Abstract：
:In the absence of a vg+ gene, extensive cell death occurs in third instar imaginal discs, which results in a complete loss of adult wing margin structures. Essentially all molecularly characterized vg alleles are associated with deletions or insertions of DNA into the vg locus. These alterations reduce or eliminate a 3.8-kb vg-specific transcript, resulting in recessive loss of function alleles. We report here the analysis of two dominant vg alleles which have been identified (vgU and vgW). The vgU allele is associated with a chromosomal inversion which splits the vg locus, resulting in a gene fusion between vg and the mastermind (mam) neurogenic locus. Reversion analysis of vgU indicates that sequences from the mam locus are required for vgU dominance. The vgW allele is also the result of a chromosomal inversion, in this case resulting in a gene fusion between vg and the homeobox-containing invected (inv) gene. It is also associated with novel dominant homeotic transformations. Revertant analysis indicates that sequences from inv are required for the dominant wing and dominant homeotic effects of vgW. The vg dominance does not appear to be mediated through a reduction of vg expression or a novel fusion transcript in either vgU or vgW. The results are consistent with a model in which inappropriate expression of inv causes the dominant homeotic effects seen in vgW.
journal_name
Geneticsjournal_title
Geneticsauthors
Williams JA,Scott IM,Atkin AL,Brook WJ,Russell MA,Bell JBsubject
Has Abstractpub_date
1990-08-01 00:00:00pages
833-44issue
4eissn
0016-6731issn
1943-2631journal_volume
125pub_type
杂志文章相关文献
GENETICS文献大全abstract：:Dosage compensation refers to the equal expression of X-linked genes despite the difference in copy number between the two sexes. The male-specific lethal (MSL) complex is concentrated on the X chromosome in males. A gene expression assay for embryos was developed to examine the function of this complex. In mutant mal...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.036020
更新日期：2005-04-01 00:00:00
abstract：:Different electrophoretic alleles of amylase show associations with particular chromosome 3 inversions in D. pseudoobscura and D. persimilis. Relative adult amylase activities were compared in 37, 37 and 10 strains of D. pseudoobscura, D. persimilis and D. miranda, respectively. Strains carrying the same electrophoret...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1980-05-01 00:00:00
abstract：:Previously we have shown that the nucleolus organizer region (NOR) of Neurospora crassa changes size frequently during the premeiotic portion of the sexual phase. Here, we have investigated whether these changes in size originate only in specific regions of the NOR, or are distributed throughout the NOR. In two specia...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Pseudo-homothallism is a reproductive strategy elected by some fungi producing heterokaryotic sexual spores containing genetically different but sexually compatible nuclei. This lifestyle appears as a compromise between true homothallism (self-fertility with predominant inbreeding) and complete heterothallism (with ex...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.159988
更新日期：2014-05-01 00:00:00
abstract：:Mitomycin C (MMC) is a genotoxic agent that induces DNA cross-links, DNA alkylation, and the production of reactive oxygen species (ROS). MMC induces the SOS response and RpoS regulons in Escherichia coli SOS-encoded functions are required for DNA repair, whereas the RpoS regulon is typically induced by metabolic stre...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.199471
更新日期：2017-07-01 00:00:00
abstract：:A combination of nuclear and chloroplast simple sequence repeats (SSRs) have been used to investigate the levels and pattern of variability detected in Glycine max and G. soja genotypes. Based on the analysis of 700 soybean genotypes with 115 restriction fragment length polymorphism (RFLP) probes, 12 accessions were i...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:The protein phosphatase calcineurin is central to Ca2+ signaling pathways from yeast to humans. Full activation of calcineurin requires Ca2+ binding to the regulatory subunit CNB, comprised of four Ca2+-binding EF hand domains, and recruitment of Ca2+-calmodulin. Here we report the consequences of disrupting Ca2+ bind...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.118.300911
更新日期：2018-07-01 00:00:00
abstract：:We show how the idea of monotone coupling from the past can produce simple algorithms for simulating samples at a nonneutral locus under a range of demographic models. We specifically consider a biallelic locus and either a general variable population size mode or a general migration model for population subdivision. ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.060681
更新日期：2006-11-01 00:00:00
abstract：:A plausible explanation for many MHC-linked diseases is lacking. Sequencing of the MHC class I region (coding units or full contigs) in several human and nonhuman primate haplotypes allowed an analysis of single nucleotide variations (SNV) across this entire segment. This diversity was not evenly distributed. It was r...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.057034
更新日期：2006-07-01 00:00:00
abstract：:Apomixis (asexual seed formation) is the result of a plant gaining the ability to bypass the most fundamental aspects of sexual reproduction: meiosis and fertilization. Without the need for male fertilization, the resulting seed germinates a plant that develops as a maternal clone. This dramatic shift in reproductive ...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.114.163105
更新日期：2014-06-01 00:00:00
abstract：:Interspecific hybridization in the genus Mus results in male sterility and X-linked placental dysplasia. We have generated several congenic laboratory mouse lines (Mus musculus) in which different parts of the maternal X chromosome were derived from M. spretus. A strict positive correlation between placental weight an...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:The recessive mutation, hop1-1, was isolated by use of a screen designed to detect mutations defective in homologous chromosomal pairing during meiosis in Saccharomyces cerevisiae. Mutants in HOP1 displayed decreased levels of meiotic crossing over and intragenic recombination between markers on homologous chromosomes...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:Understanding variation in allele frequencies across populations is a central goal of population genetics. Classical models for the distribution of allele frequencies, using forward simulation, coalescent theory, or the diffusion approximation, have been applied extensively for demographic inference, medical study des...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.117.200493
更新日期：2017-07-01 00:00:00
abstract：:Evolutionary forces shape patterns of genetic diversity within populations and contribute to phenotypic variation. In particular, recurrent positive selection has attracted significant interest in both theoretical and empirical studies. However, most existing theoretical models of recurrent positive selection cannot e...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.113.156935
更新日期：2014-05-01 00:00:00
abstract：:The additive genomic variance in linear models with random marker effects can be defined as a random variable that is in accordance with classical quantitative genetics theory. Common approaches to estimate the genomic variance in random-effects linear models based on genomic marker data can be regarded as estimating ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.119.302324
更新日期：2019-10-01 00:00:00
abstract：:Use of the CRISPR/Cas9 RNA-guided endonuclease complex has recently enabled the generation of double-strand breaks virtually anywhere in the C. elegans genome. Here, we present an improved strategy that makes all steps in the genome editing process more efficient. We have created a toolkit of template-mediated repair ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.180679
更新日期：2015-10-01 00:00:00
abstract：:Evolution through natural selection suggests unnecessary genes are lost. We observed that the yeast Candida glabrata lost the gene encoding a phosphate-repressible acid phosphatase (PHO5) present in many yeasts including Saccharomyces cerevisiae. However, C. glabrata still had phosphate starvation-inducible phosphatas...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.110.120824
更新日期：2010-11-01 00:00:00
abstract：:Translation of the chloroplast psbC mRNA in the unicellular eukaryotic alga Chlamydomonas reinhardtii is controlled by interactions between its 547-base 5' untranslated region and the products of the nuclear loci TBC1, TBC2, and possibly TBC3. In this study, a series of site-directed mutations in this region was gener...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:A major correlation has been found between the incidence of glucocorticoid-induced cleft palate and the chromosome 8 segment identified by N-acetyl transferase in mice. The resistant strain became fully susceptible while the susceptible strain became resistant when this chromosomal region, representing less than 0.7% ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:Satellite DNA is an enigmatic component of genomic DNA with unclear function that has been regarded as "junk." Yet, persistence of these tandem highly repetitive sequences in heterochromatic regions of most eukaryotic chromosomes attests to their importance in the genome. We explored the Anopheles gambiae genome for t...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.034264
更新日期：2005-01-01 00:00:00
abstract：:A recent sperm-typing study by Jeffreys and Neumann suggested that recombination rates in different individuals at the DNA2 recombination hotspot appeared to be highly dependent on their genotype at a particular A/G SNP, FG11. Specifically, individuals who carried at least one copy of the A allele at this SNP exhibite...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.104.039271
更新日期：2006-03-01 00:00:00
abstract：:Mutant alleles of two genetic regulatory elements, which underlie a three- to sixfold reduction in beta-glucuronidase (GUS) activity levels, distinguish mice of the H haplotype from those of the other two common GUS haplotypes, A and B. Both elements are tightly linked to the GUS structural gene over which they exert ...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:We have tested the hypothesis that genetic differences among conspecific populations may result in diverse responses to selection, using natural populations of Drosophila melanogaster. Selection for ethanol tolerance in a tube measuring knockdown resistance was imposed on five West Coast populations. In 24 generations...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1986-09-01 00:00:00
abstract：:Robust and synchronous repression of E2F-dependent gene expression is critical to the proper timing of cell cycle exit when cells transition to a postmitotic state. Previously NuA4 was suggested to act as a barrier to proliferation in Drosophila by repressing E2F-dependent gene expression. Here we show that NuA4 activ...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.116.188581
更新日期：2016-07-01 00:00:00
abstract：:Circadian ( approximately 24 hr) rhythms of behavior and physiology are driven by molecular clocks that are endogenous to most organisms. The mechanisms underlying these clocks are remarkably conserved across evolution and typically consist of auto-regulatory loops in which specific proteins (clock proteins) rhythmica...
journal_title：Genetics
pub_type： 杂志文章,评审
doi：10.1534/genetics.107.088658
更新日期：2008-03-01 00:00:00
abstract：:During animal development, transcription factor activities are modulated by several means, including subcellular localization. The Hox cofactor Extradenticle (Exd) has a dynamic subcellular localization, such that Exd is cytoplasmic by default, but is nuclear when complexed with another homeodomain protein, Homothorax...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.066449
更新日期：2007-04-01 00:00:00
abstract：:A sulfonamide-resistant mutant of pneumococcus, sulr-c, displays a genetic instability, regularly segregating to wild type. DNA extracts of derivatives of the strain possess transforming activities for both the mutant and wild-type alleles, establishing that the strain is a partial diploid. The linkage of sulr-c to st...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:Biological robustness, the ability of an organism to maintain a steady-state output as genetic or environmental inputs change, is critical for proper development. MicroRNAs have been implicated in biological robustness mechanisms through their post-transcriptional regulation of genes and gene networks. Previous resear...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.115.179184
更新日期：2015-08-01 00:00:00
abstract：:The ability of a virus population to colonize a novel host is predicted to depend on the equilibrium frequency of potential colonists (i.e., genotypes capable of infecting the novel host) in the source population. In this study, we investigated the determinants of the equilibrium frequency of potential colonists in th...
journal_title：Genetics
pub_type： 杂志文章
doi：10.1534/genetics.106.064634
更新日期：2007-06-01 00:00:00
abstract：:The occurrence and patterns of linkage disequilibrium between an inversion and allozymic loci within it or nearby have been used in attempts to discriminate among different hypotheses for the maintenance of variability. The interpretation of the data on the best-documented case, that of the nonrandom association betwe...
journal_title：Genetics
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
