Genetic and physical mapping of telomeres in the rice blast fungus, Magnaporthe grisea.

abstract：:Double-strand DNA breaks can be repaired by any of several alternative mechanisms that differ greatly in the nature of the final repaired products. We used a reporter construct, designated "Repair reporter 3" (Rr3), to measure the relative usage of these pathways in Drosophila germ cells. The method works by creating ...

journal_title：Genetics

authors： Preston CR,Flores CC,Engels WR

更新日期：2006-02-01 00:00:00

abstract：:The formation of the Aspergillus nidulans fruiting body is affected by a number of genetic and environmental factors. Here, the nsdC (never in sexual development) gene-encoding a putative transcription factor carrying a novel type of zinc-finger DNA-binding domain consisting of two C(2)H(2)'s and a C(2)HC motif that a...

journal_title：Genetics

authors： Kim HR,Chae KS,Han KH,Han DM

更新日期：2009-07-01 00:00:00

abstract：:Dopamine acts through two classes of G protein-coupled receptor (D1-like and D2-like) to modulate neuron activity in the brain. While subtypes of D1- and D2-like receptors are coexpressed in many neurons of the mammalian brain, it is unclear how signaling by these coexpressed receptors interacts to modulate the activi...

journal_title：Genetics

authors： Allen AT,Maher KN,Wani KA,Betts KE,Chase DL

更新日期：2011-07-01 00:00:00

abstract：:The adaptive character of inversion polymorphism in Drosophila subobscura is well established. The O(ST) and O(3+4) chromosomal arrangements of this species differ by two overlapping inversions that arose independently on O(3) chromosomes. Nucleotide variation in eight gene regions distributed along inversion O(3) was...

journal_title：Genetics

authors： Munté A,Rozas J,Aguadé M,Segarra C

更新日期：2005-03-01 00:00:00

abstract：:The binding of alpha-factor to its receptor (Ste2p) activates a G-protein-signaling pathway leading to conjugation of MATa cells of the budding yeast S. cerevisiae. We conducted a genetic screen to identify constitutively activating mutations in the N-terminal region of the alpha-factor receptor that includes transmem...

journal_title：Genetics

authors： Parrish W,Eilers M,Ying W,Konopka JB

更新日期：2002-02-01 00:00:00

abstract：:Metazoan genomes encode an abundant collection of mRNA-like, long noncoding (lnc)RNAs. Although lncRNAs greatly expand the transcriptional repertoire, we have a limited understanding of how these RNAs contribute to developmental regulation. Here, we investigate the function of the Drosophila lncRNA called yellow-achae...

journal_title：Genetics

authors： Soshnev AA,Ishimoto H,McAllister BF,Li X,Wehling MD,Kitamoto T,Geyer PK

更新日期：2011-10-01 00:00:00

abstract：:Several eukaryotic homologs of the Escherichia coli RecQ DNA helicase have been found. These include the human BLM gene, whose mutation results in Bloom syndrome, and the human WRN gene, whose mutation leads to Werner syndrome resembling premature aging. We cloned a Drosophila melanogaster homolog of the RECQ helicase...

journal_title：Genetics

authors： Kusano K,Berres ME,Engels WR

更新日期：1999-03-01 00:00:00

abstract：:Heparan sulfates (HS) are linear polysaccharides with complex modification patterns, which are covalently bound via conserved attachment sites to core proteins to form heparan sulfate proteoglycans (HSPGs). HSPGs regulate many aspects of the development and function of the nervous system, including cell migration, mor...

journal_title：Genetics

authors： Saied-Santiago K,Townley RA,Attonito JD,da Cunha DS,Díaz-Balzac CA,Tecle E,Bülow HE

更新日期：2017-08-01 00:00:00

abstract：:While evolution of coding sequences has been intensively studied, diversification of noncoding regulatory regions remains poorly understood. In this study, we investigated the molecular evolution of an enhancer region located 5 kb upstream of the transcription start site of the maize pericarp color1 (p1) gene. The p1 ...

journal_title：Genetics

authors： Zhang F,Peterson T

更新日期：2006-10-01 00:00:00

abstract：:Regulation of transcription can be a complex process in which many cis- and trans-interactions determine the final pattern of expression. Among these interactions are trans-interactions mediated by the pairing of homologous chromosomes. These trans-effects are wide ranging, affecting gene regulation in many species an...

journal_title：Genetics

authors： Lum TE,Merritt TJ

更新日期：2011-11-01 00:00:00

abstract：:We present here a molecular analysis of the region surrounding the structural gene encoding alcohol dehydrogenase (Adh) in 47 lines of Drosophila melanogaster that have each accumulated mutations for 300 generations. While these lines show a significant increase in variation of alcohol dehydrogenase enzyme activity co...

journal_title：Genetics

authors： Aquadro CF,Tachida H,Langley CH,Harada K,Mukai T

更新日期：1990-12-01 00:00:00

abstract：:Gene silencing by heterochromatin is a well-known phenomenon that, in Drosophila, is called position effect variegation (PEV). The long-held hypothesis that this gene silencing is associated with an altered chromatin structure received direct support only recently. Another gene-silencing phenomenon in Drosophila, alth...

journal_title：Genetics

authors： Boivin A,Dura JM

更新日期：1998-12-01 00:00:00

abstract：:A point connecting a pair of homologous regions of DNA duplexes moves along the homology in a reaction intermediate of the homologous recombination. Formulating this movement as a random walk, we were previously successful at explaining the dependence of the recombination frequency on the homology length. Recently, th...

journal_title：Genetics

authors： Fujitani Y,Kobayashi I

更新日期：1999-12-01 00:00:00

abstract：:Fisher's geometric model was originally introduced to argue that complex adaptations must occur in small steps because of pleiotropic constraints. When supplemented with the assumption of additivity of mutational effects on phenotypic traits, it provides a simple mechanism for the emergence of genotypic epistasis from...

journal_title：Genetics

authors： Hwang S,Park SC,Krug J

更新日期：2017-06-01 00:00:00

abstract：:A subset of cancers rely on telomerase-independent mechanisms to maintain their chromosome ends. The predominant "alternative lengthening of telomeres" pathway appears dependent on homology-directed repair (HDR) to maintain telomeric DNA. However, the molecular changes needed for cells to productively engage in telome...

journal_title：Genetics

authors： Hu Y,Bennett HW,Liu N,Moravec M,Williams JF,Azzalin CM,King MC

更新日期：2019-10-01 00:00:00

abstract：:A scheme for rapidly mapping chromosome rearrangements relative to the physical map of Caenorhabditis elegans is described that is based on hybridization patterns of cloned DNA on meiotic nuclei, as visualized by fluorescent in situ hybridization. From the nearly complete physical map, DNA clones, in yeast artificial ...

journal_title：Genetics

authors： Albertson DG

更新日期：1993-05-01 00:00:00

abstract：:The sex-ratio trait described in several Drosophila species is a type of naturally occurring X-linked meiotic drive that causes males bearing a sex-ratio X chromosome to produce progenies with a large excess of females. We have previously reported the occurrence of sex-ratio X chromosomes in Drosophila simulans. In th...

journal_title：Genetics

authors： Cazemajor M,Landré C,Montchamp-Moreau C

更新日期：1997-10-01 00:00:00

abstract：:Mitomycin C (MMC) is a genotoxic agent that induces DNA cross-links, DNA alkylation, and the production of reactive oxygen species (ROS). MMC induces the SOS response and RpoS regulons in Escherichia coli SOS-encoded functions are required for DNA repair, whereas the RpoS regulon is typically induced by metabolic stre...

journal_title：Genetics

authors： Dapa T,Fleurier S,Bredeche MF,Matic I

更新日期：2017-07-01 00:00:00

abstract：:Because some metabolic intermediates are involved in more than one pathway, crosstalk between pathways is crucial to maintaining homeostasis. AMP and histidine biosynthesis pathways are coregulated at the transcriptional level in response to adenine availability. 5'-Phosphoribosyl-4-carboxamide-5-aminoimidazole (AICAR...

journal_title：Genetics

authors： Rébora K,Laloo B,Daignan-Fornier B

更新日期：2005-05-01 00:00:00

abstract：:A cut was made on the middorsal skin of newborn mice of strains C57BL/10J, C57BL/10J-A/A, and C3H/He using fine iridectomy scissors. In the epidermis within 1 mm of the wound edge in C57BL/10J and C57BL/10J-A/A, the melanocyte population positive to the dopa reaction as well as the melanoblast-melanocyte population po...

journal_title：Genetics

authors： Hirobe T

更新日期：1988-10-01 00:00:00

abstract：:Salient features of recombination at ARG4 of Saccharomyces provoke a variation of the double-strand-break repair (DSBR) model that has the following features: (1) Holliday junction cutting is biased in favor of strands upon which DNA synthesis occurred during formation of the joint molecule (this bias ensures that cut...

journal_title：Genetics

authors： Foss HM,Hillers KJ,Stahl FW

更新日期：1999-10-01 00:00:00

abstract：:Translation of the chloroplast psbC mRNA in the unicellular eukaryotic alga Chlamydomonas reinhardtii is controlled by interactions between its 547-base 5' untranslated region and the products of the nuclear loci TBC1, TBC2, and possibly TBC3. In this study, a series of site-directed mutations in this region was gener...

journal_title：Genetics

authors： Zerges W,Auchincloss AH,Rochaix JD

更新日期：2003-03-01 00:00:00

abstract：:The large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here we test whether the compositional variation is due to mutation bias using two new tests, which do not assume composition...

journal_title：Genetics

authors： Lercher MJ,Smith NG,Eyre-Walker A,Hurst LD

更新日期：2002-12-01 00:00:00

abstract：:The yeast pheromone/filamentous growth MAPK pathway mediates both mating and invasive-growth responses. The interface between this MAPK module and the transcriptional machinery consists of a network of two MAPKs, Fus3 and Kss1; two regulators, Rst1 and Rst2 (a.k.a. Dig1 and Dig2); and two transcription factors, Ste12 ...

journal_title：Genetics

authors： Breitkreutz A,Boucher L,Breitkreutz BJ,Sultan M,Jurisica I,Tyers M

更新日期：2003-11-01 00:00:00

abstract：:We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and h...

journal_title：Genetics

authors： Durrett RT,Chen KY,Tanksley SD

更新日期：2002-01-01 00:00:00

abstract：:The rdgB mutants depend on recombinational repair of double-strand breaks. To assess other consequences of rdgB inactivation in Escherichia coli, we isolated RdgB-dependent mutants. All transposon inserts making cells dependent on RdgB inactivate genes of double-strand break repair, indicating that chromosomal fragmen...

journal_title：Genetics

authors： Lukas L,Kuzminov A

更新日期：2006-02-01 00:00:00

abstract：:Fifty-eight isochromosomal lines sampled from two natural populations of Drosophila pseudoobscura in California and one from Bogota, Colombia, were examined using four-cutter restriction mapping. A 4.6-kb region of the xanthine dehydrogenase locus was probed and 66 of 135 restriction sites scored were polymorphic. Thi...

journal_title：Genetics

authors： Riley MA,Hallas ME,Lewontin RC

更新日期：1989-10-01 00:00:00

abstract：:Estimating the fixation probability of a beneficial mutation has a rich history in theoretical population genetics. Typically, to attain mathematical tractability, we assume that generation times are fixed, while the number of offspring per individual is stochastic. However, fixation probabilities are extremely sensit...

journal_title：Genetics

authors： Hubbarde JE,Wild G,Wahl LM

更新日期：2007-07-01 00:00:00

abstract：:In lytic cycle crosses with Red-Gam-lambda phage, particles were examined that had undergone an Int-mediated exchange. It was assumed that this exchange dimerized the circular lambda, making it packageable. Among these Int-mediated recombinants, particles were identified that had, in addition, enjoyed a close double e...

journal_title：Genetics

authors： Stahl FW,Lieb M,Stahl MM

更新日期：1984-12-01 00:00:00

abstract：:Trichome development in Arabidopsis thaliana is a well-characterized model for the study of plant cell differentiation. Two genes that play an essential role in the initiation of trichome development are GL1 and TTG. Mutations in either gene prevent the initiation of most trichomes. The GL1 gene encodes a myb-related ...

journal_title：Genetics

authors： Larkin JC,Walker JD,Bolognesi-Winfield AC,Gray JC,Walker AR

更新日期：1999-04-01 00:00:00