A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity.

abstract：:Nucleotide variation at the genomic region encompassing the odorant-binding protein genes OS-E and OS-F (OS region) was surveyed in two populations of Drosophila simulans, one from Europe and the other from Africa. We found that the European population shows an atypical and large haplotype structure, which extends thr...

journal_title：Genetics

authors： Sánchez-Gracia A,Rozas J

更新日期：2007-04-01 00:00:00

abstract：:Studying phage codon adaptation is important not only for understanding the process of translation elongation, but also for reengineering phages for medical and industrial purposes. To evaluate the effect of mutation and selection on phage codon usage, we developed an index to measure selection imposed by host transla...

journal_title：Genetics

authors： Chithambaram S,Prabhakaran R,Xia X

更新日期：2014-05-01 00:00:00

abstract：:In a genetic screen for mutants showing modified splicing of an alternatively spliced GFP reporter gene in Arabidopsis thaliana, we identified mutations in genes encoding the putative U1 small nuclear ribonucleoprotein (snRNP) factors RBM25 and PRP39a. The latter has not yet been studied for its role in pre-messenger ...

journal_title：Genetics

authors： Kanno T,Lin WD,Fu JL,Chang CL,Matzke AJM,Matzke M

更新日期：2017-12-01 00:00:00

abstract：:We investigated genetic polymorphism in the Caenorhabditis elegans srh and str chemoreceptor gene families, each of which consists of approximately 300 genes encoding seven-pass G-protein-coupled receptors. Almost one-third of the genes in each family are annotated as pseudogenes because of apparent functional defects...

journal_title：Genetics

authors： Stewart MK,Clark NL,Merrihew G,Galloway EM,Thomas JH

更新日期：2005-04-01 00:00:00

abstract：:Equilibria are determined for the two-locus model in a partially selfing population when one locus is neutral and the other locus is heterotic. At an equilibrium point, the frequency of heterozygotes at the neutral locus is greater than that expected from one-locus theory, even if the heterotic locus is on a different...

journal_title：Genetics

authors： Strobeck C

更新日期：1979-05-01 00:00:00

abstract：:The rate of protein synthesis depends on both the rate of initiation of translation and the rate of elongation of the peptide chain. The rate of initiation depends on the encountering rate between ribosomes and mRNA; this rate in turn depends on the concentration of ribosomes and mRNA. Thus, patterns of codon usage th...

journal_title：Genetics

authors： Xia X

更新日期：1996-11-01 00:00:00

abstract：:The Acp26Aa and Acp26Ab genes that code for male accessory gland proteins are tandemly arranged in the species of the Drosophila melanogaster complex. An approximately 1.6-kb region encompassing both genes has been sequenced in 10, 24, and 18 lines from Spain, Ivory Coast, and Malawi, respectively; the previously stud...

journal_title：Genetics

authors： Aguadé M

更新日期：1998-11-01 00:00:00

abstract：:Thirty-five nucleotide polymorphisms were found in a 21.5-kbp region including the Est6 locus among 42 isoallelic lines extracted from a single natural population of Drosophila melanogaster. The heterozygosity per nucleotide pair was estimated to be 0.010 overall, but was lower in sequences hybridizing to transcripts ...

journal_title：Genetics

authors： Game AY,Oakeshott JG

更新日期：1990-12-01 00:00:00

abstract：:The alpha-Amylase locus in Drosophila pseudoobscura is a multigene family of one, two or three copies on the third chromosome. The nucleotide sequences of the three Amylase genes from a single chromosome of D. pseudoobscura are presented. The three Amylase genes differ at about 0.5% of their nucleotides. Each gene has...

journal_title：Genetics

authors： Brown CJ,Aquadro CF,Anderson WW

更新日期：1990-09-01 00:00:00

abstract：:Conversion between duplicated genes limits their independent evolution. Models in which conversion frequencies decrease as genes diverge are examined to determine conditions under which genes can "escape" further conversion and hence escape from a gene family. A review of results from various recombination systems sug...

journal_title：Genetics

authors： Walsh JB

更新日期：1987-11-01 00:00:00

abstract：:For most common diseases with heritable components, not a single or a few single-nucleotide polymorphisms (SNPs) explain most of the variance for these disorders. Instead, much of the variance may be caused by interactions (epistasis) among multiple SNPs or interactions with environmental conditions. We present a new ...

journal_title：Genetics

authors： Albrechtsen A,Castella S,Andersen G,Hansen T,Pedersen O,Nielsen R

更新日期：2007-06-01 00:00:00

abstract：:There are two naturally occurring functional alleles of the recombination hotspot cog, which is located 3.5 kb from the his-3 locus of Neurospora crassa. The presence of the cog+ allele in a cross significantly increases recombination in the his-3 region compared to a cross homozygous for the cog allele. Data obtained...

journal_title：Genetics

authors： Yeadon PJ,Bowring FJ,Catcheside DE

更新日期：2004-07-01 00:00:00

abstract：:mod(mdg4), also known as E(var)3-93D, is involved in a variety of processes, such as gene silencing in position effect variegation (PEV), the control of gypsy insulator sequences, regulation of homeotic gene expression, and programmed cell death. We have isolated a large number of mod(mdg4) cDNAs, representing 21 diff...

journal_title：Genetics

authors： Büchner K,Roth P,Schotta G,Krauss V,Saumweber H,Reuter G,Dorn R

更新日期：2000-05-01 00:00:00

abstract：:The percentage of crossovers is consistently higher in plants hypoploid for six B-A translocations when crossed as males than when crossed as females; in most instances, this excess of male crossing over exceeds that found in control crosses (involving normal chromosomes). Thus, there seems to be something about the h...

journal_title：Genetics

authors： Robertson DS

更新日期：1984-05-01 00:00:00

abstract：:A large offspring-number diploid biparental multilocus population model of Moran type is our object of study. At each time step, a pair of diploid individuals drawn uniformly at random contributes offspring to the population. The number of offspring can be large relative to the total population size. Similar "heavily ...

journal_title：Genetics

authors： Birkner M,Blath J,Eldon B

更新日期：2013-01-01 00:00:00

abstract：:Timely spindle disassembly is essential for coordination of mitotic exit with cytokinesis. In the budding yeast Saccharomyces cerevisiae, the microtubule-associated protein She1 functions in one of at least three parallel pathways that promote spindle disassembly. She1 phosphorylation by the Aurora kinase Ipl1 facilit...

journal_title：Genetics

authors： Pigula A,Drubin DG,Barnes G

更新日期：2014-11-01 00:00:00

abstract：:Pairwise linkage disequilibrium values (D) were estimated for 14 allozyme loci in two natural populations of lodgepole pine (Pinus contorta ssp. latifolia). Maternal multilocus genotypes were inferred from samples of (haploid) megagametophytic seed-endosperms. Coupling/repulsion double heterozygotes were distinguished...

journal_title：Genetics

authors： Epperson BK,Allard RW

更新日期：1987-02-01 00:00:00

abstract：:New rudimentary (r) mutants have been isolated following mutagenesis with ethyl methanesulfonate (r(LE)), ICR-170 (r(LI)) and X rays (r(LX)). From wing phenotype measurements on homoallelic females, it has been shown that the r(LE) mutant series includes several leaky alleles, as well as alleles that produce moderate ...

journal_title：Genetics

authors： Rawls JM,Porter LA

更新日期：1979-09-01 00:00:00

abstract：:Recombination of phage lambda attachment sites occurs by sequential exchange of the DNA strands at two specific locations. The first exchange produces a Holliday structure, and the second resolves it to recombinant products. Heterology for base substitution mutations in the region between the two strand exchange point...

journal_title：Genetics

authors： Bauer CE,Gardner JF,Gumport RI,Weisberg RA

更新日期：1989-08-01 00:00:00

abstract：:This study addresses three questions about the properties of recombination hotspots in Saccharomyces cerevisiae: How much DNA is required for double-strand-break (DSB) site recognition? Do naturally occurring DSB sites compete with each other in meiotic recombination? What role does the sequence located at the sites o...

journal_title：Genetics

authors： Haring SJ,Halley GR,Jones AJ,Malone RE

更新日期：2003-09-01 00:00:00

abstract：:The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social ...

journal_title：Genetics

authors： Johnsson M,Henriksen R,Fogelholm J,Höglund A,Jensen P,Wright D

更新日期：2018-05-01 00:00:00

abstract：:Neutrality tests based on the frequency spectrum (e.g., Tajima's D or Fu and Li's F) are commonly used by population geneticists as routine tests to assess the goodness-of-fit of the standard neutral model on their data sets. Here, I show that these neutrality tests are specific instances of a general model that encom...

journal_title：Genetics

authors： Achaz G

更新日期：2009-09-01 00:00:00

abstract：:The Drosophila melanogaster Chd3 gene encodes a member of the CHD group of SNF2/RAD54 ATPases. CHD proteins are conserved from yeast to man and many are subunits of chromatin-remodeling complexes that facilitate transcription. Drosophila CHD3 proteins are not found in protein complexes, but as monomers that remodel ch...

journal_title：Genetics

authors： Cooper MT,Conant AW,Kennison JA

更新日期：2010-07-01 00:00:00

abstract：:The segregation and random assortment of characters observed by Mendel have their basis in the behavior of chromosomes in meiosis. But showing this actually to be the case requires a correct understanding of the meiotic behavior of chromosomes. This was achieved only gradually, over several decades, with much dispute ...

journal_title：Genetics

authors： Koszul R,Meselson M,Van Doninck K,Vandenhaute J,Zickler D

更新日期：2012-06-01 00:00:00

abstract：:Age-specific effects of spontaneous mutations on mortality rates in Drosophila are inferred from three large demographic experiments. Data were collected from inbred lines that were allowed to accumulate spontaneous mutations for 10, 19, and 47 generations. Estimates of age-specific mutational variance for mortality w...

journal_title：Genetics

authors： Pletcher SD,Houle D,Curtsinger JW

更新日期：1999-10-01 00:00:00

abstract：:Positive selection in genes and genomes can point to the evolutionary basis for differences among species and among races within a species. The detection of positive selection can also help identify functionally important protein regions and thus guide protein engineering. Many existing tests for positive selection ar...

journal_title：Genetics

authors： Wagner A

更新日期：2007-08-01 00:00:00

abstract：:Chromosomal double-strand breaks (DSBs) that have only one end with homology to a donor duplex undergo repair by strand invasion followed by replication to the chromosome terminus (break-induced replication, BIR). Using a transformation-based assay system, it was previously shown that BIR could occur by several rounds...

journal_title：Genetics

authors： Stafa A,Donnianni RA,Timashev LA,Lam AF,Symington LS

更新日期：2014-04-01 00:00:00

abstract：:The pathogenic life cycle of the rice blast fungus Magnaporthe oryzae involves a series of morphogenetic changes, essential for its ability to cause disease. The smo mutation was identified > 25 years ago, and affects the shape and development of diverse cell types in M. oryzae, including conidia, appressoria, and asc...

journal_title：Genetics

authors： Kershaw MJ,Basiewicz M,Soanes DM,Yan X,Ryder LS,Csukai M,Oses-Ruiz M,Valent B,Talbot NJ

更新日期：2019-01-01 00:00:00

abstract：:Many of the transcription factors and target genes that pattern the developing adult remain unknown. In the present study, we find that an ortholog of the poorly understood transcription factor, glucose transporter (GLUT4) enhancer factor (Glut4EF, GEF) [also known as the Huntington's disease gene regulatory region-bi...

journal_title：Genetics

authors： Yazdani U,Huang Z,Terman JR

更新日期：2008-02-01 00:00:00

abstract：:Sister-chromatid exchanges (SCE) were studied in allium cepa L. meristematic cells at the second and third divisions after BrdUrd-substitution during just the first or during the second and third cycles, respectively. The observed SCE nonreciprocal/reciprocal ratios detected at the third division in both experiments, ...

journal_title：Genetics

authors： Schvartzman JB,Cortés F,González-Fernández A,Gutiérrez C,López-Sáez JF

更新日期：1979-08-01 00:00:00