Dosage Compensation in DROSOPHILA MELANOGASTER Triploids. II. Glucose-6-Phosphate Dehydrogenase Activity.

abstract：:The rag4 mutant of Kluyveromyces lactis was previously isolated as a fermentation-deficient mutant, in which transcription of the major glucose transporter gene RAG1 was affected. The wild-type RAG4 was cloned by complementation of the rag4 mutation and found to encode a protein homologous to Snf3 and Rgt2 of Saccharo...

journal_title：Genetics

authors： Betina S,Goffrini P,Ferrero I,Wésolowski-Louvel M

更新日期：2001-06-01 00:00:00

abstract：:Levels of genetic variation and linkage disequilibrium (LD) are critical factors in association mapping methods as well as in identification of loci that have been targets of selection. Maize, an outcrosser, has a high level of sequence variation and a limited extent of LD. Sorghum, a closely related but largely self-...

journal_title：Genetics

authors： Hamblin MT,Mitchell SE,White GM,Gallego J,Kukatla R,Wing RA,Paterson AH,Kresovich S

更新日期：2004-05-01 00:00:00

abstract：:We examined the inheritance of allelic variation at an isozyme locus, MDH-B, duplicated by ancestral polyploidy in salmonid fishes. We detected only disomic segregation in females. Segregation ratios in males were best explained by a mixture of disomic and tetrasomic inheritance. We propose a two-stage model of pairin...

journal_title：Genetics

authors： Allendorf FW,Danzmann RG

更新日期：1997-04-01 00:00:00

abstract：:Parentage analysis is an important method that is used widely in zoological and ecological studies. Current mathematical models of parentage analyses usually assume that a population has a uniform genetic structure and that mating is panmictic. In a natural population, the geographic or social structure of a populatio...

journal_title：Genetics

authors： Huang K,Mi R,Dunn DW,Wang T,Li B

更新日期：2018-12-01 00:00:00

abstract：:Cell diversity in multicellular organisms relies on coordination between cell proliferation and the acquisition of cell identity. The equilibrium between these two processes is essential to assure the correct number of determined cells at a given time at a given place. Using genetic approaches and correlative microsco...

journal_title：Genetics

authors： Simon F,Ramat A,Louvet-Vallée S,Lacoste J,Burg A,Audibert A,Gho M

更新日期：2019-07-01 00:00:00

abstract：:Restriction map variation in two 5-6-kb chloroplast DNA regions of five diploid Aegilops species in the section Sitopsis and two wild tetraploid wheats, Triticum dicoccoides and Triticum araraticum, was investigated with a battery of four-cutter restriction enzymes. A single accession each of Triticum durum, Triticum ...

journal_title：Genetics

authors： Miyashita NT,Mori N,Tsunewaki K

更新日期：1994-07-01 00:00:00

abstract：:A supposed sporulation-deficient mutation of Saccharomyces cerevisiae is found to affect mating in haploids and in diploids, and to be inseparable from the mating-type locus by recombination. The mutation is regarded as a defective a allele and is designated a*. This is confirmed by its dominance relations in diploids...

journal_title：Genetics

authors： Kassir Y,Simchen G

更新日期：1976-02-01 00:00:00

abstract：:Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...

journal_title：Genetics

authors： Bruinsma JJ,Schneider DL,Davis DE,Kornfeld K

更新日期：2008-06-01 00:00:00

abstract：:Synthetics play an important role in quantitative genetic research and plant breeding, but few studies have investigated the application of genomic prediction (GP) to these populations. Synthetics are generated by intermating a small number of parents ([Formula: see text] and thereby possess unique genetic properties,...

journal_title：Genetics

authors： Schopp P,Müller D,Technow F,Melchinger AE

更新日期：2017-01-01 00:00:00

abstract：:In Saccharomyces cerevisiae, genes located at the telomeres and the HM loci are subject to transcriptional silencing. Here, we report results of screening a Gal4 DNA-binding domain hybrid library for proteins that cause silencing when targeted to a silencer-defective HMR locus. ...

journal_title：Genetics

authors： Andrulis ED,Zappulla DC,Alexieva-Botcheva K,Evangelista C,Sternglanz R

更新日期：2004-01-01 00:00:00

abstract：:Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combatin...

journal_title：Genetics

authors： Bradford BR,Briand NE,Fassnacht N,Gervasio ED,Nowakowski AM,FitzGibbon TC,Maurina S,Benjamin AV,Kelly M,Checchi PM

更新日期：2020-12-01 00:00:00

abstract：:We have examined the stability of the tandemly repeated genes that encode the ribosomal RNA in Coprinus cinereus. These genes are contained within two linked HindIII fragments in a 3.0-Mb chromosome. We monitored the size of these fragments in both mitotic and meiotic segregants using the contour-clamped homogeneous e...

journal_title：Genetics

authors： Pukkila PJ,Skrzynia C

更新日期：1993-02-01 00:00:00

abstract：:The maize ligule is an adaxial membranous structure on the leaf that develops at the boundary of the sheath and blade. The ligule and the associated auricle are dispensable structures, amenable to genetic manipulation. We present here a genetic analysis of liguleless1 (lg1) and liguleless2 (lg2), the two genes known t...

journal_title：Genetics

authors： Harper L,Freeling M

更新日期：1996-12-01 00:00:00

abstract：:We present a two-part system for conditional FLP-out of FRT-flanked sequences in Caenorhabditis elegans to control gene activity in a spatially and/or temporally regulated manner. Using reporters, we assess the system for efficacy and demonstrate its use as a cell lineage marking tool. In addition, we construct and te...

journal_title：Genetics

authors： Voutev R,Hubbard EJ

更新日期：2008-09-01 00:00:00

abstract：:Programmed cell death (PCD) is regulated by multiple evolutionarily conserved mechanisms to ensure the survival of the cell. Here we describe pvl-5, a gene that likely regulates PCD in Caenorhabditis elegans. In wild-type hermaphrodites at the L2 stage there are 11 Pn.p hypodermal cells in the ventral midline arrayed ...

journal_title：Genetics

authors： Joshi P,Eisenmann DM

更新日期：2004-06-01 00:00:00

abstract：:We analyzed linkage and chromosomal positions of genes in A. lyrata ssp. petraea that are located near the centromere (CEN) regions of A. thaliana, using at least two genes from the short and long arms of each chromosome. In our map, genes from all 10 A. thaliana chromosome arms are also tightly linked in A. lyrata. G...

journal_title：Genetics

authors： Kawabe A,Hansson B,Hagenblad J,Forrest A,Charlesworth D

更新日期：2006-07-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are repaired by homologous recombination (HR) and nonhomologous end-joining (NHEJ). NHEJ in yeast chromosomes has been observed only when HR is blocked, as in rad52 mutants or in the absence of a homologous repair template. We detected yKu70p-dependent imprecise NHEJ at a frequency of a...

journal_title：Genetics

authors： Clikeman JA,Khalsa GJ,Barton SL,Nickoloff JA

更新日期：2001-02-01 00:00:00

abstract：:To investigate the regulation of Drosophila melanogaster behavior by biogenic amines, we have exploited the broad requirement of the vesicular monoamine transporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters. We used the Drosophila VMAT (dVMAT) null mutant to globally ab...

journal_title：Genetics

authors： Chen A,Ng F,Lebestky T,Grygoruk A,Djapri C,Lawal HO,Zaveri HA,Mehanzel F,Najibi R,Seidman G,Murphy NP,Kelly RL,Ackerson LC,Maidment NT,Jackson FR,Krantz DE

更新日期：2013-01-01 00:00:00

abstract：:We have shown that the phenotypes resulting from hypomorphic mutations (causing reduction but not complete loss of function) in two X-linked genes can be used as a genetic assay for X-chromosome dosage compensation in Caenorhabditis elegans between males (XO) and hermaphrodites (XX). In addition we show that recessive...

journal_title：Genetics

authors： Meneely PM,Wood WB

更新日期：1987-09-01 00:00:00

abstract：:A canon of population genetics concerns the properties of FST, a descriptor of spatial genetic structure. Interest for FST arose from Wright's early insights linking FST to dispersal parameters as well as to his concept of effective population size (e.g., Wright 1938, 1951). Although there is continued interest in thi...

journal_title：Genetics

authors： Rousset F

更新日期：2013-07-01 00:00:00

abstract：:Neurospora crassa is an established reference organism to investigate carotene biosynthesis and light regulation. However, there is little evidence of its capacity to produce secondary metabolites. Here, we report the role of the fungal-specific regulatory velvet complexes in development and secondary metabolism (SM) ...

journal_title：Genetics

authors： Bayram ÖS,Dettmann A,Karahoda B,Moloney NM,Ormsby T,McGowan J,Cea-Sánchez S,Miralles-Durán A,Brancini GTP,Luque EM,Fitzpatrick DA,Cánovas D,Corrochano LM,Doyle S,Selker EU,Seiler S,Bayram Ö

更新日期：2019-07-01 00:00:00

abstract：:Immunosenescence, the age-related decline in immune system function, is a general hallmark of aging. While much is known about the cellular and physiological changes that accompany immunosenescence, we know little about the genetic influences on this phenomenon. In this study we combined age-specific measurements of b...

journal_title：Genetics

authors： Felix TM,Hughes KA,Stone EA,Drnevich JM,Leips J

更新日期：2012-07-01 00:00:00

abstract：:Heterologous yeast artificial chromosomes (YACs) do not recombine with each other and missegregate in 25% of meiosis I events. Recombination hot spots in the yeast Saccharomyces cerevisiae have previously been shown to be associated with sites of meiosis-induced double-strand breaks (DSBs). A 6-kb fragment containing ...

journal_title：Genetics

authors： Sears DD,Hieter P,Simchen G

更新日期：1994-12-01 00:00:00

abstract：:The reproductive success of individual fire ant queens (Solenopsis invicta) previously has been shown to be strongly influenced by their genotype at a single enzyme-encoding gene, designated Pgm-3. This paper presents evidence that a second, tightly linked gene, designated Gp-9, is under similarly strong selection in ...

journal_title：Genetics

authors： Ross KG

更新日期：1997-04-01 00:00:00

abstract：:Changes in genome structure and gene expression have been documented in both resynthesized and natural allopolyploids that contain two or more divergent genomes. The underlying mechanisms for rapid and stochastic changes in gene expression are unknown. Arabidopsis suecica is a natural allotetraploid derived from the e...

journal_title：Genetics

authors： Chen M,Ha M,Lackey E,Wang J,Chen ZJ

更新日期：2008-04-01 00:00:00

abstract：:Seventeen lines, each homozygous for a different X chromosome but all with a common autosomal genetic blackground, were constructed and assayed for abdominal bristle number to determine whether dosage compensation operates for sex-linked genes affecting this character. --The regression coefficient of male mean on fema...

journal_title：Genetics

authors： Frankham R

更新日期：1977-01-01 00:00:00

abstract：:Sexual reproduction and recombination are important for maintaining a stable copy number of transposable elements (TEs). In sexual populations, elements can be contained by purifying selection against host carriers with higher element copy numbers; however, in the absence of sex and recombination, asexual populations ...

journal_title：Genetics

authors： Dolgin ES,Charlesworth B

更新日期：2006-10-01 00:00:00

abstract：:While bacteria divide clonally, horizontal gene transfer followed by homologous recombination is now recognized as an important contributor to their evolution. However, the details of how the competition between clonality and recombination shapes genome diversity remains poorly understood. Using a computational model,...

journal_title：Genetics

authors： Dixit PD,Pang TY,Maslov S

更新日期：2017-09-01 00:00:00

abstract：:Malaria control projects based on the introduction and spread of transgenes into mosquito populations depend on the extent of isolation between those populations. On the basis of the distribution of paracentric inversions, Anopheles gambiae has been subdivided into five subspecific chromosomal forms. Estimating gene f...

journal_title：Genetics

authors： Tripet F,Dolo G,Lanzaro GC

更新日期：2005-01-01 00:00:00

abstract：:Hybrid sterility in the heterogametic sex is a common feature of speciation in animals. In house mice, the contribution of the Mus musculus musculus X chromosome to hybrid male sterility is large. It is not known, however, whether F1 male sterility is caused by X-Y or X-autosome incompatibilities or a combination of b...

journal_title：Genetics

authors： Campbell P,Good JM,Dean MD,Tucker PK,Nachman MW

更新日期：2012-08-01 00:00:00