Abstract：
:We consider a population that adapts to a gradually changing environment. Our aim is to describe how ecological and genetic factors combine to determine the genetic basis of adaptation. Specifically, we consider the evolution of a polygenic trait that is under stabilizing selection with a moving optimum. The ecological dynamics are defined by the strength of selection, sigma, and the speed of the optimum, v; the key genetic parameters are the mutation rate Theta and the variance of the effects of new mutations, omega. We develop analytical approximations within an "adaptive-walk" framework and describe how selection acts as a sieve that transforms a given distribution of new mutations into the distribution of adaptive substitutions. Our analytical results are complemented by individual-based simulations. We find that (i) the ecological dynamics have a strong effect on the distribution of adaptive substitutions and their impact depends largely on a single composite measure gamma=v/(sigmaThetaomega(3)), which combines the ecological and genetic parameters; (ii) depending on gamma, we can distinguish two distinct adaptive regimes: for large gamma the adaptive process is mutation limited and dominated by genetic constraints, whereas for small gamma it is environmentally limited and dominated by the external ecological dynamics; (iii) deviations from the adaptive-walk approximation occur for large mutation rates, when different mutant alleles interact via linkage or epistasis; and (iv) in contrast to predictions from previous models assuming constant selection, the distribution of adaptive substitutions is generally not exponential.
journal_name
Geneticsjournal_title
Geneticsauthors
Kopp M,Hermisson Jdoi
10.1534/genetics.109.106195subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1453-76issue
4eissn
0016-6731issn
1943-2631pii
genetics.109.106195journal_volume
183pub_type
杂志文章相关文献
GENETICS文献大全abstract：:The Drosophila melanogaster Gld gene has multiple and diverse developmental and physiological functions. We report herein that interactions among proximal promoter elements and a cluster of intronically located enhancers and silencers specify the complex regulation of Gld that underlies its diverse functions. Gld expr...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-02-01 00:00:00
abstract：:Adaptation in diploids is predicted to proceed via mutations that are at least partially dominant in fitness. Recently, we argued that many adaptive mutations might also be commonly overdominant in fitness. Natural (directional) selection acting on overdominant mutations should drive them into the population but then,...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.185165
更新日期：2016-07-01 00:00:00
abstract：:In a subdivided population, the interaction between natural selection and stochastic change in allele frequency is affected by the occurrence of local extinction and subsequent recolonization. The relative importance of selection can be diminished by this additional source of stochastic change in allele frequency. Res...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.166.2.1105
更新日期：2004-02-01 00:00:00
abstract：:l(3)S12 is a vital locus whose function is required in embryos, early larvae, late pupae and oogenesis. We have identified a cold-sensitive allele, l(3)S12(3), and characterized conditional misexpression of the gene associated with this mutation as well as with several euchromatic insertions of l(3)S12+ transposons. S...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:In this article, we utilize stochastic search variable selection methodology to develop a Bayesian method for identifying multiple quantitative trait loci (QTL) for complex traits in experimental designs. The proposed procedure entails embedding multiple regression in a hierarchical normal mixture model, where latent ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
abstract：:Evidence from many organisms indicates that the conserved RecQ helicases function in the maintenance of genomic stability. Mutation of SGS1 and WRN, which encode RecQ homologues in budding yeast and humans, respectively, results in phenotypes characteristic of premature aging. Mutation of SRS2, another DNA helicase, c...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:The percentage of crossovers is consistently higher in plants hypoploid for six B-A translocations when crossed as males than when crossed as females; in most instances, this excess of male crossing over exceeds that found in control crosses (involving normal chromosomes). Thus, there seems to be something about the h...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：:Aspergillus nidulans is an important experimental organism, and it is a model organism for the genus Aspergillus that includes serious pathogens as well as commercially important organisms. Gene targeting by homologous recombination during transformation is possible in A. nidulans, but the frequency of correct gene ta...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.105.052563
更新日期：2006-03-01 00:00:00
abstract：:Yeast DNA fragments that confer multiple drug resistance when amplified were isolated. Cells containing a yeast genomic library cloned in the high copy autonomously replicating vector, YEp24, were plated on medium containing cycloheximide. Five out of 100 cycloheximide-resistant colonies were cross-resistant to the un...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-05-01 00:00:00
abstract：:We performed a comparative study of four subfamilies of olfactory receptor genes first identified in the dog to assess changes in the gene family during mammalian evolution, and to begin linking the dog genetic map to that of humans. The human subfamilies were localized to chromosomes 7, 11, and 19. The two subfamilie...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:In meiosis, multiple different DNA sequence motifs help to position homologous recombination at hotspots in the genome. How do the seemingly disparate cis-acting regulatory modules each promote locally the activity of the basal recombination machinery? We defined molecular mechanisms of action for five different hotsp...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302679
更新日期：2019-11-01 00:00:00
abstract：:We report the identification of bang senseless (bss), a Drosophila melanogaster mutant exhibiting seizure-like behaviors, as an allele of the paralytic (para) voltage-gated Na(+) (Na(V)) channel gene. Mutants are more prone to seizure episodes than normal flies because of a lowered seizure threshold. The bss phenotype...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.123299
更新日期：2011-02-01 00:00:00
abstract：:We have established the DNA sequence and analyzed the transcription and translation products of a series of putative nodulation (nod) genes in Rhizobium meliloti strain 1021. Four loci have been designated nodF, nodE, nodG and nodH. The correlation of transposon insertion positions with phenotypes and open reading fra...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:The net rate of mutation to deleterious but nonlethal alleles and the sizes of effects of these mutations are of great significance for many evolutionary questions. Here we describe three replicate experiments in which mutations have been accumulated on chromosome 3 of Drosophila melanogaster by means of single-male b...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.103.025262
更新日期：2004-06-01 00:00:00
abstract：:The characterization of the distribution of mutational effects is a key goal in evolutionary biology. Recently developed deep-sequencing approaches allow for accurate and simultaneous estimation of the fitness effects of hundreds of engineered mutations by monitoring their relative abundance across time points in a si...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.190462
更新日期：2016-09-01 00:00:00
abstract：:Determining the patterns of DNA sequence variation in the human genome is a useful first step toward identifying the genetic basis of a common disease. A haplotype map (HapMap), aimed at describing these variation patterns across the entire genome, has been recently developed by the International HapMap Consortium. In...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.029603
更新日期：2004-09-01 00:00:00
abstract：:Transcription of the Saccharomyces MAL structural genes is induced 40-fold by maltose and requires the MAL-activator and maltose permease. To identify additional players involved in regulating MAL gene expression, we carried out a genetic selection for MAL constitutive mutants. Strain CMY4000 containing MAL1 and integ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.029611
更新日期：2004-10-01 00:00:00
abstract：:Parameters of continuous distributions of effects and rates of spontaneous mutation for relative viability in Drosophila are estimated by maximum likelihood from data of two published experiments on accumulation of mutations on protected second chromosomes. A model of equal mutant effects gives a poor fit to the data ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1994-12-01 00:00:00
abstract：:The idea of trait-based linkage analysis in half-sibs is extended by comparing the frequency of parental marker haplotypes in animals with different phenotypes. This article first presents the likelihood of observing different classes of paternal haplotypes in a half-sib family, where only family members of a certain ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:A multivariate quantitative genetic model is analyzed that is based on the assumption that the genetic variation at a locus j primarily influences an underlying physiological variable yj, while influence on the genotypic values is determined by a kind of "developmental function" which is not changed by mutations at th...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Two alternate transcripts of the single copy Alcohol dehydrogenase (Adh) gene accumulate with developmental specificity in all of 12 species of Hawaiian picture-winged Drosophila which have been examined. Relative to the paradigm species D. affinidisjuncta, the Adh transcript normally restricted to larvae is found to ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-10-01 00:00:00
abstract：:Samples of Rhynchosporium secalis were collected from two experimental barley populations known to carry a diverse array of alleles for resistance to this fungal pathogen. Classification of 163 isolates for four putative isozyme systems, a colony color dimorphism and 20 ribosomal DNA restriction fragment length varian...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:Anxious behavior in the mouse is a complex quantitative phenotype that varies widely among inbred mouse strains. We examined a panel of chromosome substitution strains bearing individual A/J chromosomes in an otherwise C57BL/6J background in open-field and light-dark transition tests. Our results confirmed previous re...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.031492
更新日期：2005-02-01 00:00:00
abstract：:A combination of nuclear and chloroplast simple sequence repeats (SSRs) have been used to investigate the levels and pattern of variability detected in Glycine max and G. soja genotypes. Based on the analysis of 700 soybean genotypes with 115 restriction fragment length polymorphism (RFLP) probes, 12 accessions were i...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Population structure leads to systematic patterns in measures of mean relatedness between individuals in large genomic data sets, which are often discovered and visualized using dimension reduction techniques such as principal component analysis (PCA). Mean relatedness is an average of the relationships across locus-s...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.301747
更新日期：2019-01-01 00:00:00
abstract：:Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that h...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.109.112516
更新日期：2010-04-01 00:00:00
abstract：:The cut gene in Drosophila is necessary in at least one cell type, the external sensory organs, for proper cell type specification and morphogenesis. It is also expressed in a variety of other tissues, where its function is less well characterized. Previous work has demonstrated that mutations affecting all the tissue...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Receptor tyrosine kinases (RTKs) are an important family of signaling molecules with the unusual property that they are able to transduce their signals using the same downstream pathways. This has led to an unresolved debate as to whether individual receptors are interchangeable, or if each receptor can mediate specif...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.108.098475
更新日期：2009-04-01 00:00:00
abstract：:The Snf1 protein kinase of the glucose signaling pathway in Saccharomyces cerevisiae is regulated by an autoinhibitory interaction between the regulatory and catalytic domains of Snf1p. Transitions between the autoinhibited and active states are controlled by an upstream kinase and the Reg1p-Glc7p protein phosphatase ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-02-01 00:00:00
abstract：:As one of the world's most important food crops, the potato (Solanum tuberosum L.) has spurred innovation in autotetraploid genetics, including in the use of SNP arrays to determine allele dosage at thousands of markers. By combining genotype and pedigree information with phenotype data for economically important trai...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.300685
更新日期：2018-05-01 00:00:00
