Involvement of the PP2C-like phosphatase Ptc2p in the DNA checkpoint pathways of Saccharomyces cerevisiae.

abstract：:In Drosophila melanogaster, heterochromatin-induced silencing or position-effect variegation (PEV) of a reporter gene has provided insights into the properties of heterochromatin. Class I modifiers suppress PEV, and class II modifiers enhance PEV when the modifier gene is present in fewer than two doses. We have exami...

journal_title：Genetics

authors： Sass GL,Henikoff S

更新日期：1998-02-01 00:00:00

abstract：:Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from those expected under neutral evolution and described statistically by Kingman's...

journal_title：Genetics

authors： Dayarian A,Shraiman BI

更新日期：2014-07-01 00:00:00

abstract：:The distribution of fitness effects (DFE) encompasses the fraction of deleterious, neutral, and beneficial mutations. It conditions the evolutionary trajectory of populations, as well as the rate of adaptive molecular evolution (α). Inferring DFE and α from patterns of polymorphism, as given through the site frequency...

journal_title：Genetics

authors： Tataru P,Mollion M,Glémin S,Bataillon T

更新日期：2017-11-01 00:00:00

abstract：:Extensive Monte Carlo simulations are conducted of spatial distributions of two-locus genotypes in large, continuous populations under isolation by distance models. The results show that substantial patches of double homozygotes are present in the spatial structures, even when loci are unlinked. The stochastic spread ...

journal_title：Genetics

authors： Epperson BK

更新日期：1995-05-01 00:00:00

abstract：:Genetic and developmental analysis of an X-linked vital locus vnd was undertaken. Embryos hemizygous for the original allele vnd did not hatch and exhibited a disorganized ventral nervous system (VNS). The mutation maps in the region 1B6-7 to 1B9-10, a subregion of an area previously shown to be essential to normal ne...

journal_title：Genetics

authors： White K,DeCelles NL,Enlow TC

更新日期：1983-07-01 00:00:00

abstract：:The segregation distortion phenomenon occurs in Drosophila melanogaster males carrying an SD second chromosome and an SD+ homolog. In such males the SD chromosome is transmitted to the progeny more frequently than the expected 50% because of an abnormal differentiation of the SD+-bearing sperms. Three major loci are i...

journal_title：Genetics

authors： Pimpinelli S,Dimitri P

更新日期：1989-04-01 00:00:00

abstract：:Studying phage codon adaptation is important not only for understanding the process of translation elongation, but also for reengineering phages for medical and industrial purposes. To evaluate the effect of mutation and selection on phage codon usage, we developed an index to measure selection imposed by host transla...

journal_title：Genetics

authors： Chithambaram S,Prabhakaran R,Xia X

更新日期：2014-05-01 00:00:00

abstract：:Over one-third of human genome sequence is a product of non-LTR retrotransposition. The retrotransposon that currently drives this process in humans is the highly abundant LINE-1 (L1) element. Despite the ubiquitous nature of L1's in mammals, we still lack a complete mechanistic understanding of the L1 replication cyc...

journal_title：Genetics

authors： Dong C,Poulter RT,Han JS

更新日期：2009-01-01 00:00:00

abstract：:A consensus microsatellite-based linkage map of the turbot (Scophthalmus maximus) was constructed from two unrelated families. The mapping panel was derived from a gynogenetic family of 96 haploid embryos and a biparental diploid family of 85 full-sib progeny with known linkage phase. A total of 242 microsatellites we...

journal_title：Genetics

authors： Bouza C,Hermida M,Pardo BG,Fernández C,Fortes GG,Castro J,Sánchez L,Presa P,Pérez M,Sanjuán A,de Carlos A,Alvarez-Dios JA,Ezcurra S,Cal RM,Piferrer F,Martínez P

更新日期：2007-12-01 00:00:00

abstract：:Segregation data were obtained for 1260 potato linkage group I-specific AFLP loci from a heterozygous diploid potato population. Analytical tools that identified potential typing errors and/or inconsistencies in the data and that assembled cosegregating markers into bins were applied. Bins contain multiple-marker data...

journal_title：Genetics

authors： Isidore E,van Os H,Andrzejewski S,Bakker J,Barrena I,Bryan GJ,Caromel B,van Eck H,Ghareeb B,de Jong W,van Koert P,Lefebvre V,Milbourne D,Ritter E,van der Voort JR,Rousselle-Bourgeois F,van Vliet J,Waugh R

更新日期：2003-12-01 00:00:00

abstract：:An approximately 135-bp sequence called the A1/A2 repeat was isolated from the transcribed region of the 26-18S rDNA intergenic spacer (IGS) of Nicotiana tomentosiformis. Fluorescence in situ hybridization (FISH) and Southern blot analysis revealed its occurrence as an independent satellite (termed an A1/A2 satellite)...

journal_title：Genetics

authors： Lim KY,Skalicka K,Koukalova B,Volkov RA,Matyasek R,Hemleben V,Leitch AR,Kovarik A

更新日期：2004-04-01 00:00:00

abstract：:A radiation-induced translocation, T(IIR----IIIL), has been shown to be nonreciprocal and to have most of IIR, including its terminus, attached uninverted to the terminus of IIIL.--Progeny with the IIR segment in duplicate, obtained from crosses of T(IIR----IIIL) to strains with a standard genome, were unstable at mit...

journal_title：Genetics

authors： Daud F,Ortori GS,Roper JA

更新日期：1985-06-01 00:00:00

abstract：:The present report is a study of 60 intragenic suppressors located in the A or E group of the b2 spore-color locus of Ascobolus immersus. The frameshift nature of the suppressors was shown by 19 combinations of plus and minus suppressor mutations. The location of the mutation sites on the genetic map of group A was de...

journal_title：Genetics

authors： Leblon G

更新日期：1979-08-01 00:00:00

abstract：:A key quantity in the analysis of structured populations is the parameter K, which describes the number of subpopulations that make up the total population. Inference of K ideally proceeds via the model evidence, which is equivalent to the likelihood of the model. However, the evidence in favor of a particular value o...

journal_title：Genetics

authors： Verity R,Nichols RA

更新日期：2016-08-01 00:00:00

abstract：:Recombination and chromosome synapsis bring homologous chromosomes together, creating chiasmata that ensure accurate disjunction during reductional division. SPO13 is a key gene required for meiosis I (MI) reductional segregation, but dispensable for recombination, in Saccharomyces cerevisiae. Absence of SPO13 leads t...

journal_title：Genetics

authors： Rutkowski LH,Esposito RE

更新日期：2000-08-01 00:00:00

abstract：:Mendelian loci that control the expression levels of transcripts are called expression quantitative trait loci (eQTL). When mapping eQTL, we often deal with thousands of expression traits simultaneously, which complicates the statistical model and data analysis. Two simple approaches may be taken in eQTL analysis: (1)...

journal_title：Genetics

authors： Jia Z,Xu S

更新日期：2007-05-01 00:00:00

abstract：:The swi8+ gene of Schizosaccharomyces pombe appears to be involved in the termination step of copy synthesis during mating-type (MT) switching. Mutations in swi8 confer a general mutator phenotype and, in particular, generate specific mutations in the MT region. Sequencing of the MT cassettes of the h90 swi8-137 mutan...

journal_title：Genetics

authors： Fleck O,Rudolph C,Albrecht A,Lorentz A,Schär P,Schmidt H

更新日期：1994-11-01 00:00:00

abstract：:We study a situation that arises in the somatic evolution of cancer. Consider a finite population of replicating cells and a sequence of mutations: type 0 can mutate to type 1, which can mutate to type 2. There is no back mutation. We start with a homogeneous population of type 0. Mutants of type 1 emerge and either b...

journal_title：Genetics

authors： Iwasa Y,Michor F,Nowak MA

更新日期：2004-03-01 00:00:00

abstract：:Wolbachia-induced cytoplasmic incompatibility (CI) is expressed when infected males are crossed with either uninfected females or females infected with Wolbachia of different CI specificity. In diploid insects, CI results in embryonic mortality, apparently due to the the loss of the paternal set of chromosomes, usuall...

journal_title：Genetics

authors： Zabalou S,Apostolaki A,Pattas S,Veneti Z,Paraskevopoulos C,Livadaras I,Markakis G,Brissac T,Merçot H,Bourtzis K

更新日期：2008-04-01 00:00:00

abstract：:The banded portion of Drosophila melanogaster chromosome 4 exhibits euchromatic and heterochromatic characteristics. Reminiscent of heterochromatin, it contains a high percentage of repetitive elements, does not undergo recombination, and exhibits high levels of HP1 and histone-3 lysine-9 dimethylation. However, in th...

journal_title：Genetics

authors： Riddle NC,Leung W,Haynes KA,Granok H,Wuller J,Elgin SC

更新日期：2008-03-01 00:00:00

abstract：:In both pedigree linkage studies and in population-based association studies there has been much interest in the use of modern dense genetic marker data to infer segments of gene identity by descent (ibd) among individuals not known to be related, to increase power and resolution in localizing genes affecting complex ...

journal_title：Genetics

authors： Brown MD,Glazner CG,Zheng C,Thompson EA

更新日期：2012-04-01 00:00:00

abstract：:Genetic information can be altered by base substitutions, frameshift mutations, and addition or deletion of nucleotides. Deletions represent an important class of genetic aberration occurring at DNA sequences where it is often possible to predict the existence of intermediates of mutation. Instability within tracts of...

journal_title：Genetics

authors： Bichara M,Schumacher S,Fuchs RP

更新日期：1995-07-01 00:00:00

abstract：:The Standard and Sex Ratio gene arrangements of the X chromosome of D. pseudobscura differ from each other in allele frequencies at the four X chromosome loci, esterase-5, adult acid phosphatase-6, phosphoglucomutase-1 and octanol dehydrogenase-3. The Standard arrangement which is the common arrangement in all populat...

journal_title：Genetics

authors： Prakash S

更新日期：1974-08-01 00:00:00

abstract：:Interactions between Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) RNAs and CRISPR-associated (Cas) proteins form an RNA-guided adaptive immune system in prokaryotes. The adaptive immune system utilizes segments of the genetic material of invasive foreign elements in the CRISPR locus. The loci are ...

journal_title：Genetics

authors： Fu BX,Wainberg M,Kundaje A,Fire AZ

更新日期：2017-08-01 00:00:00

abstract：:The level of activity of the enzyme glucose-6-phosphate dehydrogenase was determinel in flies having seven different chromosomic constitutions. All those having an integral number of chromosomes [XAA, XXAA, XAAA, XXAAA, and XXXAAA (X=Xchromosome, A=set of autosomes)] were found to have similar units of enzyme activity...

journal_title：Genetics

authors： Maroni G,Plaut W

更新日期：1973-06-01 00:00:00

abstract：:Centric regions of eukaryotic genomes are packaged into heterochromatin, which possesses the ability to spread along the chromosome and silence gene expression. The process of spreading has been challenging to study at the molecular level due to repetitious sequences within centric regions. A heterochromatin protein 1...

journal_title：Genetics

authors： Hines KA,Cryderman DE,Flannery KM,Yang H,Vitalini MW,Hazelrigg T,Mizzen CA,Wallrath LL

更新日期：2009-08-01 00:00:00

abstract：:In order to examine the operation of diversifying selection as the maintenance mechanism of excessive additive genetic variance for viability in southern populations in comparison with northern populations of Drosophila melanogaster, two sets of experiments were conducted using second chromosomes extracted from the Og...

journal_title：Genetics

authors： Takano T,Kusakabe S,Mukai T

更新日期：1987-10-01 00:00:00

abstract：:Disease resistance to the bacterial pathogen Pseudomonas syringae pv. tomato (Pst) in the cultivated tomato, Lycopersicon esculentum, and the closely related L. pimpinellifolium is triggered by the physical interaction between plant disease resistance protein, Pto, and the pathogen avirulence protein, AvrPto. To inves...

journal_title：Genetics

authors： Rose LE,Langley CH,Bernal AJ,Michelmore RW

更新日期：2005-09-01 00:00:00

abstract：:A lethal locus (l(2)br7;35B6-10), near Adh on chromosome arm 2L of D. melanogaster, is identified with Plunkett's dominant suppressor of Hairless (H). Of eight new alleles, seven act as dominant suppressors of H, the eighth is a dominant enhancer of H. One of the suppressor alleles is both a leaky lethal and a weak s...

journal_title：Genetics

authors： Ashburner M

更新日期：1982-07-01 00:00:00

abstract：:Robust and synchronous repression of E2F-dependent gene expression is critical to the proper timing of cell cycle exit when cells transition to a postmitotic state. Previously NuA4 was suggested to act as a barrier to proliferation in Drosophila by repressing E2F-dependent gene expression. Here we show that NuA4 activ...

journal_title：Genetics

authors： Flegel K,Grushko O,Bolin K,Griggs E,Buttitta L

更新日期：2016-07-01 00:00:00