Frequency spectrum neutrality tests: one for all and all for one.

abstract：:Two composite multiple regression-interval mapping analyses were performed to identify candidate quantitative trait loci (QTL) affecting components of wing shape in Drosophila melanogaster defined by eight relative warp-based measures. A recombinant inbred line design was used to map QTL for the shape of two intervein...

journal_title：Genetics

authors： Zimmerman E,Palsson A,Gibson G

更新日期：2000-06-01 00:00:00

abstract：:The fission yeast Schizosaccharomyces pombe does not form tripartite synaptonemal complexes during meiotic prophase, but axial core-like structures (linear elements). To probe the relationship between meiotic recombination and the structure, pairing, and segregation of meiotic chromosomes, we genetically and cytologic...

journal_title：Genetics

authors： Molnar M,Bähler J,Sipiczki M,Kohli J

更新日期：1995-09-01 00:00:00

abstract：:We estimated DNA sequence variation in a 5.7-kb fragment of the furrowed (fw) gene region within and between four populations of Drosophila ananassae; fw is located in a chromosomal region of very low recombination. We analyzed gene flow between these four populations along a latitudinal transect on the Indian subcont...

journal_title：Genetics

authors： Chen Y,Marsh BJ,Stephan W

更新日期：2000-07-01 00:00:00

abstract：:Site-specific recombinases are widely used tools for analysis of genetics, development, and cell biology, and many schemes have been devised to alter gene expression by recombinase-mediated DNA rearrangements. Because the FRT and lox target sites for the commonly used FLP and Cre recombinases are asymmetrical, and mus...

journal_title：Genetics

authors： Titen SWA,Johnson MTB,Capecchi M,Golic KG

更新日期：2020-08-01 00:00:00

abstract：:We have identified a new locus involved in gibberellin (GA) signal transduction by screening for suppressors of the Arabidopsis thaliana GA biosynthetic mutant gal-3. The locus is named RGA for repressor of gal-3. Based on the recessive phenotype of the digenic rga/gal-3 mutant, the wild-type gene product of RGA is pr...

journal_title：Genetics

authors： Silverstone AL,Mak PY,Martínez EC,Sun TP

更新日期：1997-07-01 00:00:00

abstract：:We test models for the evolution of helical regions of RNA sequences, where the base pairing constraint leads to correlated compensatory substitutions occurring on either side of the pair. These models are of three types: 6-state models include only the four Watson-Crick pairs plus GU and UG; 7-state models include a ...

journal_title：Genetics

authors： Savill NJ,Hoyle DC,Higgs PG

更新日期：2001-01-01 00:00:00

abstract：:We use the ancestral influence graph (AIG) for a two-locus, two-allele selection model in the limit of a large population size to obtain an analytic approximation for the probability of ultimate fixation of a single mutant allele A. We assume that this new mutant is introduced at a given locus into a finite population...

journal_title：Genetics

authors： Lessard S,Kermany AR

更新日期：2012-02-01 00:00:00

abstract：:Strains of Dictyostelium discoideum resistant to cobaltous chloride have been isolated at a frequency of approximately 10(-6). The resistant strains have one of three phenotypes, recessive to wild type, dominant to wild type and dominant to wild type but requiring the presence of cobaltous chloride to maintain resista...

journal_title：Genetics

authors： Williams KL

更新日期：1978-09-01 00:00:00

abstract：:A recent sperm-typing study by Jeffreys and Neumann suggested that recombination rates in different individuals at the DNA2 recombination hotspot appeared to be highly dependent on their genotype at a particular A/G SNP, FG11. Specifically, individuals who carried at least one copy of the A allele at this SNP exhibite...

journal_title：Genetics

authors： Hellenthal G,Pritchard JK,Stephens M

更新日期：2006-03-01 00:00:00

abstract：:Thirty-four independent nonviable c-locus mutations (types cal, albino lethal and cas, albino subvital), derived from radiation experiments, were tested for involvement of nearby markers tp, Mod-2, sh-1, and Hbb: 10, 22, and 2 involved, respectively, none of these markers, Mod-2 alone, and Mod-2 plus sh-1. When classi...

journal_title：Genetics

authors： Russell LB,Montgomery CS,Raymer GD

更新日期：1982-03-01 00:00:00

abstract：:Chromatin organization and structure are crucial for transcriptional regulation, DNA replication, and damage repair. Although initially characterized in remodeling cell wall glucans, the β-1,3-glucanosyltransferase Gas1 was recently discovered to regulate transcriptional silencing in a manner separable from its activi...

journal_title：Genetics

authors： Eustice M,Pillus L

更新日期：2014-04-01 00:00:00

abstract：:Genetic and developmental analysis of an X-linked vital locus vnd was undertaken. Embryos hemizygous for the original allele vnd did not hatch and exhibited a disorganized ventral nervous system (VNS). The mutation maps in the region 1B6-7 to 1B9-10, a subregion of an area previously shown to be essential to normal ne...

journal_title：Genetics

authors： White K,DeCelles NL,Enlow TC

更新日期：1983-07-01 00:00:00

abstract：:Some populations of maize's closest relatives, the annual teosintes of Mexico, are unreceptive to maize pollen. When present in the pistil (silk and ovary) a number of maize genes discriminate against or exclude pollen not carrying the same allele. An analogous gene Tcb1-s was found in some teosinte populations but no...

journal_title：Genetics

authors： Kermicle JL

更新日期：2006-01-01 00:00:00

abstract：:Use of the CRISPR/Cas9 RNA-guided endonuclease complex has recently enabled the generation of double-strand breaks virtually anywhere in the C. elegans genome. Here, we present an improved strategy that makes all steps in the genome editing process more efficient. We have created a toolkit of template-mediated repair ...

journal_title：Genetics

authors： Norris AD,Kim HM,Colaiácovo MP,Calarco JA

更新日期：2015-10-01 00:00:00

abstract：:Most studies of mutation rates implicitly assume that they remain constant throughout development of the germline. However, researchers recently used a novel statistical framework to reveal that mutation rates differ dramatically during sperm development in Drosophila melanogaster. Here a general framework is describe...

journal_title：Genetics

authors： Fu YX

更新日期：2013-08-01 00:00:00

abstract：:The parasitoid wasp Nasonia represents a genus of four species that is emerging as a powerful genetic model system that has made and will continue to make important contributions to our understanding of evolutionary biology, development, ecology, and behavior. Particularly powerful are the haplodiploid genetics of the...

journal_title：Genetics

authors： Lynch JA

更新日期：2015-04-01 00:00:00

abstract：:Initial events in double-strand break repair by homologous recombination in vivo involve homology searching, 3' strand invasion, and new DNA synthesis. While studies in yeast have contributed much to our knowledge of these processes, in comparison, little is known of the early events in the integrated mammalian system...

journal_title：Genetics

authors： Si W,Mundia MM,Magwood AC,Mark AL,McCulloch RD,Baker MD

更新日期：2010-06-01 00:00:00

abstract：:Peroxisomes are organelles containing a diverse array of enzymes. In fungi they are important for carbon source utilization, pathogenesis, development, and secondary metabolism. We have studied Aspergillus nidulans peroxin (pex) mutants isolated by virtue of their inability to grow on butyrate or by the inactivation o...

journal_title：Genetics

authors： Hynes MJ,Murray SL,Khew GS,Davis MA

更新日期：2008-03-01 00:00:00

abstract：:In this article we define and characterize the smellblind gene (sbl). We show that two mutants, sbl and olfDx9, both isolated by virtue of their olfactory phenotypes and analyzed extensively by others with respect to courtship behavior, contain mutations at a single locus. Meiotic recombination, duplication, and defic...

journal_title：Genetics

authors： Lilly M,Carlson J

更新日期：1990-02-01 00:00:00

abstract：:Sixty independent UGA suppressors of Saccharomyces cerevisiae have been studied. They are dominant and are divided into 16 groups (loci) by recombination. Suppressors representing these loci are divided into two classes by action spectra; four in class 1 (a broad action spectrum) and 12 in class 2 (a narrow action spe...

journal_title：Genetics

authors： Ono BI,Fujimoto R,Ohno Y,Maeda N,Tsuchiya Y,Usui T,Ishino-Arao Y

更新日期：1988-01-01 00:00:00

abstract：:In Xiphophorus, the causative genetic information for melanoma formation has been assigned by classical genetics to chromosomal loci, which are located on the sex chromosomes. In our attempts to molecularly clone these melanoma-determining loci, named Tu, we have looked for restriction-fragment-length markers (RFLMs) ...

journal_title：Genetics

authors： Schartl M

更新日期：1988-07-01 00:00:00

abstract：:The molecular basis of the maternally inherited, heteroplasmic NCS2 mutant of maize was investigated. Analysis of the NCS2 mtDNA showed that it closely resembles the progenitor cmsT mitochondrial genome, except that the mutant genome contains a fused nad4-nad7 gene and is deleted for the small fourth exon of nad4. The...

journal_title：Genetics

authors： Marienfeld JR,Newton KJ

更新日期：1994-11-01 00:00:00

abstract：:Several adhesins are induced by pheromones during mating in Saccharomyces cerevisiae, including Aga1p, Aga2p, Sag1p (Agalpha1p), and Fig2p. These four proteins all participate in or influence a well-studied agglutinin interaction mediated by Aga1p-Aga2p complexes and Sag1p; however, they also play redundant and essent...

journal_title：Genetics

authors： Huang G,Dougherty SD,Erdman SE

更新日期：2009-05-01 00:00:00

abstract：:Estimating the fixation probability of a beneficial mutation has a rich history in theoretical population genetics. Typically, to attain mathematical tractability, we assume that generation times are fixed, while the number of offspring per individual is stochastic. However, fixation probabilities are extremely sensit...

journal_title：Genetics

authors： Hubbarde JE,Wild G,Wahl LM

更新日期：2007-07-01 00:00:00

abstract：:Transcription is repressed in regions of the fission yeast genome close to centromeres, telomeres, or the silent mating-type cassettes mat2-P and mat3-M. The repression involves the chromo-domain proteins Swi6 and Clr4. We report that two other chromo-domain proteins, Chp1 and Chp2, are also important for these positi...

journal_title：Genetics

authors： Thon G,Verhein-Hansen J

更新日期：2000-06-01 00:00:00

abstract：:The Mre11/Rad50/Nbs1 (MRN) complex is required for eukaryotic DNA double-strand break (DSB) repair and meiotic recombination. We cloned the Coprinus cinereus rad50 gene and showed that it corresponds to the complementation group previously named rad12, identified mutations in 15 rad50 alleles, and mapped two of the mu...

journal_title：Genetics

authors： Acharya SN,Many AM,Schroeder AP,Kennedy FM,Savytskyy OP,Grubb JT,Vincent JA,Friedle EA,Celerin M,Maillet DS,Palmerini HJ,Greischar MA,Moncalian G,Williams RS,Tainer JA,Zolan ME

更新日期：2008-12-01 00:00:00

abstract：:To understand long terminal repeat (LTR)-retrotransposon copy number dynamics, Ty1 elements were reintroduced into a "Ty-less" Saccharomyces strain where elements had been lost by LTR-LTR recombination. Repopulated strains exhibited alterations in chromosome size that were associated with Ty1 insertions, but did not b...

journal_title：Genetics

authors： Garfinkel DJ,Nyswaner KM,Stefanisko KM,Chang C,Moore SP

更新日期：2005-04-01 00:00:00

abstract：:The RecQ helicase family is critical during DNA damage repair, and mutations in these proteins are associated with Bloom, Werner, or Rothmund-Thompson syndromes in humans, leading to cancer predisposition and/or premature aging. In the budding yeast Saccharomyces cerevisiae, mutations in the RecQ homolog, SGS1, phenoc...

journal_title：Genetics

authors： Bernstein KA,Mimitou EP,Mihalevic MJ,Chen H,Sunjaveric I,Symington LS,Rothstein R

更新日期：2013-12-01 00:00:00

abstract：:Gain or loss of chromosomes resulting in aneuploidy can be important factors in cancer and adaptive evolution. Although chromosome gain is a frequent event in eukaryotes, there is limited information on its genetic control. Here we measured the rates of chromosome gain in wild-type yeast and sister chromatid cohesion ...

journal_title：Genetics

authors： Covo S,Puccia CM,Argueso JL,Gordenin DA,Resnick MA

更新日期：2014-02-01 00:00:00

abstract：:Most species of the Drosophila genus and other Diptera are polymorphic for paracentric inversions. A common observation is that successful inversions are of intermediate size. We test here the hypothesis that the selected property is the recombination length of inversions, not their physical length. If so, physical le...

journal_title：Genetics

authors： Cáceres M,Barbadilla A,Ruiz A

更新日期：1999-09-01 00:00:00