Abstract:
:Gene mapping studies to determine the order of alpha- and beta-interferon (Ifa, Ifb), aminolevulinate dehydratase (Lv), and alpha-1 acid glycoprotein-1 and -2 (Orm-1, Orm-2) relative to each other and to the reference genes brown (b), B-cell maturation factor responsiveness (Bmfr-1), and major urinary protein-1 (Mup-1) are reported. The most likely order was Mup-1--Lv--b--Orm-1, Orm-2--Ifa, Ifb--Bmfr-1. This order suggested that two chromosomal segments located on chromosome 4 in the mouse and chromosome 9 in man have been conserved since divergence of lineages leading to man and mouse; these segments are marked by soluble aconitase-1 (Aco-1) and galactose-1 phosphate uridyl transferase (Galt) and by Lv and Orm-1. This order also demonstrated that, although genes located on opposite arms of chromosome 9 in man remain syntenic in the mouse, gene order has not been conserved; Ifa and Ifb are not located in their expected locations near Aco-1 and Galt. The position of Ifa and Ifb between Orm-1 and Bmfr-1 could not be determined with certainty because of apparent heterogeneity in recombination frequencies between crosses involving conventional laboratory strains of mice and crosses involving interspecific matings between laboratory mice and Mus spretus. This result suggests that caution must be exercised when using M. spretus in linkage crosses.
journal_name
Geneticsjournal_title
Geneticsauthors
Nadeau JH,Berger FG,Kelley KA,Pitha PM,Sidman CL,Worrall Nsubject
Has Abstractpub_date
1986-12-01 00:00:00pages
1239-55issue
4eissn
0016-6731issn
1943-2631journal_volume
114pub_type
杂志文章相关文献
GENETICS文献大全abstract::We identified and characterized 14 extragenic mutations that suppressed the dominant egg-laying defect of certain lin-12 gain-of-function mutations. These suppressors defined seven genes: sup-17, lag-2, sel-4, sel-5, sel-6, sel-7 and sel-8. Mutations in six of the genes are recessive suppressors, whereas the two mutat...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::Centromere H3 proteins (CenH3's) are variants of histone H3 specialized for packaging centromere DNA. Unlike canonical H3, which is among the most conserved of eukaryotic proteins, CenH3's are rapidly evolving, raising questions about orthology and conservation of function across species. To gain insight on CenH3 evol...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.062794
更新日期:2006-11-01 00:00:00
abstract::This study addresses three questions about the properties of recombination hotspots in Saccharomyces cerevisiae: How much DNA is required for double-strand-break (DSB) site recognition? Do naturally occurring DSB sites compete with each other in meiotic recombination? What role does the sequence located at the sites o...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Robust and synchronous repression of E2F-dependent gene expression is critical to the proper timing of cell cycle exit when cells transition to a postmitotic state. Previously NuA4 was suggested to act as a barrier to proliferation in Drosophila by repressing E2F-dependent gene expression. Here we show that NuA4 activ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.116.188581
更新日期:2016-07-01 00:00:00
abstract::Mitochondrial DNA (mtDNA) deletions are associated with sporadic and inherited diseases and age-associated neurodegenerative disorders. Approximately 85% of mtDNA deletions identified in humans are flanked by short directly repeated sequences; however, mechanisms by which these deletions arise are unknown. A limitatio...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.138214
更新日期:2012-03-01 00:00:00
abstract::Predicting the chromosomal location of mapped markers has been difficult because linkage maps do not reveal differences in crossover frequencies along the physical structure of chromosomes. Here we combine a physical crossover map based on the distribution of recombination nodules (RNs) on Solanum lycopersicum (tomato...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.074138
更新日期:2007-08-01 00:00:00
abstract::An extending axon growth cone is subjected to attractant and repellent cues. It is not clear how these growth cones discriminate the two opposing forces and select their projection paths. Here, we report that in the Drosophila nerve cord the growth cones of longitudinal tracts are subjected to attraction by the Netrin...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.036863
更新日期:2005-05-01 00:00:00
abstract::In plants, many major regulatory genes that control plant growth and development have been identified and characterized. Despite a detailed knowledge of the function of these genes little is known about how they contribute to the natural variation for complex traits. To determine whether major regulatory genes of maiz...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.107.080424
更新日期:2007-12-01 00:00:00
abstract::The identification of a second structural gene mutation at the feline arylsulfatase B locus (MPS VIb) provided the opportunity to investigate the expression of allelism by characterization of the residual enzymatic activity in feline mucopolysaccharidosis VI, an animal analogue of human Maroteaux-Lamy syndrome. Mating...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1985-08-01 00:00:00
abstract::Cell diversity in multicellular organisms relies on coordination between cell proliferation and the acquisition of cell identity. The equilibrium between these two processes is essential to assure the correct number of determined cells at a given time at a given place. Using genetic approaches and correlative microsco...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.119.302234
更新日期:2019-07-01 00:00:00
abstract::The genetic structure of green turtle (Chelonia mydas) rookeries located around the Australian coast was assessed by (1) comparing the structure found within and among geographic regions, (2) comparing microsatellite loci vs. restriction fragment length polymorphism analyses of anonymous single copy nuclear DNA (ascnD...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::When a polygenic character is exposed to natural selection in which the curve giving fitness as a function of phenotype is a mixture of two Gaussian (normal) curves, the population may respond either by evolving to a specialized phenotype near one of the two optimum phenotypes, or by evolving to a generalized phenotyp...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1979-11-01 00:00:00
abstract::The bristle worm Platynereis dumerilii displays many interesting biological characteristics. These include its reproductive timing, which is synchronized to the moon phase, its regenerative capacity that is hormonally controlled, and a slow rate of evolution, which permits analyses of ancestral genes and cell types. A...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.112.148254
更新日期:2014-05-01 00:00:00
abstract::A female frog heterozygous at two unlinked loci, specifying electrophoretic forms of mannosephosphate isomerase (MPI) and malate dehydrogenase (MDH) was crossed to male frogs homozygous for different alleles at each locus. In the offspring approximately ten percent proved to be triploid according to nucleolar and chro...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract::The small ovary gene (sov) is required for the development of the Drosophila ovary. Six EMS-induced recessive alleles have been identified. Hypomorphic alleles are female sterile and have no effect on male fertility, whereas more severe mutations result in lethality. The female-sterile alleles produce a range of mutan...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract::An SSR-based linkage map was constructed in Brassica rapa. It includes 113 SSR, 87 RFLP, and 62 RAPD markers. It consists of 10 linkage groups with a total distance of 1005.5 cM and an average distance of 3.7 cM. SSRs are distributed throughout the linkage groups at an average of 8.7 cM. Synteny between B. rapa and a ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.038968
更新日期:2006-05-01 00:00:00
abstract::In Drosophila there exist several examples of gene expression that can be modified by an interaction between alleles; this effect is known as transvection. The inference that alleles interact comes from the observations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrangements ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::Transposable elements (TEs) constitute a substantial fraction of the eukaryotic genome and, as a result, have a complex relationship with their host that is both adversarial and dependent. To minimize damage to cellular genes, TEs possess mechanisms that target integration to sequences of low importance. However, the ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.115.181602
更新日期:2015-11-01 00:00:00
abstract::Determining parentage is a fundamental problem in biology and in applications such as identifying pedigrees. Difficulties inferring parentage derive from extensive inbreeding within the population, whether natural or planned; using an insufficient number of hypervariable loci; and from allele mismatches caused by muta...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Maintenance of proper neuronal excitability is vital to nervous system function and normal behavior. A subset of Drosophila mutants that exhibit altered behavior also exhibit defective motor neuron excitability, which can be monitored with electrophysiological methods. One such mutant is the P-element insertion mutant...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::Microarray experiments have been used recently in genetical genomics studies, as an additional tool to understand the genetic mechanisms governing variation in complex traits, such as for estimating heritabilities of mRNA transcript abundances, for mapping expression quantitative trait loci, and for inferring regulato...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.106.057281
更新日期:2006-10-01 00:00:00
abstract::We present a genetic map based on microsatellite polymorphisms for the African human malaria vector, Anopheles gambiae. Polymorphisms in laboratory strains were detected for 89% of the tested microsatellite markers. Genotyping was performed for individual mosquitos from 13 backcross families that included 679 progeny....
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract::Small regulatory RNAs, such as small interfering RNAs (siRNAs) and PIWI-interacting RNAs, regulate splicing, transcription, and genome integrity in many eukaryotes. In Caenorhabditis elegans, siRNAs bind nuclear Argonautes (AGOs), which interact with homologous premessenger RNAs to recruit downstream silencing effecto...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.120.303631
更新日期:2020-12-01 00:00:00
abstract::I have studied nucleotide polymorphism and linkage disequilibrium using multilocus data from 77 fragments, with an average length of fragments of 550 bp, in the deciduous tree Populus tremula (Salicaceae). The frequency spectrum across loci showed a modest excess of mutations segregating at low frequency and a marked ...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.090431
更新日期:2008-09-01 00:00:00
abstract::We consider a population that adapts to a gradually changing environment. Our aim is to describe how ecological and genetic factors combine to determine the genetic basis of adaptation. Specifically, we consider the evolution of a polygenic trait that is under stabilizing selection with a moving optimum. The ecologica...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.106195
更新日期:2009-12-01 00:00:00
abstract::The accumulation of slightly deleterious mutations in populations leads to the buildup of a genetic load and can cause the extinction of populations of small size. Mutation-accumulation experiments have been used to study this process in a wide variety of organisms, yet the exact mutational underpinnings of genetic lo...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.066142
更新日期:2007-01-01 00:00:00
abstract::Differential expression of mRNA among animal strains is one of the mechanisms for their diversity. cDNA microarray analysis of the prostates of BUF/Nac (BUF) and ACI/N (ACI) rats, which show different susceptibility to prostate cancers, found 195 differentially expressed genes. To identify loci that control differenti...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.104.038174
更新日期:2005-11-01 00:00:00
abstract::Studying phage codon adaptation is important not only for understanding the process of translation elongation, but also for reengineering phages for medical and industrial purposes. To evaluate the effect of mutation and selection on phage codon usage, we developed an index to measure selection imposed by host transla...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.114.162842
更新日期:2014-05-01 00:00:00
abstract::In Drosophila melanogaster, heterochromatin-induced silencing or position-effect variegation (PEV) of a reporter gene has provided insights into the properties of heterochromatin. Class I modifiers suppress PEV, and class II modifiers enhance PEV when the modifier gene is present in fewer than two doses. We have exami...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract::We analyzed linkage and chromosomal positions of genes in A. lyrata ssp. petraea that are located near the centromere (CEN) regions of A. thaliana, using at least two genes from the short and long arms of each chromosome. In our map, genes from all 10 A. thaliana chromosome arms are also tightly linked in A. lyrata. G...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.057182
更新日期:2006-07-01 00:00:00