A redundant function for the N-terminal tail of Ndc80 in kinetochore-microtubule interaction in Saccharomyces cerevisiae.

abstract：:Conditional lethal mutant systems developed in T-even bacteriophages T2, T4 and T6 have been used to study the partial exclusion which characterizes mixed infections of these phages. In bacteria mixedly infected with T2 and T4, the dominant phage (T4) acts against localized exclusion sensitivity determinants in the ge...

journal_title：Genetics

authors： Russell RL,Huskey RJ

更新日期：1974-12-01 00:00:00

abstract：:Cytoplasmic male sterility (CMS), the maternally inherited failure to produce functional pollen, has been used in the breeding of sugar beet (Beta vulgaris ssp. vulgaris). At least three different sources of CMS can be distinguished from one another as well as from normal fertile cytoplasm by polymorphisms in their mi...

journal_title：Genetics

authors： Nishizawa S,Mikami T,Kubo T

更新日期：2007-11-01 00:00:00

abstract：:We compared allele sequences of two loci near the Arabidopsis lyrata self-incompatibility (S) loci with sequences of A. thaliana orthologs and found high numbers of shared polymorphisms, even excluding singletons and sites likely to be highly mutable. This suggests maintenance of entire S-haplotypes for long evolution...

journal_title：Genetics

authors： Charlesworth D,Kamau E,Hagenblad J,Tang C

更新日期：2006-04-01 00:00:00

abstract：:The presence of large genomic regions with suppressed recombination (SR) is a key shared property of some sex- and mating-type determining (mat) chromosomes identified to date in animals, plants, and fungi. Why such regions form and how they evolve remain central questions in evolutionary genetics. The smut fungus Mic...

journal_title：Genetics

authors： Whittle CA,Votintseva A,Ridout K,Filatov DA

更新日期：2015-03-01 00:00:00

abstract：:The early steps of symbiotic nodule formation by Rhizobium on plants require coordinate expression of several nod gene operons, which is accomplished by the activating protein NodD. Three different NodD proteins are encoded by Sym plasmid genes in Rhizobium meliloti, the alfalfa symbiont. NodD1 and NodD2 activate nod ...

journal_title：Genetics

authors： Swanson JA,Mulligan JT,Long SR

更新日期：1993-06-01 00:00:00

abstract：:Drosophila dishevelled (dsh) functions in two pathways: it is necessary to transduce Wingless (Wg) signaling and it is required in planar cell polarity. To learn more about how Dsh can discriminate between these functions, we performed genetic screens to isolate additional dsh alleles and we examined the potential rol...

journal_title：Genetics

authors： Penton A,Wodarz A,Nusse R

更新日期：2002-06-01 00:00:00

abstract：:Transposons can impact the host genome by altering gene expression and participating in chromosome rearrangements. Therefore, organisms evolved different ways to minimize the level of transposition. In Saccharomyces cerevisiae and its close relative S. paradoxus, Ty1 copy number control (CNC) is mediated by the self-e...

journal_title：Genetics

authors： Ahn HW,Tucker JM,Arribere JA,Garfinkel DJ

更新日期：2017-12-01 00:00:00

abstract：:RecQ helicases function in the maintenance of genome stability in many organisms. The filamentous fungus Neurospora crassa has two RecQ homologs, QDE3 and RECQ2. We found that the qde-3 recQ2 double mutant showed a severe growth defect. The growth defect was alleviated by mutation in mei-3, the homolog of yeast RAD51,...

journal_title：Genetics

authors： Kato A,Inoue H

更新日期：2006-01-01 00:00:00

abstract：:Interactions with bacteria play a major role in immune responses, ecology, and evolution of all animals, but they have been neglected until recently in the case of C. elegans. We report a genetic investigation of the interaction of C. elegans with the nematode-specific pathogen Microbacterium nematophilum, which colon...

journal_title：Genetics

authors： Gravato-Nobre MJ,Nicholas HR,Nijland R,O'Rourke D,Whittington DE,Yook KJ,Hodgkin J

更新日期：2005-11-01 00:00:00

abstract：:Putzig (Pzg) was originally identified as being an integral component of the TRF2/DREF complex in Drosophila melanogaster, thereby regulating the transcriptional activation of replication-related genes. In a DREF-independent manner, Pzg was shown to mediate Notch target gene activation. This function of Pzg entails an...

journal_title：Genetics

authors： Kugler SJ,Gehring EM,Wallkamm V,Krüger V,Nagel AC

更新日期：2011-05-01 00:00:00

abstract：:We discuss the conceptual conflict between a slow series of gene substitutions as the mechanism of evolutionary change, and the apparent need for rapid and coordinated changes at many loci simultaneously in producing complex adaptations. To improve on the limitations of classical theory and accommodate the enormous am...

journal_title：Genetics

authors： Koehler DO,Whitten BL,Gregg TG

更新日期：1980-03-01 00:00:00

abstract：:Cell surface immunoglobulin superfamily (IgSF) proteins play important roles in the development and function of the nervous system . Here we define the role of a Caenorhabditis elegans IgSF protein, RIG-3, in the function of the AVA command interneuron. This study reveals that RIG-3 regulates the abundance of the glut...

journal_title：Genetics

authors： Bhardwaj A,Pandey P,Babu K

更新日期：2020-01-01 00:00:00

abstract：:We explicitly solve and analyze a series of deterministic continent-island models to delimit the effects of pollen and seed migration on cytonuclear frequencies and disequilibria in random-mating, mixed-mating and self-fertilized populations. Given the critical assumption of maternal cytoplasmic inheritance, five majo...

journal_title：Genetics

authors： Asmussen MA,Schnabel A

更新日期：1991-07-01 00:00:00

abstract：:According to theory, F(2) hybrid breakdown (lethality or sterility) is due to incompatibilities between interacting genes of the different species (i.e., the breaking up of coadapted gene complexes). Detection of such incompatibilities is particularly straightforward in haplodiploid species, because virgin F(1) hybrid...

journal_title：Genetics

authors： Gadau J,Page RE Jr,Werren JH

更新日期：1999-12-01 00:00:00

abstract：:The availability of genomewide dense markers brings opportunities and challenges to breeding programs. An important question concerns the ways in which dense markers and pedigrees, together with phenotypic records, should be used to arrive at predictions of genetic values for complex traits. If a large number of marke...

journal_title：Genetics

authors： de los Campos G,Naya H,Gianola D,Crossa J,Legarra A,Manfredi E,Weigel K,Cotes JM

更新日期：2009-05-01 00:00:00

abstract：:Mutants at the snail locus are zygotically acting embryonic lethals that affect dorsoventral patterning. A comparison of seven mutant alleles shows considerable variation in expressivity and a graded effect along the dorsoventral axis: more extreme alleles result in the abnormal development of the dorsally derived ect...

journal_title：Genetics

authors： Grau Y,Carteret C,Simpson P

更新日期：1984-10-01 00:00:00

abstract：:Hybridization between related species results in the formation of an allopolyploid with multiple subgenomes. These subgenomes will each contain complete, yet evolutionarily divergent, sets of genes. Like a diploid hybrid, allopolyploids will have two versions, or homeoalleles, for every gene. Partial functional redund...

journal_title：Genetics

authors： Santantonio N,Jannink JL,Sorrells M

更新日期：2019-03-01 00:00:00

abstract：:Multilocus surveys of sequence variation can be used to identify targets of directional selection, which are expected to have reduced levels of variation. Following a population bottleneck, the signal of directional selection may be hard to detect because many loci may have low variation by chance and the frequency sp...

journal_title：Genetics

authors： Hamblin MT,Casa AM,Sun H,Murray SC,Paterson AH,Aquadro CF,Kresovich S

更新日期：2006-06-01 00:00:00

abstract：:A reversion study of EMS- or ICR170-induced ascospore color mutants in Ascobolus immersus is reported. Twenty-three new intragenic suppressors were isolated within the b2 locus. These are localized within three distinct groups on a genetic fine-structure map containing 21 identifiable sites. The pattern of reversion i...

journal_title：Genetics

authors： Leblon G,Paquette N

更新日期：1978-11-01 00:00:00

abstract：:The size of the genome in the opportunistic fungus Candida albicans is 15.6 Mb. Whole-genome shotgun sequencing was carried out at Stanford University where the sequences were assembled into 412 contigs. C. albicans is a diploid basically, and analysis of the sequence is complicated due to repeated sequences and to se...

journal_title：Genetics

authors： Chibana H,Oka N,Nakayama H,Aoyama T,Magee BB,Magee PT,Mikami Y

更新日期：2005-08-01 00:00:00

abstract：:We have tested the hypothesis that genetic differences among conspecific populations may result in diverse responses to selection, using natural populations of Drosophila melanogaster. Selection for ethanol tolerance in a tube measuring knockdown resistance was imposed on five West Coast populations. In 24 generations...

journal_title：Genetics

authors： Cohan FM,Hoffmann AA

更新日期：1986-09-01 00:00:00

abstract：:The transmission profiles of sperm mtDNA introduced into fertilized eggs were examined in detail in F1 hybrids of mouse interspecific crosses by addressing three aspects. The first is whether the leaked paternal mtDNA in fertilized eggs produced by interspecific crosses was distributed stably to all tissues after the ...

journal_title：Genetics

authors： Shitara H,Hayashi JI,Takahama S,Kaneda H,Yonekawa H

更新日期：1998-02-01 00:00:00

abstract：:High-density genotyping of single-nucleotide polymorphisms (SNPs) enables detection of quantitative trait loci (QTL) by linkage disequilibrium (LD) mapping using LD between markers and QTL and the subsequent use of this information for marker-assisted selection (MAS). The success of LD mapping and MAS depends on the e...

journal_title：Genetics

authors： Andreescu C,Avendano S,Brown SR,Hassen A,Lamont SJ,Dekkers JC

更新日期：2007-12-01 00:00:00

abstract：:Movement of transposons causes insertions, deletions, and chromosomal rearrangements potentially leading to premature lethality in Drosophila melanogaster. To repress these elements and combat genomic instability, eukaryotes have evolved several small RNA-mediated defense mechanisms. Specifically, in Drosophila somati...

journal_title：Genetics

authors： Russo J,Harrington AW,Steiniger M

更新日期：2016-01-01 00:00:00

abstract：:The spatial model of Levene (1953) was examined in a finite population and compared to a temporal model. The spatial model was much more effective in retaining genetic variation in a finite population. Furthermore, the haploid spatial model was more effective in retaining genetic variation than the analogous diploid a...

journal_title：Genetics

authors： Hedrick PW

更新日期：1978-06-01 00:00:00

abstract：:Two replications of a complete diallel cross experiment were performed among four partially inbred lines of mice. These inbred lines originated from a random-bred ICR strain and were produced by 12 generations of full sibbing (F congruent to 92%). Individual body weight was recorded for each animal at 12, 21, 42 and 5...

journal_title：Genetics

authors： Jamison MG,White JM,Vinson WE,Hinkelmann K

更新日期：1975-10-01 00:00:00

abstract：:As a genetic mutation is passed down across generations, it distinguishes those genomes that have inherited it from those that have not, providing a glimpse of the genealogical tree relating the genomes to each other at that site. Statistical summaries of genetic variation therefore also describe the underlying geneal...

journal_title：Genetics

authors： Ralph P,Thornton K,Kelleher J

更新日期：2020-07-01 00:00:00

abstract：:We have amplified and sequenced the gene encoding Esterase-P (Est-P) in 10 strains of Drosophila melanogaster. Three premature termination codons occur in the coding region of the gene in two strains. This observation, together with other indirect evidence, leads us to propose that Est-P may be a pseudogene in D. mela...

journal_title：Genetics

authors： Balakirev ES,Ayala FJ

更新日期：1996-12-01 00:00:00

abstract：:MiRNAs bear an increasing number of functions throughout development and in the aging adult. Here we address their role in establishing sexually dimorphic traits and sexual identity in male and female Drosophila. Our survey of miRNA populations in each sex identifies sets of miRNAs differentially expressed in male and...

journal_title：Genetics

authors： Fagegaltier D,König A,Gordon A,Lai EC,Gingeras TR,Hannon GJ,Shcherbata HR

更新日期：2014-10-01 00:00:00

abstract：:We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and h...

journal_title：Genetics

authors： Durrett RT,Chen KY,Tanksley SD

更新日期：2002-01-01 00:00:00