Abstract:
:Parentage analysis is an important method that is used widely in zoological and ecological studies. Current mathematical models of parentage analyses usually assume that a population has a uniform genetic structure and that mating is panmictic. In a natural population, the geographic or social structure of a population, and/or nonrandom mating, usually leads to a genetic structure and results in genotypic frequencies deviating from those expected under the Hardy-Weinberg equilibrium (HWE). In addition, in the presence of null alleles, an observed genotype represents one of several possible true genotypes. The true father of a given offspring may thus be erroneously excluded in parentage analyses, or may have a low or negative LOD score. Here, we present a new mathematical model to estimate parentage that includes simultaneously the effects of inbreeding, null alleles, and negative amplification. The influences of these three factors on previous model are evaluated by Monte-Carlo simulations and empirical data, and the performance of our new model is compared under controlled conditions. We found that, for both simulated and empirical data, our new model outperformed other methods in many situations. We make available our methods in a new, free software package entitled parentage This can be downloaded via http://github.com/huangkang1987/parentage.
journal_name
Geneticsjournal_title
Geneticsauthors
Huang K,Mi R,Dunn DW,Wang T,Li Bdoi
10.1534/genetics.118.301592subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1467-1481issue
4eissn
0016-6731issn
1943-2631pii
genetics.118.301592journal_volume
210pub_type
杂志文章相关文献
GENETICS文献大全abstract::The extent of mtDNA length variation and heteroplasmy as well as DNA sequences of the control region and two tRNA genes were determined for four North American sturgeon species: Acipenser transmontanus, A. medirostris, A. fulvescens and A. oxyrhnychus. Across the Continental Divide, a division in the occurrence of len...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract::Laboratory strains of mice are thought to be derived from wild populations of Mus domesticus. Many instances of non-domesticus genetic information fixed in these strains have been described, however, and the amount of strain-to-strain genetic variation exceeds that found in wild domesticus populations. In order to est...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1986-12-01 00:00:00
abstract::Much of the material taken into cells by endocytosis is rapidly returned to the plasma membrane by the endocytic recycling pathway. Although recycling is vital for the correct localization of cell membrane receptors and lipids, the molecular mechanisms that regulate recycling are only partially understood. Here we sho...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.108.087247
更新日期:2008-05-01 00:00:00
abstract::For more than 60 years, evolutionary cytogeneticists have been using naturally occurring chromosomal inversions to infer phylogenetic histories, especially in insects with polytene chromosomes. The validity of this method is predicated on the assumption that inversions arise only once in the history of a lineage, so t...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-10-01 00:00:00
abstract::The recessive mutation, hop1-1, was isolated by use of a screen designed to detect mutations defective in homologous chromosomal pairing during meiosis in Saccharomyces cerevisiae. Mutants in HOP1 displayed decreased levels of meiotic crossing over and intragenic recombination between markers on homologous chromosomes...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::Mutant alleles of two genetic regulatory elements, which underlie a three- to sixfold reduction in beta-glucuronidase (GUS) activity levels, distinguish mice of the H haplotype from those of the other two common GUS haplotypes, A and B. Both elements are tightly linked to the GUS structural gene over which they exert ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::We demonstrate that recent data from human males are consistent with constant interference levels among chromosomes under the two-pathway model, whereas inappropriately fitting shape parameters of Gamma distributions to immunofluorescent interfoci distances observed on finite chromosomes generates false interpretation...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.103853
更新日期:2009-09-01 00:00:00
abstract::Nucleotide variation at the genomic region encompassing the odorant-binding protein genes OS-E and OS-F (OS region) was surveyed in two populations of Drosophila simulans, one from Europe and the other from Africa. We found that the European population shows an atypical and large haplotype structure, which extends thr...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.106.068015
更新日期:2007-04-01 00:00:00
abstract::Sixty independent UGA suppressors of Saccharomyces cerevisiae have been studied. They are dominant and are divided into 16 groups (loci) by recombination. Suppressors representing these loci are divided into two classes by action spectra; four in class 1 (a broad action spectrum) and 12 in class 2 (a narrow action spe...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract::The human pathogen Candida albicans is considered an obligate commensal of animals, yet it is occasionally isolated from trees, shrubs, and grass. We generated genome sequence data for three strains of C. albicans that we isolated from oak trees in an ancient wood pasture, and compared these to the genomes of over 200...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.118.301482
更新日期:2019-01-01 00:00:00
abstract::Apomixis (asexual seed formation) is the result of a plant gaining the ability to bypass the most fundamental aspects of sexual reproduction: meiosis and fertilization. Without the need for male fertilization, the resulting seed germinates a plant that develops as a maternal clone. This dramatic shift in reproductive ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.114.163105
更新日期:2014-06-01 00:00:00
abstract::The determination of segment identity in Drosophila melanogaster appears to be controlled by a small number of genes. In order to identity new components in the process, we have systematically screened the autosomal complement for loci that show a dosage-dependent interaction with mutations in previously characterized...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract::A maximum-likelihood method to estimate the recombination fraction and its sampling variance using informative and noninformative half-sib offspring is derived. Estimates of the recombination fraction are biased up to 20 cM when noninformative offspring are discarded. In certain scenarios, the sampling variance can be...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract::We formalize the use of allele frequency and geographic information for the construction of gene trees at the intraspecific level and extend the concept of evolutionary parsimony to molecular variance parsimony. The central principle is to consider a particular gene tree as a variable to be optimized in the estimation...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::The parentals of the interspecific cross Cucurbita maxima xC. ecuadorensis had different isozyme phenotypes for 12 enzyme systems. Characterization of the systems demonstrated that the expression and intracellular distribution of the isozymes were similar to those in other plant taxa; however, a considerable number of...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1986-10-01 00:00:00
abstract::Currently used tests of Hardy-Weinberg proportions do not take into account the nature of the alternative hypothesis, which is generally a heterozygote deficiency. Different exact tests, appropriate for small sample size and large number of alleles, are proposed in this perspective, and their properties are evaluated ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1995-08-01 00:00:00
abstract::All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.112.147207
更新日期:2013-03-01 00:00:00
abstract::The swi8+ gene of Schizosaccharomyces pombe appears to be involved in the termination step of copy synthesis during mating-type (MT) switching. Mutations in swi8 confer a general mutator phenotype and, in particular, generate specific mutations in the MT region. Sequencing of the MT cassettes of the h90 swi8-137 mutan...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::The Podospora anserina PaMpk1 MAP kinase (MAPK) signaling pathway can generate a cytoplasmic and infectious element resembling prions. When present in the cells, this C element causes the crippled growth (CG) cell degeneration. CG results from the inappropriate autocatalytic activation of the PaMpk1 MAPK pathway durin...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.112.139469
更新日期:2012-06-01 00:00:00
abstract::We have isolated 136 independent mutations in haploid yeast strains that exhibit decreased chromosome transmission fidelity in mitosis. Eighty-five percent of the mutations are recessive and 15% are partially dominant. Complementation analysis between MATa and MAT alpha isolates identifies 11 chromosome transmission f...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-02-01 00:00:00
abstract::In California, Drosophila simulans females from some populations (type W) produce relatively few adult progeny when crossed to males from some other populations (type R), but the productivity of the reciprocal cross is comparable to within-population controls. These two incompatibility types are widespread in North Am...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::The recent progress in sequencing technologies makes possible large-scale medical sequencing efforts to assess the importance of rare variants in complex diseases. The results of such efforts depend heavily on the use of efficient study designs and analytical methods. We introduce here a unified framework for associat...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.111.131813
更新日期:2011-11-01 00:00:00
abstract::In the absence of a vg+ gene, extensive cell death occurs in third instar imaginal discs, which results in a complete loss of adult wing margin structures. Essentially all molecularly characterized vg alleles are associated with deletions or insertions of DNA into the vg locus. These alterations reduce or eliminate a ...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1990-08-01 00:00:00
abstract::Mutations in genes of Saccharomyces cerevisiae that code for proteins that interact with beta-tubulin were sought by screening for unlinked mutations that fail to complement mutations in the single beta-tubulin-encoding gene (TUB2). Among the first three noncomplementing mutations examined, two are linked to TUB2 whil...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1988-06-01 00:00:00
abstract::A newly characterized Drosophila melanogaster gene, logjam (loj), functions in female reproduction by modulating oviposition behavior. The locus encodes at least six overlapping transcripts with unique 5' ends. P-element mutants that express very low levels of loj transcripts are unable to oviposit mature eggs. This p...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::The construction in bacteriophage lambda of a set of long DNA palindromes with paired changes in the central sequence is described. Identical palindrome centers were previously used by others to test the S-type model for cruciform extrusion in vitro. Long DNA palindromes prevent the propagation of carrier phage lambda...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::Mutations in maternally transmitted symbionts can affect host fitness. In this study we investigate a mutation in an obligate bacterial symbiont (Buchnera), which has dramatic effects on the heat tolerance of pea aphid hosts (Acyrthosiphon pisum). The heat-sensitive allele arises through a single base deletion in a ho...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.110.117440
更新日期:2010-09-01 00:00:00
abstract::Circadian ( approximately 24 hr) rhythms of behavior and physiology are driven by molecular clocks that are endogenous to most organisms. The mechanisms underlying these clocks are remarkably conserved across evolution and typically consist of auto-regulatory loops in which specific proteins (clock proteins) rhythmica...
journal_title:Genetics
pub_type: 杂志文章,评审
doi:10.1534/genetics.107.088658
更新日期:2008-03-01 00:00:00
abstract::We show that major chromosomal rearrangements can occur upon T-DNA transformation of Arabidopsis thaliana. In the ACL4 line, two T-DNA insertion loci were found; one is a tandem T-DNA insert in a head-to-head orientation, and the other is a truncated insert with only the left part of the T-region. The four flanking DN...
journal_title:Genetics
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::In many organisms, female and male meiosis display extensive sexual dimorphism in the temporal meiotic program, the number and location of recombination events, sex chromosome segregation, and checkpoint function. We show here that both meiotic prophase timing and germ-line apoptosis, one output of checkpoint signalin...
journal_title:Genetics
pub_type: 杂志文章
doi:10.1534/genetics.109.110338
更新日期:2010-03-01 00:00:00