The Y chromosome of Drosophila melanogaster exhibits chromosome-wide imprinting.

abstract：:Predicting the chromosomal location of mapped markers has been difficult because linkage maps do not reveal differences in crossover frequencies along the physical structure of chromosomes. Here we combine a physical crossover map based on the distribution of recombination nodules (RNs) on Solanum lycopersicum (tomato...

journal_title：Genetics

authors： Chang SB,Anderson LK,Sherman JD,Royer SM,Stack SM

更新日期：2007-08-01 00:00:00

abstract：:Dravet syndrome is a developmental epileptic encephalopathy caused by pathogenic variation in SCN1A To characterize the pathogenic substitution (p.H939R) of a local individual with Dravet syndrome, fibroblast cells from the individual were reprogrammed to pluripotent stem cells and differentiated into neurons. Sodium ...

journal_title：Genetics

authors： Dyment DA,Schock SC,Deloughery K,Tran MH,Ure K,Nutter LMJ,Creighton A,Yuan J,Banderali U,Comas T,Baumann E,Jezierski A,Care4Rare Canada Consortium,.,Boycott KM,Mackenzie AE,Martina M

更新日期：2020-08-01 00:00:00

abstract：:The satellite DNA's from the embryos of five species of Drosophila (D. melanogaster, D. simulans, D. nasuta, D. virilis and D. hydei) have been analyzed for the presence of closed circular duplex DNA molecules, as determined by CsCl-EBr gradients. Circular DNA molecules were found in every species but D. melanogaster....

journal_title：Genetics

authors： Travaglini EC,Schultz J

更新日期：1972-11-01 00:00:00

abstract：:The Drosophila melanogaster sex-peptide (melSP) is a seminal fluid component that induces postmating responses (PMR) of females via the sex-peptide receptor (SPR) . Although SP orthologs are found in many Drosophila species, their functions remain poorly characterized. It is unknown whether SP functions are conserved ...

journal_title：Genetics

authors： Tsuda M,Peyre JB,Asano T,Aigaki T

更新日期：2015-08-01 00:00:00

abstract：:Nonallelic gene conversion has been proposed as a major force in homogenizing the sequences of paralogous genes. In this work, we investigate the extent and characteristics of gene conversion among gene families in nine species of the genus Drosophila. We carried out a genome-wide study of 2855 gene families (includin...

journal_title：Genetics

authors： Casola C,Ganote CL,Hahn MW

更新日期：2010-05-01 00:00:00

abstract：:The neurogenic loci comprise a small group of genes which are required for proper division between the neural and epidermal pathways of differentiation within the neuroectoderm. Loss of neurogenic gene function results in the misrouting of prospective epidermal cells into neuroblasts. A molecular analysis of the neuro...

journal_title：Genetics

authors： Yedvobnick B,Smoller D,Young P,Mills D

更新日期：1988-03-01 00:00:00

abstract：:Genetic studies of multidimensional phenotypes can potentially link genetic variation, gene expression, and physiological data to create multi-scale models of complex traits. The challenge of reducing these data to specific hypotheses has become increasingly acute with the advent of genome-scale data resources. Multi-...

journal_title：Genetics

authors： Tyler AL,Ji B,Gatti DM,Munger SC,Churchill GA,Svenson KL,Carter GW

更新日期：2017-06-01 00:00:00

abstract：:Animal microRNAs (miRNA) are implicated in the control of nearly all cellular functions. Due to high sequence redundancy within the miRNA gene pool, loss of most of these 21- to 24-bp long RNAs individually does not cause a phenotype. Thus, only very few miRNAs have been associated with clear functional roles. We cons...

journal_title：Genetics

authors： Schertel C,Rutishauser T,Förstemann K,Basler K

更新日期：2012-12-01 00:00:00

abstract：:We demonstrate the involvement of suppressor of meiotic silencing-2 (sms-2(+)), a Neurospora gene coding for an Argonaute-like protein, in meiotic silencing and normal sexual development. ...

journal_title：Genetics

authors： Lee DW,Pratt RJ,McLaughlin M,Aramayo R

更新日期：2003-06-01 00:00:00

abstract：:Bonus, a Drosophila TIF1 homolog, is a nuclear receptor cofactor required for viability, molting, and numerous morphological events. Here we establish a role for Bonus in the modulation of chromatin structure. We show that weak loss-of-function alleles of bonus have a more deleterious effect on males than on females. ...

journal_title：Genetics

authors： Beckstead RB,Ner SS,Hales KG,Grigliatti TA,Baker BS,Bellen HJ

更新日期：2005-02-01 00:00:00

abstract：:Bacteriophages are the most abundant biological entities in our biosphere, characterized by their hyperplasticity, mosaic composition, and the many unknown functions (ORFans) encoded by their immense genetic repertoire. These genes are potentially maintained by the bacteriophage to allow efficient propagation on hosts...

journal_title：Genetics

authors： Ang D,Georgopoulos C

更新日期：2012-03-01 00:00:00

abstract：:Individual inbreeding and historical demography can be estimated by analyzing runs of homozygosity (ROH), which are indicative of chromosomal segments of identity by descent (IBD). Such analyses have so far been rare in natural populations due to limited genomic resources. We analyzed ROH in whole genome sequences fro...

journal_title：Genetics

authors： Kardos M,Qvarnström A,Ellegren H

更新日期：2017-03-01 00:00:00

abstract：:The standard approaches to estimation of quantitative genetic parameters and prediction of response to selection on quantitative traits are based on theory derived for populations undergoing random mating. Many studies demonstrate, however, that mating systems in natural populations often involve inbreeding in various...

journal_title：Genetics

authors： Shaw RG,Byers DL,Shaw FH

更新日期：1998-12-01 00:00:00

abstract：:We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering approximately 77% of the Release 5.1 genome. Using a previously reported collection of FRT-bearing P-element insertions, we have generated 655 new deletions and verifi...

journal_title：Genetics

authors： Ryder E,Ashburner M,Bautista-Llacer R,Drummond J,Webster J,Johnson G,Morley T,Chan YS,Blows F,Coulson D,Reuter G,Baisch H,Apelt C,Kauk A,Rudolph T,Kube M,Klimm M,Nickel C,Szidonya J,Maróy P,Pal M,Rasmuson-Lestan

更新日期：2007-09-01 00:00:00

abstract：:We present a two-layer hidden Markov model to detect the structure of haplotypes for unrelated individuals. This allows us to model two scales of linkage disequilibrium (one within a group of haplotypes and one between groups), thereby taking advantage of rich haplotype information to infer local ancestry of admixed i...

journal_title：Genetics

authors： Guan Y

更新日期：2014-03-01 00:00:00

abstract：:Two Podospora mutants carrying mutations modE and modF were persumed to be quiescent defective, because, when grown under glucose limitation, they differed from the wild-type strain in an excess of dry weight production and a reduction of cell survival. New insight on the action of modE and modF mutations was provided...

journal_title：Genetics

authors： Durrens P,Bernet J

更新日期：1985-01-01 00:00:00

abstract：:COTRANS is a program for analyzing cotransduction data. It calculates distances from pairwise cotransduction frequencies, computes crossovers required to obtain each observed recombinant class, and applies rules to draw conclusions about order. The rules are based on the correlation between the frequency of the classe...

journal_title：Genetics

authors： Berlyn MB,Letovsky S

更新日期：1992-05-01 00:00:00

abstract：:Cyclic guanosine monophosphate (cGMP) is a key secondary messenger used in signal transduction in various types of sensory neurons. The importance of cGMP in the ASE gustatory receptor neurons of the nematode Caenorhabditis elegans was deduced by the observation that multiple receptor-type guanylyl cyclases (rGCs), en...

journal_title：Genetics

authors： Smith HK,Luo L,O'Halloran D,Guo D,Huang XY,Samuel AD,Hobert O

更新日期：2013-08-01 00:00:00

abstract：:Gametes are produced in plants through mitotic divisions in the haploid gametophytes. We investigated the role of EXPORTIN1 (XPO1) genes during the development of both female and male gametophytes of Arabidopsis. Exportins exclude target proteins from the nucleus and are also part of a complex recruited at the kinetoc...

journal_title：Genetics

authors： Blanvillain R,Boavida LC,McCormick S,Ow DW

更新日期：2008-11-01 00:00:00

abstract：:A recent sperm-typing study by Jeffreys and Neumann suggested that recombination rates in different individuals at the DNA2 recombination hotspot appeared to be highly dependent on their genotype at a particular A/G SNP, FG11. Specifically, individuals who carried at least one copy of the A allele at this SNP exhibite...

journal_title：Genetics

authors： Hellenthal G,Pritchard JK,Stephens M

更新日期：2006-03-01 00:00:00

abstract：:We describe here a family of P elements that we refer to as type I repressors. These elements are identified by their repressor functions and their lack of any deletion within the first two-thirds of the canonical P sequence. Elements belonging to this repressor class were isolated from P strains and were made in vitr...

journal_title：Genetics

authors： Gloor GB,Preston CR,Johnson-Schlitz DM,Nassif NA,Phillis RW,Benz WK,Robertson HM,Engels WR

更新日期：1993-09-01 00:00:00

abstract：:We have characterized Unstable factor for orange1 (Ufo1), a dominant, allele-specific modifier of expression of the maize pericarp color1 (p1) gene. The p1 gene encodes an Myb-homologous transcriptional activator of genes required for biosynthesis of red phlobaphene pigments. The P1-wr allele specifies colorless kerne...

journal_title：Genetics

authors： Chopra S,Cocciolone SM,Bushman S,Sangar V,McMullen MD,Peterson T

更新日期：2003-03-01 00:00:00

abstract：:Strains of Dictyostelium discoideum resistant to cobaltous chloride have been isolated at a frequency of approximately 10(-6). The resistant strains have one of three phenotypes, recessive to wild type, dominant to wild type and dominant to wild type but requiring the presence of cobaltous chloride to maintain resista...

journal_title：Genetics

authors： Williams KL

更新日期：1978-09-01 00:00:00

abstract：:Mounting evidence suggests that natural populations can harbor extensive fitness diversity with numerous genomic loci under selection. It is also known that genealogical trees for populations under selection are quantifiably different from those expected under neutral evolution and described statistically by Kingman's...

journal_title：Genetics

authors： Dayarian A,Shraiman BI

更新日期：2014-07-01 00:00:00

abstract：:We have analyzed two variants of Drosophila melanogaster (RS and RE) which lead to the dual phenotype of elevated DDC activity and increased resistance to dietary alpha-methyldopa relative to Oregon-R controls. Both phenotypes show tight genetic linkage to the dopa decarboxylase, Ddc, and l(2)amd genes (i.e., less tha...

journal_title：Genetics

authors： Marsh JL,Wright TR

更新日期：1986-02-01 00:00:00

abstract：:Critically shortened telomeres can be subjected to DNA repair events that generate end-to-end chromosome fusions. The resulting dicentric chromosomes can enter breakage-fusion-bridge cycles, thereby impeding elucidation of the structures of the initial fusion events and a mechanistic understanding of their genesis. Cu...

journal_title：Genetics

authors： Lowden MR,Meier B,Lee TW,Hall J,Ahmed S

更新日期：2008-10-01 00:00:00

abstract：:The allozymic variation at at the esterase-6 locus examined in fourteen samples of natural populations of Drosophila simulans collected in two different localities. The samples were collected from different species of fruits in the two localities and from banana baits located some meters apart from the fruits. The ana...

journal_title：Genetics

authors： de Albuquerque CM,Napp M

更新日期：1981-06-01 00:00:00

abstract：:A coalescent theory for a sample of DNA sequences from a partially selfing diploid population and an algorithm for simulating such samples are developed in this article. Approximate formulas are given for the expectation and the variance of the number of segregating sites in a sample of k sequences from n individuals....

journal_title：Genetics

authors： Fu YX

更新日期：1997-08-01 00:00:00

abstract：:The maize r locus encodes a transcription factor that regulates the developmental expression of the plant pigment anthocyanin. In an unusual example of gene regulatory diversity, the R-sc (Sc, strong seed color) and the R-p (P, plant color) alleles of r have nonoverlapping tissue specificity and nonhomologous 5' flank...

journal_title：Genetics

authors： Li Y,Bernot JP,Illingworth C,Lison W,Bernot KM,Eggleston WB,Fogle KJ,DiPaola JE,Kermicle J,Alleman M

更新日期：2001-12-01 00:00:00

abstract：:An SSR-based linkage map was constructed in Brassica rapa. It includes 113 SSR, 87 RFLP, and 62 RAPD markers. It consists of 10 linkage groups with a total distance of 1005.5 cM and an average distance of 3.7 cM. SSRs are distributed throughout the linkage groups at an average of 8.7 cM. Synteny between B. rapa and a ...

journal_title：Genetics

authors： Suwabe K,Tsukazaki H,Iketani H,Hatakeyama K,Kondo M,Fujimura M,Nunome T,Fukuoka H,Hirai M,Matsumoto S

更新日期：2006-05-01 00:00:00