Maintaining two mating types: structure of the mating type locus and its role in heterokaryosis in Podospora anserina.

abstract：:Dopamine acts through two classes of G protein-coupled receptor (D1-like and D2-like) to modulate neuron activity in the brain. While subtypes of D1- and D2-like receptors are coexpressed in many neurons of the mammalian brain, it is unclear how signaling by these coexpressed receptors interacts to modulate the activi...

journal_title：Genetics

authors： Allen AT,Maher KN,Wani KA,Betts KE,Chase DL

更新日期：2011-07-01 00:00:00

abstract：:The level of activity of the enzyme glucose-6-phosphate dehydrogenase was determinel in flies having seven different chromosomic constitutions. All those having an integral number of chromosomes [XAA, XXAA, XAAA, XXAAA, and XXXAAA (X=Xchromosome, A=set of autosomes)] were found to have similar units of enzyme activity...

journal_title：Genetics

authors： Maroni G,Plaut W

更新日期：1973-06-01 00:00:00

abstract：:In Drosophila melanogaster, the endogenous retrovirus gypsy is repressed by the functional alleles (restrictive) of an as-yet-uncloned heterochromatic gene called flamenco. Using gypsy-lacZ transcriptional fusions, we show here that this repression takes place not only in the follicle cells of restrictive ovaries, as ...

journal_title：Genetics

authors： Sarot E,Payen-Groschêne G,Bucheton A,Pélisson A

更新日期：2004-03-01 00:00:00

abstract：:We have studied the natural variation at microsatellite loci in two African and five non-African populations of Drosophila melanogaster. Ten dinucleotide simple sequence loci were cloned from chromosomally mapped P1 clones and typed for single individuals from isofemale lines of the respective populations. We find tha...

journal_title：Genetics

authors： Schlötterer C,Vogl C,Tautz D

更新日期：1997-05-01 00:00:00

abstract：:A major challenge in undergraduate life science curricula is the continual evaluation and development of courses that reflect the constantly shifting face of contemporary biological research. Synthetic biology offers an excellent framework within which students may participate in cutting-edge interdisciplinary researc...

journal_title：Genetics

authors： Dymond JS,Scheifele LZ,Richardson S,Lee P,Chandrasegaran S,Bader JS,Boeke JD

更新日期：2009-01-01 00:00:00

abstract：:All living organisms require nutrient minerals for growth and have developed mechanisms to acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment, these elements exist as charged ions that, together with protons and hydroxide ions, facilitate biochemical reactions and establish ...

journal_title：Genetics

authors： Cyert MS,Philpott CC

更新日期：2013-03-01 00:00:00

abstract：:The past century has seen substantial theoretical and empirical progress on the genetic basis of adaptation. Over this same period, a pressing need to prevent the evolution of drug resistance has uncovered much about the potential genetic basis of persistence in declining populations. However, we have little theory to...

journal_title：Genetics

authors： Osmond MM,Otto SP,Martin G

更新日期：2020-02-01 00:00:00

abstract：:Methodologies for mapping of genes underlying quantitative traits have advanced considerably but have not been accompanied by a parallel development of new population structures. We present a novel population consisting of 50 introgression lines (ILs) originating from a cross between the green-fruited species Lycopers...

journal_title：Genetics

authors： Eshed Y,Zamir D

更新日期：1995-11-01 00:00:00

abstract：:In response to an external source of adenine, yeast cells repress the expression of purine biosynthesis pathway genes. To identify necessary components of this signalling mechanism, we have isolated mutants that are constitutively active for expression. These mutants were named bra (for bypass of repression by adenine...

journal_title：Genetics

authors： Guetsova ML,Lecoq K,Daignan-Fornier B

更新日期：1997-10-01 00:00:00

abstract：:To reveal phenotypic and functional genomic patterns of mitonuclear adaptation, a laboratory adaptation study with Caenorhabditis elegans nematodes was conducted in which independently evolving lines were initiated from a low-fitness mitochondrial electron transport chain (ETC) mutant, gas-1 Following 60 generations o...

journal_title：Genetics

authors： Wernick RI,Christy SF,Howe DK,Sullins JA,Ramirez JF,Sare M,Penley MJ,Morran LT,Denver DR,Estes S

更新日期：2019-03-01 00:00:00

abstract：:Microtubules are dynamic structures that must elongate, disassemble, and be cleaved into smaller pieces for proper neuronal development and function. The AAA ATPase Spastin severs microtubules along their lengths and is thought to regulate the balance between long, stable filaments and shorter fragments that seed exte...

journal_title：Genetics

authors： Ozdowski EF,Gayle S,Bao H,Zhang B,Sherwood NT

更新日期：2011-09-01 00:00:00

abstract：:The RecQ helicase family is critical during DNA damage repair, and mutations in these proteins are associated with Bloom, Werner, or Rothmund-Thompson syndromes in humans, leading to cancer predisposition and/or premature aging. In the budding yeast Saccharomyces cerevisiae, mutations in the RecQ homolog, SGS1, phenoc...

journal_title：Genetics

authors： Bernstein KA,Mimitou EP,Mihalevic MJ,Chen H,Sunjaveric I,Symington LS,Rothstein R

更新日期：2013-12-01 00:00:00

abstract：:According to the ratchet mechanism hypothesis, deleterious mutations should accumulate in clonal genomes of unisexual fish of the genus Poeciliopsis. This study defines one such mutant, a silent carboxylesterase allele (ES-5 degrees) which is found in the heterozygous condition in a particular population of P. monacha...

journal_title：Genetics

authors： Spinella DG,Vrijenhoek RC

更新日期：1982-02-01 00:00:00

abstract：:Rodent inbred line crosses are widely used to map genetic loci associated with complex traits. This approach has proven to be powerful for detecting quantitative trait loci (QTL); however, the resolution of QTL locations, typically approximately 20 cM, means that hundreds of genes are implicated as potential candidate...

journal_title：Genetics

authors： Li R,Lyons MA,Wittenburg H,Paigen B,Churchill GA

更新日期：2005-03-01 00:00:00

abstract：:The Podospora anserina PaMpk1 MAP kinase (MAPK) signaling pathway can generate a cytoplasmic and infectious element resembling prions. When present in the cells, this C element causes the crippled growth (CG) cell degeneration. CG results from the inappropriate autocatalytic activation of the PaMpk1 MAPK pathway durin...

journal_title：Genetics

authors： Lalucque H,Malagnac F,Brun S,Kicka S,Silar P

更新日期：2012-06-01 00:00:00

abstract：:Isogenic lines, in which chromosomes sampled from natural populations of C. melanogaster are substituted into a common genetic background, were used to detect and partially characterize autosomal factors that affect the activities of the two pentose phosphate pathway enzymes, glucose 6-phosphate dehydrogenase (G6PD) a...

journal_title：Genetics

authors： Laurie-Ahlberg CC,Williamson JH,Cochrane BJ,Wilton AN,Chasalow FI

更新日期：1981-09-01 00:00:00

abstract：:When ultraviolet-irradiated bacteriophage T4 is assayed at plating temperatures ranging from 20 degrees to 40 degrees, its survival increases at the higher temperatures. This "thermal rescue" requires an intact WXY system but not the denV pyrimidine dimer excision system. Mutation rates decrease with increasing temper...

journal_title：Genetics

authors： Conkling MA,Drake JW

更新日期：1984-08-01 00:00:00

abstract：:Stem cells have a fascinating biology and offer great prospects for therapeutic applications, stimulating intense research on what controls their properties and behavior. Although there have been significant advances in our understanding of how local microenvironments, or niches, control the maintenance and activity o...

journal_title：Genetics

authors： Drummond-Barbosa D

更新日期：2008-12-01 00:00:00

abstract：:Divergent phenotypes are often detected in domesticated plants despite the existence of invariant phenotypes in their wild forms. One such example in rice is the occurrence of varying degrees of apiculus coloration due to anthocyanin pigmentation, which was previously reported to be caused by a series of alleles at th...

journal_title：Genetics

authors： Saitoh K,Onishi K,Mikami I,Thidar K,Sano Y

更新日期：2004-10-01 00:00:00

abstract：:We have found that temperature can have a striking effect upon protein export in Escherichia coli, suggesting that there is a cold-sensitive step in the protein export pathway. Cs mutations comprise the largest class of mutations affecting the membrane-localized Sec proteins SecD, SecE, SecF and SecY. Although some of...

journal_title：Genetics

authors： Pogliano KJ,Beckwith J

更新日期：1993-04-01 00:00:00

abstract：:Mutants of Salmonella typhimurium lacking DNA adenine methylase were isolated; they include insertion and deletion alleles. The dam locus maps at 75 min between cysG and aroB, similar to the Escherichia coli dam gene. Dam- mutants of S. typhimurium resemble those of E coli in the following phenotypes: (1) increased sp...

journal_title：Genetics

authors： Torreblanca J,Casadesús J

更新日期：1996-09-01 00:00:00

abstract：:Selection during evolution, whether natural or artificial, acts through the phenotype. For multifaceted phenotypes such as plant and inflorescence architecture, the underlying genetic architecture is comprised of a complex network of interacting genes rather than single genes that act independently to determine the tr...

journal_title：Genetics

authors： Studer AJ,Wang H,Doebley JF

更新日期：2017-10-01 00:00:00

abstract：:Chromosome 1A(m) of Triticum monococcum is closely homeologous to T. aestivum chromosome 1A but recombines with it little in the presence of the wheat suppressor of homeologous chromosome pairing, Ph1. In the absence of Ph1, the two chromosomes recombine as if they were completely homologous. Chromosomes having either...

journal_title：Genetics

authors： Luo MC,Dubcovsky J,Dvorák J

更新日期：1996-11-01 00:00:00

abstract：:Four species of the Hawaiian Drosophila planitibia subgroup which are homosequential in their polytene chromosomes are resident on the islands of Molokai, Maui and Hawaii. Comparisons of DNA sequence divergence in these four have been made by hybridization of total single-copy radiolabeled tracer DNA from each of the ...

journal_title：Genetics

authors： Hunt JA,Carson HL

更新日期：1983-06-01 00:00:00

abstract：:Gastrulation is fundamental to the development of multicellular animals. Along with neurulation, gastrulation is one of the major processes of morphogenesis in which cells or whole tissues move from the surface of an embryo to its interior. Cell internalization mechanisms that have been discovered to date in Caenorhab...

journal_title：Genetics

authors： Goldstein B,Nance J

更新日期：2020-02-01 00:00:00

abstract：:Previous mathematical analyses of mutation-selection balance for metric traits assume that selection acts on the relevant loci only through the character(s) under study. Thus, they implicitly assume that all of the relevant mutation and selection parameters are estimable. A more realistic analysis must recognize that ...

journal_title：Genetics

authors： Turelli M

更新日期：1985-09-01 00:00:00

abstract：:Expectations for the time scale and structure of allelic genealogies in finite populations are formed under three models of sporophytic self-incompatibility. The models differ in the dominance interactions among the alleles that determine the self-incompatibility phenotype: In the SSIcod model, alleles act codominantl...

journal_title：Genetics

authors： Schierup MH,Vekemans X,Christiansen FB

更新日期：1998-11-01 00:00:00

abstract：:We examined mutations that disrupt muscle activation in Caenorhabditis elegans. Fifteen of 17 of these genes were identified previously and we describe new mutations in three of them. We also describe mutations in two new genes, exp-3 and exp-4. We assessed the degree of defect in pharyngeal, body-wall, egg-laying, an...

journal_title：Genetics

authors： Reiner DJ,Weinshenker D,Thomas JH

更新日期：1995-11-01 00:00:00

abstract：:The first five steps in de novo purine biosynthesis are involved in the formation of the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. We show here that the first enzyme in de novo purine biosynthesis, PurF, is required for thiamine synthesis during aerobic growth on some but not other carbon s...

journal_title：Genetics

authors： Petersen L,Enos-Berlage J,Downs DM

更新日期：1996-05-01 00:00:00

abstract：:The Triplo-lethal locus (Tpl) is unique in its dosage sensitivity; no other locus in Drosophila has been identified that is lethal when present in three doses. Tpl is also haplo-lethal, and its function is still a mystery. Previous workers have found it nearly impossible to mutationally inactive Tpl other than by comp...

journal_title：Genetics

authors： Dorer DR,Christensen AC

更新日期：1990-08-01 00:00:00