Abstract：
:The fission yeast Schizosaccharomyces pombe does not form tripartite synaptonemal complexes during meiotic prophase, but axial core-like structures (linear elements). To probe the relationship between meiotic recombination and the structure, pairing, and segregation of meiotic chromosomes, we genetically and cytologically characterized the rec8-110 mutant, which is partially deficient in meiotic recombination. The pattern of spore viability indicates that chromosome segregation is affected in the mutant. A detailed segregational analysis in the rec8-110 mutant revealed more spores disomic for chromosome III than in a wild-type strain. Aberrant segregations are caused by precocious segregation of sister chromatids at meiosis I, rather than by nondisjunction as a consequence of lack of crossovers. In situ hybridization further showed that the sister chromatids are separated prematurely during meiotic prophase. Moreover, the mutant forms aberrant linear elements and shows a shortened meiotic prophase. Meiotic chromosome pairing in interstitial and centromeric regions is strongly impaired in rec8-110, whereas the chromosome ends are less deficient in pairing. We propose that the rec8 gene encodes a protein required for linear element formation and that the different phenotypes of rec8-110 reflect direct and indirect consequences of the absence of regular linear elements.
journal_name
Geneticsjournal_title
Geneticsauthors
Molnar M,Bähler J,Sipiczki M,Kohli Jsubject
Has Abstractpub_date
1995-09-01 00:00:00pages
61-73issue
1eissn
0016-6731issn
1943-2631journal_volume
141pub_type
杂志文章相关文献
GENETICS文献大全abstract：:Heterozygous inactivation of either human TSC1 or TSC2 causes tuberous sclerosis (TSC), in which development of benign tumors, hamartomas, occurs via a two-hit mechanism. In this study, fission yeast genes homologous to TSC1 and TSC2 were identified, and their protein products were shown to physically interact like th...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Differential expression of mRNA among animal strains is one of the mechanisms for their diversity. cDNA microarray analysis of the prostates of BUF/Nac (BUF) and ACI/N (ACI) rats, which show different susceptibility to prostate cancers, found 195 differentially expressed genes. To identify loci that control differenti...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.038174
更新日期：2005-11-01 00:00:00
abstract：:Distributive disjunction is defined as the first division meiotic segregation of either nonhomologous chromosomes that lack homologs or homologous chromosomes that have not recombined. To determine if chromosomes from the yeast Saccharomyces cerevisiae were capable of distributive disjunction, we constructed a strain ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-03-01 00:00:00
abstract：:The presence of large genomic regions with suppressed recombination (SR) is a key shared property of some sex- and mating-type determining (mat) chromosomes identified to date in animals, plants, and fungi. Why such regions form and how they evolve remain central questions in evolutionary genetics. The smut fungus Mic...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.114.171702
更新日期：2015-03-01 00:00:00
abstract：:When a local colonization in a new niche occurs, the new derived population should be subject to different selective pressures from that in the original parental population; consequently it is likely that many loci will be subject to directional selection. In such a quick adaptation event through environmental changes...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.086835
更新日期：2008-07-01 00:00:00
abstract：:The Standard and Sex Ratio gene arrangements of the X chromosome of D. pseudobscura differ from each other in allele frequencies at the four X chromosome loci, esterase-5, adult acid phosphatase-6, phosphoglucomutase-1 and octanol dehydrogenase-3. The Standard arrangement which is the common arrangement in all populat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1974-08-01 00:00:00
abstract：:The nucleotide sequences encoding the mature portion of 31 ribulose 1.5-bisphosphate carboxylase small subunit (SSU) genes from 17 genera of plants, green algae and cyanobacteria were examined. Among the 465 pairwise sequence comparisons, SSU multigene family members within the same species were more similar to each o...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-12-01 00:00:00
abstract：:The additive genomic variance in linear models with random marker effects can be defined as a random variable that is in accordance with classical quantitative genetics theory. Common approaches to estimate the genomic variance in random-effects linear models based on genomic marker data can be regarded as estimating ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302324
更新日期：2019-10-01 00:00:00
abstract：:The noncanonical Frizzled/planar cell polarity (PCP) pathway regulates establishment of polarity within the plane of an epithelium to generate diversity of cell fates, asymmetric, but highly aligned structures, or to orchestrate the directional migration of cells during convergent extension during vertebrate gastrulat...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.181438
更新日期：2016-03-01 00:00:00
abstract：:The third hypervariable (V3) region of the HIV-1 gp120 protein is responsible for many aspects of viral infectivity. The tertiary structure of the V3 loop seems to influence the coreceptor usage of the virus, which is an important determinant of HIV pathogenesis. Hence, the information about preferred conformations of...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.051508
更新日期：2006-03-01 00:00:00
abstract：:Clinal variation is common for enzymes in the glycolytic pathway for Drosophila melanogaster and is generally accepted as an adaptive response to different climates. Although the enzyme phosphoglucomutase (PGM) possesses several allozyme polymorphisms, it is unique in that it had been reported to show no clinal variat...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:Genes in nematode and ascidian genomes frequently occur in operons--multiple genes sharing a common promoter to generate a polycistronic primary transcript--and such genes comprise 15-20% of the coding genome for Caenorhabditis elegans and Ciona intestinalis. Recent work in nematodes has demonstrated that the identity...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.115766
更新日期：2010-06-01 00:00:00
abstract：:The rate of decline in reproductive fitness in populations of Drosophila melanogaster inbred at an initial rate of approximately 1% per generation has been investigated under both competitive and noncompetitive conditions. Breeding population size was variable in the inbred lines with an estimated harmonic mean of 66....
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The challenges of breeding autotetraploid potato (Solanum tuberosum) have motivated the development of alternative breeding strategies. A common approach is to obtain uniparental dihaploids from a tetraploid of interest through pollination with S. tuberosum Andigenum Group (formerly S. phureja) cultivars. The mechanis...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302843
更新日期：2020-02-01 00:00:00
abstract：:We have investigated meiotic changes in CAG repeat tracts embedded in a yeast chromosome. Repeat tracts undergo either conversion events between homologs or expansion and contraction events that appear to be confined to a single chromatid. We did not find evidence for conversion of tract interruptions or excess exchan...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:Stabilizing selection for an intermediate optimum is generally considered to deplete genetic variation in quantitative traits. However, conflicting results from various types of models have been obtained. While classical analyses assuming a large number of independent additive loci with individually small effects indi...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-06-01 00:00:00
abstract：:This paper describes a perturbation experiment on the frequency of the F and S Alcohol dehydrogenase (Adh) alleles of D. melanogaster. Fifty-four iso-female lines set up from three wild populations and with initial F frequencies of either 0.25, 0.50 or 0.75 were maintained on standard laboratory food medium at 22 degr...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:Recessive mutations in three autosomal genes, him-1, him-5 and him-8, cause high levels of X chromosome nondisjunction in hermaphrodites of Caenorhabditis elegans, with no comparable effect on autosomal disjunction. Each of the mutants has reduced levels of X chromosome recombination, correlating with the increase in ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:Mobile P elements in Drosophila melanogaster cause hybrid dysgenesis if their mobility is not repressed. One type of repression, termed P cytotype, is a complex interaction between chromosomes carrying P elements and cytoplasm and is transmitted through the cytoplasm only of females. Another type of repression is foun...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：:Gene mapping studies to determine the order of alpha- and beta-interferon (Ifa, Ifb), aminolevulinate dehydratase (Lv), and alpha-1 acid glycoprotein-1 and -2 (Orm-1, Orm-2) relative to each other and to the reference genes brown (b), B-cell maturation factor responsiveness (Bmfr-1), and major urinary protein-1 (Mup-1...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
abstract：:Programmed cell death (PCD) is regulated by multiple evolutionarily conserved mechanisms to ensure the survival of the cell. Here we describe pvl-5, a gene that likely regulates PCD in Caenorhabditis elegans. In wild-type hermaphrodites at the L2 stage there are 11 Pn.p hypodermal cells in the ventral midline arrayed ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.103.020503
更新日期：2004-06-01 00:00:00
abstract：:A wheat (Triticum aestivum L. emend Thell) disomic addition line (2n = 6x = 44), SH1-152-2, with a pair of Elytrigia pontica (Podp.) Holub 2n = 10x = 70 [syn. Agropyron elongatum (Host) P.B.] chromosomes controlling blue aleurone color was crossed with a short-statured spring wheat ;Sonora 64' (T. aestivum). Isoline p...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：:The complex structure and repetitive nature of eukaryotic ribosomal DNA (rDNA) is a challenge for genome assembly, thus the consequences of sequence variation in rDNA remain unexplored. However, renewed interest in the role that rDNA variation may play in diverse cellular functions, aside from ribosome production, hig...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302351
更新日期：2019-09-01 00:00:00
abstract：:The supramolecular striatin-interacting phosphatases and kinases (STRIPAK) complex is conserved from yeast to human, and regulates a variety of key biological processes. In animals, this complex consists of the scaffold protein striatin, the protein phosphatase 2A, and kinases, such as germinal center kinase (GCK) III...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301261
更新日期：2018-09-01 00:00:00
abstract：:In order to define more precisely the most proximal portion of chromosome 3R in Drosophila melanogaster, several new chromosome aberrations involving this region have been recovered and analyzed. These new arrangements were recovered as induced reversions of two dominant mutations, ANTPNs and dsxD, located in the regi...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:Brassica self-incompatibility (SI) is controlled by SLG and SRK expressed in the stigma and by SP11/SCR expressed in the anther. We determined the sequences of the S domains of 36 SRK alleles, 13 SLG alleles, and 14 SP11 alleles from Brassica oleracea and B. rapa. We found three S haplotypes lacking SLG genes in B. ra...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-10-01 00:00:00
abstract：:The existence of temporally stable frequency clines for In(2L)t in natural populations of Drosophila melanogaster suggests a role for selection in the maintenance of this polymorphism. We have collected nucleotide polymorphism data from the proximal breakpoint junction regions of In(2L)t to infer its evolutionary hist...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Dosage compensation in Drosophila has been studied at the steady state RNA level for several single-copy genes; however, an important point is addressed by analyzing a repetitive, transposable element for dosage compensation. The two issues of gene-specific cis control and genomic position can be studied by determinin...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:The banded portion of Drosophila melanogaster chromosome 4 exhibits euchromatic and heterochromatic characteristics. Reminiscent of heterochromatin, it contains a high percentage of repetitive elements, does not undergo recombination, and exhibits high levels of HP1 and histone-3 lysine-9 dimethylation. However, in th...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.081828
更新日期：2008-03-01 00:00:00
abstract：:We present theoretical explanations and show through simulation that the individual admixture proportion estimates obtained by using ancestry informative markers should be seen as an error-contaminated measurement of the underlying individual ancestry proportion. These estimates can be used in structured association t...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.107.075408
更新日期：2007-07-01 00:00:00
