Evidence for a piwi-dependent RNA silencing of the gypsy endogenous retrovirus by the Drosophila melanogaster flamenco gene.

abstract：:The contribution of epigenetic alterations to natural variation for gene transcription levels remains unclear. In this study, we investigated the functional targets of the maize chromomethylase ZMET2 in multiple inbred lines to determine whether epigenetic changes conditioned by this chromomethylase are conserved or v...

journal_title：Genetics

authors： Makarevitch I,Stupar RM,Iniguez AL,Haun WJ,Barbazuk WB,Kaeppler SM,Springer NM

更新日期：2007-10-01 00:00:00

abstract：:We have studied a genome-wide set of single-nucleotide polymorphism (SNP) allele frequency measures for African-American, East Asian, and European-American samples. For this analysis we derived a simple, closed mathematical formulation for the spectrum of expected allele frequencies when the sampled populations have e...

journal_title：Genetics

authors： Marth GT,Czabarka E,Murvai J,Sherry ST

更新日期：2004-01-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) are integral membrane proteins that initiate stimulus-dependent activation of cognate heterotrimeric G-proteins, triggering ensuing downstream cellular responses. Tight regulation of GPCR-evoked pathways is required because prolonged stimulation can be detrimental to an organism. St...

journal_title：Genetics

authors： Alvaro CG,Aindow A,Thorner J

更新日期：2016-05-01 00:00:00

abstract：:In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can bring together beneficial alleles from different backgrounds, but tightly linked ...

journal_title：Genetics

authors： Weissman DB,Hallatschek O

更新日期：2014-04-01 00:00:00

abstract：:Telomeric restriction fragments were genetically mapped to a previously described linkage map of Magnaporthe grisea, using RFLPs identified by a synthetic probe. (TTAGGG)3. Frequent rearrangement of telomeric sequences was observed in progeny isolates creating a potential for misinterpretation of data. Therefore a con...

journal_title：Genetics

authors： Farman ML,Leong SA

更新日期：1995-06-01 00:00:00

abstract：:Host variation in Toll-like receptors and other innate immune signaling molecules alters infection susceptibility. However, only a portion of the variability observed in the innate immune response is accounted for by known genes in these pathways. Thus, the identification of additional genes that regulate the response...

journal_title：Genetics

authors： Alper S,Warg LA,De Arras L,Flatley BR,Davidson EJ,Adams J,Smith K,Wohlford-Lenane CL,McCray PB Jr,Pedersen BS,Schwartz DA,Yang IV

更新日期：2016-09-01 00:00:00

abstract：:We reported previously that the product of the DNA damage-inducible gene of Saccharomyces cerevisiae, DIN7, belongs to a family of proteins that are involved in DNA repair and replication. The family includes S. cerevisiae proteins Rad2p and its human homolog XPGC, Rad27p and its mammalian homolog FEN-1, and Exonuclea...

journal_title：Genetics

authors： Fikus MU,Mieczkowski PA,Koprowski P,Rytka J,Sledziewska-Gójska E,Ciésla Z

更新日期：2000-01-01 00:00:00

abstract：:Prions have revived interest in hereditary change that is due to change in cellular structure. How pervasive is structural inheritance and what are its mechanisms? Described here is the initial characterization of [Leu(P)], a heritable structural change of the mitochondrion of Saccharomyces cerevisiae that often but n...

journal_title：Genetics

authors： Lockshon D

更新日期：2002-08-01 00:00:00

abstract：:Schizosaccharomyces pombe cells that contain a mutation within rad9 are sensitive to ionizing radiation, UV light and hydroxyurea, relative to wild-type strains. In addition, the mutants are moderately hypomutable by UV and unable to delay initiation of mitosis after treatment with radiation or hydroxyurea. Three radi...

journal_title：Genetics

authors： Lieberman HB

更新日期：1995-09-01 00:00:00

abstract：:Genetically marked P elements inserted into the subtelomeric satellites of Drosophila show repression and variegation of the reporter gene. One such white+ reporter, inserted between the subtelomeric satellite and the terminal HeT-A array in the left arm of chromosome 2 (2L), is sensitive to its context; changes in th...

journal_title：Genetics

authors： Golubovsky MD,Konev AY,Walter MF,Biessmann H,Mason JM

更新日期：2001-07-01 00:00:00

abstract：:A variety of Saccharomyces strains were examined for the presence of 2micro DNA and, if present, for the pattern of fragments produced by its digestion with site-specific (restriction) endonucleases. Two strains were found that did not contain detectable levels of 2micro DNA, and two strains contained 2micro DNA molec...

journal_title：Genetics

authors： Livingston DM

更新日期：1977-05-01 00:00:00

abstract：:Two sets of overlapping experiments were conducted to examine recombination and spontaneous mutation events within clusters of resistance genes in lettuce. Multiple generations were screened for recombinants using PCR-based markers flanking Dm3. The Dm3 region is not highly recombinagenic, exhibiting a recombination f...

journal_title：Genetics

authors： Chin DB,Arroyo-Garcia R,Ochoa OE,Kesseli RV,Lavelle DO,Michelmore RW

更新日期：2001-02-01 00:00:00

abstract：:Progress in understanding the evolution of variation at the MHC has been slowed by an inability to assess the relative roles of mutation vs. intragenic recombination in contributing to observed polymorphism. Recent theoretical advances now permit a quantitative treatment of the problem, with the result that the amount...

journal_title：Genetics

authors： Richman AD,Herrera LG,Nash D

更新日期：2003-05-01 00:00:00

abstract：:Identifying loci under natural selection from genomic surveys is of great interest in different research areas. Commonly used methods to separate neutral effects from adaptive effects are based on locus-specific population differentiation coefficients to identify outliers. Here we extend such an approach to estimate d...

journal_title：Genetics

authors： Foll M,Gaggiotti O

更新日期：2008-10-01 00:00:00

abstract：:Transposable element activity is repressed in the germline in animals by PIWI-interacting RNAs (piRNAs), a class of small RNAs produced by genomic loci mostly composed of TE sequences. The mechanism of induction of piRNA production by these loci is still enigmatic. We have shown that, in Drosophila melanogaster, a clu...

journal_title：Genetics

authors： Hermant C,Boivin A,Teysset L,Delmarre V,Asif-Laidin A,van den Beek M,Antoniewski C,Ronsseray S

更新日期：2015-12-01 00:00:00

abstract：:An exact sampling formula for a Wright-Fisher population of fixed size N under the infinitely many neutral alleles model is deduced. This extends the Ewens formula for the configuration of a random sample to the case where the sample is drawn from a population of small size, that is, without the usual large-N and smal...

journal_title：Genetics

authors： Lessard S

更新日期：2007-10-01 00:00:00

abstract：:Pigmentation is a rapidly evolving trait that can play important roles in mimicry, sexual selection, thermoregulation, and other adaptive processes in many groups of animals. In Drosophila, pigmentation can differ dramatically among closely related taxa, presenting a good opportunity to dissect the genetic changes und...

journal_title：Genetics

authors： Ng CS,Hamilton AM,Frank A,Barmina O,Kopp A

更新日期：2008-09-01 00:00:00

abstract：:Over one-third of human genome sequence is a product of non-LTR retrotransposition. The retrotransposon that currently drives this process in humans is the highly abundant LINE-1 (L1) element. Despite the ubiquitous nature of L1's in mammals, we still lack a complete mechanistic understanding of the L1 replication cyc...

journal_title：Genetics

authors： Dong C,Poulter RT,Han JS

更新日期：2009-01-01 00:00:00

abstract：:Movement of transposons causes insertions, deletions, and chromosomal rearrangements potentially leading to premature lethality in Drosophila melanogaster. To repress these elements and combat genomic instability, eukaryotes have evolved several small RNA-mediated defense mechanisms. Specifically, in Drosophila somati...

journal_title：Genetics

authors： Russo J,Harrington AW,Steiniger M

更新日期：2016-01-01 00:00:00

abstract：:The long terminal repeat retrotransposon, Magnaporthe gypsy-like element (MAGGY), has been shown to be targeted for cytosine methylation in a subset of Magnaporthe oryzae field isolates. Analysis of the F1 progeny from a genetic cross between methylation-proficient (Br48) and methylation-deficient (GFSI1-7-2) isolates...

journal_title：Genetics

authors： Ikeda K,Van Vu B,Kadotani N,Tanaka M,Murata T,Shiina K,Chuma I,Tosa Y,Nakayashiki H

更新日期：2013-11-01 00:00:00

abstract：:Selective genotyping and phenotyping strategies are used to lower the cost of quantitative trait locus studies. Their efficiency has been studied primarily in simplified contexts--when a single locus contributes to the phenotype, and when the residual error (phenotype conditional on the genotype) is normally distribut...

journal_title：Genetics

authors： Sen S,Johannes F,Broman KW

更新日期：2009-04-01 00:00:00

abstract：:Eukaryotic chromosome segregation requires a protein complex known as the kinetochore that mediates attachment between mitotic spindle microtubules and centromere-specific nucleosomes composed of the widely conserved histone variant CENP-A. Mutations in kinetochore proteins of the fission yeast Schizosaccharomyces pom...

journal_title：Genetics

authors： Gao C,Langbein L,Kamal F,George AA,Walworth NC

更新日期：2017-10-01 00:00:00

abstract：:Three sex-transforming genes (ix, tra-D, and dsx) in D. melanogaster were examined with respect to possible interactions with the NSR strain SR-spirochetes. The SR-spirochetes exerted a lethal effect on XY but not on XX individuals, regardless of whether they were phenotypically males, intersexes, or females. These re...

journal_title：Genetics

authors： Miyamoto C,Oishi K

更新日期：1975-01-01 00:00:00

abstract：:Wright's method of estimating the number of genes contributing to the difference in a quantitative character between two populations involves observing the means and variances of the two parental populations and their hybrid populations. Although simple, Wright's method provides seriously biased estimates, largely due...

journal_title：Genetics

authors： Zeng ZB

更新日期：1992-08-01 00:00:00

abstract：:In its hypermutable state, an unstable singed allele, sn(w), mutates in the germline to two other alleleic forms at a total frequency usually between 40 and 60%. In its stable state, the mutation rate of sn(w) is essentially zero. Its state depends on an extrachromosomal condition indistinguishable from a property cal...

journal_title：Genetics

authors： Engels WR

更新日期：1981-07-01 00:00:00

abstract：:Position effect variegation results from chromosome rearrangements which translocate euchromatic genes close to the heterochromatin. The euchromatin-heterochromatin association is responsible for the inactivation of these genes in some cell clones. In Drosophila melanogaster the Y chromosome, which is entirely heteroc...

journal_title：Genetics

authors： Dimitri P,Pisano C

更新日期：1989-08-01 00:00:00

abstract：:While bacteria divide clonally, horizontal gene transfer followed by homologous recombination is now recognized as an important contributor to their evolution. However, the details of how the competition between clonality and recombination shapes genome diversity remains poorly understood. Using a computational model,...

journal_title：Genetics

authors： Dixit PD,Pang TY,Maslov S

更新日期：2017-09-01 00:00:00

abstract：:Gametes are produced in plants through mitotic divisions in the haploid gametophytes. We investigated the role of EXPORTIN1 (XPO1) genes during the development of both female and male gametophytes of Arabidopsis. Exportins exclude target proteins from the nucleus and are also part of a complex recruited at the kinetoc...

journal_title：Genetics

authors： Blanvillain R,Boavida LC,McCormick S,Ow DW

更新日期：2008-11-01 00:00:00

abstract：:The RPS5 disease resistance gene of Arabidopsis mediates recognition of Pseudomonas syringae strains that possess the avirulence gene avrPphB. By screening for loss of RPS5-specified resistance, we identified five pbs (avrPphB susceptible) mutants that represent three different genes. Mutations in PBS1 completely bloc...

journal_title：Genetics

authors： Warren RF,Merritt PM,Holub E,Innes RW

更新日期：1999-05-01 00:00:00

abstract：:Gene duplication is arguably the most significant source of new functional genetic material. A better understanding of the processes that lead to the stable incorporation of gene duplications into the genome is important both because it relates to interspecific differences in genome composition and because it can shed...

journal_title：Genetics

authors： Proulx SR

更新日期：2012-02-01 00:00:00