Bonus, a Drosophila TIF1 homolog, is a chromatin-associated protein that acts as a modifier of position-effect variegation.

abstract：:The L1 family of single-pass transmembrane cell adhesion molecules (L1CAMs) is conserved from Caenorhabditis elegans and Drosophila to vertebrates and is required for axon guidance, neurite outgrowth, and maintenance of neuronal positions. The extracellular region of L1CAMs mediates cell adhesion via interactions with...

journal_title：Genetics

authors： Zhou S,Opperman K,Wang X,Chen L

更新日期：2008-11-01 00:00:00

abstract：:If multiple linked polymorphisms are under natural selection, then conflicts arise and the efficiency of natural selection is hindered relative to the case of no linkage. This simple interaction between linkage and natural selection creates an opportunity for mutations that raise the level of recombination to increase...

journal_title：Genetics

authors： Hey J

更新日期：1998-08-01 00:00:00

abstract：:The prion-like behavior of Sup35p, the eRF3 homolog in the yeast Saccharomyces cerevisiae, mediates the activity of the cytoplasmic nonsense suppressor known as [PSI(+)]. Sup35p is divided into three regions of distinct function. The N-terminal and middle (M) regions are required for the induction and propagation of [...

journal_title：Genetics

authors： Jensen MA,True HL,Chernoff YO,Lindquist S

更新日期：2001-10-01 00:00:00

abstract：:The heterotrimeric G protein Gq regulates neuronal activity through distinct downstream effector pathways. In addition to the canonical Gq effector phospholipase Cβ, the small GTPase Rho was recently identified as a conserved effector of Gq. To identify additional molecules important for Gq signaling in neurons, we pe...

journal_title：Genetics

authors： Coleman B,Topalidou I,Ailion M

更新日期：2018-06-01 00:00:00

abstract：:Nonrandom associations between alleles at different loci can be tested for using Fisher's exact test. Extensive simulations show that there is a substantial probability of obtaining significant nonrandom associations between closely or completely linked polymorphic neutral loci in a population of constant size at equi...

journal_title：Genetics

authors： Slatkin M

更新日期：1994-05-01 00:00:00

abstract：:The translation elongation factor EF-Tu is a GTPase that delivers amino-acylated tRNAs to the ribosome during the elongation step of translation. EF-Tu/GDP is recycled by the guanine nucleotide exchange factor EF-Ts. Whereas EF-Ts is lacking in S. cerevisiae, both translation factors are found in S. pombe and H. sapie...

journal_title：Genetics

authors： Chiron S,Suleau A,Bonnefoy N

更新日期：2005-04-01 00:00:00

abstract：:Equilibria are determined for the two-locus model in a partially selfing population when one locus is neutral and the other locus is heterotic. At an equilibrium point, the frequency of heterozygotes at the neutral locus is greater than that expected from one-locus theory, even if the heterotic locus is on a different...

journal_title：Genetics

authors： Strobeck C

更新日期：1979-05-01 00:00:00

abstract：:We describe allelic variation at 28 gene loci in natural populations of D. willistoni. Seventy samples were studied from localities extending from Mexico and Florida, through Central America, the West Indies, and tropical South America, down to South Brazil. At least several hundred, and often several thousand, genome...

journal_title：Genetics

authors： Ayala FJ,Powell JR,Tracey ML,Mourão CA,Pérez-Salas S

更新日期：1972-01-01 00:00:00

abstract：:During animal development, transcription factor activities are modulated by several means, including subcellular localization. The Hox cofactor Extradenticle (Exd) has a dynamic subcellular localization, such that Exd is cytoplasmic by default, but is nuclear when complexed with another homeodomain protein, Homothorax...

journal_title：Genetics

authors： Stevens KE,Mann RS

更新日期：2007-04-01 00:00:00

abstract：:Studies of genetic variation at allozyme loci, assumed to be selectively neutral, have provided valuable insights into the genetic structure of numerous populations. The degree to which population structure of allozyme variation reflects that of quantitative traits, however, is not well resolved. Here, we compare esti...

journal_title：Genetics

authors： Podolsky RH,Holtsford TP

更新日期：1995-06-01 00:00:00

abstract：:The initiation of postembryonic cell divisions by the gonadal precursors of C. elegans requires the activity of gon-2. gon-2 encodes a predicted cation channel (GON-2) of the TRPM subfamily of TRP proteins and is likely to mediate the influx of Ca(2+) and/or Mg(2+). We report here that mutations in gem-4 (gon-2 extrag...

journal_title：Genetics

authors： Church DL,Lambie EJ

更新日期：2003-10-01 00:00:00

abstract：:Mating type interconversion in Saccharomyces cerevisiae occurs by transposition of copies of the a or alpha mating type cassettes from inactive loci, HML and HMR, to an active locus, MAT. The lack of expression of the a and alpha genes at the silent loci results from repression by trans-acting regulators encoded by SI...

journal_title：Genetics

authors： Rine J,Herskowitz I

更新日期：1987-05-01 00:00:00

abstract：:In finite populations, an allele disappears or reaches fixation due to two main forces, selection and drift. Selection is generally thought to accelerate the process: a selected mutation will reach fixation faster than a neutral one, and a disadvantageous one will quickly disappear from the population. We show that ev...

journal_title：Genetics

authors： Mafessoni F,Lachmann M

更新日期：2015-12-01 00:00:00

abstract：:A previously employed method that uses the composition of noncoding DNA as the basis of a test for selection between synonymous codons in plastid genes is reevaluated. The test requires the assumption that in the absence of selective differences between synonymous codons the composition of silent sites in coding seque...

journal_title：Genetics

authors： Morton BR

更新日期：2001-09-01 00:00:00

abstract：:Genetic analysis of 131 independent transpositions of the tetracycline-resistance element Tn10 from a single site in phage P22 into the histidine operon of Salmonella typhimurium reveals that Tn10 insertions are not randomly distributed along this chromosomal target. The insertions occur in 22 different "clusters"; in...

journal_title：Genetics

authors： Kleckner N,Steele DA,Reichardt K,Botstein D

更新日期：1979-08-01 00:00:00

abstract：:Sxl appears to head a regulatory gene hierarchy that controls Drosophila sexual dimorphism in response to the X chromosome/autosome balance. Only XXAA cells normally have Sxl(+) activity. It maintains both the female morphogenetic sequence and a level of X-linked dosage-compensated gene expression compatible with dipl...

journal_title：Genetics

authors： Cline TW

更新日期：1984-06-01 00:00:00

abstract：:PGM plays a central role in the glycolytic pathway at the branch point leading to glycogen metabolism and is highly polymorphic in allozyme studies of many species. We have characterized the nucleotide diversity across the Pgm gene in Drosophila melanogaster and D. simulans to investigate the role that protein polymor...

journal_title：Genetics

authors： Verrelli BC,Eanes WF

更新日期：2000-12-01 00:00:00

abstract：:The type and frequency of simple sequence repeats (SSRs) in plant genomes was investigated using the expanding quantity of DNA sequence data deposited in public databases. In Arabidopsis, 306 genomic DNA sequences longer than 10 kb and 36,199 EST sequences were searched for all possible mono- to pentanucleotide repeat...

journal_title：Genetics

authors： Cardle L,Ramsay L,Milbourne D,Macaulay M,Marshall D,Waugh R

更新日期：2000-10-01 00:00:00

abstract：:The opportunistic human pathogen Penicillium marneffei exhibits a temperature-dependent dimorphic switch. At 25 degrees, multinucleate, septate hyphae that can undergo differentiation to produce asexual spores (conidia) are produced. At 37 degrees hyphae undergo arthroconidiation to produce uninucleate yeast cells tha...

journal_title：Genetics

authors： Zuber S,Hynes MJ,Andrianopoulos A

更新日期：2003-06-01 00:00:00

abstract：:A locus is described in Drosophila melanogaster that modifies the expression of the white eye color gene. This trans-acting modifier reduces the expression of the white gene in the eye, but elevates the expression in other adult tissues. Because of the eye phenotype in which the expression of white is lessened but not...

journal_title：Genetics

authors： Birchler JA,Bhadra U,Rabinow L,Linsk R,Nguyen-Huynh AT

更新日期：1994-08-01 00:00:00

abstract：:In random mating autopolyploid populations which have not reached equilibrium, two alleles may be interdependent as a result of the phenomenon of gametic recombination, i.e. the maintenance through successive gamete generations of an association of two alleles from the same gamete in a source reference generation. Any...

journal_title：Genetics

authors： Gallais A

更新日期：1974-03-01 00:00:00

abstract：:Positive selection on a new mutant allele can increase the frequencies of closely linked alleles (through hitchhiking), as well as create linkage disequilibrium between them. Because this disequilibrium is induced by the selected allele, one may be able to identify loci under selection by measuring the influence of a ...

journal_title：Genetics

authors： Grote MN,Klitz W,Thomson G

更新日期：1998-11-01 00:00:00

abstract：:During segmentation of vertebrate embryos, somites form in accordance with a periodic pattern established by the segmentation clock. In the zebrafish (Danio rerio), the segmentation clock includes six hairy/enhancer of split-related (her/hes) genes, five of which oscillate due to negative autofeedback. The nonoscillat...

journal_title：Genetics

authors： Schwendinger-Schreck J,Kang Y,Holley SA

更新日期：2014-06-01 00:00:00

abstract：:The presence of large genomic regions with suppressed recombination (SR) is a key shared property of some sex- and mating-type determining (mat) chromosomes identified to date in animals, plants, and fungi. Why such regions form and how they evolve remain central questions in evolutionary genetics. The smut fungus Mic...

journal_title：Genetics

authors： Whittle CA,Votintseva A,Ridout K,Filatov DA

更新日期：2015-03-01 00:00:00

abstract：:Dauer formation in Caenorhabditis elegans is induced by chemosensation of high levels of a constitutively secreted pheromone. Seven genes defined by mutations that confer a dauer-formation constitutive phenotype (Daf-c) can be congruently divided into two groups by any of three criteria. Group 1 genes (daf-11 and daf-...

journal_title：Genetics

authors： Thomas JH,Birnby DA,Vowels JJ

更新日期：1993-08-01 00:00:00

abstract：:Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes during meiosis. Several models describing the molecular mechanism of meiotic recombination have been proposed. These models differ in the arrangement of heteroduplex DNA (hDNA) in recombination ...

journal_title：Genetics

authors： Radford SJ,Sabourin MM,McMahan S,Sekelsky J

更新日期：2007-05-01 00:00:00

abstract：:Stabilizing selection for an intermediate optimum is generally considered to deplete genetic variation in quantitative traits. However, conflicting results from various types of models have been obtained. While classical analyses assuming a large number of independent additive loci with individually small effects indi...

journal_title：Genetics

authors： Bürger R,Gimelfarb A

更新日期：1999-06-01 00:00:00

abstract：:Zinc plays many critical roles in biological systems: zinc bound to proteins has structural and catalytic functions, and zinc is proposed to act as a signaling molecule. Because zinc deficiency and excess result in toxicity, animals have evolved sophisticated mechanisms for zinc metabolism and homeostasis. However, th...

journal_title：Genetics

authors： Bruinsma JJ,Schneider DL,Davis DE,Kornfeld K

更新日期：2008-06-01 00:00:00

abstract：:Though much has been learned about the process of ovarian follicle maturation through studies of oogenesis in both vertebrate and invertebrate systems, less is known about how follicles form initially. In Drosophila, two somatic follicle stem cells (FSCs) in each ovariole give rise to all polar cells, stalk cells, and...

journal_title：Genetics

authors： Nystul T,Spradling A

更新日期：2010-02-01 00:00:00

abstract：:Host variation in Toll-like receptors and other innate immune signaling molecules alters infection susceptibility. However, only a portion of the variability observed in the innate immune response is accounted for by known genes in these pathways. Thus, the identification of additional genes that regulate the response...

journal_title：Genetics

authors： Alper S,Warg LA,De Arras L,Flatley BR,Davidson EJ,Adams J,Smith K,Wohlford-Lenane CL,McCray PB Jr,Pedersen BS,Schwartz DA,Yang IV

更新日期：2016-09-01 00:00:00