Molecular analysis of the neurogenic locus mastermind of Drosophila melanogaster.

abstract：:The type and frequency of simple sequence repeats (SSRs) in plant genomes was investigated using the expanding quantity of DNA sequence data deposited in public databases. In Arabidopsis, 306 genomic DNA sequences longer than 10 kb and 36,199 EST sequences were searched for all possible mono- to pentanucleotide repeat...

journal_title：Genetics

authors： Cardle L,Ramsay L,Milbourne D,Macaulay M,Marshall D,Waugh R

更新日期：2000-10-01 00:00:00

abstract：:Many complex human traits exhibit differences between sexes. While numerous factors likely contribute to this phenomenon, growing evidence from genome-wide studies suggest a partial explanation: that males and females from the same population possess differing genetic architectures. Despite this, mapping gene-by-sex (...

journal_title：Genetics

authors： Funkhouser SA,Vazquez AI,Steibel JP,Ernst CW,Los Campos G

更新日期：2020-05-01 00:00:00

abstract：:The human pathogen Candida albicans is considered an obligate commensal of animals, yet it is occasionally isolated from trees, shrubs, and grass. We generated genome sequence data for three strains of C. albicans that we isolated from oak trees in an ancient wood pasture, and compared these to the genomes of over 200...

journal_title：Genetics

authors： Bensasson D,Dicks J,Ludwig JM,Bond CJ,Elliston A,Roberts IN,James SA

更新日期：2019-01-01 00:00:00

abstract：:The RPS5 disease resistance gene of Arabidopsis mediates recognition of Pseudomonas syringae strains that possess the avirulence gene avrPphB. By screening for loss of RPS5-specified resistance, we identified five pbs (avrPphB susceptible) mutants that represent three different genes. Mutations in PBS1 completely bloc...

journal_title：Genetics

authors： Warren RF,Merritt PM,Holub E,Innes RW

更新日期：1999-05-01 00:00:00

abstract：:The gilthead sea bream (Sparus aurata L.) is a marine fish of great importance for fisheries and aquaculture. It has also a peculiar sex-determination system, being a protandrous hermaphrodite. Here we report the construction of a first-generation genetic linkage map for S. aurata, based on 204 microsatellite markers....

journal_title：Genetics

authors： Franch R,Louro B,Tsalavouta M,Chatziplis D,Tsigenopoulos CS,Sarropoulou E,Antonello J,Magoulas A,Mylonas CC,Babbucci M,Patarnello T,Power DM,Kotoulas G,Bargelloni L

更新日期：2006-10-01 00:00:00

abstract：:Environmental toxicants are chemicals that negatively affect human health. Although there are numerous ways to limit exposure, the ubiquitous nature of certain environmental toxicants makes it impossible to avoid them entirely. Consequently, scientists are continuously working toward developing strategies for combatin...

journal_title：Genetics

authors： Bradford BR,Briand NE,Fassnacht N,Gervasio ED,Nowakowski AM,FitzGibbon TC,Maurina S,Benjamin AV,Kelly M,Checchi PM

更新日期：2020-12-01 00:00:00

abstract：:Establishing durable disease resistance in agricultural crops, where much of the plant defense is provided through effector-R gene interactions, is complicated by the ability of pathogens to overcome R gene resistance by losing the corresponding effector gene. Many proposed methods to maintain disease resistance in th...

journal_title：Genetics

authors： Wichmann G,Bergelson J

更新日期：2004-02-01 00:00:00

abstract：:This study concerns the problem of odor receptor gene choice in the fruit fly Drosophila melanogaster. From a family of 60 Odor receptor genes, only one or a small number are selected for expression by each olfactory receptor neuron. Little is known about how an olfactory receptor neuron selects a receptor, or how the...

journal_title：Genetics

authors： Miller CJ,Carlson JR

更新日期：2010-09-01 00:00:00

abstract：:The RecQ helicase family is critical during DNA damage repair, and mutations in these proteins are associated with Bloom, Werner, or Rothmund-Thompson syndromes in humans, leading to cancer predisposition and/or premature aging. In the budding yeast Saccharomyces cerevisiae, mutations in the RecQ homolog, SGS1, phenoc...

journal_title：Genetics

authors： Bernstein KA,Mimitou EP,Mihalevic MJ,Chen H,Sunjaveric I,Symington LS,Rothstein R

更新日期：2013-12-01 00:00:00

abstract：:MCM (minichromosome maintenance) proteins function as a replication licensing factor (RLF-M), which contributes to limiting initiation of DNA replication to once per cell cycle. In the present study we show that a truncation of the pol II CTD in a S. cerevisiae strain harboring a mutation in mcm5 partially reverses it...

journal_title：Genetics

authors： Gauthier L,Dziak R,Kramer DJ,Leishman D,Song X,Ho J,Radovic M,Bentley D,Yankulov K

更新日期：2002-11-01 00:00:00

abstract：:Damaged DNA-binding proteins 1 and 2 (DDB1 and DDB2) are subunits of the damaged DNA-binding protein complex (DDB). DDB1 is also found in the same complex as DE-ETIOLATED 1 (DET1), a negative regulator of light-mediated responses in plants. Arabidopsis has two DDB1 homologs, DDB1A and DDB1B. ddb1a single mutants have ...

journal_title：Genetics

authors： Al Khateeb WM,Schroeder DF

更新日期：2007-05-01 00:00:00

abstract：:Use of the CRISPR/Cas9 RNA-guided endonuclease complex has recently enabled the generation of double-strand breaks virtually anywhere in the C. elegans genome. Here, we present an improved strategy that makes all steps in the genome editing process more efficient. We have created a toolkit of template-mediated repair ...

journal_title：Genetics

authors： Norris AD,Kim HM,Colaiácovo MP,Calarco JA

更新日期：2015-10-01 00:00:00

abstract：:Mutants of Paramecium caudatum with abnormal swimming behavior or responses to cations were obtained by mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. Some of the mutants, like pawn in P. tetraurelia, cannot swim backward and are called CNR. Seven independently obtained CNR mutants belonged to three complement...

journal_title：Genetics

authors： Takahashi M

更新日期：1979-03-01 00:00:00

abstract：:Putzig (Pzg) was originally identified as being an integral component of the TRF2/DREF complex in Drosophila melanogaster, thereby regulating the transcriptional activation of replication-related genes. In a DREF-independent manner, Pzg was shown to mediate Notch target gene activation. This function of Pzg entails an...

journal_title：Genetics

authors： Kugler SJ,Gehring EM,Wallkamm V,Krüger V,Nagel AC

更新日期：2011-05-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are secreted signaling molecules that control important developmental events in many different organisms. Previous studies have shown that BMPs are expressed at the earliest stages of skeletal development, and are required for formation of specific skeletal features, strongly suggest...

journal_title：Genetics

authors： DiLeone RJ,Russell LB,Kingsley DM

更新日期：1998-01-01 00:00:00

abstract：:Phenoxazinone synthetase, which catalyzes the condensation of 3-hydroxykynurenine to xanthommatin, the brown eye pigment of Drosophila, is shown to exist in association with a particle which resembles the cytologically defined Type I pigment granule. Several classical eye color mutants (v, cn, st, ltd, cd, w), includi...

journal_title：Genetics

authors： Phillips JP,Forrest HS,Kulkarni AD

更新日期：1973-01-01 00:00:00

abstract：:To further understand how the nematode Caenorhabditis elegans defends itself against pathogen attack, we analyzed enhanced pathogen resistance (epr) mutants obtained from a forward genetic screen. We also examined several well-characterized sterile mutants that exhibit an Epr phenotype. We found that sterility and pat...

journal_title：Genetics

authors： Miyata S,Begun J,Troemel ER,Ausubel FM

更新日期：2008-02-01 00:00:00

abstract：:Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...

journal_title：Genetics

authors： Bruinsma JJ,Schneider DL,Davis DE,Kornfeld K

更新日期：2008-06-01 00:00:00

abstract：:Translation of the chloroplast psbC mRNA in the unicellular eukaryotic alga Chlamydomonas reinhardtii is controlled by interactions between its 547-base 5' untranslated region and the products of the nuclear loci TBC1, TBC2, and possibly TBC3. In this study, a series of site-directed mutations in this region was gener...

journal_title：Genetics

authors： Zerges W,Auchincloss AH,Rochaix JD

更新日期：2003-03-01 00:00:00

abstract：:Injury triggers regeneration of axons and dendrites. Research has identified factors required for axonal regeneration outside the CNS, but little is known about regeneration triggered by dendrotomy. Here, we study neuronal plasticity triggered by dendrotomy and determine the fate of complex PVD arbors following laser ...

journal_title：Genetics

authors： Oren-Suissa M,Gattegno T,Kravtsov V,Podbilewicz B

更新日期：2017-05-01 00:00:00

abstract：:Mating behavior in adult male nematodes can be assayed by mating efficiency, i.e., the number of cross progeny sired by males under standard conditions. Mutant males from 220 strains, representing most of the known complementation groups of C. elegans, have been examined for mating efficiency and for anatomical abnorm...

journal_title：Genetics

authors： Hodgkin J

更新日期：1983-01-01 00:00:00

abstract：:The evolutionary processes governing variability within genomic regions of low recombination have been the focus of many studies. Here, I investigate the statistical properties of a measure of interlocus genetic associations under the assumption that mutations are selectively neutral and sites are completely linked. T...

journal_title：Genetics

authors： Kelly JK

更新日期：1997-07-01 00:00:00

abstract：:The existence of temporally stable frequency clines for In(2L)t in natural populations of Drosophila melanogaster suggests a role for selection in the maintenance of this polymorphism. We have collected nucleotide polymorphism data from the proximal breakpoint junction regions of In(2L)t to infer its evolutionary hist...

journal_title：Genetics

authors： Andolfatto P,Wall JD,Kreitman M

更新日期：1999-11-01 00:00:00

abstract：:A leucine, leucyl-tRNA synthetase-dependent pathway activates TorC1 kinase and its downstream stimulation of protein synthesis, a major nitrogen consumer. We previously demonstrated, however, that control of Gln3, a transcription activator of catabolic genes whose products generate the nitrogenous precursors for prote...

journal_title：Genetics

authors： Tate JJ,Rai R,Cooper TG

更新日期：2015-02-01 00:00:00

abstract：:In this paper we study the process of allele frequency change in finite populations with overlapping generations with the purpose of evaluating the possibility of estimating the effective size from observations of temporal frequency shifts of selectively neutral alleles. Focusing on allele frequency changes between su...

journal_title：Genetics

authors： Jorde PE,Ryman N

更新日期：1995-02-01 00:00:00

abstract：:We examined the inheritance of allelic variation at an isozyme locus, MDH-B, duplicated by ancestral polyploidy in salmonid fishes. We detected only disomic segregation in females. Segregation ratios in males were best explained by a mixture of disomic and tetrasomic inheritance. We propose a two-stage model of pairin...

journal_title：Genetics

authors： Allendorf FW,Danzmann RG

更新日期：1997-04-01 00:00:00

abstract：:Studies in the fly, Drosophila melanogaster, have revealed that several signaling pathways are important for the regulation of growth. Among these, the insulin receptor/phosphoinositide 3-kinase (PI3K) pathway is remarkable in that it affects growth and final size without disturbing pattern formation. We have used a s...

journal_title：Genetics

authors： Coelho CM,Kolevski B,Walker CD,Lavagi I,Shaw T,Ebert A,Leevers SJ,Marygold SJ

更新日期：2005-10-01 00:00:00

abstract：:Preliminary studies with restriction fragment length polymorphisms of mitochondrial DNA (mtDNA) in natural populations of Drosophila melanogaster revealed considerable variation in terms of nucleotide sequence and overall size. In this report we present data from more isofemale lines and more restriction enzymes, and ...

journal_title：Genetics

authors： Hale LR,Singh RS

更新日期：1991-09-01 00:00:00

abstract：:The Mre11/Rad50/Nbs1 (MRN) complex is required for eukaryotic DNA double-strand break (DSB) repair and meiotic recombination. We cloned the Coprinus cinereus rad50 gene and showed that it corresponds to the complementation group previously named rad12, identified mutations in 15 rad50 alleles, and mapped two of the mu...

journal_title：Genetics

authors： Acharya SN,Many AM,Schroeder AP,Kennedy FM,Savytskyy OP,Grubb JT,Vincent JA,Friedle EA,Celerin M,Maillet DS,Palmerini HJ,Greischar MA,Moncalian G,Williams RS,Tainer JA,Zolan ME

更新日期：2008-12-01 00:00:00

abstract：:Arabidopsis seedlings repair UV-induced DNA damage via light-dependent and independent pathways. The mechanism of the "dark repair" pathway is still unknown. To determine the number of genes required for dark repair and to investigate the substrate-specificity of this process we isolated mutants with enhanced sensitiv...

journal_title：Genetics

authors： Jiang CZ,Yen CN,Cronin K,Mitchell D,Britt AB

更新日期：1997-11-01 00:00:00