A simple formula useful for positional cloning.

abstract：:The allozymic variation at at the esterase-6 locus examined in fourteen samples of natural populations of Drosophila simulans collected in two different localities. The samples were collected from different species of fruits in the two localities and from banana baits located some meters apart from the fruits. The ana...

journal_title：Genetics

authors： de Albuquerque CM,Napp M

更新日期：1981-06-01 00:00:00

abstract：:Genic variation in natural populations of Drosophila simulans was surveyed using allozymic and two-dimensional electrophoretic techniques. Consistent with some previous reports, allozymic heterozygosity appeared lower than in the sibling species D. melanogaster (0.07 vs. 0.16). No variation was detected by two-dimensi...

journal_title：Genetics

authors： Ohnishi S,Leigh Brown AJ,Voelker RA,Langley CH

更新日期：1982-01-01 00:00:00

abstract：:Vertebrate retrotransposons have been used extensively for phylogenetic analyses and studies of molecular evolution. Information can be obtained from specific inserts either by comparing sequence differences that have accumulated over time in orthologous copies of that insert or by determining the presence or absence ...

journal_title：Genetics

authors： Cantrell MA,Filanoski BJ,Ingermann AR,Olsson K,DiLuglio N,Lister Z,Wichman HA

更新日期：2001-06-01 00:00:00

abstract：:This study concerns the problem of odor receptor gene choice in the fruit fly Drosophila melanogaster. From a family of 60 Odor receptor genes, only one or a small number are selected for expression by each olfactory receptor neuron. Little is known about how an olfactory receptor neuron selects a receptor, or how the...

journal_title：Genetics

authors： Miller CJ,Carlson JR

更新日期：2010-09-01 00:00:00

abstract：:A long-standing prediction in evolutionary biology is that organisms experience a so-called "cost of complexity" manifested as a decreasing rate of adaptation in populations as organisms or selective environments become increasingly complex. This theory assumes the ubiquity of antagonistic pleiotropy, or trade-offs in...

journal_title：Genetics

authors： Sackman AM,Rokyta DR

更新日期：2019-05-01 00:00:00

abstract：:During the first weeks of human immunodeficiency virus-1 (HIV-1) infection, cytotoxic T-lymphocytes (CTLs) select for multiple escape mutations in the infecting HIV population. In recent years, methods that use escape mutation data to estimate rates of HIV escape have been developed, thereby providing a quantitative f...

journal_title：Genetics

authors： Leviyang S

更新日期：2013-07-01 00:00:00

abstract：:During segmentation of vertebrate embryos, somites form in accordance with a periodic pattern established by the segmentation clock. In the zebrafish (Danio rerio), the segmentation clock includes six hairy/enhancer of split-related (her/hes) genes, five of which oscillate due to negative autofeedback. The nonoscillat...

journal_title：Genetics

authors： Schwendinger-Schreck J,Kang Y,Holley SA

更新日期：2014-06-01 00:00:00

abstract：:The contribution of mismatch repair to genetic recombination in T4 phage has been evaluated by three independent approaches: (1) testing for non-additivity of recombinant frequencies; (2) measurements of double exchange frequencies in three-factor crosses: (3) comparisons of recombination abilities of mutations occupy...

journal_title：Genetics

authors： Shcherbakov VP,Plugina LA,Kudryashova EA,Efremova OI,Sizova ST,Toompuu OG

更新日期：1982-12-01 00:00:00

abstract：:Of 313 motility-deficient mutants isolated from an LT2 his(amber) strain fixed in phase 1 by gene vh2(-), 25 regained motility when amber or ochre suppressors were introduced, in F' factors or by transduction. The fla mutants (23 amber, 1 ochre) fell in complementation groups A, B, C, F, K, a new group, M, and at leas...

journal_title：Genetics

authors： Vary PS,Stocker BA

更新日期：1973-02-01 00:00:00

abstract：:Four maternal-effect sterile genes, mes-2, mes-3, mes-4, and mes-6, are essential for germline development in Caenorhabditis elegans. Homozygous mes progeny from heterozygous mothers are themselves fertile but produce sterile progeny with underproliferated and degenerated germlines. All four mes genes encode chromatin...

journal_title：Genetics

authors： Xu L,Strome S

更新日期：2001-11-01 00:00:00

abstract：:Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of meiotic recombination have been proposed. These models differ in the arrangement of heteroduplex DNA (hDNA) in recombination ...

journal_title：Genetics

authors： Radford SJ,Sabourin MM,McMahan S,Sekelsky J

更新日期：2007-05-01 00:00:00

abstract：:The Drosophila PS1 and PS2 integrins are required to maintain the connection between the dorsal and ventral wing epithelia. If alphaPS subunits are inappropriately expressed during early pupariation, the epithelia separate, causing a wing blister. Two lines of evidence indicate that this apparent loss-of-function phen...

journal_title：Genetics

authors： Baker SE,Lorenzen JA,Miller SW,Bunch TA,Jannuzi AL,Ginsberg MH,Perkins LA,Brower DL

更新日期：2002-09-01 00:00:00

abstract：:Various measures have been proposed for characterizing the statistical association that arises between alleles at different loci. Hedrick has compared these measures with the standardized measure D' proposed by Lewontin on the grounds that this latter measure is independent of allele frequency. Although D' has the sam...

journal_title：Genetics

authors： Lewontin RC

更新日期：1988-11-01 00:00:00

abstract：:How many genes contribute to reproductive isolation between closely related species? We determined the number of genes located in the 9D-12B region of the Drosophila mauritiana X chromosome that cause hybrid male sterility in a D. simulans background. Previous low resolution studies suggested that a single hybrid ster...

journal_title：Genetics

authors： Davis AW,Wu CI

更新日期：1996-07-01 00:00:00

abstract：:Schizosaccharomyces pombe cells that contain a mutation within rad9 are sensitive to ionizing radiation, UV light and hydroxyurea, relative to wild-type strains. In addition, the mutants are moderately hypomutable by UV and unable to delay initiation of mitosis after treatment with radiation or hydroxyurea. Three radi...

journal_title：Genetics

authors： Lieberman HB

更新日期：1995-09-01 00:00:00

abstract：:Nucleostemin 3 (NS3) is an evolutionarily conserved protein with profound roles in cell growth and viability. Here we analyze cell-autonomous and non-cell-autonomous growth control roles of NS3 in Drosophila and demonstrate its GTPase activity using genetic and biochemical assays. Two null alleles of ns3, and RNAi, de...

journal_title：Genetics

authors： Hartl TA,Ni J,Cao J,Suyama KL,Patchett S,Bussiere C,Gui DY,Tang S,Kaplan DD,Fish M,Johnson AW,Scott MP

更新日期：2013-05-01 00:00:00

abstract：:Electron microscope serial section reconstruction analysis of all zygotene-pachytene nuclei of meiotic cells from three wild-type germaria (a subunit of the ovary containing the early meiotic stages arrayed in temporal developmental sequence) of Drosophila melanogaster females corroborates and extends earlier observat...

journal_title：Genetics

authors： Carpenter AT

更新日期：1979-06-01 00:00:00

abstract：:We report the isolation, characterization and analysis of the small subunit rRNA genes in Plasmodium cynomolgi (Ceylon). As in other Plasmodium species, these genes are present in low copy number, are unlinked and form two types that are distinct in sequence and are expressed stage specifically. The asexually expresse...

journal_title：Genetics

authors： Corredor V,Enea V

更新日期：1994-03-01 00:00:00

abstract：:Centric regions of eukaryotic genomes are packaged into heterochromatin, which possesses the ability to spread along the chromosome and silence gene expression. The process of spreading has been challenging to study at the molecular level due to repetitious sequences within centric regions. A heterochromatin protein 1...

journal_title：Genetics

authors： Hines KA,Cryderman DE,Flannery KM,Yang H,Vitalini MW,Hazelrigg T,Mizzen CA,Wallrath LL

更新日期：2009-08-01 00:00:00

abstract：:Mutants resistant to selenomethionine were isolated, and their properties studied. Mapping studies indicate that the mutation sites are located near the eth-1(r) locus in linkage group I, about ten map units away from the mating type locus. The sites of new mutation are either allelic to or very close to eth-1(r). The...

journal_title：Genetics

authors： Chen GS,Metzenberg RL

更新日期：1974-08-01 00:00:00

abstract：:We have precisely mapped and sequenced the three 5' exons of the Drosophila melanogaster Gld gene and have identified the start sites for transcription and translation. The first exon is composed of 335 nucleotides and does not contain any putative translation start codons. The second exon is separated from the first ...

journal_title：Genetics

authors： Whetten R,Organ E,Krasney P,Cox-Foster D,Cavener D

更新日期：1988-10-01 00:00:00

abstract：:The Drosophila mei-S332 gene acts to maintain sister-chromatid cohesion before anaphase II of meiosis in both males and females. By isolating and analyzing seven new alleles and a deficiency uncovering the mei-S332 gene we have demonstrated that the onset of the requirement for mei-S332 is not until late anaphase I. A...

journal_title：Genetics

authors： Kerrebrock AW,Miyazaki WY,Birnby D,Orr-Weaver TL

更新日期：1992-04-01 00:00:00

abstract：:The small subunit ribosomal RNA gene (srDNA) has been used extensively for phylogenetic analyses. One common assumption in these analyses is that substitution rates are biased toward transitions. We have developed a simple method for estimating relative rates of base change that does not assume rate constancy and take...

journal_title：Genetics

authors： Vawter L,Brown WM

更新日期：1993-06-01 00:00:00

abstract：:The range of possible gene interactions in a multilocus model of a complex inherited disease is studied by exploring genotype-specific risks subject to the constraint that the allele frequencies and marginal risks are known. We quantify the effect of gene interactions by defining the interaction ratio, CR=KR/KRI, wher...

journal_title：Genetics

authors： Song YS,Wang F,Slatkin M

更新日期：2010-12-01 00:00:00

abstract：:To identify in vivo pathways that compensate for impaired proliferating cell nuclear antigen (PCNA or Pol30p in yeast) activity, we performed a synthetic lethal screen with the yeast pol30-104 mutation. We identified nine mutations that display synthetic lethality with pol30-104; three mutations affected the structura...

journal_title：Genetics

authors： Merrill BJ,Holm C

更新日期：1998-02-01 00:00:00

abstract：:At pH 6.8, a substantial fraction of recombinant colonies obtained from conjugation with an HfrH donor contained multiple recombinant classes in a single colony (polygenotype colony). In contrast, when the conjugation was performed at pH 7.6, the number of polygenotypic colonies was drastically reduced, and the recomb...

journal_title：Genetics

authors： Ou JT

更新日期：1975-07-01 00:00:00

abstract：:The larval body wall muscles of Drosophila melanogaster arise by fusion of founder myoblasts (FMs) and fusion-competent myoblasts (FCMs). Sticks-and-Stones (SNS) is expressed on the surface of all FCMs and mediates adhesion with FMs and developing syncytia. Intracellular components essential for myoblast fusion are th...

journal_title：Genetics

authors： Kocherlakota KS,Wu JM,McDermott J,Abmayr SM

更新日期：2008-03-01 00:00:00

abstract：:We define a new gene, SRD1, involved in the processing of pre-rRNA to mature rRNA. The SRD1 gene was identified by selecting for second-site suppressors of the previously described rrp1-1 mutation. The rrp1-1 mutation causes temperature-sensitive growth, a conditional defect in processing of 27S pre-rRNA to mature 25S...

journal_title：Genetics

authors： Fabian GR,Hess SM,Hopper AK

更新日期：1990-03-01 00:00:00

abstract：:Chromosomal double-strand breaks (DSBs) that have only one end with homology to a donor duplex undergo repair by strand invasion followed by replication to the chromosome terminus (break-induced replication, BIR). Using a transformation-based assay system, it was previously shown that BIR could occur by several rounds...

journal_title：Genetics

authors： Stafa A,Donnianni RA,Timashev LA,Lam AF,Symington LS

更新日期：2014-04-01 00:00:00

abstract：:Whole-mount fluorescence in situ hybridization (FISH) was applied to Arabidopsis thaliana seedlings to determine the three-dimensional (3D) interphase chromosome territory (CT) arrangement and heterochromatin location within the positional context of entire tissues or in particular cell types of morphologically well-p...

journal_title：Genetics

authors： Berr A,Schubert I

更新日期：2007-06-01 00:00:00