Effects of SR-spirochete infection on Drosophila melanogaster carrying intersex genes.

abstract：:Progress in understanding the evolution of variation at the MHC has been slowed by an inability to assess the relative roles of mutation vs. intragenic recombination in contributing to observed polymorphism. Recent theoretical advances now permit a quantitative treatment of the problem, with the result that the amount...

journal_title：Genetics

authors： Richman AD,Herrera LG,Nash D

更新日期：2003-05-01 00:00:00

abstract：:The maize ligule is an adaxial membranous structure on the leaf that develops at the boundary of the sheath and blade. The ligule and the associated auricle are dispensable structures, amenable to genetic manipulation. We present here a genetic analysis of liguleless1 (lg1) and liguleless2 (lg2), the two genes known t...

journal_title：Genetics

authors： Harper L,Freeling M

更新日期：1996-12-01 00:00:00

abstract：:The distribution of fitness effects (DFE) of new mutations is of fundamental importance in evolutionary genetics. Recently, methods have been developed for inferring the DFE that use information from the allele frequency distributions of putatively neutral and selected nucleotide polymorphic variants in a population s...

journal_title：Genetics

authors： Schneider A,Charlesworth B,Eyre-Walker A,Keightley PD

更新日期：2011-12-01 00:00:00

abstract：:NudC encodes a protein of unknown biochemical function that is required for nuclear migration. In an attempt to define its function by identifying interacting proteins, a screen for extragenic suppressors of the temperature-sensitive nudC3 mutation was undertaken that identified nine snc genes. Here we demonstrate tha...

journal_title：Genetics

authors： Chiu YH,Morris NR

更新日期：1997-03-01 00:00:00

abstract：:Inverted DNA repeats are an at-risk motif for genetic instability that can induce both deletions and recombination in yeast. We investigated the role of the length of inverted repeats and size of the DNA separating the repeats for deletion and recombination. Stimulation of both deletion and recombination was directly ...

journal_title：Genetics

authors： Lobachev KS,Shor BM,Tran HT,Taylor W,Keen JD,Resnick MA,Gordenin DA

更新日期：1998-04-01 00:00:00

abstract：:To test genetic recombination in the vicinity of insertions of the transposon Tn5, crosses were performed by transduction between M. xanthus strains carrying different insertions of Tn5. One member of each pair carried resistance to kanamycin (Tn5-Km); the other carried resistance to tetracycline (Tn5-Tc). The distanc...

journal_title：Genetics

authors： Sodergren E,Cheng Y,Avery L,Kaiser D

更新日期：1983-10-01 00:00:00

abstract：:A laboratory strain of Drosophila pseudoobscura (L116) is studied that, when crossed to sex-ratio homozygous females, produces sons that exhibit varying levels of the male sex-ratio (msr) phenotype. The msr phenotype occurs only in sex-ratio males and is due to the production of a high frequency of nullo-XY sperm. The...

journal_title：Genetics

authors： Cobbs G

更新日期：1986-06-01 00:00:00

abstract：:A novel fine structure mapping method for quantitative traits is presented. It is based on Bayesian modeling and inference, treating the number of quantitative trait loci (QTLs) as an unobserved random variable and using ideas similar to composite interval mapping to account for the effects of QTLs in other chromosome...

journal_title：Genetics

authors： Sillanpää MJ,Arjas E

更新日期：1998-03-01 00:00:00

abstract：:In this work we study how mutations that change physical properties of cell proteins (stability) affect population survival and growth. We present a model in which the genotype is presented as a set folding free energies of cell proteins. Mutations occur upon replication, so stabilities of some proteins in daughter ce...

journal_title：Genetics

authors： Chen P,Shakhnovich EI

更新日期：2009-10-01 00:00:00

abstract：:Fifty-eight isochromosomal lines sampled from two natural populations of Drosophila pseudoobscura in California and one from Bogota, Colombia, were examined using four-cutter restriction mapping. A 4.6-kb region of the xanthine dehydrogenase locus was probed and 66 of 135 restriction sites scored were polymorphic. Thi...

journal_title：Genetics

authors： Riley MA,Hallas ME,Lewontin RC

更新日期：1989-10-01 00:00:00

abstract：:A large offspring-number diploid biparental multilocus population model of Moran type is our object of study. At each time step, a pair of diploid individuals drawn uniformly at random contributes offspring to the population. The number of offspring can be large relative to the total population size. Similar "heavily ...

journal_title：Genetics

authors： Birkner M,Blath J,Eldon B

更新日期：2013-01-01 00:00:00

abstract：:The polarized partitioning of proteins in cells underlies asymmetric cell division, which is an important driver of development and cellular diversity. The budding yeast Saccharomyces cerevisiae divides asymmetrically, like many other cells, to generate two distinct progeny cells. A well-known example of an asymmetric...

journal_title：Genetics

authors： Herrero E,Stinus S,Bellows E,Berry LK,Wood H,Thorpe PH

更新日期：2020-11-01 00:00:00

abstract：:Knowledge of the rate and fitness effects of mutations is essential for understanding the process of evolution. Mutations are inherently difficult to study because they are rare and are frequently eliminated by natural selection. In the ciliate Tetrahymena thermophila, mutations can accumulate in the germline genome w...

journal_title：Genetics

authors： Long HA,Paixão T,Azevedo RB,Zufall RA

更新日期：2013-10-01 00:00:00

abstract：:This report examines five different naturally occurring alcohol dehydrogenase-1 alleles via the recombinational behavior of Adh1(-) mutants induced within them. Twenty-two biochemically characterized Adh1(-) mutants have been assessed for ability to recombine intragenically, using data generated by specifically staini...

journal_title：Genetics

authors： Freeling M

更新日期：1978-05-01 00:00:00

abstract：:Mutations in the SPT10 and SPT21 genes were originally isolated as suppressors of Ty and LTR (delta) insertion mutations in Saccharomyces cerevisiae, and the genes were shown to be required for normal transcription at a number of loci in yeast. Now we have cloned, sequenced, mapped and mutagenized SPT10 and SPT21. Sin...

journal_title：Genetics

authors： Natsoulis G,Winston F,Boeke JD

更新日期：1994-01-01 00:00:00

abstract：:Host mutations in Escherichia coli K12 selected for the temperature-sensitive replication of the bacterial plasmid colicinogenic factor E(1) (ColE(1)) exhibit a pleiotropic effect with respect to the effect of the mutation on other extra-chromosomal elements. The mutations also vary with respect to the time of incubat...

journal_title：Genetics

authors： Kingsbury DT,Sieckmann DG,Helinski DR

更新日期：1973-05-01 00:00:00

abstract：:As an ancient segmental tetraploid, the maize (Zea mays L.) genome contains large numbers of paralogs that are expected to have diverged by a minimum of 10% over time. Nearly identical paralogs (NIPs) are defined as paralogous genes that exhibit > or = 98% identity. Sequence analyses of the "gene space" of the maize i...

journal_title：Genetics

authors： Emrich SJ,Li L,Wen TJ,Yandeau-Nelson MD,Fu Y,Guo L,Chou HH,Aluru S,Ashlock DA,Schnable PS

更新日期：2007-01-01 00:00:00

abstract：:From the analysis of restriction maps of the Amy region in eight sibling species belonging to the Drosophila melanogaster species subgroup, we herein show that the patterns of duplication of the Amy gene are almost the same in all species. This indicates that duplication occurred before speciation within this species ...

journal_title：Genetics

authors： Shibata H,Yamazaki T

更新日期：1995-09-01 00:00:00

abstract：:Genomic imprinting is well known as a regulatory property of a few specific chromosomal regions and leads to differential behavior of maternally and paternally inherited alleles. We surveyed the activity of two reporter genes in 23 independent P-element insertions on the heterochromatic Y chromosome of Drosophila mela...

journal_title：Genetics

authors： Maggert KA,Golic KG

更新日期：2002-11-01 00:00:00

abstract：:Mutants of Neurospora crassa have been isolated that lack the repressible alkaline phosphatase, but, unlike nuc-1 and nuc-2 mutants, are able to make the repressible acid phosphatase and the repressible phosphate permease under conditions of derepression (phosphate deprivation). The new mutants, called pho-2, map in L...

journal_title：Genetics

authors： Gleason MK,Metzenberg RL

更新日期：1974-10-01 00:00:00

abstract：:Many heterogametic organisms adjust sex chromosome expression to accommodate differences in gene dosage. This requires selective recruitment of regulatory factors to the modulated chromosome. How these factors are localized to a chromosome with requisite accuracy is poorly understood. Drosophila melanogaster males inc...

journal_title：Genetics

authors： Deshpande N,Meller VH

更新日期：2018-08-01 00:00:00

abstract：:Paramecium has long been a model eukaryote. The sequence of the Paramecium tetraurelia genome reveals a history of three successive whole-genome duplications (WGDs), and the sequences of P. biaurelia and P. sexaurelia suggest that these WGDs are shared by all members of the aurelia species complex. Here, we present th...

journal_title：Genetics

authors： McGrath CL,Gout JF,Doak TG,Yanagi A,Lynch M

更新日期：2014-08-01 00:00:00

abstract：:We describe a method for co-estimating r = C/mu (where C is the per-site recombination rate and mu is the per-site neutral mutation rate) and Theta = 4N(e)mu (where N(e) is the effective population size) from a population sample of molecular data. The technique is Metropolis-Hastings sampling: we explore a large numbe...

journal_title：Genetics

authors： Kuhner MK,Yamato J,Felsenstein J

更新日期：2000-11-01 00:00:00

abstract：:Yeast cells subjected to a reversible thermal arrest of meiosis yielded progressively fewer spores per ascus as the arrest was extended. Dissection of two-spored asci by a newly developed method that prevents selection of false asci revealed that the spores were not a random sample of the haploid meiotic products. Mos...

journal_title：Genetics

authors： Davidow LS,Goetsch L,Byers B

更新日期：1980-03-01 00:00:00

abstract：:High-throughput sequencing and bioinformatic techniques have enhanced classical genetic analysis and are essential methods for geneticists. Tsukamoto and colleagues use numerous genomic and bioinformatics methods to explore the role of ribonucleoprotein complexes in regulating oocyte meiotic maturation, which is the t...

journal_title：Genetics

authors： Thurtle-Schmidt D,Lo TW

更新日期：2018-07-01 00:00:00

abstract：:Lethal and sterility mutations were accumulated in a cage population which was initiated with lethal- and sterility-free second chromosomes of D. melanogaster. It took about 2,000 days for the frequencies of these genes to reach equilibrium levels, i.e., 18% lethal and 9% male-sterile chromosomes. Two other cage popul...

journal_title：Genetics

authors： Lee WH,Watanabe TK

更新日期：1977-07-01 00:00:00

abstract：:Three previously described genes, enhancer of yellow, 1, 2 and 3, are shown to cooperate with the zeste gene in the control of white gene expression. The mutations e(y)1u1, e(y)3u1, and to a lesser extent e(y)2u1, enhance the effect of the zeste null allele zv77h. Different combinations of e(y)1u1, e(y)2u1 and e(y)3u1...

journal_title：Genetics

authors： Georgiev PG

更新日期：1994-11-01 00:00:00

abstract：:Understanding the initiation of meiosis and the relationship of this event with other key cytogenetic processes are major goals in studying the genetic control of meiosis in higher plants. Our genetic and structural analysis of two mutant alleles of the ameiotic1 gene (am1 and am1-praI) suggest that this locus plays a...

journal_title：Genetics

authors： Golubovskaya I,Grebennikova ZK,Avalkina NA,Sheridan WF

更新日期：1993-12-01 00:00:00

abstract：:We have previously isolated mutants of Escherichia coli that replicate their DNA with increased fidelity. These mutants have a mutation in the dnaE gene, encoding the alpha subunit of DNA polymerase III. They were isolated in a mismatch-repair-defective mutL background, in which mutations can be considered to represen...

journal_title：Genetics

authors： Oller AR,Schaaper RM

更新日期：1994-10-01 00:00:00

abstract：:The SUF13 and SUF14 genes were identified among extragenic suppressors of +1 frameshift mutations. SUF13 is synonymous with MBF1, a single-copy nonessential gene coding for a POLII transcription factor. The suf13-1 mutation is a two-nucleotide deletion in the SUF13/MBF1 coding region. A suf13::TRP1 null mutant suppres...

journal_title：Genetics

authors： Hendrick JL,Wilson PG,Edelman II,Sandbaken MG,Ursic D,Culbertson MR

更新日期：2001-03-01 00:00:00