： Burki HJ,Aebersold PM

更新日期：1978-10-01 00:00:00

abstract：:We have studied how a set of male-specific sensory neurons in Caenorhabditis elegans establish axonal connections during postembryonic development. In the adult male, 9 bilateral pairs of ray sensory neurons innervate an acellular fan that serves as a presumptive tactile and olfactory organ during copulation. We visua...

journal_title：Genetics

authors： Jia L,Emmons SW

更新日期：2006-07-01 00:00:00

abstract：:Levels of genetic variation and linkage disequilibrium (LD) are critical factors in association mapping methods as well as in identification of loci that have been targets of selection. Maize, an outcrosser, has a high level of sequence variation and a limited extent of LD. Sorghum, a closely related but largely self-...

journal_title：Genetics

authors： Hamblin MT,Mitchell SE,White GM,Gallego J,Kukatla R,Wing RA,Paterson AH,Kresovich S

更新日期：2004-05-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions are associated with sporadic and inherited diseases and age-associated neurodegenerative disorders. Approximately 85% of mtDNA deletions identified in humans are flanked by short directly repeated sequences; however, mechanisms by which these deletions arise are unknown. A limitatio...

journal_title：Genetics

authors： Kalifa L,Quintana DF,Schiraldi LK,Phadnis N,Coles GL,Sia RA,Sia EA

更新日期：2012-03-01 00:00:00

abstract：:As the dynamic nature of progenitor genomes accompanies the speciation by interspecific hybridization, the extraction of the constituent subgenome(s) from a natural allopolyploid species of long history and then restitution of the progenitor(s) provides the unique opportunity to study the genome evolution and interpla...

journal_title：Genetics

authors： Zhu B,Tu Y,Zeng P,Ge X,Li Z

更新日期：2016-11-01 00:00:00

abstract：:PGM plays a central role in the glycolytic pathway at the branch point leading to glycogen metabolism and is highly polymorphic in allozyme studies of many species. We have characterized the nucleotide diversity across the Pgm gene in Drosophila melanogaster and D. simulans to investigate the role that protein polymor...

journal_title：Genetics

authors： Verrelli BC,Eanes WF

更新日期：2000-12-01 00:00:00

abstract：:A natural population of Culex tritaeniorhynchus was sampled to test the efficacy of a proposed method to detect and measure concealed variability. Thirty-nine lethals and ten recessive visible mutations were uncovered out of a total of 125 chromosomes tested. ...

journal_title：Genetics

authors： Sakai RK,Baker RH

更新日期：1972-06-01 00:00:00

abstract：:Zymograms were analyzed of a number of Triticum aestivum derivatives which incorporated a segment of the Aegilops umbellulata chromosome bearing resistance to leaf rust. Evidence has been presented which suggests that genes involved in the production of two peroxidases and a single peptidase are located on the short a...

journal_title：Genetics

authors： Macdonald T,Smith HH

更新日期：1972-09-01 00:00:00

abstract：:Yeast mitochondria form a branched tubular network. Mitochondrial inheritance is tightly coupled with bud emergence, ensuring that daughter cells receive mitochondria from mother cells during division. Proteins reported to influence mitochondrial inheritance include the mitochondrial rho (Miro) GTPase Gem1p, Mmr1p, an...

journal_title：Genetics

authors： Frederick RL,Okamoto K,Shaw JM

更新日期：2008-02-01 00:00:00

abstract：:A method for the estimation of population dynamic history from sequence data is described and used to investigate the past population dynamics of HIV-1 subtypes A and B. Using both gag and env gene alignments the effective population size of each subtype is estimated and found to be surprisingly small. This may be a r...

journal_title：Genetics

authors： Grassly NC,Harvey PH,Holmes EC

更新日期：1999-02-01 00:00:00

abstract：:A general method is proposed for calculating approximate thresholds of interval mapping tests for quantitative trait loci (QTL) detection. Simulation results show that this method, when applied to backcross and F2 populations, gives good approximations and is useful for any situation. Programs which calculate these th...

journal_title：Genetics

authors： Rebaï A,Goffinet B,Mangin B

更新日期：1994-09-01 00:00:00

abstract：:In Neurospora crassa, DNA sequence duplications are detected and altered efficiently during the sexual cycle by a process known as RIP (repeat-induced point mutation). Affected sequences are subjected to multiple GC-to-AT mutations. To explore the pattern in which base changes are laid down by RIP we examined two sets...

journal_title：Genetics

authors： Watters MK,Randall TA,Margolin BS,Selker EU,Stadler DR

更新日期：1999-10-01 00:00:00

abstract：:Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations...

journal_title：Genetics

authors： Alcazar RM,Lin R,Fire AZ

更新日期：2008-11-01 00:00:00

abstract：:R1 and R2 elements are non-LTR retrotransposons that insert specifically into the 28S rRNA genes of arthropods. The process of concerted evolution of the rDNA locus should give rise to rapid turnover of these mobile elements compared to elements that insert at sites throughout a genome. To estimate the rate of R1 and ...

journal_title：Genetics

authors： Pérez-González CE,Eickbush TH

更新日期：2002-10-01 00:00:00