Meiotic alterations in CAG repeat tracts.

abstract：:The Drosophila melanogaster Chd3 gene encodes a member of the CHD group of SNF2/RAD54 ATPases. CHD proteins are conserved from yeast to man and many are subunits of chromatin-remodeling complexes that facilitate transcription. Drosophila CHD3 proteins are not found in protein complexes, but as monomers that remodel ch...

journal_title：Genetics

authors： Cooper MT,Conant AW,Kennison JA

更新日期：2010-07-01 00:00:00

abstract：:The existence of temporally stable frequency clines for In(2L)t in natural populations of Drosophila melanogaster suggests a role for selection in the maintenance of this polymorphism. We have collected nucleotide polymorphism data from the proximal breakpoint junction regions of In(2L)t to infer its evolutionary hist...

journal_title：Genetics

authors： Andolfatto P,Wall JD,Kreitman M

更新日期：1999-11-01 00:00:00

abstract：:Previously isolated meiotic recombination (rec) mutants of Schizosaccharomyces pombe define 16 complementation groups. The rec genes cloned and sequenced to date reveal little amino acid sequence identity to other reported proteins. We examined the rec mutants for alterations in meiotic events other than recombination...

journal_title：Genetics

authors： Li YF,Smith GR

更新日期：1997-05-01 00:00:00

abstract：:Many genes that affect axon pathfinding and cell migration have been identified. Mechanisms by which these genes and the molecules they encode interact with one another in pathways and networks to control developmental events are unclear. Rac GTPases, the cytoskeletal signaling molecule Enabled, and NIK kinase have al...

journal_title：Genetics

authors： Shakir MA,Gill JS,Lundquist EA

更新日期：2006-02-01 00:00:00

abstract：:While bacteria divide clonally, horizontal gene transfer followed by homologous recombination is now recognized as an important contributor to their evolution. However, the details of how the competition between clonality and recombination shapes genome diversity remains poorly understood. Using a computational model,...

journal_title：Genetics

authors： Dixit PD,Pang TY,Maslov S

更新日期：2017-09-01 00:00:00

abstract：:Centromere H3 proteins (CenH3's) are variants of histone H3 specialized for packaging centromere DNA. Unlike canonical H3, which is among the most conserved of eukaryotic proteins, CenH3's are rapidly evolving, raising questions about orthology and conservation of function across species. To gain insight on CenH3 evol...

journal_title：Genetics

authors： Baker RE,Rogers K

更新日期：2006-11-01 00:00:00

abstract：:Conspicuous differences in floral morphology are partly responsible for reproductive isolation between two sympatric species of monkeyflower because of their effect on visitation of the flowers by different pollinators. Mimulus lewisii flowers are visited primarily by bumblebees, whereas M. cardinalis flowers are visi...

journal_title：Genetics

authors： Bradshaw HD Jr,Otto KG,Frewen BE,McKay JK,Schemske DW

更新日期：1998-05-01 00:00:00

abstract：:We showed that sufficient overexpression of the wild-type recF gene interfered with three normal cell functions: (1) UV induction of transcription from the LexA-protein-repressed sulA promoter, (2) UV resistance and (3) cell viability at 42 degrees. To show this, we altered a low-level overexpressing recF+ plasmid wit...

journal_title：Genetics

authors： Sandler SJ,Clark AJ

更新日期：1993-11-01 00:00:00

abstract：:RAD53 encodes a conserved protein kinase that acts as a central transducer in the DNA damage and the DNA replication checkpoint pathways in Saccharomyces cerevisiae. To identify new elements of these pathways acting with or downstream of RAD53, we searched for genes whose overexpression suppressed the toxicity of a do...

journal_title：Genetics

authors： Marsolier MC,Roussel P,Leroy C,Mann C

更新日期：2000-04-01 00:00:00

abstract：:Analyses of 113 putative Mutator-induced events involving the yg2 locus of chromosome 9 revealed that 11 of these events were deletions that produce albino seedlings when homozygous. This phenotype is characteristic of wd (white deficiency) deletions. All 11 wd-Mu deletions failed to complement wd1 and pyd1 (pale-yell...

journal_title：Genetics

authors： Robertson DS,Stinard PS,Maguire MP

更新日期：1994-03-01 00:00:00

abstract：:DNA extracts of several rosy-mutation-bearing strains were associated with large insertions and deletions in a defined region of the molecular map believed to include the rosy locus DNA. Large-scale, intragenic mapping experiments were carried out that localized these mutations within the boundaries of the previously ...

journal_title：Genetics

authors： Clark SH,McCarron M,Love C,Chovnick A

更新日期：1986-04-01 00:00:00

abstract：:RecQ helicases function in the maintenance of genome stability in many organisms. The filamentous fungus Neurospora crassa has two RecQ homologs, QDE3 and RECQ2. We found that the qde-3 recQ2 double mutant showed a severe growth defect. The growth defect was alleviated by mutation in mei-3, the homolog of yeast RAD51,...

journal_title：Genetics

authors： Kato A,Inoue H

更新日期：2006-01-01 00:00:00

abstract：:Genotype by environment interactions (GEI) play a major part in shaping the genetic architecture of quantitative traits and are confounding factors in genetic studies, for example, in attempts to associate genetic variation with disease susceptibility. It is generally not known what proportion of phenotypic variation ...

journal_title：Genetics

authors： Sambandan D,Carbone MA,Anholt RR,Mackay TF

更新日期：2008-06-01 00:00:00

abstract：:To further understand how the nematode Caenorhabditis elegans defends itself against pathogen attack, we analyzed enhanced pathogen resistance (epr) mutants obtained from a forward genetic screen. We also examined several well-characterized sterile mutants that exhibit an Epr phenotype. We found that sterility and pat...

journal_title：Genetics

authors： Miyata S,Begun J,Troemel ER,Ausubel FM

更新日期：2008-02-01 00:00:00

abstract：:By screening for suppressors of hypomorphic mutations of let-23, a receptor tyrosine kinase necessary for vulval induction in Caenorhabditis elegans, we recovered > or = 12 mutations defining the sli-1 (suppressor of lineage defect) locus. sli-1 mutations suppress four of five phenotypes associated with hypomorphic al...

journal_title：Genetics

authors： Jongeward GD,Clandinin TR,Sternberg PW

更新日期：1995-04-01 00:00:00

abstract：:Distance- as well as marker-dependence of genetic recombination of bacteriophage T4 was studied in crosses between rIIB mutants with known base sequences. The notion of a "basic recombination," which is the recombination within distances shorter than hybrid DNA length in the absence of mismatch repair and any marker e...

journal_title：Genetics

authors： Shcherbakov VP,Plugina LA

更新日期：1991-08-01 00:00:00

abstract：:Drosophila adult leg development provides an ideal model system for characterizing the molecular mechanisms of hormone-triggered morphogenesis. A pulse of the steroid hormone ecdysone at the onset of metamorphosis triggers the rapid transformation of a flat leg imaginal disc into an immature adult leg, largely through...

journal_title：Genetics

authors： Ward RE,Evans J,Thummel CS

更新日期：2003-11-01 00:00:00

abstract：:We leverage two complementary Drosophila melanogaster mapping panels to genetically dissect starvation resistance-an important fitness trait. Using >1600 genotypes from the multiparental Drosophila Synthetic Population Resource (DSPR), we map numerous starvation stress QTL that collectively explain a substantial fract...

journal_title：Genetics

authors： Everman ER,McNeil CL,Hackett JL,Bain CL,Macdonald SJ

更新日期：2019-04-01 00:00:00

abstract：:In Saccharomyces cerevisiae, genes located at the telomeres and the HM loci are subject to transcriptional silencing. Here, we report results of screening a Gal4 DNA-binding domain hybrid library for proteins that cause silencing when targeted to a silencer-defective HMR locus. ...

journal_title：Genetics

authors： Andrulis ED,Zappulla DC,Alexieva-Botcheva K,Evangelista C,Sternglanz R

更新日期：2004-01-01 00:00:00

abstract：:The range of possible gene interactions in a multilocus model of a complex inherited disease is studied by exploring genotype-specific risks subject to the constraint that the allele frequencies and marginal risks are known. We quantify the effect of gene interactions by defining the interaction ratio, CR=KR/KRI, wher...

journal_title：Genetics

authors： Song YS,Wang F,Slatkin M

更新日期：2010-12-01 00:00:00

abstract：:The DC2 gene was isolated previously on the basis of sequence similarity to DC0, the major Drosophila protein kinase A (PKA) catalytic subunit gene. We show here that the 67-kD Drosophila DC2 protein behaves as a PKA catalytic subunit in vitro. DC2 is transcribed in mesodermal anlagen of early embryos. This expression...

journal_title：Genetics

authors： Meléndez A,Li W,Kalderon D

更新日期：1995-12-01 00:00:00

abstract：:The small subunit ribosomal RNA gene (srDNA) has been used extensively for phylogenetic analyses. One common assumption in these analyses is that substitution rates are biased toward transitions. We have developed a simple method for estimating relative rates of base change that does not assume rate constancy and take...

journal_title：Genetics

authors： Vawter L,Brown WM

更新日期：1993-06-01 00:00:00

abstract：:Restriction site-associated DNA sequencing or genotyping-by-sequencing (GBS) approaches allow for rapid and cost-effective discovery and genotyping of thousands of single-nucleotide polymorphisms (SNPs) in multiple individuals. However, rigorous quality control practices are needed to avoid high levels of error and bi...

journal_title：Genetics

authors： Chen N,Van Hout CV,Gottipati S,Clark AG

更新日期：2014-11-01 00:00:00

abstract：:The percentage of crossovers is consistently higher in plants hypoploid for six B-A translocations when crossed as males than when crossed as females; in most instances, this excess of male crossing over exceeds that found in control crosses (involving normal chromosomes). Thus, there seems to be something about the h...

journal_title：Genetics

authors： Robertson DS

更新日期：1984-05-01 00:00:00

abstract：:Inverted chromosome duplications or palindromes are linked with genetic disorders and malignant transformation. They are considered by-products of DNA double-strand break (DSB) repair: the homologous recombination (HR) and the nonhomologous end joining (NHEJ). Palindromes near chromosome ends are often triggered by te...

journal_title：Genetics

authors： Raykov V,Marvin ME,Louis EJ,Maringele L

更新日期：2016-08-01 00:00:00

abstract：:The mitochondrial DNA (mtDNA) in animals is generally a circular molecule of approximately 15 kb, but there are many exceptions such as linear molecules and larger ones. RFLP studies indicated that the mtDNA in the terrestrial isopod Armadillidium vulgare varied from 20 to 42 kb. This variation depended on the restric...

journal_title：Genetics

authors： Raimond R,Marcadé I,Bouchon D,Rigaud T,Bossy JP,Souty-Grosset C

更新日期：1999-01-01 00:00:00

abstract：:The concept of haplotype blocks has been shown to be useful in genetics. Fields of application range from the detection of regions under positive selection to statistical methods that make use of dimension reduction. We propose a novel approach ("HaploBlocker") for defining and inferring haplotype blocks that focuses ...

journal_title：Genetics

authors： Pook T,Schlather M,de Los Campos G,Mayer M,Schoen CC,Simianer H

更新日期：2019-08-01 00:00:00

abstract：:Sponsored by the National Science Foundation and the U.S. Department of Agriculture, a wheat genome sequencing workshop was held November 10-11, 2003, in Washington, DC. It brought together 63 scientists of diverse research interests and institutions, including 45 from the United States and 18 from a dozen foreign cou...

journal_title：Genetics

authors： Gill BS,Appels R,Botha-Oberholster AM,Buell CR,Bennetzen JL,Chalhoub B,Chumley F,Dvorák J,Iwanaga M,Keller B,Li W,McCombie WR,Ogihara Y,Quetier F,Sasaki T

更新日期：2004-10-01 00:00:00

abstract：:Birds are characterized by female heterogamety; females carry the Z and W sex chromosomes, while males have two copies of the Z chromosome. We suggest here that full differentiation of the Z and W sex chromosomes of birds did not take place until after the split of major contemporary lineages, in the late Cretaceous. ...

journal_title：Genetics

authors： Ellegren H,Carmichael A

更新日期：2001-05-01 00:00:00

abstract：:The Yanomama Indians are a South American tribe distributed over an irregular area approximately 200 X 300 miles. The gene frequencies observed at 12 loci in 47 villages within this area have been analyzed for the occurrence of clines. Apparently significant clines are observed for alleles of the Rh, MNSs, Kidd, Gm, I...

journal_title：Genetics

authors： Ward RH,Neel JV

更新日期：1976-01-01 00:00:00