Cytochemical studies on the problem of macronuclear subnuclei in tetrahymena.

abstract：:Backcross populations are often used to study quantitative trait loci (QTL) after they are initially discovered in balanced populations, such as F(2), BC(1), or recombinant inbreds. While the latter are more powerful for mapping marker loci, the former have the reduced background genetic variation necessary for more p...

journal_title：Genetics

authors： Butruille DV,Guries RP,Osborn TC

更新日期：1999-10-01 00:00:00

abstract：:Homolog recombination and unequal sister chromatid recombination were monitored in rad1-1/rad1-1 diploid yeast cells deficient for excision repair, and in control cells, RAD1/rad1-1, after exposure to UV irradiation. In a rad1-1/rad1-1 diploid, UV irradiation stimulated much more sister chromatid recombination relativ...

journal_title：Genetics

authors： Kadyk LC,Hartwell LH

更新日期：1993-03-01 00:00:00

abstract：:Initial events in double-strand break repair by homologous recombination in vivo involve homology searching, 3' strand invasion, and new DNA synthesis. While studies in yeast have contributed much to our knowledge of these processes, in comparison, little is known of the early events in the integrated mammalian system...

journal_title：Genetics

authors： Si W,Mundia MM,Magwood AC,Mark AL,McCulloch RD,Baker MD

更新日期：2010-06-01 00:00:00

abstract：:Gastrulation is fundamental to the development of multicellular animals. Along with neurulation, gastrulation is one of the major processes of morphogenesis in which cells or whole tissues move from the surface of an embryo to its interior. Cell internalization mechanisms that have been discovered to date in Caenorhab...

journal_title：Genetics

authors： Goldstein B,Nance J

更新日期：2020-02-01 00:00:00

abstract：:The first five steps in de novo purine biosynthesis are involved in the formation of the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. We show here that the first enzyme in de novo purine biosynthesis, PurF, is required for thiamine synthesis during aerobic growth on some but not other carbon s...

journal_title：Genetics

authors： Petersen L,Enos-Berlage J,Downs DM

更新日期：1996-05-01 00:00:00

abstract：:The external genitalia are some of the most rapidly evolving morphological structures in insects. The posterior lobe of the male genital arch shows striking differences in both size and shape among closely related species of the Drosophila melanogaster species subgroup. Here, we dissect the genetic basis of posterior ...

journal_title：Genetics

authors： Masly JP,Dalton JE,Srivastava S,Chen L,Arbeitman MN

更新日期：2011-09-01 00:00:00

abstract：:Methods for inference and interpretation of evolutionary quantitative genetic parameters, and for prediction of the response to selection, are best developed for traits with normal distributions. Many traits of evolutionary interest, including many life history and behavioral traits, have inherently nonnormal distribu...

journal_title：Genetics

authors： de Villemereuil P,Schielzeth H,Nakagawa S,Morrissey M

更新日期：2016-11-01 00:00:00

abstract：:The formation and stability of epigenetically regulated chromatin is influenced by DNA replication and factors that modulate post-translational modifications on histones. Here we describe evidence that PCNA can affect silencing in Saccharomyces cerevisiae by facilitating deposition of H3 K56ac onto chromosomes. We pro...

journal_title：Genetics

authors： Miller A,Yang B,Foster T,Kirchmaier AL

更新日期：2008-06-01 00:00:00

abstract：:Genetic analyses of nine traits associated with stem water-soluble carbohydrate (SWSC) accumulation and remobilization at grain-filling period under drought stress (DS) and well-watered (WW) conditions were undertaken using doubled haploid lines (DHLs) derived from two Chinese common wheat cultivars. Some significantl...

journal_title：Genetics

authors： Yang DL,Jing RL,Chang XP,Li W

更新日期：2007-05-01 00:00:00

abstract：:We have identified a new locus involved in gibberellin (GA) signal transduction by screening for suppressors of the Arabidopsis thaliana GA biosynthetic mutant gal-3. The locus is named RGA for repressor of gal-3. Based on the recessive phenotype of the digenic rga/gal-3 mutant, the wild-type gene product of RGA is pr...

journal_title：Genetics

authors： Silverstone AL,Mak PY,Martínez EC,Sun TP

更新日期：1997-07-01 00:00:00

abstract：:The eukaryotic cytoplasm contains a variety of ribonucleoprotein (RNP) granules in addition to the better-understood membrane-bound organelles. These granules form in response to specific stress conditions and contain a number of signaling molecules important for the control of cell growth and survival. However, relat...

journal_title：Genetics

authors： Zhang B,Shi Q,Varia SN,Xing S,Klett BM,Cook LA,Herman PK

更新日期：2016-07-01 00:00:00

abstract：:The bovine Growth Hormone gene (bGH) is an attractive candidate gene for milk production in cattle. Single-strand conformation polymorphisms at bGH were identified and used to define haplotype configurations at this gene in the Israeli Holstein dairy cattle population (Bos taurus) and in the parent animals of the Inte...

journal_title：Genetics

authors： Lagziel A,Lipkin E,Soller M

更新日期：1996-03-01 00:00:00

abstract：:Cse4p is an essential histone H3 variant in Saccharomyces cerevisiae that defines centromere identity and is required for proper segregation of chromosomes. In this study, we investigated phenotypic consequences of Cse4p mislocalization and increased dosage of histone H3 and Cse4p, and established a direct link betwee...

journal_title：Genetics

authors： Au WC,Crisp MJ,DeLuca SZ,Rando OJ,Basrai MA

更新日期：2008-05-01 00:00:00

abstract：:Double-strand DNA breaks can be repaired by any of several alternative mechanisms that differ greatly in the nature of the final repaired products. We used a reporter construct, designated "Repair reporter 3" (Rr3), to measure the relative usage of these pathways in Drosophila germ cells. The method works by creating ...

journal_title：Genetics

authors： Preston CR,Flores CC,Engels WR

更新日期：2006-02-01 00:00:00

abstract：:The Aspergillus nidulans rcoADelta mutant exhibits growth and developmental defects. We show that the rcoADelta mutant lacks cleistothecia and is self-sterile. In crosses with wild-type strains, rcoADelta nuclei do not contribute to the cleistothecial walls. Furthermore, sexual development resulting from veA overexpre...

journal_title：Genetics

authors： Todd RB,Hynes MJ,Andrianopoulos A

更新日期：2006-11-01 00:00:00

abstract：:We have determined the complete nucleotide sequence of the mitochondrial DNA (mtDNA) of the dogfish, Scyliorhinus canicula. The 16,697-bp-long mtDNA possesses a gene organization identical to that of the Osteichthyes, but different from that of the sea lamprey Petromyzon marinus. The main features of the mtDNA of oste...

journal_title：Genetics

authors： Delarbre C,Spruyt N,Delmarre C,Gallut C,Barriel V,Janvier P,Laudet V,Gachelin G

更新日期：1998-09-01 00:00:00

abstract：:A two-locus model is used to analyze the effectiveness of a mixture of insecticides in delaying resistance, compared to the use of the insecticides singly. The effects of factors such as recombination, effective dominance, initial value of allele frequencies and initial value of linkage disequilibrium are considered. ...

journal_title：Genetics

authors： Mani GS

更新日期：1985-04-01 00:00:00

abstract：:The genetic and environmental components of variance for two quantitative characters were measured in the descendants of Drosophila melanogaster populations which had been grown for several generations at densities of 100, 200, 300, and 400 eggs per vial. Populations subject to intermediate densities had a greater pro...

journal_title：Genetics

authors： Long T,Long G

更新日期：1974-03-01 00:00:00

abstract：:A BC1 population of the self-compatible tomato Lycopersicon esculentum and its wild self-incompatible relative L. hirsutum f. typicum was used for restriction fragment length polymorphism linkage analysis and quantitative trait loci (QTL) mapping of reproductive behavior and floral traits. The self-incompatibility loc...

journal_title：Genetics

authors： Bernacchi D,Tanksley SD

更新日期：1997-10-01 00:00:00

abstract：:Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism. In this study, fission yeast genes homologous to TSC1 and TSC2 were identified, and their protein products were shown to physically interact like th...

journal_title：Genetics

authors： Matsumoto S,Bandyopadhyay A,Kwiatkowski DJ,Maitra U,Matsumoto T

更新日期：2002-07-01 00:00:00

abstract：:Genomic integrity is threatened by multiple sources of DNA damage. DNA double-strand breaks (DSBs) are among the most dangerous types of DNA lesions and can be generated by endogenous or exogenous agents, but they can arise also during DNA replication. Sister chromatid recombination (SCR) is a key mechanism for the re...

journal_title：Genetics

authors： Conde F,Refolio E,Cordón-Preciado V,Cortés-Ledesma F,Aragón L,Aguilera A,San-Segundo PA

更新日期：2009-06-01 00:00:00

abstract：:Small regulatory RNAs, such as small interfering RNAs (siRNAs) and PIWI-interacting RNAs, regulate splicing, transcription, and genome integrity in many eukaryotes. In Caenorhabditis elegans, siRNAs bind nuclear Argonautes (AGOs), which interact with homologous premessenger RNAs to recruit downstream silencing effecto...

journal_title：Genetics

authors： Wan G,Yan J,Fei Y,Pagano DJ,Kennedy S

更新日期：2020-12-01 00:00:00

abstract：:X chromosome inactivation (XCI) is an epigenetic process that almost completely inactivates one of two X chromosomes in somatic cells of mammalian females. A few genes are known to escape XCI and the mechanism for this escape remains unclear. Here, using mouse trophoblast stem (TS) cells, we address whether particular...

journal_title：Genetics

authors： Mugford JW,Starmer J,Williams RL Jr,Calabrese JM,Mieczkowski P,Yee D,Magnuson T

更新日期：2014-06-01 00:00:00

abstract：:The neurogenic loci comprise a small group of genes which are required for proper division between the neural and epidermal pathways of differentiation within the neuroectoderm. Loss of neurogenic gene function results in the misrouting of prospective epidermal cells into neuroblasts. A molecular analysis of the neuro...

journal_title：Genetics

authors： Yedvobnick B,Smoller D,Young P,Mills D

更新日期：1988-03-01 00:00:00

abstract：:The recombination frequency as influenced by five independent recessive ds genes was measured on three segments of different chromosomes of rice, Oryza sativa L. Each ds gene in the homozygous condition resulted in an almost equally reduced recombination frequency in the three segments. When the mean reduction in reco...

journal_title：Genetics

authors： Kitada K,Omura T

更新日期：1984-11-01 00:00:00

abstract：:Divergence of the hyperthermophilic Archaea, Pyrococcus furiosus and Pyrococcus horikoshii, was assessed by analysis of complete genomic sequences of both species. The average nucleotide identity between the genomic sequences is 70-75% within ORFs. The P. furiosus genome (1.908 mbp) is 170 kbp larger than the P. horik...

journal_title：Genetics

authors： Maeder DL,Weiss RB,Dunn DM,Cherry JL,González JM,DiRuggiero J,Robb FT

更新日期：1999-08-01 00:00:00

abstract：:In Saccharomyces cerevisiae, silencers flanking the HML and HMR loci initiate the establishment of transcriptional silencing. We demonstrate that the activity of a silencer pertaining to its potency and directionality is dependent on its genomic position. The context of the HML-E silencer is more permissive to silence...

journal_title：Genetics

authors： Zou Y,Yu Q,Chiu YH,Bi X

更新日期：2006-09-01 00:00:00

abstract：:The Saccharomyces cerevisiae nuclear membrane is part of a complex nuclear envelope environment also containing chromatin, integral and peripheral membrane proteins, and large structures such as nuclear pore complexes (NPCs) and the spindle pole body. To study how properties of the nuclear membrane affect nuclear enve...

journal_title：Genetics

authors： Witkin KL,Friederichs JM,Cohen-Fix O,Jaspersen SL

更新日期：2010-11-01 00:00:00

abstract：:Many data sets one could use for population genetics contain artifactual sites, i.e., sequencing errors. Here, we first explore the impact of such errors on several common summary statistics, assuming that sequencing errors are mostly singletons. We thus show that in the presence of those errors, estimators of can be ...

journal_title：Genetics

authors： Achaz G

更新日期：2008-07-01 00:00:00

abstract：:TAHRE, the least abundant of the three retrotransposons forming telomeres in Drosophila melanogaster, has high sequence similarity to the gag gene and untranslated regions of HeT-A, the most abundant telomere-specific retrotransposon. Despite TAHRE's apparent evolutionary relationship to HeT-A, we find TAHRE Gag canno...

journal_title：Genetics

authors： Fuller AM,Cook EG,Kelley KJ,Pardue ML

更新日期：2010-03-01 00:00:00